In this episode of The Oprah Podcast, Oprah sits down with Dr. Ania Jastreboff, an endocrinologist and associate professor at the Yale School of Medicine, to talk about the new GLP-1 medications like Ozempic, Wegovy, Mounjaro and Zepbound. Dr. Ania, who has been on the forefront of GLP-1 medication research for the past 20 years, will talk through why it is biologically difficult for some people to lose weight, maintain weight loss and why obesity is a disease. She explains how the new GLP-1 medications work, how they can facilitate weight loss, and if they are safe. Dr. Ania answers questions from people around the country who are taking the GLP-medications and have lost a significant amount of weight. We will also share an update from Amy Kane who told her story of losing 160 pounds on weight loss medications last year on Oprah’s ABC Special: Shame, Blame and the Weight Loss Revolution. Also referenced in this episode: "The Let Them Theory: A Life-Changing Tool That Millions of People Can’t Stop Talking About" by Mel Robbins, published by Hay House LLC is available wherever books and audio books are sold. SUPPORT THE SHOW Subscribe: https://www.youtube.com/@Oprah Find Oprah’s Interview with Mel Robbins Here. Follow Amy on Instagram Follow Amy on TikTok Follow Emma on TikTok Follow Emma on Instagram Follow Oprah Winfrey on Social: Instagram Facebook Learn more about your ad choices. Visit megaphone.fm/adchoices
Chapter 1: What are GLP-1 medications and how do they work?
Right.
And they were wrong. And they were wrong. Now I know they were so wrong. Now I know why they were wrong.
When you're living it, it is so hard.
Yeah, of course, you blame yourself. It's so hard. And any person who's watching or listening to us right now who has suffered from obesity or being overweight, you know exactly what I'm talking about.
You do not have to be on television every day to experience the same level of shame and embarrassment and why can't I do this and I'm so good at so many other things and I can take charge of my life and I can do all of this and why can't I? Right. outside world telling you that you are less than, that you should be shamed, feels like the punishment you deserve.
And it's absolutely the opposite. It's absolutely the opposite. And none of this is in our control. Somehow in society, we think that how much we weigh is in our control. And it's not. It's not. Our brain is in control.
It's like the alcoholic finally realizing that it's not my willpower that caused me to not to be able to pick up the next drink.
Yeah. And just like with alcohol, those reward motivation pathways, those regions in the brain really respond in a certain way when someone who has alcohol use disorder is drinking alcohol. In terms of obesity, those are the same brain pathways. Now, obesity is not an addiction. the thoughts of food and the wanting of food, that is something different.
And again, that's- The food noise, we call that. It's a manifestation of the biology.
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Chapter 2: Why is obesity considered a disease?
Thank you. Dr. Anya, it's always a joy to talk to you. Thank you so much for being here. We value your expertise on this topic. It must feel rewarding for you that this moment has finally come and that these medications are being made available to so many people because you get to see it in your own patients.
Yeah, absolutely. I mean, I always say, people ask me, well, how did you know that you wanted to do this? The first time that I helped a patient lose a meaningful amount of weight for that person, I was like, I'm never doing anything ever again. This is it. And I'm so grateful that I get to do this. And I'm so grateful that patients trust me. They trust me to care for them.
And, again, I couldn't imagine doing anything else.
Well, I can see how rewarding it is because you have people saying, I got my life back.
Yeah.
I got my life back.
Absolutely. And, again, it's, you know, there's good and bad things about everything, everything in life. These medicines are right now what we're seeing. They're helping people transform their lives in so many ways in terms of their health, in terms of their overall life. They're just really incredible in terms of helping people.
Well, I want to thank you, Amy. Thank you, Amina. Thank you, Emma. Thank you for all of our guests sharing your stories. Go well, everybody. Thank you for making time to be with me today. I really hope that you join me for part two of this conversation as we continue to see how these new medications result in dramatic loss of weight, almost the equivalent of an entire person.
You've lost 165 pounds. Wow. Congratulations. So what happens in the aftermath of that? The doctor said to me, when are you going to stop blaming yourself and let somebody help you? When you lose up to 100 pounds or more, do people treat you differently? Everyone was so much friendlier to me. How does that impact how you see yourself in the world and even within your own family?
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