Dr. Scott Sherr
Appearances
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
and even hormones over time because it's stimulating the system, it's clocking the system without giving it the support that methylene blue can do at the same time. The amazing thing about methylene blue is that not only is it enhancing production of energy, but it's also helping you with the detoxification side.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Most nootropics are going to be, at least the classic nootropics that we think of, are going to be giving you more energy and more focus, but they're not going to be giving you the supportive detoxification side of things as well. Now, this isn't always the case.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
If you're using caffeine, of course, in coffee, caffeine and coffee also has polyphenols, which are also going to be supportive and antioxidant at the same time as you're drinking the caffeine that's in the coffee or in tea, for example. So it's not always the case that a nootropic that's stimulating you is only going to have that capacity. In fact, coffee is great for that reason.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And tea is that great for that reason as well. What's also nice about tea, for example, a lot of tea has L-theanine in it, right? L-theanine is something that works on the GABA side of life as well. If you are supporting the GABA side, which GABA is a neurotransmitter that helps relax the brain, calm down the firing of the brain.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
and increase the what's called the parasympathetic nervous system or the rest relax digest recover nervous system then that's also going to be supportive as well as tea and coffee are great examples of nootropics that can be used over the long term because they have antioxidants in them at the same time so i'm a big fan of using methylene blue regularly especially in my clients and patients because it's a great way
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
to support that mitochondrial function. And as you described, John, what you'll find when you take it, when you find the right dose, is that you feel like you have just brighter focus. You have a little bit more endurance. You just feel like you can sustain yourself for longer.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And even on the other side of this, like on the athletic side, endurance, elite athletes, I've been working with a lot more of them using methylene blue because it can help in that capacity. In fact, I just worked with somebody recently that ran the Leadville ultra marathon race over here in Colorado. That's a hundred miles through, I think 12,000, 13,000 foot peaks. This is an intense race.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
It's takes a long time and I work with somebody and we were using This time around, we used methylene blue for him, 36 milligrams every four hours. And he shaved three hours off of his time versus the year before. And there were certain other things that we did as well.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
We supported his, actually his GI system a little bit better using an amino acid called glutamine, which we can talk about if you're interested. But in essence, the methylene blue was able to increase his endurance capacity because he was allowed, he was able to maintain his heart rate for longer without having to slow down.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
This is because methylene blue can act just like oxygen in the cells and become that final electron acceptor. So you can maintain an elevated heart rate for longer when you have methylene blue around because you have the extra capacity, the extra aerobic capacity as well.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
As I was describing, GABA-aminobutyric acid is one of our primary inhibitory or relaxing neurotransmitters in our brain. And it's the unsung hero of the brain, John. Most people think of the superstar neurotransmitters when we're thinking about the brain or neurotransmitters in general. We're thinking about dopamine, norepinephrine, and serotonin.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And these are important, obviously, but in much smaller quantities compared to how much GABA we have in the brain.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
and so methylene blue itself actually works on a system called the monoamine inhibitory system so it actually prevents the breakdown of norepinephrine dopamine and serotonin and so as a result of this you get more of those neurotransmitters and you get a mood boost as a result of having more of those neurotransmitters around you get more focus a little bit more
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
endurance just because of that piece as well. But the key also is to understand that not only do we wanna be on and focused and energized, we also wanna have time to rest, recover, detox and digest our food. And so it's very important to be thinking about the GABA system. And the problem in our world, in America especially, is that we're a hustle culture as John. We wanna be on all the time.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
We wanna be hustling all the time. It's very difficult for us to just shut down and relax. And that's the responsibility of the GABA system. And so a lot of my focus these days with my patients and the work that I do is okay, let's support mitochondrial function. Let's improve your performance.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
But at the same time, how are we going to support this GABAergic system in the brain that is so important for us to rest, recover, relax, digest, and detox.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Ah, so this is a great question. And this is one actually I talk to a lot of my fellow clinicians about because what it comes down to is that GABA deficiency is so prevalent and most of us have no idea that we're GABA deficient. If you're anxious, if you have anxiety, it's very likely that GABA is playing a role here and your GABA deficiency may be a part of this.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
If you have depression, GABA is often a cause of depression and rumination or perseverating thoughts. Do you have trouble sleeping? If you have trouble sleeping, GABA may be also involved here because GABA is here to help you relax, recover and rejuvenate. Other kinds of things, anxiety, fear, depression, short temper, phobias.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
impulsiveness, disorganization, addictions, migraines, and insomnia, they're all associated with GABA deficiency. And if you're having some of these symptoms, it could be that you're GABA deficient and don't know it. Unfortunately, Most clinicians aren't going that route.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
If you have anxiety, they're thinking about giving you maybe something that affects the GABA system, like a benzodiazepine, like Xanax or Ativan or Valium, but they're not thinking about how you can support the GABA system so that you can work on your anxiety without using those potential very challenging and very addictive medications. The same thing goes with depression.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
We know now that depression is not a serotonin deficiency. Certainly we know that taking something like an SSRI can be helpful in patients with depression. There's no doubt about that. There's good studies to show that, but we also know that depression is not a serotonin deficiency. This is actually something that came out over the last couple of years.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And it's shocking in the sense that we thought we were giving a medicine to help with depression because people had a serotonin deficiency, but they do not. However, do these patients have a GABA deficiency? The answer is very likely possible. In fact, a new drug was just approved over the last six months to be used in postpartum depression.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And it's a GABA-A agonist, meaning it works on the GABA system and it works extremely fast. Unlike SSRIs and SNRIs, these other newer generation antidepressants, GABA medications work very fast to optimize the inhibitory side of the brain. And what's also interesting as well is that if you have anxiety or depression, you have about double the number of thoughts that an average person has in a day.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Now, the average person in a day has about 70,000 thoughts per day. If you're anxious or you're depressed, you have 120, 140,000 thoughts per day. Please don't believe everything that you think. This is a lot of thoughts, John. And so what the GABAergic system is doing, GABA is doing, it's like the gate. It's the waylay station. They're called interneurons, I-N-T-E-R, neurons.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
They are the gate between the sensory information that's coming from the rest of the world and our brain and our processing. So if you can imagine, if we were processing and trying to process at least all the stuff that was coming into our brains or into our senses at any moment, it would be hugely overwhelming.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So the problem with people with GABA deficiency is that they start being unable to process all that information. They just have too much going on. They don't know how to gate that information. They get anxiety, they get depression, they get insomnia and everything else.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
As far as we have here understanding that the GABA system is responsible for regulating mood, regulating our cognitive stability. Like the GABA deficiency side is likely very much playing a role here, but it just, as far as I'm aware, hasn't really been studied in the sense that can you optimize somebody's GABA system and make them not suicidal?
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
The answer is probably yes, because if you're regulating their mood and you're regulating their anxiety and their thought patterns and being able to decrease those thoughts from 120,000 thoughts to 70,000 thoughts, you likely are going to see significant benefit. And it all goes together, right?
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
In the sense that if you're looking at suicide, you're looking at people with severe depression, with severe PTSD, with severe anxiety that aren't able to create any distance or any space from the thoughts that are in their mind. It's one thing that, you know, it's very important is to help people realize that
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
the thoughts in their mind are not them, but it's very difficult to be able to demonstrate that to people when their mind is going so fast or when they're down so down so deep. And so what I've seen at least is that if you can enhance the GABA system, you can regulate the flow of information better, you can slow down those thought processes, then you can have the conversation with people and
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
bring in a new perspective. And that's actually, it's a very important perspective. And one that I think is very impactful is just to remind people that they are not their thoughts, that thoughts are happening in their mind, but there's some other part of their brain that's not having those thoughts at the same time.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So if they're having another part of their brain not have those thoughts at the same time, then they can't be those thoughts. There's something else that they have to be if they can observe those thoughts and observe the part of their brain that's not having those thoughts at the same time. And it's like this, it's like sort of meditation ninja in some ways.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
It's like in a sense of trying to, but that's really difficult and really difficult in people that are so down or so anxious, right? So that's why like enhancing the GABA system, it's like turning off anxiety or shutting it down 50% can be huge to have this kind of conversation. So I think it very much plays into all of them.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So when it comes to epilepsy specifically, GABA regulates the flow of information within neurons and neural networks. And so what happens with epilepsy is that there is an overabundance of this other neurotransmitter that's always in a balance with GABA. So it's called glutamate. So glutamate is your primary excitatory neurotransmitter. And GABA is your primary inhibitory neurotransmitter.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And they're always in a balance. And in fact, glutamate actually turns in to GABA in the brain. There's very little GABA outside of your brain itself. And so glutamate, again, your excitatory neurotransmitter has to be in balance and actually convert into GABA in the brain. You need two cofactors to be able to do this, magnesium and vitamin B6. So if you're magnesium deficient,
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
you're gonna have a hard time converting. If you are B6 deficient, you're also gonna have a hard time converting that glutamate to GABA. So what happens in epilepsy and a lot of these other conditions as well is that you have an overabundance of this glutamate. And so glutamate is excitatory. It makes you feel on, it makes you feel connected.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
It makes you feel like you have control of like your executive function. You can think and think clearly and think fast. And the problem also though, but if you have too much, glutamate causes excitotoxicity, causes too much excitability in the brain, it can cause seizures. So one of the main reasons why people have seizures is as a glutamate toxicity and a glutamate overload.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And getting more GABA involved can be very effective here. And this is why a lot of the drugs that are involved in treating epilepsy are working on the GABA receptors themselves things like gabapentin for example which is a drug that works on the GABA receptors in a pretty novel way and actually we don't really understand exactly how that drug particularly works but that's an example of that
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
There's also some degeneration in Parkinson's and in Huntington's as well that you were describing that's also affecting the glutamate and the GABA balance. And that's why you get choreic movements with Huntington's, which is like these movements that Huntington's patients will make are because of a imbalance between your glutamate and your GABA levels.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And so this is what's happening in Parkinson's we think as well. There's also some studies that show that there's a dysregulation of the GABA neurons as well in schizophrenia at the same time. If you have an imbalance between your glutamate and your GABA systems, you're going to have excitability of the brain that is hard to control.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
It can be disease pathology like Parkinson's, Huntington's, schizophrenia, but it can also be in mental health time kinds of conditions as we were describing. depression, anxiety, insomnia, irritability, tremors as well. So all these can be a part of agglutamate overabundance versus GABA deficiency. And it's that GABA deficiency that we really need to focus on more.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
brain or neurotransmitters in general we're thinking about dopamine norepinephrine and serotonin and these are important obviously but in much smaller quantities compared to how much gaba we have in the brain methylene blue itself actually works on a system called the monoamine inhibitory system it actually prevents the breakdown of norepinephrine dopamine and serotonin as a result of this you get more of those neurotransmitters and you get a mood boost you get more focus a little bit more
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Yes, of course. And so those are the two main types of GABA receptors. GABA-A is the more common one. GABA-B is also very common. So GABA-A receptors have what are called these subunits. They have five subunits on them that change depending on where they are in the brain. GABA-A receptors are everywhere in the brain, but some are more focused on anxiety relief. Some are more focused on sleep.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Some are more focused on sensorial gating, like in the thalamic area, for example. The thalamus has lots of GABA-A receptors. And so the GABA-A receptor, the way it works is that it has a central channel called a chloride channel. And what happens is when GABA binds to the receptor, this channel opens. When this channel opens, chloride channels go, the chloride goes in.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Sorry, the chloride goes out, excuse me. Chloride goes out. And when the chloride goes out, what happens is that the GABA receptor and the GABA receptor itself, which is on a neuron, remember, is going to what's called hyperpolarize, which means that it stops firing. So that's what happens here. So I misspoke. So chloride's going in, not out. Okay, so chloride's going into the channel.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So GABA-A receptors have chloride channels that chloride goes in. It hyperpolarizes the membrane there that the receptor is in. And as a result of that, the neuron that's on what's called the postsynaptic side stops firing. So that's why it's called an inhibitory neurotransmitter because when GABA binds to its site, it opens up the receptor.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
GABA aminobutyric acid is one of our primary inhibitory or relaxing neurotransmitters in our brain. And it's the unsung hero of the brain, John. Most people think of the superstar neurotransmitters when we're thinking about
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
It prevents the firing of the neuron on that postsynaptic side. So most of the drugs that we know of affect the GABA receptor, the GABA-A receptor, and most of the drugs don't bind to where GABA binds, but they bind on what are these called, these allosteric sites, these sites around on those subunits that either enhance the affinity for GABA to bind or decrease the affinity for GABA to bind.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
The most common one that all of us know about that we have on a regular basis across the United States and the world is alcohol. Alcohol binds to an allosteric site on the GABA-A receptor, increasing the affinity for GABA to bind, increasing the chloride going in, and inhibiting that neurotransmitter, inhibiting that neuron from firing. There's lots of other ones that we can talk about.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
There's lots of drugs. There's lots of natural plants that do it as well. But we can talk about, I think, that in a little bit. When it comes down to the GABA-B receptor, GABA-B is a little bit different. GABA-B is called a G protein couple receptor. And it just basically means it has something on the presynaptic side and the postsynaptic side that are working together.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Calcium, potassium, those are the electrolytes that are going on there. And that basically has the capacity to decrease the firing of that postsynaptic neuron as well. So the major drug that works on the GABA-B receptor that most people know of is baclofen. which is an antispasmodic drug. So it works mainly in the spinal cord actually to decrease spasm of muscles.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And the other drug that's very commonly used or not very commonly used, but very commonly known as the date rate drug is GHB or gamma hydroxybutyric acid, which is GHB. And this is a, it's known as a date right drug, but it's actually a really great drug used for spasm, used for narcolepsy, used for sleep as well. And so it's got some medical benefit.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So you have your GABA-A receptor and you have your GABA-B receptor. And the GABA-A has all these subunits that other kinds of compounds can bind to that help the GABA itself bind to its site on the receptor. And then you have the GABA-B receptor as well, which is this G protein coupler receptor a little bit different.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Well, the thing about what happens is that alcohol binds very tightly to the GABA receptor, to the site where it binds on the receptor, which is again, this allosteric site, so not where GABA binds, but it increases the affinity for GABA to bind, but it does this in a very strong way.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And as a result of that, you have this strong binding of alcohol to the receptor, you have this strong affinity for GABA to bind, And what happens over time very quickly is that your body tries to compensate for this. And this is why you have tolerance. Eventually you have withdrawal when it comes to alcohol as well.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
But the tolerance part is because with alcohol binds so tightly, it starts depleting GABA very quickly. And when you start depleting GABA, the body tries to compensate that for decreasing the number of GABA receptors available and also decreasing the number of GABA sites that you have available on the GABA receptor. And so as a result of that, you need more of the alcohol to get the same effect.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
The other problem with alcohol, John, is that binds very quickly and tightly, but then it unbinds very quickly as well. And so this is why if you drink alcohol before you go to bed, you wake up, most people wake up like two or three hours later and they feel like wide awake or they feel terrible. This is how I used to feel when I was a kid and drinking alcohol.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
I could wake up two or three hours later with the worst headache ever. Why is that? because now you've all of a sudden had this overabundance of glutamate as well, because you've screwed up the balance between the two of them.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And so that GABA unbinds very quickly, the GABA gets depleted, and then all of a sudden you have all this glutamate around and then you feel terrible, you get headaches, you get irritable, all those things.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And so that's why alcohol is terrible for people who wanna, in general, alcohol is not very good for a lot of different reasons, but for sleep, it's very bad because it really affects the whole aspect of you trying to, it may help you fall asleep, But it will not help you stay asleep and you will not get good sleep if you drink alcohol.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So you want to avoid it for those reasons, at least other reasons to avoid alcohol of which there are myriad as yes.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Well, as long as you weren't drinking too much when you first started. The problem, if you're drinking a lot and you stop cold turkey, you could potentially have a very dangerous situation here, right? Where you can have severe withdrawal. You can get what's called autonomic instability, where your blood pressure gets crazy. Your heart rate gets crazy.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
This is all that overabundance of that glutamate, that excitatory neurotransmitter, because the body is so depleted from GABA, from so much alcohol use for such a long time. So that's one thing to mention. So if you're gonna stop alcohol and you've been drinking a lot of it, don't drink it, don't stop abruptly. You could potentially hurt yourself.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
The same thing goes with like benzodiazepines, for example. So the other drugs that affect the GABA receptor that are very common, your Ativan, your Xanax, your Valium, these are your benzodiazepines, along with your alcohol, of course. Like those are the main ones that we think of. But if you don't wanna stop those drugs, cold turkey either, because you've got the same problem.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
They cause such a tightly bound, increased affinity for GABA to bind, that you get a depletion of those GABA neurotransmitters over time, or the GABA neurotransmitter itself, and also the GABA receptor as well. So now, if you're gonna do this in a slow way, you're going to wanna make sure
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
that you're thinking about increasing your GABA production at the same time if at all possible nobody's really thinking about this but that's why we're talking about it and so what how do you do that and so what you want to do is thinking about the precursors that are responsible for you be making more GABA in the system so what's the precursor to GABA we talked about is something called glutamate right but what's the precursor to glutamate and that is the amino acid glutamine
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So we talked about glutamine and we've heard a little bit about glutamine before. I think many of your listeners, like glutamine is an amino acid and glutamine is extremely important for a lot of different things. It actually is the fuel for your small intestine at the same time as it is a precursor for glutamate, which then gets converted into GABA in the system.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So the first thing I think about when I'm working with my patients that are looking, that have been drinking a lot of alcohol, or if they've been on benzodiazepines and we're thinking about supporting their GABA system,
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
is looking at making sure they're getting enough glutamine in their diet, not only for their gut, if they have leaky gut, they even need more than if they have not a leaky gut, but then also thinking about the cofactors that are responsible for the conversions of your glutamine into your glutamate into your GABA. So you're thinking of vitamin B6 and magnesium mostly.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
But I alluded to it earlier, if you have a leaky gut, if your gut's not doing well, if you're having a hard time there, You're going to need more glutamine to support your small intestine before you even get over to make enough glutamate and make enough and make enough GABA. So there's lots of glutamine containing foods as well.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Your meat containing products are going to be your highest in glutamine. And so your meat, eggs, poultry, dairy, those kinds of things are going to be the highest in glutamine overall. And but there's a lot of benefits of supporting your GABA system while you're starting to wean yourself off of things like alcohol and benzos. Yeah.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
those are great foods to use. I mean, what it comes down to for me is looking at a holistic picture, right? When somebody in my estimation is GABA deficient, which is very common these days, you wanna think about it holistically. You wanna think about what are the types of foods that are gonna support GABA and glutamine production?
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
What are the minerals that you're gonna require to be able to create that? conversion very easily. And then how are you going to prevent yourself from stopping the depletion of GABA so quickly?
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Now we talked about the drugs, we talked about things like alcohol or benzodiazepines, but if you're stressed all the time, your cortisol, the stress hormone in the body is going to deplete GABA very quickly. You're also going to deplete minerals as well when you have high cortisol levels for long periods of time. And are any of us stressed? Of course, we have stress in our family.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
We have stress with our work. We have stress with just the types of exposures that we have. If we're on airplanes, we're stressed on an airplane, not only because of being on an 200 other people that you have never met before coughing all over you, but also because you're in tin box, tin can up in the sky with more radiation exposure and things like that.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So stress is everywhere and it's depleting GABA like crazy. And I think that's the main thing that I always... emphasize with the people that I work with is that if we're going to enhance the GABA system, we have to figure out ways to improve our capacity to decrease stress.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And one of the main ways that we do this is trying to find ways that we can engage people to become parasympathetic or relax and digest, right? One of the ways actually you can do this, interestingly enough, is have people sit down for a meal and eat. Eating actually makes you more parasympathetic
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
As long as you're not eating on the run and trying to feed your four children and eating at the same time, I'm not guilty of this at all ever, of course. But if you're resting and eating, you're actually going to become more parasympathetic. If you can work on your yoga, your mindfulness and your breathing techniques and increasing your exhale. So shorter inhale, longer exhale.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
that's also gonna make you more parasympathetic. And if you can do that on a regular basis, you're gonna improve your GABA system. Interestingly enough, exercise also enhances the GABA system too, because exercise is going to help with the balance between your sympathetic and parasympathetic nervous system.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And as a result of that, you're going to reset your parasympathetic nervous system, which is great. There also is the release of a factor called BDNF, brain-derived neurotrophic factor, which is extremely important as well for a lot of different reasons, for neuroplasticity, for new growth of neurons, but also for increasing GABA in the brain. And so these are some of the things I think about.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
I also think about sleep a lot too, because if you're going to enhance the GABA system, you need to reset your nervous system. And the best way to do that is by getting better sleep overall. The challenge that we have, of course, is that not everybody can do this immediately.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And so what are we gonna do to support the GABA system very quickly while people maybe are on the longer path of trying to optimize their vitamins, minerals, nutrients, their stress levels. Maybe they'll get a sleep divorce. You know what a sleep divorce is, John? Have you heard of these? This is when people...
