Andrew Huberman

Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable science-based tools for mental health, physical health, and performance.

I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.

And now my conversation with Dr. David Sinclair.

Thanks for being here.

I have a ton of questions for you about aging, longevity, lifespan, actionable protocols to increase how long we live, et cetera.

And I just want to start off with a very simple question.

What is aging?

the difference between longevity, anti-aging, and aging as a disease.

Because I associate you with the statement, aging is a disease.

That clarifies a lot for me.

Thank you.

Can we point to one specific general phenomenon in the body that underlies aging?

Well, tell us a little bit more about the epigenome.

Frame it for us, if you will.

And then we'll get into ways that one can adjust the epigenome in positive ways.

Are these changes the same sorts of changes that underlie the outward body surface manifestations of aging that most of us are familiar with?

Graying of the hair, wrinkling of the skin, drooping of the face?

Or are we talking about people that potentially are going to look older but simply live longer?

Very interesting.

I'd like to take a quick break and acknowledge one of our sponsors, David.