The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Sat, 08 Feb 2025
Tune in to The Dylan Gemelli Podcast featuring Dr. Scott Sherr! Dr. Scott Sherr is a Board-Certified Internal Medicine Physician Certified to Practice Health Optimization Medicine (HOMe) and a specialist in Hyperbaric Oxygen Therapy (HBOT). Prepare to be EDUCATED! Dr. Scott Sherr dives deep into a variety of widely important topics from Methylene Blue, to Hyperbaric Oxygen Therapy. Dylan and Dr. Scott have a deep discussion about cellular and mitochondrial health, metabolomics, understanding the GABA system and so much more!! DO NOT MISS THIS EPISODE!! Follow Dr.. Scott Sherr on Instagram@drscottsherrCheck out Dr. Scott on A4Mhttps://www.a4m.com/scott-sherr.htmlMAKE SURE to visit the Troscriptions website https://troscriptions.com/?utm_source=DylanGimelli&utm_medium=podcast&utm_campaign=PodcastWithScottSherrUSE COUPON CODE Gemelli to save!! ______________________________________________________________________Follow Dylan on Instagram, Facebook, Twitter and Tiktok @dylangemelliHuge thank you to everyone for the support! Please make sure to subscribe, like and comment!!Email [email protected]://rss.com/podcasts/the-dylan-gemelli-podcastApplehttps://podcasts.apple.com/us/podcast/the-dylan-gemelli-podcast/id1780873400I Hearthttps://www.iheart.com/podcast/269-the-dylan-gemelli-podcast-249695201/Spotifyhttps://open.spotify.com/show/3In4QlJj4IvHqq0eduKj7mPandorahttps://www.pandora.com/podcast/the-dylan-gemelli-podcast/PC:1001096187Stitcherhttps://www.stitcher.com/show/1096187FM Playerhttps://player.fm/series/the-dylan-gemelli-podcastPodchaserhttps://www.podchaser.com/podcasts/the-dylan-gemelli-podcast-5933919Listen Noteshttps://www.listennotes.com/podcasts/the-dylan-gemelli-podcast-dylan-gemelli-HDjBueWOVvG
Chapter 1: Who is Dr. Scott Sherr and what are his qualifications?
All right, everybody, welcome back to the Dylan Gemelli podcast. So if I was to put the term podcast Wealth of knowledge on my guest today, that would be far, far, far too low of a compliment. This man does it all, and I am extremely impressed. He is, well, he's an internal medicine physician. He is a certified health optimization medicine. He's certified for hyperbaric oxygen therapy.
He is the Troscriptions COO, and he is the chief medical officer and founder of One Base Health. And there's a lot more that I'm going to let him get into. But my friends, this is Dr. Scott Scherr. Good to see you, Dylan. Thank you for having me. Welcome, man. I appreciate you taking the time.
I told you beforehand how enthralled I was in your work and your videos, and we have a ton to talk about today. So I want to make sure that we utilize the time that I have you. So let's just kind of start with, I'm curious why you chose the route you went, what brought you into all of these things that you're doing? What fascinated you and what got you started? What was your motivational factors?
Chapter 2: What motivated Dr. Sherr to pursue a career in health optimization?
Well, I have a pretty crazy father is what it comes down to. So he's a chiropractor on Long Island. His name is Dr. Alan Scher. He's been in practice for 45 years and he sees 800 patients per week. So anyway, you kind of swing that if you can think of how many hours and how much time. He is a machine of significant capacity, to say the least. But what I learned from a very young age was that
Healing didn't happen immediately. Healing happened over time, but there were many things that you could do outside of the box because I didn't even know what conventional medicine was until I was almost going to medical school, to be honest, at least through high school until getting out of the house and going to UCLA for undergrad.
So my framework was always one that was very much, there was no real box of what could be, what was possible. what you could do, the various aspects of health were very different for me. And I decided to go to medical school after having conversations with my father when I was younger and also getting more experience, realizing that there's a lot of necessity for conventional medicine too.
But understanding that there was this chasm between, at that time, alternative medicine and allopathic or conventional medicine, there was really nothing in between. There's no such thing as integrative medicine anymore. really when I went to medical school.
There's no such thing as functional medicine, or maybe it was just getting started when I went to medical school in 2003 was my first year of medical training. So I decided to go to medical school with the high-minded idea of bridging that chasm, finding a way to kind of learn the conventional realms of medicine, but at the same time, keeping true to my foundation, which was my upbringing.