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
decide to sleep in separate bedrooms because their partner is snoring or keeping them up or kicking them in the face or things like that. And then that's a huge stress too. But that's a difficult conversation to have with a partner sometimes. Hey, you know what?
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Sometimes maybe we shouldn't sleep in the same bedroom because you're snoring or because you keep punching me in the face or something like that. So anyway, this stuff takes time. It takes time for people to make these kinds of changes and to see these kinds of manifest benefits while they're enhancing the GABA system.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So sometimes what we need to do is support the GABA system with natural equivalents, plants, fungi, other kinds of things that can work in conjunction with diet, with lifestyle, with supplementation. And that's really the key, I think, is that you have to look at it all different angles to really help people.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Habits are where everything starts and ends, right? I think they say, but 90% of what we do on a day-to-day basis is a habit. I read a great book by Charles Duhigg a long time ago called Habits and How We Make Them and How We Break Them. And I think it's a great book if anybody's interested.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And when it comes down to habits in general that we want to cultivate are ones that increase our capacity to become more parasympathetic, to relax. Our default as humans these days now is to be on, on. But how do you turn on your off switch? How do you do it? That is the GABA system. So creating habits that help you turn on your off switch are going to help you in so many ways.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So what are some of the things you can do? Well, first thing you don't want to do is wake up and the first thing you do is check your phone immediately for all the messages and all the other kinds of notifications that you might see there. Finding a way to create space from the world around you just a little bit can go a long way.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And this is what we were discussing earlier when we were talking about 70 to 120,000 thoughts per day. The human organism is not evolved to do this. Our human organism is evolved for two things, if you believe this.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Some people believe more, but in general, we're evolved for fitness and for function, meaning we're evolved to be able to do certain things for a certain period of time so we can procreate and pass on our genetics. And then the rest is just...
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
In our world, it would be icing on the cake even now, but especially in Paleolithic times, if you live longer than 40, 50 years old, it was a gigantic thing, right? It takes a lot of intention for us to take the time and realize that being parasympathetic is going to give us longevity.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
It's going to allow us to live a much longer, much healthier life because if we're always in sympathetic dominance, we're not gonna be able to rest, recover, heal, detox. And so if you can't detox, you're gonna build up with toxicity over time. and you are not going to live as long. Cardiovascular disease, neurodegenerative disease, these are associated with stress.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So some of the habits that I like to talk to my patients about. One of them is actually very simple, we just described, taking time in the day when you're not looking at phones or screens. This could be five minutes, it could be 10 minutes, it could be longer. I like this in the setting of meditation if people will do it, or if they're just gonna do some deep breathing.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Increasing your exhales is going to increase your GABA sympathetic, your GABA tone, and decrease your sympathetic tone. That's a very simple thing that you can do. Another thing you can do is have fun. Play, enjoy yourself. I have four kids at my house, especially when they were younger.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
They're still pretty young, but especially when they were younger, if you're rolling around the floor with your kids, you're not in sympathetic dominance. You are in parasympathetic mode. You're in rest, recover. Another great way to do this, and this is the Italian way, this is the Mediterranean way, John, is to have great meals with friends, family, and laugh
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Like crazy, laughing is a great way to reset your sympathetic and parasympathetic tone because laughing, it engages your diaphragm and then you release your diaphragm and all of a sudden you have this like relief, this relief. And that is the same way that you can increase your parasympathetic tone.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
There's so many things you can do, even just, one of the things I like to have a lot of my patients do is take walks. Not crazy walks at huge paces, but just walk in nature, getting outside, getting sunlight. There are so many things you can do behaviorally to improve your parasympathetic tone. And those are just some examples.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Yeah, it's a great meditative event in essence, because what they teach in meditation oftentimes is that the sound that your feet make when you hit the ground is just as important as those thoughts in your mind. It's all just things happening in conscious awareness in space. And so nothing really gets more weight unless you choose it to.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So you can, in those sounds that you're hearing when you're walking, you don't have a choice of whether you hear those sounds or not. But you can actually create this sort of internal presence of those sounds and understand that it has a huge, this ecosystem that you're creating inside your mind is anything you choose it to be.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And you can put any weight on these certain things that you choose to make. And having time off of computers, off of phones, or in my case, as with my kids, is a great way to remind yourself that there's more than those thoughts in your mind. And when you start doing this and you start putting these things into practice and your patients, in my case, start doing this, their health transforms.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And it may not be overnight. That's for sure. It may not be tomorrow where you take one walk in nature and then the world is an entirely different place for you, but you can start getting inclinations here. And then, and this is where supplementation, things like enhancing the GABA system can be very helpful too, along with changing mindset, along with the nature, along with
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
breath work, along with meditation. If you just start giving people like a little bit more of an accelerated capacity, that's where the power is.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
I'm fantastic, John. Thanks for having me back. It's good to see you.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
100%. We are just, we're living in a whack-a-mole triage setting at every moment of every day. And that is just because we're getting so many inputs and then we're getting depleted on things that are helping us maintain a stability and mood. in function, especially GABA as well.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So you'll find, and I see this clinically, once you start enhancing the GABA system, once you start becoming more parasympathetic, then you start getting more grounded. You feel more grounded, you have more space between your thoughts, your emotions, and your senses, and then you show up better in your life, both
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
for yourself, which is probably the most important, but of course, with the people around you. And one of the things that I often like to ask my patients about is actually, I like to ask my patients, family members about this is how are they doing? How are they like, because that's one of the best ways for people.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
A lot of us don't realize when we're improving, actually, it's actually very common in men specifically is that men don't realize that They're just not as observant in general. We just don't have the same capacity as women just naturally overall. And women have these superpowers as we know.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
But asking family members how they're doing can be very indicative on these journeys that people are having once they start doing some of the things that we're talking about. And then I'll be like, well, and then it'll be like, well, tell me about your day yesterday. How many times did you scream?
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
How many times did you get so angry that your mind just went completely blank and you couldn't think for X amounts of minutes? Think about in the last three months, how many times has that happened? Ask your kids, how many times have I yelled at you last week? If you can't remember yourself. And I've done this actually myself personally, just in various experiments that I've done.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
We're a very bad judge of how, in general, how we're doing. So sometimes, especially in the beginning, when you're starting to create more of that sense of grounding, it's helpful to have those external conversations that go like, how am I doing really? And I found that to be helpful when I'm on that path of optimizing these kinds of things.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
I think the best and the easiest way is to learn a breath practice. And it doesn't have to be something that's too crazy at all. People have heard of box breathing, for example. That's a very easy way to become more parasympathetic. I have my kids do what's called three-five, three seconds of breath in and five seconds of breath out.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Just lengthening your exhales, just doing that for two to five minutes, will make you extremely impressed at what breath can do if you start doing it consistently. So I think that's the simplest thing for people to do from a lifestyle perspective.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
The other thing to do that can be helpful is start exercising because exercise can also help balance the sympathetic and parasympathetic nervous systems. But I hesitate for that to be my first because that can also be, if you're just going to exercise and then going to do something else and then something else and something else, that's not going to be very helpful. But I think
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
When I talk to my patients, the one thing I emphasize a lot is the breath work piece. Now, if that's part of the meditative practice, all the better, but I don't even think it's necessary to start off with, to be honest. I mean, if people think meditation's too woo-woo, I get that. That's not about not having thoughts. It's just about observing your thoughts, really, in meditation.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And then there's other stages, of course, if you wanna go there, but in general,
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
breath work and just prolonging your exhales so there's the three breathing patterns i teach my patients are either box breathing something called four seven eight so you breathe in for four you hold for seven you breathe out for eight or i do the three five the three minutes the three seconds in and five seconds out there's a lots of other permutations of this and there's lots of other ways to do it i have a good friend of mine
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
named Brian McKenzie, who does a lot of work with CO2 tolerance. And these are called breath holds. And so you can learn about doing this and increasing your CO2 tolerance. And that also improves your stress over time. But I think that's secondary to just learning how to exhale for longer than you inhale. That will be transformative if you can do it on a consistent basis.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And I think what it comes down to is when you're looking to enhance the GABA receptor itself, what you want to do ideally, like from a supplementation perspective is number one, remember that GABA supplements don't work actually. GABA supplements are, GABA itself is a too big of a molecule to get across into the brain. And as a result of that, if it does work for you,
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Well, I mean, nootropic is a big category in the sense of there's lots of different definitions that people use as to what a nootropic is and what it isn't. I think we actually dove into this a lot during our last podcast. So if anybody's interested, they can go check this out. There's things like health optimization nootropics and performance optimization nootropics.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
GABA is getting through because you have a leaky blood-brain barrier, and that's also called a leaky brain. Now it sounds scary, but in essence, that just means oftentimes that you have a leaky gut. Leaky gut is when your gut's allowing things into the system that shouldn't get in there.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And as a result of that, you're getting more inflammation in the system, and that also can affect the blood-brain barrier and cause a leaky brain. So when you are supplementing to improve GABA levels, you want to be improving them by using compounds that enhance the GABA receptor, but not using GABA itself.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So what you can use there, for example, are things like kava and even some of the cannabinoids like CBD and CBG. These work on the GABA receptor, enhancing the binding of affinity for GABA to bind to that receptor too. But in addition, you also want to use something that's going to bind to the GABA receptor at the GABA site as well.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And this is called an obligate pair, which means that you do both at the same time. This is so that even if you're giving something that's safer, like kava or CBD, CBG, something called honokial, honokial from magnolia bark, these are all binding to the GABA site, the GABA receptor on separate sites. you want to also give them something that's going to replete their GABA levels at the same time.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So what I use is something called nicotinyl GABA, which is a vitamin B3 attached to the GABA molecule. That makes sure that the B3 gets across the blood-brain barrier no problem, and it takes GABA with it. And then as a result of that, you get mild B3, which is actually mildly activating, which is good.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
in essence because the gaba itself in the brain is going to help you relax so you get this sort of calm relaxation without feeling too tired which is very nice another one that i use that binds to the gaba site of the gaba receptor as well is called agarin agarin is from a psychedelic mushroom called the amanita muscaria mushroom and what's really cool about this particular compound is it's non-psychedelic and so the amanita mushroom is well known as like in santa claus mythology it's well known in like for alice in wonderland and mario brothers
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
very famous mushroom known to be psychedelic because another ingredient in it called ibotenic acid which is actually neurotoxic But the agarine works on the GABA receptor at the site where GABA would bind. And so you put that in there at the same time as you use something like Hanakyle, which is increasing the receptor binding affinity for GABA itself so that you already have this combination.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And so as a result, you don't deplete GABA over time. You decrease the risk of withdrawal with tolerance, with dependence, and you can use very low doses for long periods of time and significant impact. So the key with enhancing the GABA receptor is that you're doing both. You're enhancing it by giving it something that supports on that allosteric site.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So it binds to the GABA receptor, not where GABA is binding, but on another site. And then you're also enhancing the GABA site because you're giving something like GABA, like nicotinyl GABA, vitamin B3 attached, or the agaric. So I give that preamble, John, because when you're looking at
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
i've been very interested as always in the kind of integration of neutral nootropics with more of a comprehensive understanding of mental health physical health from a macroscopic scale from you know what it looks like when you're talking to somebody or how you feel personally but also from a microscopic scale your vitamins minerals nutrients
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
AI, when you're looking at how we're gonna use this kind of system to enhance and understand and diagnose GABA deficiency, the keys with AI always, and I know this very well because one of the guys, one of my mentors and the founder of the companies that I work with
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
is one of the founders or like one of the early guys in ai back in the 80s and 90s the most important thing about ai not only is it the algorithm itself but also the inputs the prompts as it were that you're using to create the ai system without prompts you're not going to have a great ai output when you're thinking about
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
diagnosing or enhancing the GABA system, you have to know what the inputs are going to be to create the ecosystem in the body that you're going to allow the most optimal recovery of the GABA system in this capacity. So for me, the way I see AI working is that you're going to be able to look at multiple different
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
inputs at the same time knowing what those inputs are at least in essence and then having algorithms that are trained on what's happening cellularly in various types of permutations to know what may be going on Then you can take those permutations along with the inputs that you created and the prompts, and then you have an output that's going to be fantastic.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Especially John, when you're not only looking at one subset of data, but you're looking at multiple sets of data. And the way I think about this is that right now, everybody knows about the genome, right? Everybody knows about genomics, but we have. genomics, we have transcriptomics, we have proteomics, we have metabolomics. These are all various levels of expression of our DNA.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
We have epigenomics as well. We have so many others. Then we have the capacity with AI soon to be able to, excuse me, to crunch all this data and find ways to be able to harness it to create significant change in the system. Knowing, of course, how to prompt the data beforehand to make sure that we're getting things that make sense. That's the key.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
It's not only just the data itself, but it's the prompting that is so important.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So Troscriptions is the company that we created about four years ago, and it's the for-profit entity of a nonprofit organization called Health Optimization Medicine and Practice. And that's Home Hope for short. Home Hope is training practitioners who
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
licensed practitioners, non-licensed practitioners on how to optimize health of their patients and clients without the optimizing health, without focusing on treating disease. And that's the framework shift that's very different. And the seven module certification course, the first module is metabolomics actually.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And that's what's so foundational to my own practice and to a lot of the work that we're doing. Metabolomics has been called the 21st century stethoscope for a reason. It's robust, but with AI, as you were alluding to John, Now we're looking at all these levels and how we're going to be able to integrate all this data together is going to be transformative.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
and cofactors that are responsible for truly optimizing our cellular biology.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So if you're a practitioner looking for more training, we have it's all at homehope.org. You can check out our seven module certification. With transcriptions, we have products there that can help people right now while they're on the path. to optimizing their health. And we have ones that are based on methylene blue. Those are helping with energy, with focus, with endurance, with inflammation.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
But we have a whole suite of products that are based on the GABA system. We have one called TroCalm. We have another one called TroZ. TroCalm for anxiety stress reduction. And we have TroZ, one for sleep and sleep optimization with eight different ingredients. So our focus with those products is helping you turn that on switch off.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And so if you're interested in learning about more of these products, more about the GABA system and how it all integrates with anxiety, with stress, with sleep, insomnia, depression, you can go to Troscriptions.com or you can go to Instagram at Troscriptions and find out more information. And then if you're interested in learning more about
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Me, I'm at Dr. Scott Scher, D-R-S-C-O-T-T-S-H-E-R-R on Instagram. I do a decent amount of posting there. You can also go to drscottscher.com and I have a bunch of my own resources there. I do work with patients directly. I do remote consulting in the worlds of health optimization medicine, which I have my own practice, hyperbaric medicine. I think that's enough for you. I think that's good.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And then within that, I've been, a lot of my interest always and continues to be on mitochondrial health and how improving mitochondrial health overall is going to raise your cognitive and physical bar all the time so that maybe you don't need nootropics all the time, but maybe you can only use them in more of a targeted way rather than more comprehensively or more often depending on the situation.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Thanks for being back. It was a pleasure to be back, number three. I look forward to number four.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
That's all good. Take care, John. Thanks for having me.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So it's super interesting. Methylene blue, as we talked about, it has been around a long time, but we're really starting to dial in the dosing of it, understanding that very low doses of this particular compound are fantastic for those mitochondria that we were just discussing. So what's interesting about
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
the US right now is that 94% of the US population has some element of mitochondrial dysfunction. This means that they cannot make energy effectively or they cannot detox with the energy that they make. So just to back that up for a minute for people, when you have these mitochondria in our cells, They are the powerhouse. They are what make energy.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
endurance.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And so we have a lot of mitochondria in some types of tissue and very few mitochondria in other tissue. In fact, the most mitochondria we have per cell are in our ovaries or in our sperm, depending on our gender, our brain, our heart, our liver, and our musculoskeletal tissue. So
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
In fact, I've talked to Gabrielle Lyons about this, and she likes to remind everybody that you have your most mitochondria per cell in reserve actually in your musculoskeletal tissue so you can run when you need to run.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Now, the problem, though, is that if 94% of the US population has mitochondrial dysfunction, this is going to show itself in the various tissues depending on where those tissues are having the most effect with that mitochondrial dysfunction. So is infertility an issue now, John? It's a huge issue, right? More and more people cannot get pregnant, men and women.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And that's a major reason why is because of mitochondrial dysfunction. If you have issues with your brain, if you have concentration problems, fatigue issues, if you have difficulty with your memory or verbal fluidity when you're speaking, this is all potentially a mitochondrial issue.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So cardiac issues, detoxification issues, exercise induced fatigue, this is all related to mitochondrial dysfunction. And so what methylene blue can do here
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And this is what's cool about the dosing is that we have like low doses of methylene blue, four, eight, 16, maybe 25 milligrams of methylene blue, where you're actually improving that mitochondrial function itself, where you go to higher doses around a milligram per kilogram, which is around 50 to 70 milligrams, depending on the person, maybe higher.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
That's more of an anti-infective dose and also really good for like significant acute mitochondrial stress. And one other piece of this is that mitochondria make energy, they make ATP. And this is our energy currency. We make a lot of ATP. I can't remember, but it's like almost a couple of kilograms of ATP a day. It's a lot of ATP that we make.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Now, not only do we make ATP or energy, but we also have to be able to deal with the quote unquote waste products of making energy. And those include some of the things that we know,
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
like carbon dioxide water but we also make something called reactive oxygen species or free radicals these free radicals are very important because they're signaling molecules that tell the mitochondria to make more energy not making as much energy and things like that but in essence what you see here is that you're making more energy and you have to detox from the energy that you make and if your mitochondria aren't working very well it could be either or it could be or that you're having a problem
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
now you bring in methylene blue and methylene blue what it can do is it can help on both sides it can help on the side of helping you make more energy and it can help on the side of helping you detoxify from the energy that you make and the problem with making energy for many of us now is that we have these complexes on our mitochondria there's four of them in total and many of us for especially complex one and complex two but especially complex one are not working very well and
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
I didn't say why people have mitochondrial dysfunction, John. Why is that? So the number one cause is insulin resistance. This is people that are obese, morbidly obese, super morbid obesity, where you have insulin resistance. That's the number one reason why people have mitochondrial dysfunction, and it affects that complex one. The second reason is medications.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
The third is toxins and the fourth is infection. So COVID infections, for example, were very notorious for affecting complex one and complex two and also complex four, but definitely complex one mostly. What methylene blue can do is it can bypass various complexes in your mitochondria. If they're not working very well, help regenerate some of them, help you make energy more effectively.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And at the same time, like I mentioned, you're helping with the detoxification side. So you're not getting a huge amount of stress in the system, even if you're making more energy.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So when it comes to neurodegenerative diseases, there are a couple of studies that have been ongoing looking at methylene blue specifically for Alzheimer's. And it was a very interesting initial study that they did.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
where they use very low doses methylene blue eight milligrams twice a day and this is a this is their placebo group which again is not a placebo this is very common in a lot of these studies because when you're giving somebody methylene blue you're also trying to make sure that people know that they're getting it or if they're getting it like if they're getting a high dose low dose they don't really know but the idea with methylene blue and the challenge in this case is that methylene blue makes your urine blue so what they tried to do
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
let's give a very low dose of methylene blue to the placebo group or the sham group and a much higher dose to the treatment group, okay? And so in the study, in this group of population, this population, methylene blue actually improved cognitive function in the placebo or sham group much more than it did in the treatment group, interestingly enough.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And so this is not actually surprising to me because what happens if you give a very large dose of methylene blue very quickly, it might be too much for the system to be able to handle. And this is very common, unfortunately, in brains that are already under significant stress.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
So if your brain's already under significant stress because you have mild cognitive impairment, because you have Alzheimer's, as it were, then you're going to be more susceptible to the requirements for the need. You have higher requirements of things like antioxidants, for example. And if you give a very high dose of methylene blue very quickly,
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
you're going to induce the capacity of the brain to try to make more of that antioxidant, but you're not going to be able to do it is what it comes down to. So the key with methylene blue and neurodegenerative disorders is to really focus on low dose and titrating that dose over a period of time.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
There's a researcher at the University of Texas, Austin named Dr. Francisco Gonzalez Lima, who's done a lot of great work on neurodegenerative disease and Alzheimer's models, looking at the use of methylene blue.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And if you can optimize energy production, if you can optimize the capacity of those protein complexes, the electron transport chain to work better, you're going to see improvements in cognitive function. And then if also you're improving the capacity for detoxification by using these low doses of methylene blue, you also see benefit there.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Now, when it comes to the other population, what did you mention? You mentioned neurodegenerative and the other one was, what was the other one?
