The Oprah Podcast
Oprah and Dr. Ania Jastreboff on How People Treat You Differently After Weight Loss
Tue, 21 Jan 2025
In this episode of The Oprah Podcast, Oprah continues her conversation with Dr. Ania Jastreboff, an endocrinologist and associate professor at the Yale School of Medicine, about the anti-obesity GLP-1 medications that are changing the world of weight loss. Oprah and Dr. Ania talk about what happens to a person’s mental health, body image and how the world treats them after losing a significant amount of weight. Joined by clinical psychologist Dr. Rachel Goldman, assistant professor at NYU Grossman School of Medicine, Oprah and Dr. Ania speak to people using the GLP-1 medications like long-time Harpo producer, Brian Piotrowicz, who reveals how people treat him differently now that he’s lost a significant amount of weight in a short period of time. Several other guests from across the country also share how their lives have changed after GLP-1 weight loss including a woman who lost over 160 pounds. Finally, we will get an update from several guests that appeared on the ABC Oprah Special: Shame, Blame and the Weight Loss Revolution including high school student Maggie who lost over 100 pounds. For more information on Dr. Rachel Goldman Follow Dr. Rachel on Instagram Follow Michaela on TikTok Follow Michaela on Instagram Follow Anna on Instagram Follow Jewell on TikTok Follow Jewell on Instagram Follow Jewell on YouTube Follow Marissa on Instagram Follow Marissa on TikTok Follow Oprah’s Producer Brian on Instagram Watch Part 1 Here. SUPPORT THE SHOW Subscribe: https://www.youtube.com/@Oprah Follow Oprah Winfrey on Social: Instagram Facebook TikTok Listen to the full podcast: Spotify Apple Podcasts #oprahsbookclub Learn more about your ad choices. Visit megaphone.fm/adchoices
Chapter 1: What are GLP-1 medications and how have they changed weight loss?
Both. You make yourself invisible and they don't see you either. So you're invisible on both sides of that coin. And it feels great. It feels so much better. I've always been kind, but it allows me to be even extra kindlier. Is that the word? Kindlier to people because I feel like it. Because I know I won't be shot down and I don't have to keep my head down.
Yes. And I'm just so thrilled for you, Brian. I'm just so thrilled and so happy for you and that you made the decision, really. It's a decision to save your own life and to lengthen your life and to live more productively, period.
Yeah, I'll never get off it. I thank you for the nudge. And, you know, I always get emotional, but I want to thank you. I'll have the opportunity because I do thank God twice a day for it. But to thank you because I know you've made ZipBound available to people like me. I know you've helped in that process. So, so grateful.
Bye.
Bye. All right. See you in the control room after. One half of U.S. adults are saying now that they would like to take a weight loss medication. And yet only 12% of Americans have ever taken one. I do think 12% is quite a lot in the past year because when I announced last January, I think... I was like an anomaly, an anomaly in that I was willing to say it. Yes.
And I remember Joseph, who does social media for me, said, all these haters are coming after you now. In a year, it will be normalized.
That's right. And you helped normalize it. You absolutely did. And then you came out again so... vulnerably, so bravely. And you shared your story. And again, your voice carries so much. And so I think the fact that people are embracing this now and shifting from shaming people from taking these medicines or for seeking treatment for their obesity, you've had such an incredible impact on that.
Well, I hope to continue to have an impact and let the haters hate on because, as I've shared before, my mother was an insulin-taking diabetic for most of her adult life. And if this were the dawning of insulin and I had a microphone to tell people what insulin could do for diabetics, that's what I would be doing. And I feel as strongly about that as I do about these obesity medications.
And if we had those obesity medications, perhaps you would not have developed diabetes in the first place.
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Chapter 2: How does losing weight affect self-image and mental health?
I asked you to repeat that because I know that that's going to resonate with a lot of people. When are you going to let someone else help you? And I say that to everybody who is in the struggle right now with obesity and If you could have fixed it, you would have. That's right. If it could have been fixed, because like Michaela and like myself, you've done every diet.
You've been through every program. You have boiled the soups. You have eaten the grapefruits. You have pulled the skin off the chicken and steamed that broccoli. If you could have done it, you would have done it.
Yes. A million percent. I tried everything just like you said. And now I'm 30. I feel like how I probably should have felt when I was 17. All of my comorbidities are gone every morning. And I just get to be me. I get to live my life. I get to eat. food and enjoy it and not wonder if I'm going to gain 20 pounds at the end of the week because of what I ate. I use food as fuel.
Just truly get to live my life. I feel like, Oprah, that I have been completely reborn. Like I am a new person altogether.
I'm so happy for you. I am really, truly happy for you because I see how beautiful you are. and how vibrantly you are now letting yourself be seen. You would not have worn that 165 pounds ago. You would not have even put on those earrings 165 pounds ago. I mean, I know. And I just, I rejoice in your newfound sense of self and sense of well-being.
I really do, because I know what the struggle is like. What's it been like for you being transitioning into this? I mean, 165 pounds over how much time?
It's been about two and a half years now.
Wow. You lost another full whole person in two and a half years. And I know people's reactions to you. It's unbelievable, right?
Yes. So I have truly, I wish I could say, oh my gosh, it's just been the most perfect experience ever.
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