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Huberman Lab

Essentials: Using Your Nervous System to Enhance Your Immune System

25 Sep 2025

Description

In this Huberman Lab Essentials episode, I explain how the immune system defends against infection and describe the relationship between the immune and nervous systems. I discuss the immune system's three primary layers of defense, emphasizing how each contributes to protection from infection. I share practical tools to enhance immune function and accelerate recovery from sickness, including specific breathing patterns, sleep positioning and targeted supplementation. I also explore the powerful mind-body connection, showing how mindset and nervous system activation can directly influence the body's ability to heal. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (0:00) Immune System & Nervous System (0:33) Immune System 101, Innate & Adaptive Immune Systems (8:03) Mucus & Microbiome, Tools: Nasal Breathing; Avoid Eyes; Ingest Fermented Foods (10:57) Sponsor: AG1 (12:04) Sickness Behavior & Vagus Nerve, Fever, Photophobia, Rest (16:43) Humoral Factors, Inflammatory Cytokines (18:14) Sleep & Enhancing Immune System, Glymphatic System, Tool: Elevate Feet (21:12) Sponsor: LMNT (22:44) Stress & Inflammation, Tool: Early Symptoms & Cyclic Hyperventilation (31:09) Positive Mindset & Immune Function, Dopamine (34:03) Electroacupuncture, Fascia, Catecholamines & Inflammation (36:22) Accelerating Recovery, Medication, Tool: Spirulina & Rhinitis (38:34) Recap & Key Takeaways Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

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Full Episode

0.031 - 17.033 Andrew Huberman

Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable science-based tools for mental health, physical health, and performance. I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.

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17.914 - 34.18 Andrew Huberman

Today, we are discussing the immune system, and we are also discussing how the nervous system can be used to activate and control the immune system. The first topic we have to attack is the question of what is the immune system and how does it work?

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34.2 - 62.399 Andrew Huberman

I'd like to just take a moment and do a sort of brief immune system 101, really simple, cover the basic elements of the immune system so that everyone listening or watching this can get a clear sense of how the immune system functions and what its basic parts are. It's actually really simple because it is truly elegant in design. you have three main layers of defense for your health.

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63.22 - 91.672 Andrew Huberman

And the first of those three is a physical barrier that we call your skin. And that might seem kind of obvious, but everything about you is contained in this compartment that is boundaried by your skin. If you've ever had a cut, you essentially have a breach of the boundary that is your immune system. still in category one, your body and your external surface, you have openings to that surface.

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91.872 - 108.683 Andrew Huberman

So what are those openings? Well, let's start at the top and work our way down. A primary site of potential infection are your eyes, You have your ears, you have your nostrils, you have your mouth, okay? Those are going to be the primary sites by which things can get into your system. And you need to put things into your system.

108.703 - 126.069 Andrew Huberman

You need to drink and eat, and you need to get light into your system. That's why you have those openings. And then of course, along the back of your throat, all the way down to your stomach and your digestive system and through your intestines and out your rectum, you have a tube. that you are basically a series of tubes.

126.109 - 138.527 Andrew Huberman

I've said that before in this podcast, and this is one such tube by which you extract nutrients from the outside environment. But all along that tube, including your nose and your mouth, it's lined with mucus.

138.948 - 156.592 Andrew Huberman

And while mucus might seem kind of gross to some of you, the more you learn about mucus, the more you realize that mucus is really, really cool because mucus essentially acts as a filter, as a trap. for bacteria and viruses, and it has certain ways of scrubbing or killing those bacteria and viruses.

157.413 - 180.755 Andrew Huberman

Now, inevitably, bacteria, viruses, and parasitic infections are going to make their way into our body, but whether or not they are killed off or whether or not they take over and cause us harm is going to be determined by layers two and three. So layers two and three are the so-called innate immune system and the adaptive immune system.

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