
Dhru Purohit Show
Birth Control Deep Dive: How it Changes Your Brain, Its Link to Autoimmune Conditions, and Why We Need Better Options with Sarah Hill Ph.D
Mon, 10 Feb 2025
This episode is brought to you by Cozy Earth, LMNT, and Lumebox. There’s no denying that birth control has given women greater freedom and control over their fertility. However, many young girls and women have been on birth control for decades without fully understanding the long-term effects of hormone-altering medication. Today’s guest shares her research on birth control and provides key insights into its potential impact on long-term health and wellness. Today on The Dhru Purohit Show, Dhru sits down with Dr. Sarah Hill to discuss the impact of birth control on women’s health and brain function. Dr. Hill shares her personal journey with birth control and how it led her to research this topic. She reveals what her findings say about the long-term effects of birth control on the brain and explores alternative options for women. She also explains why informed consent should include comprehensive education on birth control’s potential impacts. Dr. Hill discusses her hopes for the future of women’s health and highlights the research still needed to provide women with accessible, well-informed options for managing their health and fertility. Dr. Sarah Hill earned her PhD in evolutionary psychology from the University of Texas at Austin, where she studied under Dr. David Buss. She is currently a researcher and professor at TCU, the lead research advisor at 28, and a recognized thought leader in women’s hormones and sexual psychology. Her groundbreaking research has led to nearly 100 research publications. She is also the author of This Is Your Brain on Birth Control, which sheds critical new light on the psychological impact of women’s sex hormones and the birth control pill. Her upcoming book, The Period Brain, is set for release in September. In this episode, Dhru and Dr. Hill dive into: What Dr. Hill noticed after stopping birth control (00:25) The long-term impact of taking birth control (4:08) The benefits of birth control for women’s rights (12:20) The lack of fully informed consent in birth control decisions (16:06) Using birth control as a prescription for period problems (21:06) What happens to your brain on birth control (27:18) How birth control influences partner choice (38:15) The possible link between autoimmunity and birth control (44:15) Recommendations for young women considering birth control (51:15) Alternatives to birth control (54:15) The research we still need on birth control (59:25) Dr. Hill’s hope for more options for women (1:05:15) Also mentioned in this episode: Dr. Hill’s book This Is Your Brain on Birth Control: The Surprising Science of Women, Hormones, and the Law of Unintended Consequences For more on Dr. Hill, follow her on Instagram, Facebook, X/Twitter, LinkedIn, and her Website. This episode is brought to you by Cozy Earth, LMNT, and Lumebox. Right now, get 40% off your Cozy Earth sheets. Just head over to cozyearth.com/dhru and use code DHRUP. Right now, LMNT is offering my listeners a free sample pack with any purchase. Head over to drinkLMNT.com/dhru today. For 48 hours, from February 13th through 15th, Lumebox is offering my community $284 off their FDA-registered portable Red Light device! That's over 45% off! Go to thelumebox.com/dhru and get your Red Light device. Learn more about your ad choices. Visit megaphone.fm/adchoices
Chapter 1: What changes did Dr. Hill notice after stopping birth control?
Dr. Sarah Hill, you have a pretty wild story. Around the time your youngest child was around two years old, you stopped taking hormonal birth control. And at that point in time, for what I understand, you had been on the pill for about 10, 11 years. And when you stopped taking it, you noticed some pretty shocking changes. I'm going to hand it over to you. Can you pick up the story from there?
Yeah, I really had no idea that birth control was having any sort of an effect on me until I discontinued it. And because I was on it for, as you noted, besides the period I spent pregnant and lactating, I was on it pretty much nonstop for about 10 to 12 years. And while I was on it, I felt fine.
You know, I didn't have any major mental health breakdown or anything else that you sometimes hear that happens to women. But when I went off of it, I realized that I was different. And I realized this because when I went off at about three months after the fact, I noticed that I had more energy. And I was interested in sex a lot more than I used to be. And I was, like, noticing attractive men.
And I was...
Chapter 2: What is the long-term impact of taking birth control?
cooking and I was downloading new music on at that point it was like and it was like when iPods were still a thing I was like downloading new music on my iPod and I was cooking and it was like doing all these things that just were pleasurable um and doing them to an extent that I hadn't in a while and I just felt more vividly alive and I was like like what is this what is this and I'm like I wonder if this is because I went off of the birth control pill and
And, you know, I thought, well, maybe, but, you know, that sounds crazy. And so I kind of filed it away in the way that women do. You know, it's like we have something that happens to us and then we assume that it must be all in our head since we've been conditioned to believe that that's true from doctors from the time that we're pretty small.