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Right, so the chronic fatigue, the brain fog, those patients. And so in the end, what that really is, John, is a mitochondrial dysfunction. And so what we are seeing now, at least clinically, is that you're seeing improvements in cognitive function in all varieties of patients that are coming in with cognitive dysfunction. Is it chronic fatigue? Is it post-viral syndrome? Do you have mold?
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Do you have infection? You're gonna see improvements in mitochondrial function because of this amazing compound.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
If you're using it in an intermittent way, especially at low doses of methylene blue, it's going to be very supportive most of the time. And the reason is because it's supporting that mitochondrial function. And most of us are having some element of that on a regular basis. If you have stress in your life, does anybody have stress? Does anybody? That's also going to stress your mitochondria.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
Do you have, excuse me, do you have... exposure to toxins in your environment. Anybody have exposure to toxins in their environment? Is anybody going on an airplane tomorrow or the next day or in the next couple of months? These are all stresses on our mitochondria.
Passion Struck with John R. Miles
Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
And so what I've found is that if you're using something supportive like methylene blue, you are in a good place to use it regularly over a long period of time. Low doses, of course.
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Dr. Scott Sherr on GABA: The Unsung Hero of Brain Health and Stress Resilience | EP 575
With other types of nootropics, you might want to be a little bit more careful in the sense that if you're using a nootropic that has a lot of stimulation capacity, so if you're using something like nicotine every day or even caffeine every day, it may be something that starts depleting you of vitamins, minerals, and nutrients
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Yeah. So first question about like mitophagy, there are some small studies in animals that show that methylene blue does improve mitochondrial function on its own. So not only can it compensate for mitochondrial dysfunction, but it can actually rebuild part of the electron transport chain, specifically complex four or cytochrome oxidase and help rebuild and reboot the mitochondria itself.
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There's also some evidence that it does cause mitochondrial biogenesis as well. Really? And the reason for that, I think, is that because it's making the cells more efficient overall and there's more energy available as a result of that so that the cells make more mitochondria to actually... compensate for that or to build up a balance as a result.
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So these are preclinical, so it's hard to know overall. There's really no studies in mitophagy specifically that I've seen, but there is the sense that I have overall that you're just rebooting mitochondrial function. And so as a result of that, sometimes what's going to happen when you need to do that is actually you need to kill off mitochondria to start to make new ones, right?
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And so I think some of that is happening. I have seen, as I think about it now, there has been some literature on mitophagy in Alzheimer's models overall and how the methylene blue might be able to do this. And it's actually interesting how it might be able to do this.
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And this is kind of technical, but the low doses of methylene blue, the four milligrams, eight, 16, 20, those are really supportive to the mitochondria, okay? But higher doses like your 70s, 80s, 100s, things like that, they're also supportive, but they also stress the mitochondria at the same time. And they do that by creating hydrogen peroxide.
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And so our cells have this capacity to make hydrogen peroxide. And they do this because it's a signaling molecule in the cell. And it's also something that's an anti-infective. So the cell will make or release actually hydrogen peroxide when there's a bug around that they're trying to kill. And that comes from the part of the cell called the lysosome.
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And so what methylene blue does is increase the amount of hydrogen peroxide that's produced by binding to oxygen, making hydrogen peroxide. And so this causes stress on the system. and can cause mitochondrial biogenesis and mitophagy from mitophagy first, and then mitochondrial biogenesis as a result of that.
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And so I have seen some of this, but this is a very technical point, but what happens with these higher doses of methylene blue, when you make more hydrogen peroxide, you're also stimulating the body to produce more glutathione directly, which is our master antioxidant. And that's through a pathway called the Nrf2 pathway. And that stimulates, the hydrogen peroxide stimulates NRF2.
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That pathway produces more glutathione. But you have to make sure you have enough glutathione to be able to make it, right? Otherwise, you're going to be in a world of hurt.
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And so when people start taking methylene, when they start getting detox kinds of symptoms, especially these higher doses, it's often because they have this hydrogen peroxide production without the amount of, without the capacity to make glutathione in response to that overall. So- but I don't want to forget your endurance questions. I got off on a tangent there.
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Do you have any, do you want me to go back to endurance or do you want to have any questions about that?
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Yeah, so in the endurance performance world, two things that we're thinking about here. The first is definitely on the endurance side, knowing that methylene blue is going to increase your capacity to make energy aerobically from your mitochondria for longer.
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And so I have, I remember when I first started using methylene blue, like three or four years ago, I had one of my early clients taking it and I just had, I'm not really sure how this is going to work exactly. Let's see how you feel. Use it for exercise and let me know how it goes. And then I talked to her a couple of weeks later, she's like, Dr. Scott, I'm never going to not
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exercise with methylene blue or like i will always exercise with methylene blue i'm like well why she's like well when i go on my treadmill or maybe it was her stairmaster in the morning it's like i can keep my heart rate up higher for another 20 minutes compared to what i typically can so i can maintain a heart rate for longer without having to stop and this has been repeated now in a number of my clients and a good example would be a guy that i work with here in colorado he did the leadville 100 mile ultra mile ultra ultra marathon here relatively maybe about a
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This guy came to me because he was having a hard time finishing the race, and we were giving him 32 milligrams of methylene blue every four hours. So this is more than I would typically give most people, but this is 100 miles, man. This is a huge race, right? And so he was able to cut off four hours of his time as well. And yeah, pretty amazing, right?
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And so this is just using methylene blue as an endurance enhancer. So I've seen this also with another friend of mine. His name is Brian McKenzie. who does a lot of work with hypoxic and CO2 training. And so what he's been doing is he'll do hypoxic training, have methylene blue on board, and then do endurance work afterwards.
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And he's seen his VO2 max go up like five or 10 points, like not a small amount, by having methylene blue on board, doing hypoxic training, and then doing endurance work, right? And the reason for this, again, is that the cells are gonna be more sensitive to taking up more oxygen after you've been hypoxic. And then you have the methylene blue on board there.
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That's going to help with the endurance side, giving you more aerobic capacity. And so that's on the endurance side. And so this is pretty consistent. I've been working, I've been trying to work with a couple, you know, semi-pro teams and things like that, get them more product and work on like, you know, cyclists, especially they're doing a lot of endurance.
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But I've had a few that have been interested, definitely people that are doing, like I have a couple, we have a couple of soccer players that are using the methylene blue regularly during games now and seeing significant benefit. So it's fantastic.
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And the other piece, which is really interesting, and I was just speaking to another colleague that you know his name, Thomas DeLauer, about this on his podcast. What he's noticed, and I think this is super interesting, is that he feels that for like an anaerobic kind of workout, what he's been able to use methylene blue for is that
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he feels that you can recover pre or intra workout and even after workout faster with methylene lube is you don't need to get to it as slow of a heart rate to get the same recovery. So typically for most people, they have to get to it like a slow, like a heart rate that's going to help them recover.
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Like say if it's, if you're at 120, you need to get down to like sort of 70 or something to recover. But what he's noticed with training is that he can be at a higher heart rate, but still have a recovery because of the methylene booze on board. allows him to recover at a higher heart rate and then he can maintain his aerobic and anaerobic training and increase.
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And so he doesn't lose that anaerobic capacity as fast as a result of being, and then he can have that heart rate recovery at the higher level, which is pretty, pretty cool. Right. So that's kind of, you know, this is like a newer thing. It's, we have to test it out more and, and kind of see, but if you can recover at a higher heart rate and That means you can do more work, right? Exactly.
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It's definitely having its moment and it really got big. around mid-January or so when it was mentioned on a couple of big podcasts. And I think the linchpin in the whole thing was when RFK, the human health secretary, was filmed or caught taking methylene blue in a drink while he was on an airplane. And that just made things go crazy. And great, fantastic. Now people know about methylene blue.
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You don't have to wait for your heart rate to come down further to know that you've recovered until you can do your next set, for example.
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That's interesting, right?
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Yeah.
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Like intra-workout, and Thomas is really good about this, but intra-workout, the idea is to try to get yourself as parasympathetic between sets as possible.
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Right? Because that's going to be the most bang for your buck when it comes to performance and training and strength. But that's not easy to do. No.
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Yeah, please do. I mean, and check on your heart rate and see, because you typically, if like a lot of the guys that you know, and that I know that are in the weightlifting space, they know when they've gotten to that point where they've recovered between sets, like just is the physiology, the shift, right?
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And so just interesting to see if like, oh, I feel that physiology shift, but my heart rate's 10 points higher than usual, right? So I think what Methylene Blue is doing there is it's working on the recovery aspect of things, allowing you to kind of shed some of that oxidative stress a little bit faster and so that you don't have to go as deep to get parasympathetic. But we'll have to see.
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It's still early stages there.
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So I can just tell you what I've seen clinically because it hasn't really been studied in any definitive way to say that if you take methylene blue, it's going to decrease your CRP or decrease your SED rate or whatever. But what I've noticed and I've been reported over the years is that
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What methylene blue does is it can affect, as we've been describing, the mitochondria and help with compensation of mitochondrial dysfunction. And so if you have something that's decreasing inflammation in the system, you're going to see some of these markers get better. And I've seen, like in my own clinical practice,
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like SED rates, CRPs, inflammatory markers, otherwise, you know, like the things you mentioned, like liver, heart, kidneys, like all of it I've seen improve using methylene blue. And so it depends on the person. We've had, there's one person that I know that's been taking methylene blue for a long time that has, you know, kidney dysfunction, for example.
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And it was progressing and progressing and progressing. And maybe we're going to have to go on like hemodialysis, for example. He's been able to stabilize on a low dose of methylene blue and his kidney function stayed the same and it hasn't gotten any worse, for example.
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And so a lot of this, there's an inflammatory component of the presentation, which there often is, and the methylene blue will often have an effect on inflammatory markers related to that inflammatory ecosystem, whatever's happening there, right? And so you can look at these over time and see, Now, the other aspect of this is that where methylene blue is coming in is in the mitochondria.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
And so you can look at the mitochondria itself. And what I've seen over the years is that once you can start adding in methylene blue early into various types of protocols to optimize mitochondrial function, that's not the only thing you're doing. Of course, you're really looking at optimizing diet, lifestyle, nutrients, doing laboratory testing, hormones, all the things that you know.
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We've been doing this for a long time. So my company, Transcriptions, as you said, we were the first company to come out with a commercial product back in 2020. And Dr. Ted, our founder, our pioneer, he'd been studying methylene blue for years before we even launched the company. And we were looking at the research together and seeing how powerful this was.
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And that you can start using methylene blue early and start seeing benefits relatively quickly in some of those mitochondrial markers. But in the end, it's not being done in a silo for me, right? I'm not just using methylene blue at time zero and then at time six months or three months or whatever, and like looking at mitochondrial function afterwards.
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Like it's almost always being done, always being done really in a comprehensive way where I'm using methylene blue as a way to help start optimizing the system quickly while we're doing the harder work of optimizing vitamins, minerals, diet, lifestyle, those kinds of things.
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So it's never easy for me to know, even with inflammatory markers, that it was a methylene boo that did it because I'm not just using that one thing. But in essence... My sense of things is that, and getting reports back from customers and other, and people that, that other colleagues that are using it is that that's exactly what you'll be able to see. And it comes out clinically, right?
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So like somebody, for example, that has had chronic joint pain for years and they start taking methylene blue and all of a sudden their joint pain goes away. I don't have numbers, I don't have like inflammatory markers on that person, but do I need them to know that their inflammation is likely better, right? And so in essence, the way I use methylene blue clinically is not in a silo.
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It's not being done just with methylene blue. It's being done as a significant intervention while doing lots of other things at the same time. So it's hard to know. And I'd love to be able to do more of like controlled studies and like taking methylene blue for three months and see, but in the practical real world, that's just not fucking possible, right?
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Because you don't want to wait and just give them one thing, right? And this is like, this is what clinical medicine is all about. Like you don't just do one thing with people. You really try to give them a comprehensive approach. And then over time you peel things off.
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And, and one of the things I do peel off over time is, is nothing blue because it's a great way to support the mitochondria to get rid of reboot and re kind of get things going and jumpstart it. And then as you're doing the other things to optimize mitochondrial function, you can wean them off the methylene blue and use it significantly less in a majority of the people that I work with.
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And it was very intriguing to us as a way of delivering the a compound that had the possibility both to increase energy and to improve detox at the same time. It's called the Redox Cycler. And so over the last five years, we've had tons of clinical experience, both in our clinical practices personally. So I see patients still. I see people every week, usually over telemedicine at this point.
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So let's talk about, I think the quality first, right? So the methylene blue is, it's made in a lab. It's not made from nature as we discussed. And so the part of the production process of making methylene blue, there is a possibility of it being contaminated with heavy metals specifically.
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And so you have to be very careful, methylene blue that you're actually getting to make sure that it's as low in heavy metals as possible overall. And so if you get USP grade of methylene blue, that's the best type of methylene blue, but even grade methylene blue, can go across the map. You have all different types of levels of methylene blue contaminants that can be in there.
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So you have to be really careful. So you always want to get certificate analysis from the company that you're working with, where you're buying the methylene blue from, just to know what exactly you have in there. Now, that's number one. And I think that this is a big issue for us when we first started the company. Dylan, it took us...
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almost a year and a half longer than we thought to launch the company because we needed to find a stable and good supply and clean supply of methylene blue. Over the years, we've had to throw out thousands of dollars worth of material of methylene blue itself as the raw ingredient because it didn't meet our specifications. What will typically happen is that a company will purchase
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methylene blue from a supplier, wherever that supplier may be. And then it comes with a certificate of analysis that says it's XYZ, right? It says it's 100% pure or whatever it might say, right? But we take it another step. We test it again once we get it to make sure that it is what it is. Not a lot of companies are doing that.
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They just trust the manufacturer that they've had a C of A that says X. And then we have actually a recent story. We're always looking for new suppliers. And there was another supplier that we were looking at from Ethylene Blue. And their C of A looked pristine. It looked beautiful. And then we got it tested by our own lab. Uh-huh.
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not at all and so and they're like they apologize oh there must be something wrong with the batch we'll give you a new one so we're testing it again another batch pretty soon but companies don't do this dylan they trust the c of a from the company that uh that that is getting that's giving them the ingredient right and so they're not taking it to the next level and checking to see if it's actually what is in that what it says it is right and so we were really this is we were emphatic about this when we started making our product so we don't just trust ingredients that come in
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from our suppliers. We test everything. And this includes methylene blue. And this is why we've had to throw out thousands of dollars worth of material in the past because it didn't meet our specifications. And the other aspect of it is not only is it From a purity perspective, the heavy metal contaminants, that's also a potency issue too.
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Most of the products that we tested on the market did not meet their label claim, especially if they were liquids. So we didn't test any of the tablets because those are relatively new. But from a label claim perspective, if you're taking a dropper,
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First of all, do not ask me if you're taking the right amount if you're telling me you take 10 drops a day because I have no fucking clue how much methylene blue you're taking. Oh my gosh. And this is the problem, right? Methylene blue in a dropper form is very difficult to dose. Overall, almost all of the liquids that we tested were less potent than it said on the label.
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So if it said you were getting one milligram in a drop or whatever, you were really getting like 70 or 60 milligrams or maybe 80 milligrams in the drop at most. There was one company actually that 125% more. So it was actually even more per drop than it was supposed to be. So it's across the map. And so liquids are very difficult to maintain a consistent milligram dose per drop.
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So you really don't know how much liquid you're taking if you're taking liquid. And we had a couple of people, especially maybe two or three years ago now, telling us about taking the liquid and then taking our trochies, our And ours was significantly more potent and stronger at the same dose. And it's because it really wasn't the same dose.
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Dr. Ted still sees patients. The other docs that are on our team still see patients as well. And so we've got a lot of clinical experience on how best to use methylene blue in practice and seeing what really can happen. And like, I'll be honest, when we first started using it in 2020, I was like, I don't think this is gonna work. Like, is it really gonna work? And I was just shocked.
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Ours was actually the dose that was on the label because we test everything. And we do it like a pharmaceutical company. I'm a physician. You know this, Dylan. I work with physicians. We wanted to make our products, the trochees, as precision-dosed and pharmaceutical-grade as possible. So every single batch is tested for purity. Every single batch that we make is tested for potency.
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And again, we're not just trusting the certificates of analysis of the ingredients that we procure. We're testing them again ourselves before we even go the route of actually making it into product. And so there's no other companies that are doing that. There's no other companies that have four docs on the team that are seeing patients in clinical practice.
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And of course, trochies, nobody else is doing that either because they're not easy to make, I will say. And it's not for the faint of heart to try to scale trochie production, but What's nice about a trochee is that it's easy to break up into small parts, into a quarter, a half, or full, and find your dose so you're not relegated to a capsule or a tablet that's difficult to break up.
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And you can figure out exactly what you need and then titrate your dose over time. But to answer your second question, which was around delivery and bioavailability, I To make a point there, methylene blue is really an interesting compound for a lot of reasons, obviously. But this is another reason why it's very interesting, is that it's almost 100% bioavailable no matter how you take it.
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Whether you take it orally as a trochee, you swallow it, or even obviously in an IV. IV is going to be 100% bioavailable, no doubt about it. But It stays active even when it goes through the liver in first pass metabolism. And most things get deactivated on some level. I always give the example of N-acetylcysteine or NAC. NAC is about 10% bioavailable. So if you take 100 milligrams of NAC,
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only 10 milligrams is actually getting into the body. But if you take 16 milligrams of methylene blue, just about 16 milligrams is actually getting into the body. Now, what's different is how fast.
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Obviously, IV is going to be your fastest, and that's a good thing depending on the system or the issue with methylene blue, but it also can be the most dangerous because it's going to go to the brain the fastest, and we can talk about that. And then a trochee is going to be second fastest because a trochee is going to be dissolving directly into the mucosa of the mouth.
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And that's going to be faster than going through digestion. And obviously swallowing it is going to be slower. Now you asked about food. Now, if you have food in your stomach, when you take methylene blue, it's going to get dissolved much slower overall. So your peak is going to be lower as far as your peak concentration in the blood. Got it.
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What I typically recommend is if you're going to swallow methylene blue, It's a swallow on an empty stomach. And then you can eat about 15 or 20 minutes later and help it kind of push it through a little bit faster. But that's usually the best way to do it.
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about how many people almost out of the gate starting getting amazing experiences and seeing their pain go away, their inflammation get better, their brain fog improve, like so many different types of things. And we can talk about that. And I think we talked about some of that on the last podcast.