I grew up in my father's office, playing and doing coloring in the front. And then I was at the front desk collecting money when I was in high school and he was giving me cash under the table so I could go out with my friends. This was kind of my life for many, many years, obviously. I was adjusted when I was like a couple hours old. That's kind of the framework that you have to think about for me.
And so when I evolved my practice after finishing medical school and residency as an internal medicine physician, it really was under the frame of, well, how can I really truly help people work on their health in a foundational way? And that really evolved over many years through the fields of hyperbaric oxygen therapy,
to meeting a fantastic mentor that created something called Health Optimization Medicine and Practice, which he had, Dr. Ted Achikosa was his name, which he developed in his own practice and then was bringing here into the United States from Manila in the Philippines where he was born and had a practice there, along with DC and Europe as well.
It was a nonprofit organization that we incorporated in 2017 to train practitioners on his framework, which became the framework that I use in clinical practice. And so my evolution has sort of been in that realm, which is alternative, conventional, bringing these together, creating my own integrative practice in the image of things that were really interesting to me as I evolved.
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Chapter 3: Why is mitochondrial health critical for overall wellbeing?
And this was the foundation that I was able to lay and now have in clinical practice where I work with people that don't even go into hyperbaric chambers anymore and then just do the foundational work with me. because that is the main thing.
And that's like, I always talk about now how hyperbaric therapy is kind of my smoke screen, because if you were coming to see me, Dylan, you're like, hey, Dr. Scott, I have migraines and you wanted to consult with me. We would spend 30 minutes or an hour speaking about that. And 90% of what I spoke to you about would have nothing to do with hyperbaric therapy at all.
It would be about foundational principles, which are part of our nonprofit, like your metabolomics, your chronobiology, your circadian rhythms, your gut, your toxic exposure, et cetera. We have seven pillars in total. And so that's what I'd be spending most of my time doing with you. And then at the end of it, I'd be like, well,
hyperbaric therapy could be helpful, but let's do all of this stuff first within the framework that this really fits in for the long-term, right? Because we want all long-term benefit.
And the other thing I found in hyperbaric medicine was that if you didn't work on this foundation first, the benefits may not be as awesome initially, but certainly long-term, you would not see the benefits that you would otherwise see if you worked on the foundation first.
Love that. That's a That is, and anybody listening, and if it's too much, too quick, basically, it's like essentially saying, get yourself ready first before you go and do something. This is what I run into with a lot of people that I, once again, I'm going to relate it to some of my audience. The people that get upset with me that they want to run X, Y, and Z compound.
And I say, look, you're not ready to run it yet. You're not in the right condition. You're not the right age. I mean, there's certain things that go along with it. And it's just the same thing that Dr. Scott is saying. If you're not ready for it yet, it's not going to be beneficial for you or you're not going to get what you need out of it. Just so everyone understands. It's the same thing.
Yeah. You want to be able to walk before you run. I mean, I had one child that's my, I think my, I have four kids. My third daughter was trying to run after her, her two sisters before she could walk. That was not going well for her, right? She would fall a lot. So as an example, okay.
And so, but I mean, there are tools and techniques and things that you can use though, that might be helpful in the short term. And so Home Hope or Health Optimization Medicine in Practice is the nonprofit developed a for-profit company called Transcriptions, which is a company that helps people right now while they're on the longer path to optimizing their health.
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Chapter 4: How does hyperbaric oxygen therapy work and what are its benefits?
And so we worked on these various sort of targeted aspects of health, targeted aspects of these pain points for people that would be able to kind of bring them over the humps and be able to keep on the process of of health optimization.
And then I can use hyperbaric therapy in that context too, but only really in that context, unless, and this is the caveat, is that if you have an acute issue, hyperbaric therapy is fantastic, right?
If you have an acute trauma, acute inflammation, a surgery, like it's going to work really fast with your body to make you feel better and more efficiently heal, no doubt about it, like 30 to 70% faster. But if it's a chronic issue, then this is where this framework really is the most important for me.
So let's just say somebody's got like tennis elbow or some kind of arthritis or some kind of nagging injury. Would the hyperbaric chamber be ideal for them? Would that be helpful or would that kind of be something that you would go another route with?
Well, it depends. So like a tennis elbow, that's something that's relatively acute, then hyperbaric therapy can be very helpful for that. If it's more of like a hip osteoarthritis or a knee osteoarthritis, I have seen hyperbaric therapy. I remember this one patient of mine, she was probably 87 and she was in great health, but she had really bad knees.