But then flash forward, it was about a year later, and I was in a research talk where a researcher was talking about how the birth control pill leads women to have a blunted cortisol response to stress. And it was at that moment that I was like, oh, duh. Yeah. hormones affect everything. You know, it's like hormones are part of what our brain uses to create the experience of who we are.
So our brains affect or our hormones affect our personalities and our hormones affect other hormones like cortisol and hormones affect sexual desire and they affect who we're attracted to and they affect our energy levels. And like, of course, I felt different when I went off the pill. I was a different version of myself when I was on it.
And so it was at that moment that I had this really embarrassing epiphany. And I say that it's embarrassing because I've been studying women. You know, I've spent my career as a research psychologist studying women and studying the effects of different biological influences, including hormones, on motivational systems and the way that our brains work.
And I never put two and two together with the fact that I was changing my hormones with a pill. And then I felt so different. And so I had this embarrassing epiphany where I'm like, oh, my gosh, duh. You know, changing your hormones is going to change who you are.
And it was then that I went into the research literature and really started to dive in to try to better understand who do women become on the birth control pill. And that was what led me to write my book.
So we're going to unpack all that and we're going to jump around a little bit, but I want to start off with a topic that I know is something that you are very fascinated about. And I've seen people interview you and your own community and your Instagram comments.
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Chapter 3: How has birth control contributed to women's rights?
A lot of women in my age group that are listening to my podcast, who are in, let's say like the 40 to 60 age group, many of them are wondering why. that they started birth control early in their adolescence. And they're wondering, has that had any sort of lasting impact on their personality, on their brain, and maybe even some of the chronic conditions that they're dealing with?
What do you know about that topic?
What I know is far too little. And the reason I know far too little is because longitudinal research, looking at the impact of taking hormonal birth control early on in life and then staying on it for long periods of time is just not something that's being studied very much. And in fact, the number of studies looking at this particular question is teeny tiny.
Anything that I can tell you about this is going to be based on a very limited amount of research. Here's what we do know. We know that when women take hormonal birth control as adults, and I'm going to define an adult as being somebody who's about 20 or older, we know that the effects of hormonal birth control use are more or less, you know, sort of now you see it, now you don't, right?
Chapter 4: What is the issue with informed consent regarding birth control?
So while you're on it, you have the effects, you go off of it, and then within, you know, and sometimes it can be several months. So if you've been on it, say, for example, 10 years, and It might be a couple of months before your hormone receptors are kind of back to where they were because our hormone receptors change in response to hormone levels in the body.
And so it might take a couple of months for the body to kind of figure out what's going on again with the cycle. But given that the brain has been done developing by the time a woman started, chances are things should be relatively kind of quote unquote back to normal within some period of time. And like I said, for many women, it's within a month or two. For some women, it can be longer.
It can even be a year or so until their bodies kind of figure out what's going on. But those effects should reverse and kind of go back to normal or go back to baseline. For women who take it during adolescence, so when their brain is not done developing yet, we don't know. There's only been, and I use the word handful to mean only maybe five or six studies. Think about that for a minute.
Five or six studies. And this isn't all of science, you know. It's like in the whole body of all the science in the world. There's only about five or six studies that have really looked at what is the impact of hormonal birth control use while the brain is still developing on different types of outcomes over time. And there's just no way that it doesn't affect development.
We know that hormones play a really key role in the pubertal transition and all of the growth and development that goes on. During that sex hormone surge that you get during puberty and all of that that goes on through your late teens, early 20s. And so there's every reason to suspect that taking hormonal birth control could have a lasting impact on girls as they develop.
And there's some evidence that suggests that taking hormonal birth control during adolescence. So again, during this period when your brain is still developing. that this can lead to a heightened risk of major depressive disorder across your lifetime. So even after you've gone off of birth control.
But in terms of looking at other types of outcomes and even other types of age ranges, there's very little that's known. And so a lot of women ask, you know, is it possible that taking hormonal birth control, especially if they were taking it during adolescence, is that related to my pregnancy?
autoimmune disease or is that related to my sexual dysfunction or is that related to my dysregulation of my stress response and the answer to that is we don't know you know it's maybe because we just don't you know people really haven't taken birth control seriously and um and and when i say that i just mean that it's like you take it for this one specific cause and
You know, which is usually suppressing ovulation, so that way you prevent pregnancy. But ultimately, hormones have their fingers in the pot, you know, of almost all the systems in the body. And so it causes systemic effects. And nobody really spent a whole lot of time thinking about that.
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Chapter 5: How does birth control affect brain function?
haven't taken the issue very seriously they haven't taken the issue very seriously and there's also this component where in many of your interviews you have to share a disclaimer on your end that you know you are not against the women's rights movement right so let's get that disclaimer out of the way yeah tell us why you have to talk about it right? All right, here's a little secret.