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But when that hit in January, it was like everybody was seeing methylene blue for the first time outside of a smaller niche audience that had been knowing about it and had been learning about it. I mean, over the last four years though, Dylan, like it has been growing. Like every year on top of that,
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I appreciate the perspective because you've been doing this such a long time and you've been playing around with things that are much more tricky than I have over the years with all the peptides and things like that. And it's not safe. If you get more than you need... Methylene blue at higher doses can cause more detox symptoms. It can cause more stress on the mitochondria, as I mentioned.
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And if you think you're taking 20 milligrams a day, but you're really taking 100 or something like that, that's kind of an extreme example. But once you get to about 80 or so milligrams of methylene, 8,200 milligrams of methylene blue per day, you start building it up in the system. You don't fully...
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detox you don't feel like get rid of it like in your urine in about within about 24 hours and so if you're taking more than that on a regular basis you can get in trouble and so my usual recommendation is you're taking more than about 30 to 40 milligrams a day of methylene blue you really need to be taking at least one day off a week and if you're taking more than that a day
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then thinking about taking more days off per week to make sure you don't have the buildup in the system overall. And so I worry about the liquid because I don't know what people are getting. And people always ask me, what's the best liquid? What's the best liquid? We just haven't found one that I truly trust. And I know what we're doing. I'm supervising with Dr. Ted and the physicians on my team.
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We're supervising the whole process and looking at the C of A's. And then we're always in communication with our labs and our contract manufacturers that are making the products.
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that are allowing us to make the claims that we are and also making us feel comfortable that we can use it with our patients and with our families and and like i wouldn't want anything else overall so i appreciate you make you making a big point of it dylan because i think it's less understood the process there than people realized like you could just get a certificate of analysis from a chinese manufacturer like oh it's great it looks perfect let's just use it right and like
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No. I don't care if it's in China, India, US, it doesn't matter. It has to be my opinion and I think yours is like, don't trust the piece of paper coming from the company that's selling you a product. No. Because they have a vested interest in you buying their product. That's why we always use the third-party testing and that's why we were always doing that.
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I call it fourth-party testing or beyond USP or something like that.
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For example, when I was the first speaker at A4, one of the largest medical conferences to speak about, I spoke about also at another conference called IHS, Integrative Health Symposium, which is the largest medical conference on the East Coast as well. And so after I spoke, that was in 2023.
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Yeah, I've kind of developed this recently because I get this question a lot and I try to make it super simple. If you're using it for mitochondrial optimization specifically, so day-to-day operations, you're not using it for an acute infection or a chronic infection or like an acute stress overall.
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In general, what I recommend people do is start off with one and a quarter of our trochies, so four milligrams.
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And then... Use that for about three to five days. Increase the dose by a quarter. So increase the dose by four milligrams every three to five days until you start feeling a response. Now, depending on what that response is, is it like, holy shit, I can go run a marathon after being in a wheelchair, then you're great. But it might be more nuanced than that. It usually is, right?
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And so usually the first thing you feel is maybe a little bit of a mood elevation, a little bit of improvement overall, just feel a little bit better. And then there should be a time when you get to the right dose that you feel that something special is happening. And that could be anything from pain being better to brain fog being better. to your concentration being better.
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I said brain fog already. Maybe I have brain fog. But your endurance is getting better. There's going to be noticeable changes. Typically, that's around between 8 and 16 milligrams for most people is what we found. And so once you find the dose that works best for you, then it depends on what you're using it for.
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If you're using it more for a chronic issue that's been ongoing for a long period of time, you may need to stay on that dose for a longer period of time. It could be two, four, six weeks, sometimes six months until you can start weaning yourself down depending on what else you're doing to try to work on whatever it is that is going on in the cells that's causing the symptoms that you're having.
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But in other people that are relatively well-optimized, That's their dose. And then when they need it, that's the dose that they need. And so when do they need it? Depends on what they're using it for. It could be used for an endurance. It can be used for a bad night of sleep. It can be used when you're getting an airplane, for example.
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And so in my more optimized patients that maybe they were on methylene blue a lot initially as they were kind of working on their mitochondria, working on their cellular function, their gut. their hormones, those kinds of things. Eventually, I like to wean them down to a point where they're taking it maybe on average, maybe three days a week-ish.
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And that's a good mark for most people to use it in more of like a targeted way for those three days a week. And that could be, again, just more stress on the system, like a long exercise this day, a bad night of sleep, as I mentioned, like going on a plane. And Most of us are under stress on a regular basis.
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In 2024, we started seeing a huge amount more interest in the clinical world because from a clinical perspective, it has tons of applications because it's a mitochondrial enhancer. 94% of US adults have mitochondrial dysfunction, a part of our cells that make energy. And so clinicians started getting really, really excited about it.
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Our mitochondria are used to stress on some level, but they're not used to shitty lights and shitty food and toxic relationships and screaming kids or whatever that don't stop. I find that most people can benefit from it some of the time on a regular basis, but Some people can benefit from it on a regular basis for a longer period of time.
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But the dosing from a mitochondrial perspective, feeling the energy, feeling the detox capacity, feeling more resilient overall, usually between 4 and 16 milligrams. Man, I've been... really surprised by that. Initially, when we first came out with the product, I was like, this is going to be, I think that might be too low, but it's not.
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I mean, I have some people, a good example is I was talking to a clinician just a week ago or so, a patient of theirs who was widowed. They'd lost their spouse maybe a year prior and just hadn't been able to like break out the funk, right? They were still kind of moping around and they just weren't doing their thing. She gave this guy four milligrams of methylene blue.
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He had like the best day of his life. He was walking around. He was moving. He was doing things around his house. It was like a different person. And I have four, eight milligrams in people. I have another friend of mine. She's Dr. Stephanie Remke. She's great. And she'd be great for your podcast eventually. She's fantastic.
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But she's like, I give my little old ladies with fibromyalgia and chronic fatigue, just a little bit of methylene blue. They can go get their haircut. They can clean. Really? and clean their floors and their kitchen, and they love it. And so just these like lower doses go a long way. And of course, there's other things that these people are doing with these clinicians, right?
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But like it goes a long way. Now, if you have a chronic infection or you have severe mitochondrial stress from like an acute trauma, acute low oxygen state, this is when your dose of methylene blue should be much higher in general. So- For me, this is from an acute infection. So leave chronic infection out for a minute because that's a little bit of a different animal.
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But acute infection, acute stress, acute trauma, I'm usually dosing around one to two milligrams per kilogram for about three to five days, maybe even more than that, maybe a little bit, maybe up to seven days. So that's like 150 to about 150 milligrams of methylene blue for about three to five days. So it could be high.
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But then I slowly ramped them. I quickly ramped them down after being at the higher doses. Okay. Chronic infection though, they tend to need higher amounts of methane blue for longer periods of time, usually in combination with other things as well. And so you're talking about your chronic Lyme and co-infections, for example, chronic mold.
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These people, I know, I mean, I have a couple of colleagues and I myself do this. Use about 50 milligrams twice daily of methylene blue for five to seven days or longer. And then we ramp them down. Sometimes we need to be on even longer periods of time of methylene blue, depending on like the chronicity and what else is going on. So, but for most day-to-day operations, we're talking about
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four to 16 milligrams for the most part. And then all of my patients have a higher strength methylene blue in their medicine cabinet if they have an acute infection, acute trauma, acute stress, because that's going to be very supportive overall to the mitochondria. Using those high doses for short periods of time is very safe for the most part.
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And at the end of 2024, there were all these other companies starting to make and sell methylene blue and paying speakers to play and to speak at these conferences. that I spoke at for free the year before. And so I knew something was going on, right? And so we all knew something was going on at the company. And then really in 2025 in January is when things just went bonkers.
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Unless you're taking it with caffeine though. That's good. You know, you're taking it with caffeine. So yeah.
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Yeah.
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That's a great protocol. I mean, so the blue canitin, for those that are listening, is a combination of methylene blue with nicotine, caffeine, and CBD. So it has the stimulants in there, the nicotine and the caffeine. Low-dose nicotine, just a milligram and a full trochee. So a half a milligram is what you're taking, Dylan, there. Caffeine is just a quarter cup of coffee.
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So it's not a lot in what you're taking, but it's a fantastic... pre-workout boost because you get that stimulant effect of the nicotine and caffeine, and you get the methylene blue that's supportive and helping with energy and endurance of the things we mentioned before. So I think it's great.
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I think that the glucanetine especially, I do recommend people cycle that one for sure because that one has the stimulants on there. So it's good to take a couple of days off at least typically when people are taking that one, unless you're taking it because you're using it as a replacement for something you'd be taking from a pharmaceutical perspective.
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But even people that are taking pharmaceuticals like Adderall and Vyvanse and things like that, most of those guys and gals will be not taking it on the weekends usually.
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It's a similar kind of thing with Bucanatine where you'd probably want to stop it on the weekends if you didn't need it, if you were taking it for something as a replacement for something like that, of course, under medical supervision and things.
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And it's been a really amazing ride overall because now there's a lot more interest
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Sure. So I think a couple come to mind. The first one would be the one you just alluded to, which is blue brains. Yes. The second one would be that The only reason methylene blue works is because it increases serotonin. And the third one would be that only people that have mitochondrial disorders should take methylene blue.
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How about those three?
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As a result of all that interest, of course, there's going to be a lot more naysayers and people out there that are trying to bring things down and make various arguments that they feel are correct, maybe, or maybe they're just doing it because they know how the social media algorithms work, which is to make a conflict, make a splash and do something to cause a stir in some way and then get eyeballs that way.
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So the blue brains, I don't remember the guy's name. He did a blog on it. He's got a relatively popular blog. Forgive me, I don't remember his name.
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The second one, the serotonin thing, that's our friend, Dr. Paul Saladino. I got it. And he also talked about mitochondrial function as well. But the third one is related to Dr. Chris Masterjohn, PhD, who is a biochemist that's very, very good at biochemistry. But his translational capacity to clinical medicine, I think, needs a little bit more support overall.
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And so those are the three corresponding to what I just described. Cool.
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Yeah, sure. So they're relatively quick because it's not, especially because we've already had this whole preamble about what methylene blue does overall, but number one, blue brain. So the first, this is a blog that was very good in the sense of showing pictures of these blue brains that were shown after these patients had died.
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And they did the post-mortem, they did the autopsy and their brains were blue. And so the people in this study, It wasn't even a study.
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It was just a case report of about eight different people had gotten ridiculously high levels, amounts of methylene blue over three milligrams per kilogram in the IV as a last ditch effort to try to save their lives from shock, sepsis, cardiopulmonary arrest, and things like that. So methylene blue is used as a last...
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ditch effort in some of these indications, in some of these situations, to try to do the last thing you could do to try to save this person's life. So these people got hammered with IV methylene blue, and then they all died in this, obviously, because they were showing blue brains. And they did autopsies within about four to six hours afterwards, and all of their brains were blue.
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This is not surprising, okay? This is a huge amount of methylene blue. And so we know that methylene blue, what it does in general is concentrate in the mitochondria, which is where it's doing all its fancy work in compensating for mitochondrial dysfunction. But it's actually changing color all the time, between blue to colorless, depending on its redox state.
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But in essence, they got so much methylene blue that it's not surprising that their brains were blue as a result of it. If you're taking low doses of methylene blue, 4, 8 milligrams, 16, 25, even a little bit higher than that, your brain is not going to turn blue. your mitochondria are going to have a concentration of blue pigment for a short period of time, and then it's going to go away.
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Your brain is not going to get stained blue. It's not like that's going to happen. This is a great sensational piece where showing blue brains, like you're taking methylene blue, your brain's going to turn blue. No, it's not going to do that.
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Now, if your brain is going to turn blue because of three milligrams per kilogram of IV methylene blue, it's because they were trying to save your life, okay? They failed, but they tried. And so it was a great headline, your brain's turning blue when taking methylene blue. Yes, if you're taking it at huge IV doses to save your life because you're going to die,
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Oh, by all means, your brain's going to turn blue for a short period of time. I doubt it would have stayed blue if these people had actually lived to see the next day, all right? Because this would have come out of the system over time. But low doses of methylene blue are not turning your brain blue. It's only concentrating the mitochondria.
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And then it's out of your system within about four to six hours. That's the half-life. So within about 18 hours, it's fully out of the system and comes out through your urine. All that blue pigment is gone, okay? So no blue brains have been harmed. in the world of transcriptions and others using methylene blue. So that's number one. Any questions on that?
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So it was because of what happened in January that everybody is talking about. It's trendy now. And I have mixed feelings about that, right? Because anything that's trendy, people have a significant, interesting, mixed relationship typically, right? And like what I'm hoping for is that the knowledge is now coming to the fore. We've been doing this for so many years.
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We've put out a lot of stuff over the last month or two with all this, but it's, it's all good. You know, like no, you know, all, all press is good press on some level, because I get to have these conversations with you, Dylan, and say, look, this is really, what's the brass tacks of the whole thing. Damn right. And so, and then you had Paul Saladino who came on to talk about how
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his response to all of this was, you know, methylene blue is only working because it increases serotonin. It has no effect on mitochondrial function because if you have optimized mitochondrial function, you don't need methylene blue. That's kind of his whole argument, right? And so first off, the first part is complete bullshit, you know, in the sense that methylene blue does increase serotonin.
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That is true. But the idea that the only effects that you have are because you have increased serotonin are completely out of, I don't even know where he got that from overall. So we have studies that show what methylene blue does in the mitochondria. We know what it does to compensate for mitochondrial dysfunction. We know it can help with energy. We know it can help with detox.
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And so that's completely ludicrous to say that methylene blue only works because it increases serotonin. So methylene blue also not only works in the mitochondria, but also works as a monoimmune oxidase inhibitor, an MAOI, reversible one, which means that it prevents the breakdown of norepinephrine, dopamine, and serotonin.
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As a result of that, you will have more of those neurotransmitters around when you're taking methylene blue. And it is a reason why you have to be careful, actually, if you're on serotonergic drugs like SSRIs or SNRIs, which are like a newer class of antidepressants. If you're on medications for Parkinson's that increase dopamine, it can be an interaction there. You have to be careful.
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And if you are taking those meds, it doesn't mean you can't take low-dose methylene blue, but you should take it with the supervision of a healthcare provider, okay? So Paul's first argument there was that it was a serotonin effect that was improving people's function, but there's no way that that's actually what's happening.
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clinically, like working with patients, which Paul does not do, you would see and get that experience very quickly and get the response very quickly that this has nothing to do with serotonin. I mean, there's something going on with serotonin, but the effects that we're getting are not related to that at all.
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You can go back and look at all of our blogs and all of our lectures and interviews and things like that, that I've done, that Dr. Ted has done on the team. So you can see that there's gravitas here. There's legitimacy in what we're doing. This is not just a trend. What I've said is believe the hype, but be careful the bandwagon, right? In the sense of the hype is true.
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Yeah. I mean, I think it, I think it's. it's good to have a counterpoint in the whole situation to talk about why that counterpoint is wrong. And from clinical experience, we know that what he's saying is not correct.
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The other aspect of it is, he talked about this and Chris Masterjohn also spoke about it in various ways, is that if you have optimized mitochondria, you shouldn't take methylene blue because it can make the mitochondria worse. And so this is an important point to distinguish. And so first of all, 94% percent of the U.S. population has some element of mitochondrial dysfunction.
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So there's very few people who fall in this category of optimized mitochondria, number one.
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And even people that have optimized mitochondria still have significant stress on the mitochondria on a relatively regular clip if they are on an airplane, if all the things we mentioned before, poor sleep, stress, toxins, getting infection, all these other reasons why somebody with optimized mitochondria will still have stress on their mitochondria, okay? So for that reason, for the first part,
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My first part of coming back to this is saying that 94% of the US population has some element of mitochondrial dysfunction. So as a secondary piece to that is what Chris Masterjohn initially said in one of his first treaties on methylene blue, which is a fantastic biochemistry It was really great for biochemistry. He did a great job.
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But his conclusion was that you should only take methylene blue if you have an inherited mitochondrial disorder. And this is also crazy because 94% of the US population has some element of mitochondrial dysfunction. they may not benefit as much as somebody that has an inherited mitochondrial disorder, but they can still benefit.
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And we're seeing this on a regular basis on how these people can benefit with sort of any level of mitochondrial dysfunction. The amount of methylene blue that you need may be different. The amount of methylene blue that you need to take on a regular basis may be different, but they can still benefit if they have mitochondrial stress overall. So that's also a big piece of it.
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And then the final one, which is important is that they both discussed that you should not take methylene blue if you have optimized mitochondria. And so, okay, we've already kind of discussed that most of us have stress in our mitochondria at all time. But in the case that you have optimized mitochondria, should you take methylene blue?
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And they're both pointing to a study that was done in stroke patients, in stroke animals actually. And in these stroke animals, You gave methylene blue immediately after you gave an animal a stroke, the size of their infarct, the size of the area of the stroke was significantly less. They had better perfusion in that area.
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So they actually had a smaller area where they had the stroke if you gave methylene blue very, very quickly. Again, one of the reasons why I have all of my patients with methylene blue in their medicine cabinet, just in case.
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In that same study, they showed that an area that wasn't affected by the stroke was mildly stressed from an energy perspective, making energy from a mitochondrial perspective. So the mitochondria were stressed in an area that was normal, but in the abnormal area had significant improvements, right? So their argument is like, well, if you have normal mitochondria, you shouldn't take methylene blue.
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Methylene blue has got fantastic potential, but be careful about just following what everybody else is doing without understanding why you're taking methylene blue and how you can best leverage it in your own particular situation.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
But number one, if you have a stroke, it could be very, very potentially very, very effective, which is fantastic. But in addition, the piece that they left out is that they're using pretty high doses of methylene blue IV again in these animals, right? And so methylene blue, at least a milligram per kilogram in the IV is
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
were given to these animals showing some mitochondrial stress in an area with normal mitochondria. So this actually proves my point that higher doses of methylene blue, especially IV, should only be reserved for acute situations. If you're taking methylene blue on a regular basis, it should be oral, it should be lower dose, and it's not going to cause that mitochondrial stress.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
We just haven't seen it clinically. And If I can't see it clinically, then that means that it's very likely related to their study design using higher doses of methylene blue in the IV, causing mitochondrial stress in normal areas of the tissue in the animal.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
So in essence, low doses of methylene blue, not IV especially, are not causing mitochondrial stress in normal mitochondria in people that are well-optimized, as well as all the other reasons why it's important to make these distinctions between all these different types of populations.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
You just actually hit another point where I just realized as well, right? So we are not supposed to live until after about 40 years of age, right? Right. Evolutionarily, we're supposed to be dead by then. And so most of us can pretty well have well-optimized mitochondria in our 20s and 30s because that's when we're most optimized to do almost anything, right? Right. Especially our 20s.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
But if you're trying to live a long life with optimized mitochondria, it's very difficult to do if you're not supporting them in other ways. Yes. After we get about over the age of 40 or so, for sure. So that's the other piece that I never really thought about until you just said it is that aging will deteriorate your mitochondria no matter what. Right. And so we need the support, right?