And there's not a lot of data that hyperbaric therapy for arthritis can be very effective, but there is an inflammatory component. Let's try it. Let's try it. Right. And so we gave, she just did like three hyperbaric sessions. She felt like a new lady and she felt fantastic. And I didn't see her again for a year when she came back, when her symptoms came back.
But she's like, my knee pain's back and I come back for three treatments, which is very unusual. Usually if you have like a chronic issue, it's going to take you much more hyperbaric therapy to see the benefit. But she was one of these hyper responders that I wish we could study. But She just did three hyperbaric sessions and her arthritis was gone.
Now, in general, though, if it's a chronic issue, if it's a chronic, like for example, mild cognitive impairment, dementia, like these are not things that happened overnight, right? There's a lot of things that are going on there. So you're looking at much more hyperbaric therapy to see the benefit in general than just a couple of treatments here or there.
And a much more comprehensive approach, like we've been talking about here, like with the foundation that we have, the health optimization medicine framework, it's certainly one framework. It's a very different than
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Chapter 5: What is the role of metabolomics in health optimization?
And we've seen this before, and it's pretty well studied in the sense that this kind of goes to the conversation of these chronic viral syndromes, chronic Lyme even, and things like that. where if you can improve the immune system itself, you can often see the body kind of take care of itself in the sense that oftentimes, you're never going to have this virus completely go away.
If it's an HSV virus, if it's a herpes zoster, or if it's a varicella virus, et cetera, these things stay in our nervous systems and they are... once we're infected with them, they're not going to go away completely. The cure is a very difficult word here, but can your immune system fully suppress these and make them so they're inactive? The answer is absolutely, right?
And so once the immune system takes a hit, that's when you see the viral reactivations happening of HSV and EBV and you have the zoster and you have Even Lyme, that wasn't an issue before, causing an issue because the immune system got so trounced.
And this became a really big issue and still is now because of severe COVID infections across the world for the three or four years that that was happening. Because that was a huge immune system hit for so many people that they had this sort of post, suddenly they had mold, suddenly they had Lyme.
A lot of this had to do with a leaky gut and a leaky brain that happened because of the inflammation and things that were kind of walled off or being suppressed by the immune system were unable to be done, unable to be walled off and suppressed any further.
And so addressing the foundation of all this stuff is going back to working on the immune system, working on the gut where 80% of our immune system lives anyway. So if you're working on the gut, you're working on 80% of your immune system right there. So the gut is a primary source target here when we're talking about immune system optimization.
And so that's kind of where I would be thinking about going. And that's kind of my sense here is that if you're optimizing immune system function you're going to optimize for viral reactivations, you're going to be preventing viral reactivations, or you're going to be suppressing viral load if you improve immune system function. And so hyperbaric therapy can be a helpful tool here, right?
It can be a helpful tool to do that. It decreases inflammation in the system. It can help optimize the immune system if you have all the machinery and capacity to be able to do that. And again, that's how I always like to remind people that you need to have that machinery. Otherwise, you're not going to see the benefit as much in the hyperbaric chamber.
I'm not sure if you do any of this, write prescriptions for this at all, but theoretically, I'm just thinking in my head, would a combination of like BPC-157 with the hyperbaric chamber, would that be a good combination for healing? And do you do anything like that or have you seen anything like that?
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Chapter 6: How can methylene blue support mitochondrial function?
And if you have some support to mitochondrial function, then they can start regenerating themselves and they can start having the whole system shift from an inflammatory immune system going crazy state to anti-inflammatory immune system modulation state where things are more able to be controlled by our immune system because our mitochondria are working better.
And so I use a lot of methylene blue in this capacity to decrease inflammation, improve energy production. This is where we have a bunch of transcriptions products, as you know, that have methylene blue in them. We have another version, we have another type of product that's based off the cordyceps mushroom and the active ingredient in that is something called cordycepin, which is highly potent.
We use it because it works on the adenosine system. Adenosine is the system that helps you make energy, but also helps you feel sleepy. So it increases your deep sleep when you take high doses of cordycepin at night, but also it's a profound anti-inflammatory. So it works on things like mTOR and the NF-kappa-B pathways and AMPK and things like that that helps modulate the immune system that way.
So as we were kind of alluding to all here is that many people have been sick for a long time and want to feel better, like you said, Dylan, right away with a pill or a potion or an exercise or whatever that's going to make them be able to do. But it's very difficult It takes time.
And so, and while you're kind of working on that foundation, having tools and techniques, it really can be very helpful. Something like methylene blue can be very helpful. Cordycepic can be very helpful working on the GABA system. So I do all these things and then, It's about stacking, like the biohacking kind of thing, but stacking in a methodical relationship.