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Chapter 6: What is the potential link between birth control and autoimmunity?
And so that way, each woman has all the information that she needs to be able to make a decision about whether or not this is something that makes sense for her at this point in her life. And so, you know, we have to recognize the importance of maintaining women's access to birth control while also at the same time saying it's not perfect.
I think what I've noticed is where a lot of women who start to take care of their health, they're in their 30s, maybe they've already had kids or they want to have kids in the future. And they're sort of unwinding and they're paying attention to different sources of media coming across your podcast interviews across the spectrum of all different types of podcasts you've been on.
There's this internal feeling that people have, again, this is just something that I've noticed, that, man, is there some sort of big cover-up going on?
Because if it really is about the trade-offs, why didn't anybody sit me down, this is the women that I'm hearing saying this, and tell me that there was a higher likelihood of, as an adolescent, taking birth control, taking the pill, that I could have anxiety, that I could have some lifelong changes that were in my brain that I could be suffering with low libido.
It doesn't mean that it happens with everybody, but how come nobody mentioned that to me? So is there some big conspiracy? Is there some big pharma conspiracy or what led to many women feeling like I didn't have informed consent?
So I'll say this. I don't think that there is a big pharma conspiracy. Do I think that the drug companies do a really good job of promoting research that makes it look like birth control has absolutely no side effects? Yeah, 100% they do. I mean, it's like when you look at who funds many of these studies that find no side effects, it's usually the drug companies.
So I've no doubt that there is a hand in That's being played by the drug companies in terms of contributing to this. But I don't think that there's a widespread conspiracy. Instead, what I think it is largely is the result of the fact that, you know, science and, you know, and this includes medical science, tends to have what we call in science is the silo problem.
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Chapter 7: What recommendations does Dr. Hill have for young women considering birth control?
And this is this tendency for different people. bands of research to just live within their own little research fiefdom, and then never to get outside of that fiefdom. So for example, neuroscience lives in one silo, right?
And so people who study the brain and study behavior, all of our research is published in these journals, and we read each other's journals, and we talk about each other's research. But we don't look at the research in the other silos, right? So we cardiac health, right? We don't look at the research in cognition. We don't look at the research in development, right?
It's like we look at this research over here in neuroscience. Medical science is the same way. So within the field of medicine, people who study medicine and clinical practice, they tend to look at medical research journals. And most medical research, when they're looking at the effects of pharmaceutical drugs, are interested in two questions. Safety, is it going to kill you?
Chapter 8: What alternatives to birth control are available?
And then efficacy, does it work? And these are obviously incredibly important questions when we're talking about drugs. We want to make sure that every drug that we take is safe and that it works. But there's a lot more to it than that. It's like the psychological effects of a medication are a big deal. And that tends to be in the field of neuroscience.
Neuroscientists study this stuff and psychologists study this stuff. And so that research is published over here in these journals. that most doctors have no familiarity with. Because the fact of the matter is, you know, medicine as a practice was something that was developed, you know, long before people realized that there was no mind-body split.
You know, it used to be thought that, you know, the body lived over here, right, and followed these sets of rules, and that the mind was this, you know, product of the soul and lived over and had these other sets of rules. And because of that, medicine has never really been integrated with psychological experiences.
And this is why you have a lot of medications that have psychological side effects. But that's all you get, right, is this will cause psychological side effects. It's like, what the hell does that mean? You know, it's like, there could be a personality change. That could be that you have no conscience anymore, which I've heard happens to some people on some antidepressants.
I mean, it could be a whole range of effects. And so what you get in your little birth control pamphlet is because people just put this down as a side effect, is, you know, any range of things, including, you know, lack of libido and things like, you know, inability to regulate your emotional responses or inability to cope with stress.
All of those are just put into a thing like sexual side effects and mood. You know, and so sometimes sometimes women are told about that. Sometimes they're not. And when they are told about it, it's usually in a very blanket way, like, oh, this might affect mood. But like, what does that mean?
And so they're not really told about this whole, you know, rich body of other research because their doctors aren't reading it. Right. And it's not because their doctors are terrible people who don't care. It's just that this is the way that things have been done in science since science has been, you know, something that people did.
And the result is that many women, when they're making decisions about going on birth control, don't have all of the information. Like, they don't actually understand the tradeoffs that they're going to be made. And again, you know, I do think that the drug companies are very...
intentional in trying to make sure that all of the messaging around birth control is about the positive things that it does, which it does a lot of really positive things. I mean, people go on it for a reason. It prevents pregnancy, it can clear up your skin, and it makes it where you don't have to worry about period problems, right? Because it suppresses your HPG axis.
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