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
What you say is like the mitochondria is sort of like your common denominator for almost all signs of aging and deterioration. Your mitochondria, they're making a lot of energy, so they make a lot of rust over time. They rust the system. And that's one of the things that ages the system over time too, the oxidative stress. related to making energy. And that affects the mitochondria itself.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
It affects the cell membranes. It affects other areas, the DNA, of course, too.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
No, you can definitely do the stacks. We have more and more people using mitochondrial peptides along with methylene blue. Again, these are other ways to help support the mitochondria while you're trying to work on optimizing them as best you can with diet, with lifestyle, with supplementation and other kinds of things.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
So we have people that are using a lot of NAD with methylene blue, for example. And I think this is not a bad idea, but it's also important to think about it in context of how else you're supporting the mitochondria. So Like, I don't think, you know, a peptide plus methylene blue is going to do it.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
For example, I think that you really got to be thinking, I mean, it can help in the short term, but long-term you really want to be supporting the mitochondria in the ways that's going to help them be as resilient and more self-perpetuating in their function and optimization as possible.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
100%. Yeah. It's all about giving that perspective. Of course, what I love about methylene blue is that you can use it very early on in the process to help motivate people. Becoming more of like a cornerstone habit, like exercise where you'd start doing exercise, everything else gets better. You start feeling better. It's like your energy starts getting better. You're going to start doing more.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
You're going to start taking that walk around the block or getting to the gym in the morning, whatever it might be. So I use it that way a lot in my patients too.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
Yeah, Molly's great.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
It's a cultural thing, Dylan, you know, like we'll sleep when we're dead. Right. When I was in medical school, we had shirts made that said sleep is for quitters. This is the hustle that is just part of American culture in general. Sleep is thought of as something that you do last in your day.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
I may have mentioned this last time, I don't remember, but something that Dr. Ted, who I work with, said very early on when I was working with him was to flip that around. Make sleep the first thing you do every day rather than the last thing. the first thing you do every day is go to sleep rather than wake up.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
So if you use it as the first thing you check off rather than the last thing you check off, you start understanding the priority over it all, right? And so the problem is that most of us are just on, on, on all the time and we don't want to turn off. And this is the off system of our brain, the off switch of the brain is the GABA system overall. The GABA is our most important neurotransmitter.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
It helps relax the nervous system, calm brain firing. Our brains are firing all the time. We have a hard time relaxing because many of us, most of us are actually deficient in this neurotransmitter in GABA. It gets depleted because of stress, because of poor diets, because of leaky guts, because of vitamin and mineral deficiencies.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
And if you don't have enough GABA around, you have more anxiety, you have more stress, you have more depression, and you can't sleep. Because GABA is really important in all the stages of helping you sleep better. It helps you with inducing of sleep, helps you with maintenance of sleep as well.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
And so if you're GABA deficient, you're going to have a hard time falling asleep, you're going to have a hard time staying asleep. And so it's really important when you think about sleep to think about how much of an... It's really important to think about how we've put it sort of on this sort of like...
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
underneath the ground is something that's important and put up the pedestal of like being productive, you know, as being the most important thing that we do every day. But you're so much more productive and you're so much more ready to conquer your day, if you want to say it that way, if you've gotten better sleep in the process. And so I emphasize sleep a lot.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
with my patients and I'm really leveraging the GABA system to do that in various ways with meditation, with breath work, especially near bedtime and trying to turn off the sympathetic nervous system. So getting off your bright lights, getting off your TVs and your screens, even if you have blue blockers and yellow blockers or whatever on you,
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
If you're still watching John Wick 3 before you go to bed, you're still not going to be ready for bed, man. I don't care what blue bockers you're wearing. So I really want all of my patients and people that I work with to take at least 30 minutes off of screens before they go to bed. And it is a very difficult thing for a lot of people, like scrolling right before they go to bed.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
And then as soon as they wake up in the morning, the first thing they do is scroll on their phone to see what's going on, right? And this is how exactly not to do it in general. The more parasympathetic you can get, the better you're going to sleep. The more relaxation you can get before you can go to sleep, the better you're going to sleep and the better your sleep scores are going to be.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
And so people have a hard time. I get it. I know in my life, people in my life, for a long time, it was once the kids go to bed, that's when the glass of wine comes out. That's when the beer comes out. And you think it's great. Alcohol is working on the GABA system. It's helping relax you. But the problem with alcohol is that it trashes your sleep.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
When it does, it binds to the GABA receptor very tightly and it depletes you with GABA very quickly. And then GABA is always in balance with another neurotransmitter called glutamate. Glutamates are primary excitatory neurotransmitter. And in the brain, it is converted into GABA using vitamin B6 and magnesium. And if you deplete your GABA very quickly with alcohol, for example,
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
That's why you wake up two hours later with a massive headache because you have all this glutamine, glutamate, excuse me, in the brain. And that's your neurotransmitter that makes you awake and on and ready. And MSG syndrome right here, by going to a Chinese restaurant and having a bunch of MSG and getting headaches, that's from glutamate toxicity as well, or a lack of GABA to balance it out.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
And so anxiety, stress, insomnia, these are all related to glutamate. imbalances where you have too much glutamate, some element of toxicity compared to the GABA in the brain. And so the key is to understand this is what's happening and then be able to try to support the system in various ways to help support the GABA system and to balance the glutamate and GABA levels.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
So making sure your vitamin B6 and your magnesium levels are optimized. making sure your gut is optimized. If you have a leaky gut, that's also going to mess up your GABA levels for a number of different reasons. It's going to mess them up because of the signaling in your gut itself. But your small intestines fuel is actually glutamine, which is the amino acid where glutamate is made from.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
And so you're going to have a lack of supply to get the glutamate in the brain and then all these other kinds of things. And then your, your blood brain barrier is going to get leaky too. And then that's not going to be cool. You get more inflammation. And this is why people take GABA supplements. Like they shouldn't work.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
GABA supplements, GABA is too big of a molecule to get across the blood brain barrier. But if you take GABA and it works for you, it can be almost diagnostic that your blood brain barrier is not doing what it's supposed to do. And so the way we formulated it to prescriptions was ways to get things across into the brain and
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
hopefully because your blood-brain barrier is intact, and then help support the GABA system in a very comprehensive way so that you're not depleting GABA while you're also enhancing the GABA system. And that's kind of like the secret sauce at Transcriptions. We have something called like an obligate pair or oblipair, which we've actually patented this actual way of formulating.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
This is all Dr. Ted's brainchild, but patented in a way where you're supporting the GABA system by binding things on the GABA receptor to where GABA would bind, and also a separate site where you increase the affinity for GABA to bind.
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And by doing them in combination, you decrease the risk of tolerance, withdrawal, or any other side effects of binding the GABA system too tightly and depleting GABA over time, which is what alcohol does. It's what the benzodiazepines do. It's what barbiturates do. This is what Ambien does and those drugs as well.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
They shouldn't. If they do, it means that the blood-brain barrier is likely not doing its job. Really? But a lot of these supplements also have a combination of things in there. So they have things like L-theanine or that they have kava or lemon balm or ashwagandha. These are all things that can get across the blood-brain barrier and do have an effect on the GABA system in various ways.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
You're like, you're one of the OGs when it comes to this, right?
The Dylan Gemelli Podcast
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So the GABA itself in there is not doing much, but the other ones could be potentially. So that's what's going on. And so if you're taking a GABA supplement, GABA by itself, then that's when you're thinking, well, is this really working? Is it working? And why is it working? Oh God, my blood-brain barrier is leaky. And so if that's the case, don't get scared. It's okay. It's common.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
The most common reason is that you have a leaky gut and the leaky gut needs to be addressed overall. And that's a whole nother conversation. But in general, if you can seal up the gut, you're going to seal up the blood-brain barrier too. And so for me, sleep is a dance of a lot of neurotransmitters. It's not just GABA, of course.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
Yeah. And a big piece for me, Dylan, is that A lot of the advice out there isn't bad, but a lot of it is not good either. And wading through that is really hard. It's not easy as a consumer, as somebody that's consuming social media, looking for good advice and education. It's hard overall. And so I totally understand that. The key, I think, is that
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
You have your melatonin, you have your 5-HTP, and you have your cortisol, and making sure your cortisol rhythms are optimized, your melatonin rhythms are optimized, and et cetera, et cetera. But enhancing the GABA system really is kind of like the one that rules them all overall as far as being able to maintain sleep and really see overall stability in your sleep patterns over time too.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
Yeah, so Trozy is our comprehensive sleep formula. It has eight different ingredients in it that are all very supportive onto the GABA system, the serotonin, melatonin, the endocannabinoid system with CBD and CBN in there, which are both affecting the GABA receptors as well.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
It has something called cordycepin from the cordyceps mushroom, which is a fantastic immune system activator along with increasing deep sleep. And so it's very comprehensive in looking at all stages of sleep and really supporting sleep architecture.
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Overall, my hope, though, is that people don't need sleep to take Trozy every night, that they can find other ways naturally with a good sleep routine and like an eye mask and the right temperature in their room and all the things that you and I know and obviously that your Sleep as a Skill podcast hosts, Molly, know very well.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
Once you can dial that stuff in, most people don't need a lot of support, maybe a little bit, but you usually don't need a lot of support.
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If you're taking Trozy regularly, like every night, and you stop taking it after a couple weeks, if you're taking it for a couple weeks, for example, and stop it, you will find that the next night when you stop it, you may not sleep as well, but that's not surprising. There's really no withdrawal that we've seen.
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And we haven't seen any dependence on it at all either in the sense that you can stop it at any time. You might not sleep well the night after stopping it if you've had it for a number of days in a row, but that's just because the neurotransmitter ecosystem needs to kind of figure itself out over a couple of days. But it hasn't been dramatic overall.
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So what I find is that Trozy and Trocom, Trocom is really for anxiousness and stress and it can be taken during the day because it doesn't make you feel tired. They're really used more as a PRN, as an ad needed kind of thing, as needed kind of thing. And my hope is that over time, when I'm working with clients, they need less and less of Trocom, but they use it when they need it.
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Like, you know, for example, with me, if I'm traveling, it's a crazy day. Trocom is fantastic. If I had a crazy day at work and I have to cook dinner, which is what I have to do after this podcast, I'm going to take some Trocom. I'm going to drop it down a little bit and I'm just going to smooth through dinner. It's going to be perfect, right? Yeah.
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And instead of the wine, it's a great way to kind of drop that nervous system down. a little bit. And it doesn't make you tired. And that's the beautiful thing about Trocom specifically, because you can take it during the day. We like to say from the boardroom, from the bedroom, Dylan, right?
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You can take it in the boardroom to actually do better, make better presentations, engage because you're not overstressed. And in the bedroom, it's going to help you sleep. It's going to turn off your brain. It's also going to give you less performance anxiety if that's what you care about in the But to your question about Trocom and Trozy together, yes, I have it used that way.
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when it comes to methylene blue, at least a bit, and this is not just methylene blue, it's sort of across the board, is that be careful taking advice from people that don't see patients or clients for a living is what I say, because they don't really know what it is to actually treat people and see the nuances of clinical care. It doesn't fall on a page. Your mug shot is like, you can't,
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So some people will use some Trocom with Trozy, but you have to be just careful with the dosing. You know, what I typically say is you start off at really low doses, like a quarter of each and see how you feel. And then you can kind of go up from there. If you have more of an issue falling asleep, Trocom is really great for that because it helps quiet the mind.
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If you have more issues staying asleep, then TroZ is a little bit better than Trocom for that. And so you can kind of balance your dosing depending on which ones you have the hardest time with overall. If you do wake up in the middle of the night, For example, at like one or two, three o'clock in the morning, I don't recommend taking TroZ because it's too long acting.
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I would recommend, you know, thinking about TroCom in that case, because again, TroCom is going to calm the mind and all those crazy thoughts that everybody gets at two o'clock in the morning that keeps them up at night, you know, or keeps them from getting back to bed, those kinds of things.
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Yeah, yeah. What's up?
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
Well, you can take GABA and see if it works for you. That's number one. Number two is that if you have a leaky gut in general, like if you've been tested, you have a leaky gut and you're working on that, it's likely that you also have a leaky brain too. Also know that if you get a severe stress, like a severe infection, severe trauma, these also oftentimes will cause
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
a temporary leaky gut and leaky brain. So severe trauma, stress, severe infection, these all can cause it. It's common. It typically doesn't last for very long, but it can cause a perpetuation of those afterwards where you don't fully heal from those kinds of things.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
But if you have a lot of brain fog, a lot of concentration problems, like a lot of sort of, you know, even depression, bipolar, some of the mental health issues, maybe that were new for you that haven't been an issue until recently, this could be related to a blood-brain barrier permeability issue. You can't really test the blood-brain barrier permeability directly is what it comes down to.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
It's more of a clinical diagnosis, and then you can correlate it to other kind of laboratory testing as well, meaning like leaky gut, for example.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
Yeah, I usually test people's stool.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
Yeah, you test their stool. You check for their gut integrity by looking at various markers. There's one called a zonulin level, for example. The zonulin is the protein that connects the cells in the gut itself. And if that level is elevated, oftentimes it's a leaky gut. You can also take a look at the types of bacteria, microbiota that are there, signs of gut inflammation, things like that.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
And also symptomatically, clinically, like how's somebody presenting, right? So those are the main ways you do it is usually through stool testing. You can get some ideas through like urine organic acid testing as well, but that's a little bit more indirect compared to looking at the poop directly and having that fun. So, you know, collect your shit, send it to a lab that's reputable.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
I use Genova's 3D GI effects in mine.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
Somebody like, for example, in medical school, you learn about a medical disease, like a condition, right? And like it's on a page, you read about it, but you go see somebody in person and then they don't fit that book. That's not like it's exactly that, right? And so you have to be ready to be more nuanced about how you look at people and how you work with them and how you...
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
Sure. So personally, you can find me on mostly on Instagram at Dr. Scott Scher, D-R-S-E-O-T-T-S-H-E-R-R. Also the company, Troscriptions, also on Instagram at Troscriptions, troscriptions.com. We have our methylene blue containing products, our Just Blue, Blue Canitine, our GABAergic ones, our Trocom, our Trozy, which we spoke about today, Trocom for anxiety and anxiousness and Trozy for sleep.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
And then if you're otherwise interested, we have a nonprofit that trains practitioners on a optimizing health perspective and really trying to shift the focus from disease into health. And that's health optimization, medicine, and practice. And that's homehope.org.
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If you're interested in me and consulting with me directly, you can find me at probably the best place is my health optimization practice. It's home-sf.co. And that's where you can learn more about my consulting health optimization practice. What else am I missing? I think those are the main places, Dylan.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
I think it's really great to have you have this platform to bring people on like me to kind of do some myth busting and create some context and come from a clinical perspective. Because when you work with patients, again, it's very different than talking to people on Instagram about what you do for a living and what they should do if you don't see patients or see clients for a living.
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So thank you for the opportunity to hang out with you, man.
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try to help them overall. And so getting advice from people that don't see patients or clients and don't have the understanding of the breadth of responses that people have is kind of dangerous in some ways, right? If you're following this person's stack and that person's stack, and then, you know, Brian Johnson's a great example of this, right?
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
I think Brian's doing some great work overall, but Brian's doing everything himself and he's taking hundreds to be vegan, right? And so I've had a number of people, my clients come to see me that have done terribly, on something similar because they can't do what he does on a regular basis and don't have millions of dollars to spend. So that's his protocol. Fantastic.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
But is that protocol going to work for you? Probably not. And so the main thing I always like to point out is that If you're looking to take advice for people that are on the socials and influencers in general, try to understand whether they are seeing patients or clients and then how they're framing their advice overall. In general, it's like, look, this is what I do.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
This is what's worked for me. Fantastic, right? But if this is what you should do because this is what I do, you got to be careful with that is what it comes down to.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
Exactly. Right. It's one thing to read about it in a book. It's another about to actually use it in clinical practice. It's an entirely different animal.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
Yes, sure. So methylene blue has been around a long time. It's a compound that was developed in a lab. So it's actually a synthetic ingredient. And so it's not made from nature. And that's one of the arguments that we can talk about later. Not everything that is from nature is good for you, just like not everything synthetic is bad for you, I promise. And we can talk about why.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
But so it was the first drug that was registered with the FDA back in 1897. And from that point on, it had a number of different sort of chapters overall. In general, though, to keep it really short, Higher doses of methylene blue are anti-infective, significantly anti-inflammatory. It can be used to reverse things like low oxygen states overall. And it does this in various ways.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
Lower doses are mostly for mitochondrial optimization, and they help improve mitochondrial function in various ways, including what's called being a redox cycler, which means that methylene blue has this really interesting capacity of being able to donate electrons to your electron transport chain, compensate for electron transport chain dysfunction, mitochondrial dysfunction,
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
And at the same time, act just like an antioxidant and pick up free electrons just like an antioxidant would. There's very few other compounds out there that can do this. And the power of methylene blue is that it works so well in the mitochondria to compensate for mitochondrial dysfunction. And
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
As I alluded to earlier, Dylan, 94% of the US population has some element of mitochondrial dysfunction. And the mitochondria are not either making energy effectively or they're not detoxing from the energy that they make. So most people don't realize that when you make energy, it's like putting gasoline in a car, okay? When you put gasoline in a car, you can run it, but you also have exhaust.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
Our cells have exhaust too. These exhaust, not all of it is negative. We have carbon dioxide, we have water. We also have reactive oxygen species, free radicals, as they're called, or oxidative stress. So the body always is making these and trying to balance out how much it's making with an antioxidant capacity, the number of antioxidants we have in the system.
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And so many of us are having a difficult time as we don't have enough antioxidants around to help balance out that stress from making energy. And then on the other side, even before that happens, we can't make the energy effectively because we don't have the vitamins, minerals, nutrients, and cofactors to be able to do that. And so you have this mitochondrial dysfunction.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
There's a lot of reasons why this happens. Stress is a huge one. So it could be stress from environmental stress, toxic stress, sleep stress, not getting enough sleep. Medications can do this. Toxins on our environment otherwise. What else am I missing? Infections can cause mitochondrial stress, as well as insulin resistance is actually the number one reason why people have mitochondrial stress.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
And that's a huge amount of the US population. So if you're pre-diabetic, if you have insulin resistance, your mitochondria aren't very happy is what it comes down to. And like in seventh grade and eighth grade, when you learned about the cell, you learned that there was a nucleus and cytoplasm and Golgi bodies.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
Good to be back with you, Dylan, for part two. That's right. Depending on which language you want to go. Part two. Okay.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
It's kind of my favorite name for any, for any organelles, the Golgi body, I always liked that name. And then endoplasmic reticulum. And then the mitochondria, you saw a cell with one
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mitochondria but that's not the case there's some cells in our body have thousands of mitochondria and some cells actually have zero mitochondria the red blood cells in our body do not have any mitochondria they actually got rid of their mitochondria so they can carry more oxygen they initially had one when they first then they first develop and then they lose their mitochondria over time
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But the cells with the most mitochondria per cell are the eggs and sperm, the brain, the heart, the liver, and the musculoskeletal tissue. That has the most in reserve. Makes sense, right? Because you need to make a lot of energy fast if you're running from some sort of animal that's trying to eat you kind of deal. And so mitochondrial stress is rampant, okay?
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
And the methylene blue overall has this capacity to really support the mitochondria. And that's what makes it so powerful, right? And these lower doses, four milligrams, eight milligrams, eight, 16 or so, they're really great at mitochondrial optimization. And then when you get up to about one milligram per kilogram or above, that's about 70 milligrams of methylene blue and above.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
That's when you're becoming more anti-infective. That's when you're focused on more chronic infection as well. Not only acute infection, but chronic infection. And then you also have like severe mitochondrial stress, hypoxic conditions, like low oxygen conditions. Because methylene blue can also act just like oxygen in the cells and maintain aerobic respiration for longer.
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Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
So I have a lot of athletes that are using it now for endurance, for example, as a result of being able to be able to go farther aerobically when they have methylene blue on board. So in general... Short story, methylene blue is a compound that was developed in 1897 or a little bit before that, but it was the first FDA drug at that time.
The Dylan Gemelli Podcast
Episode #28 Featuring Dr. Scott Sherr PART 2! THE METHYLENE BLUE CLINIC! Debunking Methylene Blue Myths, "Blue Brains," Mechanism of Action, Mitochondrial and Athletic Performance Benefits, Proper Dosing Protocols, Quality Control and MORE!!