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Chapter 7: What are the implications of mitochondrial dysfunction?
So it's not like, here's everything on day one. No, let's see how you do for a couple of weeks or a couple of months doing X, then add Y, then add Z, or start at A and add to Z if you need to. But it's about a stepwise, intentional way of working with people and not just throwing shit at the wall, unless you absolutely need to if it's like an acute issue.
But in general, let's not throw shit at the wall. Let's be more methodical about things.
Yes, I love that. And I did this myself. I found out about something genetic with my heart, with my LP little a, and then I threw every fucking thing I possibly could at it. And while I got that number to drop drastically, it was like Rob Peter to pay Paul. My liver value shot up. My kidney value shot up because I was doing way too much shit.
And that's why it's like what you said, test a little bit, see how it goes, then move forward and keep going. So I love that because... A lot of us have the tendency to just panic and just want to throw the kitchen sink at it.
Not good. Yeah, well, we have a different term here. Health optimization medicine and practice is the nonprofit or home hope. And Dr. Ted has created this word called Well, I think that the background here is there's something called the holobiont. Have you heard of the holobiont before? No. So the holobiont is a cool word. It basically means that we are a holo-organism in ourselves.
We're not just made up of human cells. We're made up of bacteria, virus, fungus, and we are made up of the food and the light and the environment and the toxicity and everything else is all holobiont. us. We're not just human. In fact, we're outnumbered. In fact, with all the other types of cells that are in us, the trillions of bacteria, fungus, and virus. So this whole organism is us.
So we're not, I'm not you, you're not me. We're all different. So we're not individuals just in a population and ecosystem of outside in the world, but around us, we have our aura of everything happening inside. So we can test all this using metabolomics, but the word holobiont is what we're testing here.
We're testing the exogenous things outside the environment, endogenous, the things that are happening inside the environment. And so we call this, this is a study of holobiontology. And instead of being biohackers, as many people say they are, in our world, we're biont hackers, B-I-O-N-T hackers, holobiont hackers, because we're
we're hacking our own biology using a intentional framework called metabolomics to look at all these pillars of health optimization, medicine, and practice in a holistic way. So that is the difference, right? So we're not just throwing shit at the wall and seeing what like cool supplement or cool technology or look at the score or look at there, look at there.
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Chapter 8: How does the holobiont concept relate to health optimization?
It was also used in laboratory staining in chemistry labs. And this is actually how I first learned about it when I was in college. And the interesting thing about where it stains the cell is not surprisingly in the mitochondria itself. And so it concentrates in the mitochondria.
And so over the last several decades, there's been a lot of interest in what's actually happening with methylene blue in the mitochondria. And why is it concentrating in there? What's happening? And so what we now know is that methylene blue at very low doses, you know, 4, 8, 16, 25 milligrams is a fantastic mitochondrial optimizer. And it has a very cool effect, which is very unusual.
And it's called the redox cycler. What that means is that it helps you make energy. It helps you make ATP, the energy currency. And it can do this even if some of the mitochondria isn't working very well.
Even if some of the complexes that are responsible for you being able to make energy in the mitochondria are not working as well as they're supposed to, you can still compensate for that using methylene blue. Now, on the other end of it, it's also working as an antioxidant. So it can actually pick up free radicals or oxidative stress. And so there's very few compounds out there that can do both.
They help you can not only increase the amount of energy you're making, but also help with the detoxification capacity at the same time. So these low doses are extremely potent at working in the mitochondria. There's also some effects on how well methylene blue can be carried, excuse me, how oxygen can be carried on red blood cells.
Red blood cells, by the way, are the only cells in our body that do not have mitochondria. That's a fun fact. But the red blood cells carry oxygen, as we all know, and that methylene blue helps that become more efficient. And at the same time, methylene blue is working at the neurotransmitter level, helping improve your mood and your focus by increasing norepinephrine, serotonin, dopamine together.
At these low doses, it could be fantastically potent as a mitochondrial optimizer, as a mood booster, as an energy enhancer.
And then at higher doses, around a milligram per kilogram, a little bit more, definitely a little bit higher sometimes, a little bit more, like one or two milligrams per kilogram, and sometimes a little bit lower than one milligram per kilogram, you get an anti-infective capacity to it.
So it's an antiviral, it's an antifungal, it's an antibacterial, it's used previously for urinary tract infections and other infections, but also still used that way in many countries around the world. And then even becoming more used again for malaria,
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