It's a mitochondrial enhancer, it's an anti-infective, it's an anti-inflammatory, and it's a redox cycler overall. And so it's got these fantastic capacities.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And that's like, I always talk about now how hyperbaric therapy is kind of my smoke screen, because if you were coming to see me, Dylan, you're like, hey, Dr. Scott, I have migraines and you wanted to consult with me. We would spend 30 minutes or an hour speaking about that. And 90% of what I spoke to you about would have nothing to do with hyperbaric therapy at all.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
It would be about foundational principles, which are part of our nonprofit, like your metabolomics, your chronobiology, your circadian rhythms, your gut, your toxic exposure, et cetera. We have seven pillars in total. And so that's what I'd be spending most of my time doing with you. And then at the end of it, I'd be like, well,
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
hyperbaric therapy could be helpful, but let's do all of this stuff first within the framework that this really fits in for the long-term, right? Because we want all long-term benefit.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And the other thing I found in hyperbaric medicine was that if you didn't work on this foundation first, the benefits may not be as awesome initially, but certainly long-term, you would not see the benefits that you would otherwise see if you worked on the foundation first.
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Yeah. You want to be able to walk before you run. I mean, I had one child that's my, I think my, I have four kids. My third daughter was trying to run after her, her two sisters before she could walk. That was not going well for her, right? She would fall a lot. So as an example, okay.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And so, but I mean, there are tools and techniques and things that you can use though, that might be helpful in the short term. And so Home Hope or Health Optimization Medicine in Practice is the nonprofit developed a for-profit company called Transcriptions, which is a company that helps people right now while they're on the longer path to optimizing their health.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Healing didn't happen immediately. Healing happened over time, but there were many things that you could do outside of the box because I didn't even know what conventional medicine was until I was almost going to medical school, to be honest, at least through high school until getting out of the house and going to UCLA for undergrad.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Because again, walk before you run, but how can you walk if you're just in bed and you can't move? And then in that case, the path to health optimization is one that can be very challenging for people and it doesn't happen overnight. It can happen six months, a year. Some people that I've worked with has taken three or four years. And part of that's compliance for sure.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
But part of it is just that people are pretty messed up sometimes. And it's not their fault. Oftentimes, like people don't know what they're doing is bad for them until they hit some sort of threshold and they just get pounded in the ground and like, they can't move and
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This happened to so many people that, some of my friends and colleagues, even in the medical space, but definitely my patients that I work with over the years. And so that's where some of our products came into play.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
How can you use something like methylene blue, for example, which is a fantastic mitochondrial optimizer while somebody's getting better and optimizing that energy production, that vitamin, mineral, nutrient cofactor, antioxidant, blah, blah. You can do all that. That takes time, but you can use things
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
like methylene blue, for example, like working on the GABAergic system, which is a system that helps relax our nervous system because if we're always stressed all the time, by the way, if you're always stressed, you can't heal. You also can't build muscle. You can't recover.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And so we worked on these various sort of targeted aspects of health, targeted aspects of these pain points for people that would be able to kind of bring them over the humps and be able to keep on the process of of health optimization.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And then I can use hyperbaric therapy in that context too, but only really in that context, unless, and this is the caveat, is that if you have an acute issue, hyperbaric therapy is fantastic, right?
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
If you have an acute trauma, acute inflammation, a surgery, like it's going to work really fast with your body to make you feel better and more efficiently heal, no doubt about it, like 30 to 70% faster. But if it's a chronic issue, then this is where this framework really is the most important for me.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Well, it depends. So like a tennis elbow, that's something that's relatively acute, then hyperbaric therapy can be very helpful for that. If it's more of like a hip osteoarthritis or a knee osteoarthritis, I have seen hyperbaric therapy. I remember this one patient of mine, she was probably 87 and she was in great health, but she had really bad knees.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And there's not a lot of data that hyperbaric therapy for arthritis can be very effective, but there is an inflammatory component. Let's try it. Let's try it. Right. And so we gave, she just did like three hyperbaric sessions. She felt like a new lady and she felt fantastic. And I didn't see her again for a year when she came back, when her symptoms came back.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
So my framework was always one that was very much, there was no real box of what could be, what was possible. what you could do, the various aspects of health were very different for me. And I decided to go to medical school after having conversations with my father when I was younger and also getting more experience, realizing that there's a lot of necessity for conventional medicine too.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
But she's like, my knee pain's back and I come back for three treatments, which is very unusual. Usually if you have like a chronic issue, it's going to take you much more hyperbaric therapy to see the benefit. But she was one of these hyper responders that I wish we could study. But She just did three hyperbaric sessions and her arthritis was gone.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Now, in general, though, if it's a chronic issue, if it's a chronic, like for example, mild cognitive impairment, dementia, like these are not things that happened overnight, right? There's a lot of things that are going on there. So you're looking at much more hyperbaric therapy to see the benefit in general than just a couple of treatments here or there.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And a much more comprehensive approach, like we've been talking about here, like with the foundation that we have, the health optimization medicine framework, it's certainly one framework. It's a very different than
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
functional medicine, because functional medicine is looking more for the root causes of illness, where we're looking at the root causes of health and creating the first standard of care for health and not disease. And so our focus is how can you keep people healthy?
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How can you optimize your levels of vitamins, minerals, and nutrients and cofactors, the things that help you make energy that I was mentioning earlier? Can you optimize these to the levels when you were between 21 and 30 years of age, not just optimizing it for your normal for your age? The problem with a lot of laboratory tests out there
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
as you likely know, Dylan, is like, what's a normal range anyway? Do you want to be normal for a 50-year-old and normal for a 75-year-old? Probably not. You probably want to be normal for somebody between 21 and 30. That's when you're at the most optimized levels of hormones and be able to be the most resilient and the most ability to procreate, et cetera.
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That's where we want to stay, and that's what we do at Health Optimization Medicine. That's different than functional medicine or other types of alternative medicines out there, but they're all able to be used in conjunction with each other. So I don't want to say that this takes the place of those.
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This is just a foundation I feel like that's missing in even conventional alternative, all the health space.
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Yeah, it's very challenging.
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So twofold. The first to say is that there is some pretty good data that fibromyalgia is can respond to hyperbaric therapy.
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In fact, there were some pretty good studies done out of Israel that described fibromyalgia post-traumatic brain injury, that these are like severe concussions or mild, actually moderate to severe concussions, I think that were in the study, or maybe mild to moderate concussion. But regardless, these patients with concussions who develop fibromyalgia
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were given hyperbaric therapy, were treated with hyperbaric therapy for 40 sessions, which is a common protocol for more of a chronic issue, and their fibromyalgia symptoms went away. Okay. So, and probably this was because they were healing up the brain injury that was kind of the impetus or the nidus for their fibromyalgia. Okay. That's a bit of a unique case.
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But understanding that there was this chasm between, at that time, alternative medicine and allopathic or conventional medicine, there was really nothing in between. There's no such thing as integrative medicine anymore. really when I went to medical school.
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And there also is another study done at using hyperbaric therapy for fibromyalgia. But the challenge I have found over the years is that fibromyalgia is basically a It's like the common denominator diagnosis for a lot of other things that are going on.
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And so if you just use hyperbaric therapy for fibromyalgia, you may see benefit sometimes, but I can promise you the majority of those patients are going to have those symptoms recur over time if what was going on that was the impetus for the fibromyalgia was not also addressed most of the time. This means...
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what's going on cellularly, what's going on in the gut, what's going on hormonally, what's going on otherwise to sort of create this myalgic encephalitis or fibromyalgia, as it used to be called.
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And if you can work on brain inflammation, if you can work on the gut, if you can work on vitamins, minerals, nutrients, and cofactors at the same time as optimizing in a hyperbaric chamber, that's when I see the most power.
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So if, for example, somebody like you, Dylan, said, hey, Dr. Scott, I really want to use hyperbaric therapy for fibromyalgia, I'd be like, the first question I would ask them, are you working with an integrative provider that's helping you underneath the conventional model, understand why you may be having this symptomatology?
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If the answer is no, then it's absolutely do not go into hyperbaric chamber right now. Because we ought to wait three to six months, have you find an integrative provider, work with me, work with somebody else that can at least help you understand more what's going on under the hood. Have you changed your diet? Have you changed your behaviors? Are you still eating McDonald's, drinking alcohol?
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Are you still, you're going to the gym and you can't do that because whatever, whatever it might be. The key for me is to understand where people are, you know, in that sense. But because what a lot of people, even the researchers in the hyperbaric field will tell you is that we don't study people after we finish their hyperbaric protocol. We don't know how they do afterwards, right?
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There's no such thing as functional medicine, or maybe it was just getting started when I went to medical school in 2003 was my first year of medical training. So I decided to go to medical school with the high-minded idea of bridging that chasm, finding a way to kind of learn the conventional realms of medicine, but at the same time, keeping true to my foundation, which was my upbringing.
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This is, and the classic one here is our, my friends in Israel who did a great, great study on longevity, looking at how hyperbaric therapy can be a potential longevity tool, decreasing the telomeric age, decreasing the number of senescent cells in the body, which are zombie cells, which are these cells that build up as we get older. They're these cells in our body that cause degeneration.
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They can cause risk of cancer, risk of inflammatory diseases, autoimmune problems, and things like that. What hyperbaric therapy can do is decrease the number of those cells. Great. Fantastic. But after a hyperbaric protocol, how long does that last? Nobody knows. And so what was cool about that study is that they didn't change diet. They didn't change any lifestyle.
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They didn't change any behavior. Well, they can't for a study because those are other things that they would be changing and that gets confounding and all these other things with studies. But In general, that was very exciting to me, that study.
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It was like, well, if they were able to do this without changing anything else, what could we do if we did change all those other things too or optimize them?
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In essence, your question on fibromyalgia is a fantastic one because most of the time, if you're not working with an integrative provider and working on foundational health metrics, then it's not the time to go into a hyperbaric chamber if you want long-term benefits.
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Well, the way I would say it is this. What hyperbaric therapy is able to do is improve immune system function, improve the immune system, and the ability of the immune system to suppress infection as a result of having a more optimized immune system is absolutely the case.
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And we've seen this before, and it's pretty well studied in the sense that this kind of goes to the conversation of these chronic viral syndromes, chronic Lyme even, and things like that. where if you can improve the immune system itself, you can often see the body kind of take care of itself in the sense that oftentimes, you're never going to have this virus completely go away.
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If it's an HSV virus, if it's a herpes zoster, or if it's a varicella virus, et cetera, these things stay in our nervous systems and they are... once we're infected with them, they're not going to go away completely. The cure is a very difficult word here, but can your immune system fully suppress these and make them so they're inactive? The answer is absolutely, right?
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I grew up in my father's office, playing and doing coloring in the front. And then I was at the front desk collecting money when I was in high school and he was giving me cash under the table so I could go out with my friends. This was kind of my life for many, many years, obviously. I was adjusted when I was like a couple hours old. That's kind of the framework that you have to think about for me.
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And so once the immune system takes a hit, that's when you see the viral reactivations happening of HSV and EBV and you have the zoster and you have Even Lyme, that wasn't an issue before, causing an issue because the immune system got so trounced.
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And this became a really big issue and still is now because of severe COVID infections across the world for the three or four years that that was happening. Because that was a huge immune system hit for so many people that they had this sort of post, suddenly they had mold, suddenly they had Lyme.
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A lot of this had to do with a leaky gut and a leaky brain that happened because of the inflammation and things that were kind of walled off or being suppressed by the immune system were unable to be done, unable to be walled off and suppressed any further.
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And so addressing the foundation of all this stuff is going back to working on the immune system, working on the gut where 80% of our immune system lives anyway. So if you're working on the gut, you're working on 80% of your immune system right there. So the gut is a primary source target here when we're talking about immune system optimization.
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And so that's kind of where I would be thinking about going. And that's kind of my sense here is that if you're optimizing immune system function you're going to optimize for viral reactivations, you're going to be preventing viral reactivations, or you're going to be suppressing viral load if you improve immune system function. And so hyperbaric therapy can be a helpful tool here, right?
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It can be a helpful tool to do that. It decreases inflammation in the system. It can help optimize the immune system if you have all the machinery and capacity to be able to do that. And again, that's how I always like to remind people that you need to have that machinery. Otherwise, you're not going to see the benefit as much in the hyperbaric chamber.
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Yeah, we do it. There's a lot of my colleagues and I that will use various peptides, various other wound healing drugs. or mitochondrial optimization peptides or compounds. And this is where I use a ton of methylene blue specifically because methylene blue is working in the mitochondria, the part of our cells that make energy.
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And if you have some support to mitochondrial function, then they can start regenerating themselves and they can start having the whole system shift from an inflammatory immune system going crazy state to anti-inflammatory immune system modulation state where things are more able to be controlled by our immune system because our mitochondria are working better.
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And so I use a lot of methylene blue in this capacity to decrease inflammation, improve energy production. This is where we have a bunch of transcriptions products, as you know, that have methylene blue in them. We have another version, we have another type of product that's based off the cordyceps mushroom and the active ingredient in that is something called cordycepin, which is highly potent.
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And so when I evolved my practice after finishing medical school and residency as an internal medicine physician, it really was under the frame of, well, how can I really truly help people work on their health in a foundational way? And that really evolved over many years through the fields of hyperbaric oxygen therapy,
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We use it because it works on the adenosine system. Adenosine is the system that helps you make energy, but also helps you feel sleepy. So it increases your deep sleep when you take high doses of cordycepin at night, but also it's a profound anti-inflammatory. So it works on things like mTOR and the NF-kappa-B pathways and AMPK and things like that that helps modulate the immune system that way.
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So as we were kind of alluding to all here is that many people have been sick for a long time and want to feel better, like you said, Dylan, right away with a pill or a potion or an exercise or whatever that's going to make them be able to do. But it's very difficult It takes time.
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And so, and while you're kind of working on that foundation, having tools and techniques, it really can be very helpful. Something like methylene blue can be very helpful. Cordycepic can be very helpful working on the GABA system. So I do all these things and then, It's about stacking, like the biohacking kind of thing, but stacking in a methodical relationship.
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So it's not like, here's everything on day one. No, let's see how you do for a couple of weeks or a couple of months doing X, then add Y, then add Z, or start at A and add to Z if you need to. But it's about a stepwise, intentional way of working with people and not just throwing shit at the wall, unless you absolutely need to if it's like an acute issue.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
But in general, let's not throw shit at the wall. Let's be more methodical about things.
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Not good. Yeah, well, we have a different term here. Health optimization medicine and practice is the nonprofit or home hope. And Dr. Ted has created this word called Well, I think that the background here is there's something called the holobiont. Have you heard of the holobiont before? No. So the holobiont is a cool word. It basically means that we are a holo-organism in ourselves.
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We're not just made up of human cells. We're made up of bacteria, virus, fungus, and we are made up of the food and the light and the environment and the toxicity and everything else is all holobiont. us. We're not just human. In fact, we're outnumbered. In fact, with all the other types of cells that are in us, the trillions of bacteria, fungus, and virus. So this whole organism is us.
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So we're not, I'm not you, you're not me. We're all different. So we're not individuals just in a population and ecosystem of outside in the world, but around us, we have our aura of everything happening inside. So we can test all this using metabolomics, but the word holobiont is what we're testing here.
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to meeting a fantastic mentor that created something called Health Optimization Medicine and Practice, which he had, Dr. Ted Achikosa was his name, which he developed in his own practice and then was bringing here into the United States from Manila in the Philippines where he was born and had a practice there, along with DC and Europe as well.
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We're testing the exogenous things outside the environment, endogenous, the things that are happening inside the environment. And so we call this, this is a study of holobiontology. And instead of being biohackers, as many people say they are, in our world, we're biont hackers, B-I-O-N-T hackers, holobiont hackers, because we're
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
we're hacking our own biology using a intentional framework called metabolomics to look at all these pillars of health optimization, medicine, and practice in a holistic way. So that is the difference, right? So we're not just throwing shit at the wall and seeing what like cool supplement or cool technology or look at the score or look at there, look at there.
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We're like, no, this is an intentional framework. It's a framework that every biohacker should use, honestly, is that we have, it's called the holobiont hacking framework or biont hacking, as we say.
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There was a paper that was published in like 2013, 2014, that called metabolomics the stethoscope of the 21st century. So just to kind of give you some gravitas of what we're saying here. In essence, in simplistic terms, metabolomics is real time what's happening in your cells.
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It's the interaction between the environment outside of you and the internal environment, as well as your cells and your genes, all at the same time, what's happening real time. So vitamins, minerals, nutrients, and cofactors, how they're working on energy metabolism, how well you're breaking down your macronutrients, how well you're optimizing your micronutrients.
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These are all things that you can measure at the metabolomic level, whether you're measuring them directly or you're measuring the products of their metabolism or their breakdown or their processing inside the cell. And so the testing that we use a lot that many people may have heard of, or some people may have heard is organic acid testing.
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Organic acid testing is usually a urine-based test that's looking at these kinds of markers, okay? And so the power of this is that it's the interaction between external and internal environments.
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The way we think about this at Home Hope is that you have your exogenous metabolites, like your food, your microbes, your cosmetics, your drugs, your sunlight, your water, your magnetism, and you have your endogenous metabolites that are coming from your nucleus, your cytoplasm, your mitochondria, your hormones, your neurotransmitters, and your microorganisms, your microbiota as well.
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So all of those things are coming together and we can measure them all at the metabolomic level and then make real-time assessments that are clinically actionable, which means we can do something about them right now and see how that shifts over time as we make these various interventions. Dr. Ted, the founder here, likes to say like, We don't deal in theoreticals.
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It was a nonprofit organization that we incorporated in 2017 to train practitioners on his framework, which became the framework that I use in clinical practice. And so my evolution has sort of been in that realm, which is alternative, conventional, bringing these together, creating my own integrative practice in the image of things that were really interesting to me as I evolved.
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I don't want to deal in theoreticals. We want to deal with what the fuck can you do with somebody right now? They're right in front of you. How are you going to help them right now? As opposed to what may happen in 30 years if they have an APOE allele or LP little a. That's all important, but it's not as important in our estimation as what's happening right now.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
The other stuff you can fill in, your genetics, if you're getting really cool, you can get your transcriptomics involved, your proteomics. There's something called the narcissome, which is actually a term that was developed out of Stanford, which is basically, as humans, at some point, we're going to have what's called our narcissome, which is our DNA transcribed, our proteins, our transcriptome.
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we're going to have it all. We have to have genetics, we'll have it all, and then we'll be able to have it all on our wrist and we can look at it and we can make real-time assessments and metabolomics as well.
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But for now, what we can use that's clinically actionable right now is metabolomics and we can use vitamins, minerals, and nutrients and supplementation and change diet and change our lifestyle and behaviors and get out of shitty relationships and sleep in a different room if your wife snores or whatever. You're going to see the effects of that looking at metabolomic testing over time.
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Mitochondrial optimization is a very, very, very important piece, if not the foundational piece to what I do, because it dovetails the work I do in hyperbaric medicine. It's the foundation of the metabolomic work that we do in clinical practice as home health practitioners. And it has a significant amount to do with what we're doing at our for-profit company, Transcriptions.
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to try to help people because 94% of the US population has mitochondria that doesn't work as optimally as it could. And so that's 6% are metabolically healthy. And so maybe some people have heard of that term like metabolically healthy. What does that mean? What metabolically healthy really means is that you're able to take those macronutrients and make energy from them.
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And then also detox from the energy that you make. So the stuff we've been talking about here. So if you're not able to do any of those things optimally, then you have some element of mitochondrial dysfunction. So where do we have our most mitochondria? Dylan, this is a quiz question for you. Where do we have our most mitochondria per cell? Do you know? Yes. Your gut.
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Your gut has a lot, but there are more places. So number one place for men is in their sperm. Number one place for women is going to be in their ovaries and their eggs. And then after that, we have our brain, our heart, and our liver. And then our musculoskeletal system, of course. So if you have...
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brain fog, if you have concentration problems, if you have chronic fatigue, if you have exercise-induced fatigue, if you have detoxification issues, cardiac issues, these all are mitochondrial issues.
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If you are having a hard time getting pregnant, if you're female, or if you're having a hard time inseminating a female because you have sperm that don't work very well because your mitochondria there are not working well. So infertility, you mentioned this earlier with testosterone levels, this is also a mitochondrial issue significantly as well. However,
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
In essence, if your mitochondria aren't working well, your cells aren't going to work well. And then there's all these cascades of things that happen as a result of that. So if you are looking at it from a gut perspective, which you mentioned, our gut microbiota, our bacteria...
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in our gut are communicating with the mitochondria in our cells as well through these things called extracellular vesicles as well. And this is called interkingdom crosstalk, which means that our bacteria are communicating with these mitochondria in our cells to tell them what's going on and how to interact and how to work with the immune system and how to change DNA expression.
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And it's a very complicated system. But the lowest or the main common denominator here for most disease is mitochondrial dysfunction. So that doesn't mean that's the only thing you want to address. But oftentimes, if you think about what's causing mitochondrial dysfunction, it's the most common thing right now in the world, but especially in the US, is insulin resistance.
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So people that are obese and overweight, if you're insulin resistant, you have a higher risk of having metabolic dysfunction and then mitochondrial dysfunction. If you take medications that affect mitochondrial function as well, the most common one that's commonly used in longevity actually is metformin.
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Yeah, yeah. I mean, for a long time, when I finished my residency and I got more involved in hyperbaric medicine, I found this a fantastic tool, a fantastic tool for healing, for accelerating performance, for recovery. But I was missing a foundation to it because I found that if you put people in a chamber too early, if they had chronic issues... that they wouldn't do as well as I anticipated.
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Metformin actually destroys the first of the four major complexes that run the mitochondria themselves. The idea is to destroy it and then you can make new ones that are better. That's the idea with Metformin at least. It may work in diabetics, but probably not for everybody. So medications or toxins in our environment, so infections, these are all things that can affect our mitochondria.
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Why is it so important? Because it's the final common denominator for almost all disease that we have. Now you have to think about addressing all those other aspects of what's causing mitochondrial dysfunction. But if you're looking at the mitochondria and you're testing for it, then you can start optimizing for vitamins, minerals, nutrients, for cofactors, start using things that can help
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regenerate or restore mitochondrial function while you're trying to work on the behavior, the lifestyle, the diet, those aspects of other things that have been affecting the mitochondria so much as well.
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Yeah, I mean, oftentimes it depends on sort of the reason, like what's going on to cause the mitochondrial dysfunction, but that's not, so it's like being exposed to a heavy metal. If you have heavy metals in the system, you need to detox from those and have various pathways to kind of upregulate to do that, but you also have to take away the exposure at the same time.
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So you can't do one without the other. Now you can start the detox process with heavy metals. You can start the process of mitochondrial optimization without understanding exactly what those toxins or those other issues are. And you can get some of the way there, but eventually you have to be thinking about behavior, lifestyle, diet as well as optimizing the mitochondria from the inside out.
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But it can take a lot of time to do this. It's not like you can just start working with somebody and you can see their mitochondria just regenerate over a couple of days. And so there are things you can use in the short term to help.
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And one of the things that I've mentioned a couple of times is something called methylene blue, which is a synthetic dye, which is invented over a hundred years ago, which initially was used at high doses for infection. It's a fantastic anti-infective, but at low doses, it supports mitochondrial function.
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It supports the capacity to compensate for defects and for deficiencies in what's called the electron transport chain, which is the chain of proteins that's on your mitochondria that allows you to make energy. And for many people, that is what's wrong. You're having a hard time, especially with the first two complexes that are taking electrons from your food.
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I mean, most people like to eat, but the reason why we have these mechanisms that tell us that we like to eat is because we need food to make electrons. That's what we need the food for, at least especially for fat and for carbohydrates. For protein, it's for lots of other things, but in essence, not as much for this.
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But from a perspective of making energy, we need electrons from our food to be able to do that. And so we have this electron transport chain in a mitochondria that has this whole process in play to create all that energy so that we can make that energy currency to run all the processes that we want. And for so many of us, there is a problem with that. And if you have...
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I would try to figure out, well, what was going on here? So I would refer over to my friends that were doing functional medicine. And then I was like, well, this is good, but I need to be doing something on my own, something that I could do in my own clinical practice to really be able to support these patients.
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A problem with that, you likely know it if you have brain fog, if you have infertility, if you have cardiac or detoxification issues, if you have muscle, if you have exercise-induced fatigue, these are mitochondrial issues.
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And so you can use something like methylene blue, which happens, you're going to get inside the system very quickly, and you can start seeing benefit very, very fast, energy better, inflammation better, brain fog better, exercise-induced fatigue better, while you're doing the other work of optimizing your
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behavior, lifestyle, diet, along with doing the testing and seeing where you can work in the system itself to kind of target and to support the mitochondrial energy production system, detoxification system, et cetera.
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Yeah. So there's a couple of different tests. The one that I typically use is the organic acid testing, which is urine-based. There are a couple tests out there that purportedly can give you a sense of mitochondrial health. But those tests are pretty new. I don't, you know, Dr. Youth and I have actually had discussions about this.
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Dr. Elizabeth Youth, we don't believe some of the other testing out there. It may be kind of like the Oura Ring where you can watch things over time and see things change. But even that, I'm not even sure about. I mean, we just don't know yet. There's something called the mito swab, for example, that may be good, but I just don't have enough personal knowledge experience with it.
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And I know Dr. Yurta was feeling the same way when I asked her about this not too long ago. So there really are, there's a couple other ways to do mitochondrial testing, but they're pretty invasive. You can get like a punch biopsy. You can get like a biopsy of muscle and look at mitochondrial function.
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There's also this really cool machine out of Belgium that does mitochondrial testing, but it's very, very expensive. Actually, a really cool side note there is that the guy that invented it, the demonstration that he makes is he has it hooked up to him in an area of his skin, and then he rubs cyanide cream, just like very 1% cyanide. And what you can see happen is that
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And that's when I met Dr. Ted and I met this framework that he was developing that really looked at energy and mitochondria and sort of cellular health first before anything else.
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the electron transport chain, the mitochondria goes down to zero because cyanide is a mitochondrial poison. And so actually the antidote for cyanide poisoning is actually methylene blue because it can rescue the mitochondria and prevent you from dying from cyanide. So if you're going anywhere that you might get cyanide poison, you should always have methylene blue with you. And that's for sure.
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But I hope nobody listening has that particular adventure ahead of them. But In essence, they were able to prove that you're actually looking at mitochondrial ATP production and the utilization of oxygen by showing that you can use cyanide on the skin and see how their oxygen, their energy capacity, their energy production capacity goes to zero. Pretty cool, actually.
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But I would try that at home, ladies and gentlemen.
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There's a couple. So there's a couple labs that do it. The one that we use typically is Genova Diagnostics. Genova is based out of North Carolina. There's another lab called Great Plains. There's another one called Vibrant. There's a number of companies out there that do them.
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The nice thing about Genova is that they do optimal ranges, which is that their normal levels of their labs are standardized in a healthy group of individuals between 21 and 30 years of age. as opposed to Vibrant and others that use a much larger age range, usually 18 to 65 is what they use. And so that's okay, but it's not necessarily optimal as far as I'm concerned.
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And that really gravitated, that really was something I gravitated towards because I realized, and that's really what I was doing in the chamber, was really trying to push energy production, push the processes of the body to recover and heal. But if you didn't have the machinery to be able to do that, if you didn't have the machinery to be able to
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But, you know, you can also, there's also some new companies out there like Fullscript, for example, that are creating their own optimal ranges with their new system, which I'm pretty excited about. So Fullscript is a supplement aggregator online that many people know about already. So they're pretty cool in how they're doing and then
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even our nonprofit, Home Hope, we're doing a number of things in the world of AI to help us, not just fake AI, but real AI. Not everybody says AI, but Dr. Ted is actually one of the true pioneers of AI back in the 1980s. He was actually able to fully transcribe the worm C. elegans.
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He was able to compute the nervous system of C. elegans back in the 90s and create a mathematical model of consciousness that way. But just to give you a sense, we're also doing things internally to work on these kinds of systems too.
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I mean, I usually say if you're healthy and otherwise doing well, somewhere in your mid-30s would be a good idea to start getting like a baseline of kind of where you are. Maybe early 30s, but I mean, the sad truth is that more and more people are getting sicker, much younger, and starting doing the testing earlier may be helpful.
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I've worked with some elite athletes and others using the testing, and I've actually been pretty surprised about what I've found overall in toxicities, deficiencies, et cetera. So working on this stuff earlier can be beneficial, but certainly in adults is what I've mostly used the testing on, although I have pediatrician colleagues that do use it in kids as well.
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optimize the mitochondria to help with energy to help with detox to help with blood flow etc like you weren't going to get as far as you could within a hyperbaric context and so for me that that was really a big big turning point for me as i was creating my own practice was like i didn't have that foundation and now and then i did create that you know with with the help of dr ted and then this framework in 2019 or so that became a big part of what i do
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Well, I would even counter that to some degree and say, that's important, but what about inflammation in the system? What about mitochondrial dysfunction? Because that's the fuel, that's the gasoline on the fire, right? You have elevated ApoB, it doesn't matter to me. If your inflammatory markers are well established, controlled.
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If you have optimized mitochondrial function, it's not going to be an issue. So they go together, right? So I think the key for us and the way we think about things at what's the foundational aspects of things that we're addressing, optimizing for inflammation, optimizing for mitochondrial function, for gut health, immune system support, hormonal health, et cetera.
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And then looking at those markers can be helpful. But if you're just looking at those markers and just treating them without looking at the inflammatory side of things, it's like going to a chamber without hyperbaric chamber without doing the legwork or the groundwork before going in.
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Yeah, so methylene blue has been around a long time. I'm just going to cut for a second. Can you hear my daughter playing piano in the background? Can you not hear that? Nope, I don't hear it. Sound doesn't sound at all. Okay. I just want to make sure. Okay. I just want to make sure before I got started on this, it wasn't too late, too loud. Okay, I'll go back into it.
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I just wanted to just do that real quick before.
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I was like, otherwise, people are thinking I'm in a piano recital or something.
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Yeah, yeah. So methylene blue has been around a long time. It was first developed in the 1870s as a textile dye, actually. But in the 1890s, it was realized that it actually worked like a magic bullet. They called it that because... You could give very high doses of it and it would kill pathogens in humans, but it would not harm normal cells.
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And that was kind of like the high pinnacle that they were trying to find at the time because there really were no antimicrobials at the time at all. I mean, except for some natural things, but very, very few. And they had a very few things in their repertoire. So they started using methylene blue in 1897. It was FDA approved. It was the first drug registered with the FDA back in 1897.
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And it was actually treatment for malaria. But in the next 50 years or so after it was developed, it was used as an antimicrobial and one of the most significant and most potent that was available. So it was used in World War II. Pilots had to take it when they were in the Pacific and the jungles and fighting in the Japanese, etc. They were actually taking prophylactic methylene blue.
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There were stories about methylene blue and songs about it because at higher doses for infection, it actually causes your urine to be blue And so when you take methylene blue orally, it concentrates in your urine. You take an IV, it's the same thing, but it concentrates in your urine and you will urinate blues.
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That's something that it's not, it's a benign effect, but it is an effect and it's surprising if you don't know it's going to happen. But when antimicrobials came on the scene in the 1950s, Methylene blue became more out of favor, just got out of favor because you had these newer, fancier antimicrobials, which were very good.
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You had penicillin at the time and then others that were being developed in the 1950s. And so it had a long history from then. The first antipsychotics were derived from methylene blue, actually, because methylene blue also works on the neurotransmitter system, increasing serotonin. dopamine and norepinephrine. And so the first antipsychotic in the 1950s was developed out of methylene blue itself.
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It was also used in laboratory staining in chemistry labs. And this is actually how I first learned about it when I was in college. And the interesting thing about where it stains the cell is not surprisingly in the mitochondria itself. And so it concentrates in the mitochondria.
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And so over the last several decades, there's been a lot of interest in what's actually happening with methylene blue in the mitochondria. And why is it concentrating in there? What's happening? And so what we now know is that methylene blue at very low doses, you know, 4, 8, 16, 25 milligrams is a fantastic mitochondrial optimizer. And it has a very cool effect, which is very unusual.
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And it's called the redox cycler. What that means is that it helps you make energy. It helps you make ATP, the energy currency. And it can do this even if some of the mitochondria isn't working very well.
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Even if some of the complexes that are responsible for you being able to make energy in the mitochondria are not working as well as they're supposed to, you can still compensate for that using methylene blue. Now, on the other end of it, it's also working as an antioxidant. So it can actually pick up free radicals or oxidative stress. And so there's very few compounds out there that can do both.
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They help you can not only increase the amount of energy you're making, but also help with the detoxification capacity at the same time. So these low doses are extremely potent at working in the mitochondria. There's also some effects on how well methylene blue can be carried, excuse me, how oxygen can be carried on red blood cells.
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Red blood cells, by the way, are the only cells in our body that do not have mitochondria. That's a fun fact. But the red blood cells carry oxygen, as we all know, and that methylene blue helps that become more efficient. And at the same time, methylene blue is working at the neurotransmitter level, helping improve your mood and your focus by increasing norepinephrine, serotonin, dopamine together.
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At these low doses, it could be fantastically potent as a mitochondrial optimizer, as a mood booster, as an energy enhancer.
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And then at higher doses, around a milligram per kilogram, a little bit more, definitely a little bit higher sometimes, a little bit more, like one or two milligrams per kilogram, and sometimes a little bit lower than one milligram per kilogram, you get an anti-infective capacity to it.
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So it's an antiviral, it's an antifungal, it's an antibacterial, it's used previously for urinary tract infections and other infections, but also still used that way in many countries around the world. And then even becoming more used again for malaria,
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because a lot of the drugs that we were using for it after the drugs were developed now no longer work against malaria because they're resistant to the organism or the organism is resistant to the medications.
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Yeah. So if you are pregnant or breastfeeding, you shouldn't take methylene blue. If you're taking SSRIs, SNRIs, or dopaminergic drugs, drugs that increase dopamine, you have to be really careful because methylene blue is already increasing those particular neurotransmitters.
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Now, it's not like absolutely you can't take methylene blue, but if you're going to try it, then I would use it in conjunction with working closely with a healthcare provider to kind of work with the dosing, making sure you're feeling okay, et cetera.
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I mean, the other thing that is if you're a hypertensive, if you're on antihypertensive medications, especially like three or more antihypertensives, then you really got to think about using methylene blue very carefully because it can raise blood pressure in some people a little bit or some people more if they already have blood pressure issues.
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So they don't help them as much as you could help them, right? So, yeah, that's for sure.
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You can also get detoxification, like detox kinds of reactions using methylene blue because you're enhancing energy and detox at the same time. But if you start off with really low dosing and you titrate it over time, like that's really where you can find that usually you're maximizing the benefits with minimizing the risks of having, you know, detox kinds of reactions like herd timing,
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Alzheimer type of reactions as well, that kind of thing. And it's been amazing, Dylan. I mean, I've been involved now working with Methylene Blue for like four and a half years, almost five years. And I've just been floored by the profound impact that it's had on so many people, like with inflammation, with pain, with brain fog, with concentration, with cardiac function, with liver detoxification.
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And in a lot of people that have tried almost everything, and they're still feeling terrible. And then all of a sudden they start taking methylene blue and like their life can come back in a couple of days sometimes. I was just speaking to somebody that had a lot of issues with mold. She's a practitioner and she dealt with the mold. The mold was gone, but she still felt terrible.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And she started methylene blue A week later, she was back to work and like she had been out of work for two years. And so this is not just like a one-off kind of story. We're hearing this all the time. The key with the dosing is to titrate it slowly and find the right dose for you. So oftentimes that starts with very, very low doses, like four milligrams, eight milligrams.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
10, 16, 12, somewhere around there. And then slowly increasing the dose every three to five days until you're finding the benefit. But it's been fantastically effective with so many of my own personal patients and many stories that we've heard over the years as well.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
So you can get it over the counter as well as a prescription. It's kind of an interesting one like that because it's been around as long as it has been. So you can go buy it on Amazon, but I don't recommend doing that because the problem with methylene blue is that it can often be contaminated.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Even the pharmaceutical grade can be contaminated with heavy metals like lead, mercury, cadmium, and arsenic. So you don't want that. So if you're going to get methylene blue, you have to make sure that you're getting the certificate of analysis from the company that's making it. But I would still not buy anything on Amazon because you don't know what you're getting.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
So at Troscriptions, our company, we have a couple of different products with methylene blue in them. We've had to throw out, honestly, like thousands of dollars worth of product in the past because it didn't meet our specs. And so it's really difficult.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And as a clinician, I wanted to make sure we all, there's four docs on the team, including me, and we wanted to make sure that every product that we made, we would want to use with our families, with our patients in clinical practice as well. So we've had to throw out a whole bunch over the years that didn't meet our spec.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And so that's a big thing with methylene blue is making sure you're getting good quality stuff. And so we test every batch. We make sure that everything is up to exactly what our specs should be, which is, you know, very, very low or zero heavy metals. And, you know, this is something you should be asking, you know, the companies that you're looking at. It's difficult to dose in some ways too.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Like a lot of the companies will make drops, like little dropper, a Bethlehem blue that you have to kind of drop out and you don't know exactly how much you're getting. And we have tested a lot of the drops ourselves. And the potency is not what's usually on the label. Oftentimes, it's like 20% to 60% less than what they're actually telling you. And drops are also very messy.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
So we developed something called a troche, or T-R-O-C-H-E, which is a dissolvable lozenge that can go up between your upper cheek and gum. But it can also be swallowed as well.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Methylene blue, the nice thing about it is that it's highly bioavailable, which means that almost 100% of it gets into the system, whether you get it in IV, which of course would be 100% bioavailable, or if you just take it in a trochee or you swallow it. And so that's nice about it is you can just swallow it. Although if you want a blue mouth, you can put it up here and let it dissolve.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
What's nice about the blue mouth for some people though, is that It works faster this way. So trochees are nice because if they dissolve in the mouth up between your upper cheek and gum, they're going to go in the system faster. They're going to get the effect faster.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
If you have a lot of chronic brain fog and other issues, like mentally, like up here will potentially be a benefit, but you have to balance that with having potentially a blue mouth overall. We have a lower strength called JustBlue. We have a higher strength called TroPlusBlue.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
The higher strength is more for infection, for acute mitochondrial support, and the lower strength is more for mitochondrial optimization overall.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Good question. So if you're coming in with a chronic complex medical illness, then oftentimes it's going to be something you want to take regularly for a period of time. It may be two weeks, it may be four weeks, it may be a couple months, maybe even longer in some people. And that's totally okay as long as you're monitoring things over the time, hopefully working with a practitioner.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
But very low doses are very, very safe when it comes down to it. We're talking about 4, 8, 16 milligrams. This is all very, very low dose and all very, very, very safe. If you're getting to be like above 50, especially above 100 milligrams a day of methylene blue, then that's more of an anti-infective dose.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
That's something that should be monitored over time with a practitioner if you're going to be on those kinds of doses. Now, if you're using it more for like... endurance, for example, because we know that what methylene blue also can do is it can take place of oxygen and be just like oxygen and help you make more energy, even if you don't have as much oxygen around.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
So what that means for bodybuilder performance people is that your aerobic threshold will be longer. You will reach anaerobic threshold in a longer time. It will take you longer to get there. So you have more endurance capacity.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And I've worked with a number of athletes doing ultra marathoners, doing hypoxic training, using methylene blue, eight, 16 milligrams pre-hypoxic training, and then endurance or pre-endurance and doing some fantastic, fantastic work with their times, with their overall performance. So because it works on that energy production capacity. So in that capacity, you can use it sort of as ad hoc, right?
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
As needed. You don't have to use it every day. Oftentimes, if you do need it, more often, say you need it beginning seven days a week because you have a chronic mitochondrial issue, what we try to do over time, at least clinically, is wean people off, wean people down. So they're taking it maybe two or three times a week.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
If you're traveling a lot, if you're on airplanes like I am a lot, then it's also great for jet lag because it protects you from being on an airplane at low oxygen levels up there with more radiation and more prone to getting infections and things like that. So we have really significant interest in helping people, like if you're coming to visit me in Colorado, come take some methylene blue.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
It's going to help you. And also we have jet lag protocols and things like that on our website too.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Yeah, we're looking at that, at least anecdotally. We don't have any studies there, but we're looking at how we can do that and also help you maintain a heart rate at a level for longer. So that's what a lot of my patients will say to me is like, I won't exercise without methylene blue because I can keep my heart rate up for longer without getting tired.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
So transcriptions was developed as the for-profit arm of our nonprofit health optimization medicine and practice. It was the idea- that we needed to help people right now while they're on the longer path to optimizing their health. And so methylene blue was one of the first compounds that we looked at because we saw such significant potential from a mitochondrial perspective.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And so we developed a number of products that have methylene blue in them that are direct to consumers. So you can go online at transcriptions.com and buy... Just Blue and Blue Cannatine. So Just Blue is pure methylene blue, 16 milligram trochees can be broken up easily because the trochees are breakable.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
You can break them up to quarter halves or fulls, and it can find your right dose and optimize it over time. You have another one called Blue Cannatine, which is a combination of methylene blue with nicotine, caffeine, and CBD. This is like your biohacker special. This is your Adderall without the jitters.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
This is your focus productivity, get shit done about three to five hours without come down or crash. And this is actually the first product we came out with in February of 2020. So right just before the pandemic. And it's a fantastically effective product. product. It worked very, very well. If you're looking to have three to five hours of focus, this is the product to do it.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And we've had clinicians do a really good job, including myself, being able to wean our patients off of ADHD meds slowly and carefully using this particular product as well. And I use them in combination. I use Bucanitine with Just Blue together all the time.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Bucanitine in the morning because it gives you the stimulation, and then Just Blue, 16 milligrams of Methylene Blue in the early afternoon to keep people going and without giving them the stimulation and having them have a hard time going to bed in the evenings because of stimulants, et cetera. So Transcriptions was developed to
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
fill the gap of the now, helping people right now while they're on the longer path to health optimization. And then we have a whole additional level of products called our TroPlus line, which is for practitioners only. And this is for practitioners who want to sell our products either in their offices, or if they have a telemedicine practice, they can drop ship our products to their patients.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
We have one called TroPlus Blue, which is our higher strength methylene blue, 50 milligrams, 5-0 strength. We have another one called TroPlus Immune, We talked a little bit earlier about cordycepin, which is a fantastic anti-inflammatory coming from the cordyceps mushroom. So we have a TRO plus immune product as well for immune system optimization, decreasing inflammation, et cetera.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
In general, yes. In general, the answer is yes. I don't want to say that you don't want to take those drugs if they're prescribed to you or if they're necessary, but certainly the side effect profile of something like methylene blue or cordycepin is much, much less significant than NSAIDs in general.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Well, the good news is that the low doses are very easy to purchase and to monitor on your own over time. If you do have a significant medical issue, if you're on medications, if you're following with a practitioner already, it is a good idea, of course, to work with a clinician. We have a number of
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
clinicians now that, you know, that are part of our network that have, that are using Troscoption's products. And so we have a resource map available for those practitioners if you're interested in working with a practitioner. But in essence, the lower doses can be titrated over time. And we have a lot of resources on our website to help people kind of understand what that looks like.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
When it comes, we have blogs on methylene blue. We have lots of information. We have practitioners that are prescribing the higher dose as well, then working closely with their patients to kind of monitor them over time as well. But in essence, it's a very safe compound, and it could be used pretty much on your own as long as you're kind of making sure that you're understanding the
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
what risk you have of taking it, which is probably pretty low, but just in case you're looking at, are you on blood pressure medications? Are you on SSRIs and et cetera, et cetera.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
So if you're on prescribed medications, you really should be working with a healthcare practitioner and talking to them about anything else that you're bringing in to your body that you're going to be taking, because that's always an important thing.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Yeah, sure. So GABA is our primary inhibitory neurotransmitter. So it's the neurotransmitter in our brain that helps calm things down. It calms down neuron firing. This is very much associated with the increased tone of our parasympathetic nervous system, our nervous system that helps calm us down, rest, digest, recover, detoxify. That's what parasympathetic is all about.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
The sympathetic nervous system on the other converse side is our side that makes us feel more awake, more alert, ready to go, hustle, hustle, hustle, bustle, move, go, don't stop, that kind of thing. And so the emphasis in American culture is on the sympathetic nervous system, right?
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
you know hustling you know pounding the pavement like not sleeping you know getting done and i was i've been definitely guilty of this in my own life in many times as many of us that are trying to run 10 miles a day and taking three ibuprofen a day just to do it are doing but if we forget is that the parasympathetic nervous system helps us heal and if we cannot heal we can't recover
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
we're not going to be able to perform at our best. And so optimizing the GABA system is extremely important. Many of us these days are GABA deficient, which means we don't have enough GABA in the system. If you don't have enough GABA in your brain, you're going to feel depressed. You can feel anxious. You're not going to sleep well. You're going to have mood instability.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
You're just not going to feel good overall. So the key with the GABA system is to optimize it. And so how can we do that? There's a lot of different ways you can do it. You can The thing about GABA itself is that it's really just made in the brain. And it's made from something called glutamate, which is our primary excitatory neurotransmitter. So there is the excitatory neurotransmitter glutamate.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And then there is the inhibitory neurotransmitter GABA. And there's a balance between these two always. And so if you're too much on the glutamate side, you're going to feel edgy. You're going to feel headaches. You're going to feel like you're just kind of like off and hustling. You're just like not going to be able to feel relaxed.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
I think over the years, it's getting bigger and bigger and the number of people that are moving or interested in alternative kind of medical treatments or medical care or outside of the conventional system because it fails so many people.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And it's very rare to feel too much GABA, but too much GABA is like I can't get off the couch. Like it's like you can't move. It's very, very unusual unless you're taking things that are enhancing the GABA system. So the first thing to think about when you're enhancing or optimizing the GABA system is optimizing the conversion. of that excitatory neurotransmitter glutamate to GABA itself.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And the two cofactors that are required there are vitamin B6 and magnesium. You also have to think about stress and other things that can be depleting GABA. Like if you're overexercising, if you're overstressed, that's going to deplete GABA over time too. Mineral deficiencies can do this.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
The problem with GABA supplementation is that GABA supplements, GABA itself doesn't get across into the brain very easily. It doesn't get across the blood-brain barrier. If it does get across, it means that your brain is probably leaky, which means that it's leaking things in there that shouldn't get in there. That's not good, obviously. And that often corresponds with having a leaky gut.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
leaky GI system. So if you work on the GI system, you're going to work on the brain as well. And so if you have a severe infection, inflammation, severe trauma, or it can be a physical or emotional trauma, your gut can get leaky all of a sudden, your brain can get leaky all of a sudden, and then shit goes haywire.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
So if GABA supplements work for you, it likely means that your brain barrier is not doing what it's supposed to do. So there are ways to enhance GABA. Otherwise, you can't use GABA itself. you can use things like kava, which is a great one, or CBD or CBG, these cannabinoids that are non-psychoactive.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
So at Troscriptions, we have something called TroCalm, which works on anxiety, stress relief, and tension. By using kava, CBD, CBG, and something called nicotinyl GABA, which is a vitamin B attached to a GABA, which allows it to get across very easily because of the B3. And then in the brain, you get the GABA there and you get some B3. So the B3 is mildly activating.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
So you feel less anxious and less stressed, but you don't feel tired. So that's a nice kind of combination. What we've done at transcriptions is combine something that binds to the GABA receptor at where GABA binds itself, and also where you have the GABA receptor site where GABA binds, and also a separate site where something else can bind, like kava, for example.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
I think you have to give doctors a little bit of leeway here in the conventional system because they're just in a system that's very much laid out in a certain way. It's very difficult to do anything inside of that system other than what they already do. And the mitochondria, shocking are complicated.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
That combination increases the affinity of the GABA receptor to work well, and then at the same time doesn't deplete GABA over time too. So that's what we have TROCOM for.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
It also has something called TroZ, which works on the GABA system by working on the combination, something that binds to the GABA site, something called agarine this time, which is actually from a psychedelic mushroom called the Amanita mushroom. But it's not psychedelic at low doses.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
It just comes from the mushroom that can cause psychedelic experiences, Santa Claus, reindeer flying, shamanistic rituals, and Christmas, Merry Christmas and Happy New Year. But the agarine itself is a long-acting compound that works on the GABA receptor. And we have that included in combination with something called Honokyle, Honokyle from Magnolia Bark.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
That combination works on the GABA receptor, enhancing the capacity for GABA system to be increased. And so you get more relaxation and it's long acting, so you get better sleep that way too. So the key with working, understanding GABA high level is that if you don't have a lot of it, you're going to be more anxious, you're going to be more stressed, you're going to be more depressed.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
and I'd be able to sleep. So you want to look at foundational biomarkers to support the GABA system. And you also want to think about supplementation that's going to support GABA and not taking GABA supplements directly because they don't work. If they do, you likely have a leaky blood-brain barrier, which needs to be addressed.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
There's no direct testing for GABA because GABA is only made in the brain primarily. And so you have to look at the precursors to GABA. So we talked about glutamate. Glutamate comes from the amino acid glutamine. So you can test glutamine, like plasma amino acid levels of glutamine or urine to kind of get a sense of glutamine levels.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
You can test vitamin B6 and magnesium, which are cofactors that are responsible for the conversion of glutamate to GABA. But in essence, it's a clinical diagnosis that not many practitioners are thinking about. They're thinking about neurotransmitters like dopamine and norepinephrine and serotonin. But we know that serotonin deficiency is not what causes depression, right?
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
We know that it's not norepinephrine or dopamine deficiency that causes depression. So those drugs could be helpful, especially SSRIs in some people, but that's not really the reason why somebody's depressed is because they're low serotonin, right? But they can be depressed because they have low GABA, actually. And so... In my clinical practice, obviously I've done a lot of work in this world.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
It's one of the main things that I'm thinking about is like, no, let's not go directly to serotonergic or dopaminergic or norepinephrine. Let's go to the GABA system. Let's work on rest, relax, parasympathetic, supporting the GABA system. Breath work can work and support the GABA system.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And it's not something that is that easy for practitioners to really understand without a lot of focus and a lot of work to kind of make sure that you understand what's going on at that level. I mean, in medical school, we learn about the mitochondria. We learn about all the intermediates that are required and how we break down our food and the electron transport chain.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Like yoga, mindfulness, even exercise can help if it's done in short bursts because exercise helps increase something called BDNF, which increases the amount of GABA as well. But there's also other drugs and supplements that can help support the GABA system too. There's lots of things like things like ashwagandha and even progesterone can help as well.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
So there's lots of things here, but the key is to have it on your radar as a clinical practitioner. And also, if you're just somebody that has a hard time sleeping or anxious or depressed, think about the GABA system and think about using some supplementation that may support that to see if it works for you. And then you have a good sense that, yeah, this is what's going on.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
This is at least a part of what may be happening.
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Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Yeah. I mean, you can, you can do your own diagnostic testing on some level. If you take GABA supplements and they work, that could just mean that, you know, you've got something going on there now, and then you should go see a practitioner to check if you have a leaky gut.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
But you also can try something like Trocom or, Trozee and say, hey, do these things help with my anxiety or with my stress or with my sleep? Then, okay, well, then there's something potentially going on with my GABA system here. So how can I not only just take these supplements when I need them, but how can I support the system holistically so I don't need these things all the time?
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And that would be fine for me. I'd rather people be able to do this without supplementation, quote unquote, naturally with behavior, with lifestyle, with diet. That's ideal. I would ideally like now people to have to take the Troscriptions product for the long term, but they're there when you need them, that kind of thing.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Yeah, just go to Troscriptions.com, check it out. We have most of our products are direct to consumer and direct to you. We have a couple that are for practitioners only. So if you are a practitioner, you can go ahead and register with our practitioner portal in our page and you can get access to wholesale pricing and drop shipping.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
If you like or interested in a Troplus product, but you're not a practitioner, And you can look at our, you can request a practitioner in your area. We can help set you up with somebody to potentially be able to prescribe those products to you as well. So yeah, those would be the main ways. And then we have a lot of information at transcriptions.com.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Also on Instagram at transcriptions as well are places to go.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
So my consulting practice is a combination of many things, but the main aspects of it are hyperbaric oxygen therapy, health optimization medicine, and I focus on those two mostly. Sometimes I will consult with people on methylene blue if it integrates with those things, typically not on its own, along with the GABAergic stuff as well.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
I can sometimes work with people to kind of help them and kind of steer them in the right direction. But I've been working with patients all over the world for years, you know, just helping kind of guide in various ways on clinical practice, on various types of protocols.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
But then as soon as you learn it, you have to shove it out of your brain so you can learn something else. I have a good story of, I think it was after my anatomy surgery, final. I went to go get money from the ATM when we still did that. And I couldn't remember my pin code. It was like the same code it had been for like five or 10 years at that point, but it was just gone.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And I work with clinicians and help set up hyperbaric facilities and integrate other technologies alongside hyperbaric therapy, creating protocols that way too.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
My pleasure. My pleasure. I mean, if people are interested in learning more about me, like on Instagram, I'm at Dr. Scott Scherr, D-R-S-C-O-T-T-S-H-E-R-R. My hyperbaric consulting is at integrativehbot.com. And then my hyperbaric company is called One Base Health, the number one spelled out. And that's a company that I developed three or four years ago.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
working on new technology and sensors and integrations with education and app-based technology to kind of bring hyperbaric therapy to the next level along with other tech as well.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
My pleasure. Thanks for having me, Dylan. This has been a pleasure.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Like the amount of information that I had to shove into my brain for a short period of time, which I was very good at. But what I didn't learn in medical school was that you could operationalize the capacity to learn mitochondria, electron transport chain,
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
the macronutrients, the micronutrients, and be able to actually use that in clinical practice and use it in real time using something called the science of metabolomics, which is the science of metabolism, the science of understanding what's happening in the real time in your cells right now.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
The interaction between your genes and your environment, so your internal environment, your DNA, and your external environment is most easily understood at the metabolomic level. This is something that's been around for over 20 years in... in the science world, in the world of practice, but it really hasn't hit clinical practice yet, even though it's been around for 20 years.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And everybody thinks about the genes and how these are important. Of course, genomics is important, but that only tells you what might happen, right? Then you have things like proteomics and transcriptomics, or you have transcriptomics and then proteomics. Those are other levels outside of your DNA that we can look at various types of proteins or the transcriptome, the RNA and things like that.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
But really where the most operational work at the operational capacity and ecosystem is right now is metabolomics. And so medical school didn't teach me that we could do any of these kinds of things with that kind of data, right? We learned about mitochondria, learned about electron transfer chain, et cetera, but we didn't learn that you could actually measure it and then actually
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
optimize somebody and then watch things change over time. So that was really important for me. And I think that a lot of doctors are just so much in the weeds of having to do what they have to do because of insurance reasons or reimbursement reasons or salary reasons or incentivized reasons.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
There's lots of incentives in the system to put people on statins, to put people on blood pressure medications, not to wait six months and see if they can do things on their own because And they get less bonus at the end of the year and things like that. So the incentives are all fucked up is what it comes down to.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And so if you want to find practitioners that are going to help you, oftentimes you're going to have to be paying some sort of money to be able to do that. And that's not easy for everybody. And I get that.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
It was very simple for me. It was realizing that using hyperbarotoxin therapy
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
as a modality, as the main modality, which I became known for over many years, speaking about it, doing it, like I was a medical director of multiple facilities in the Bay Area, realizing people weren't doing as well as I anticipated, as we were alluding to earlier, I realized that the issue was that when you're in a hyperbaric chamber, in essence, what we're doing is bringing a huge amount of more oxygen in circulation.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
We're doing that with an increased atmospheric pressure. We're If you're going to bring all this oxygen in circulation, can the body do what you want it to do with all of that oxygen, i.e. make energy, i.e. have the capacity to shift some of what's called your epigenetics, somehow the ways that your DNA is being expressed, various ways of genes expression, that can change over time.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
and oxygen can be an insider of that. But if you don't have the capacity to make energy well, or you don't have the capacity to detoxify from the energy that you make, because every time we make energy, it comes at a cost. And our cells have waste products that we make after we make energy or ATP. This is so you have, you make water, you make carbon dioxide,
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
and you make these things called reactive oxygen species or free radicals or oxidative stress. And some of these molecules, these are signaling molecules at small doses, but at high doses, they can be stressful to the system. But the body keeps them in a very fine balance with having a balancing effect with something called an antioxidant, which all of us have heard of before.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
So our body has antioxidants in the system that helps neutralize oxidative stress or these reactive oxygen species. So if you're going into a Heisenberg chamber, You're going to flood the body with more oxygen. You're going to make more energy. Can you do that? Number one, do you have the vitamins, minerals, nutrients, and the machinery to be able to do that? That's number one.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
That's a lot of number ones. There's a lot of things in that. And number two is once you make all that energy, do you have the capacity to detoxify from that? Do you have the ability to create a neutralization effect so that all that oxidative load that you've created because of all the energy that you've made is going to be neutralized?
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And I found out very quickly after I started doing this work and meeting Dr. Ted in 2017 and starting working on
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
testing oxidative stress levels, testing for antioxidants, testing for inflammation, testing for vitamin, mineral, nutrient deficiencies using metabolomic testing that many of my patients, especially those that had chronic inflammatory disorders, chronic inflammatory issues, that they had autoimmune issues, they had infections that wouldn't go away for long periods of time, they had dementia, they had Parkinson's, they had any number of chronic issues that you can imagine.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
Well, I have a pretty crazy father is what it comes down to. So he's a chiropractor on Long Island. His name is Dr. Alan Scher. He's been in practice for 45 years and he sees 800 patients per week. So anyway, you kind of swing that if you can think of how many hours and how much time. He is a machine of significant capacity, to say the least. But what I learned from a very young age was that
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
they all had issues where they were not doing well, either making energy or detoxing and likely both. So if I found this to be the case, which was often, and I optimized, and I still do this in practice, levels of vitamins, minerals, nutrients, and cofactors that are responsible for making energy.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And then I optimized antioxidant capacity so that you have the ability to neutralize the stress of making all that energy.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
which is really important that's how hyperbaric therapy is working right but you need that but you don't want to completely destroy the system and just overload the system not destroy but overload the system with so much oxidative stress that the body can't tolerate it so like yeah i'll give you an example like somebody would go into a hyperbaric chamber and they couldn't walk for three days after going in right they were they had like severe muscle pain they had abdominal discomfort they had headaches like these are called like a detoxification kind of reaction
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And I saw this happen often when I first started doing hyperbaric medicine, when I would have people coming in for like things like Lyme disease, for example, like Lyme is a pretty substantial. I mean, if you believe on it and it's not always, none of it believes in chronic Lyme disease, but, and I have actually mixed opinions about everybody that says they have chronic Lyme, but in general,
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
chronic line going to a hyperbaric chamber, if you're not 60% or 70% better already, you're not going to do well in the chamber. Just my experience. And that's kind of across the board for me is that if you have a chronic complex medical issue, you need to be about 60% or 70% better overall to really significantly benefit from being in the chamber.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And that 60% or 70% benefit is really in the sense that you're making energy better. You're detoxing better from the energy that you make. That's it. So when I got involved in with Dr. Ted and our nonprofit, it was because I realized that there was a significant deficiency in what I was doing to support my patients.
The Dylan Gemelli Podcast
Episode #9 Featuring Dr. Scott Sherr PART 1! Methylene Blue, Hyperbaric Oxygen Therapy, Cellular and Mitochondrial Health, Metabolomics, Understanding the GABA system and SO MUCH MORE!!
And this was the foundation that I was able to lay and now have in clinical practice where I work with people that don't even go into hyperbaric chambers anymore and then just do the foundational work with me. because that is the main thing.