EP. 201: On this quick-and-dirty solo episode, I'm diving into a brand-new article just published in Diabetes Care (March 2025, Vol. 48): "One Size Does Not Fit All: Understanding Microdosing Semaglutide for Diabetes and Multi-Dose Pens." This opinion piece by respected endocrinologists signals a massive shift in the conversation—one I’ve been screaming from the rooftops for over a year. While I’m not claiming credit (ok maybe a little), I am thrilled to see microdosing GLP-1s being acknowledged by mainstream medicine… even if they’re still getting a lot of it, well, OFF. Let’s be clear: microdosing was NEVER meant to be a weight loss strategy, even thought that’s what everyone seems to think it’s for. And if you’re NOT using these drugs without a full metabolic support plan—protein, lifting, hormones, insulin sensitivity—you’re setting yourself (or your patients) up to fail. Topics Discussed: What the pen-click method is and why it's a game-changer Why splitting up a full dose is not microdosing (despite what TikTok tells you) The difference between low-dosing, standard dosing, and true microdosing Why microdosing isn’t a long-term solution for weight loss or type 2 diabetes How this concept can support tolerability, access, and personalized care Why most “microdosing” marketing is just sloppy semantics The real clinical rationale behind true microdosing How to use GLP-1s intelligently as part of a broader metabolic protocol I break it all down in this episode, and if you want to go deeper, grab my free 4-part video series at drtyna.com/ozempicuncovered — it’ll walk you straight into the most comprehensive GLP-1 course available for clinicians and smart self-healers alike. Sponsored By: Qualia Go to qualialife.com/DRTYNA and use code DRTYNA at checkout for up to 15% off your purchase. LVLUP Head over to LVLUPHealth.com and use code DRTYNA at checkout to get 20% off your order sitewide. Manukora Head to manukora.com/DRTYNA to get $25 off the Starter Kit, which comes with an MGO 850+ Manuka Honey jar On This Episode We Cover: 00:00:00 - Introduction & Milestone 00:02:45 - Ozempic: Weight Loss & Dosing 00:10:28 - Semaglutide Research Highlights 00:14:12 - Pen-Click Microdosing Method 00:16:06 - GLP-1s in Treatment Plans Further Listening: GLP1s Uncovered FREE 4 Part Video Series Show Links: One Size Does Not Fit All: Understanding Microdosing Semaglutide for Diabetes in Multidose Pens Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.
Chapter 1: What is the significance of microdosing GLP-1s?
This isn't a medical study, but it is in a medical journal. So we can talk about it. I'm not sure that I can take any credit for this whatsoever, but I feel like I've had a huge part in this conversation. I took the heat early on when nobody else was willing to have this discussion.
Now, before I get into this, I do want to say this was never meant to be a diabetes treatment, nor was it ever meant to be a weight loss strategy. And I talk about that in depth inside of my course. I have a big course on the topic. It's for clinicians. It's for practitioners. I also let the general public in. I've made sure that it's friendly for both groups.
Chapter 2: Why isn't microdosing a weight loss strategy?
And because I have a lot of really smart people who follow me and they need to become empowered, they need to learn this information because their doctors don't know it. So... I really encourage you to check that out. I've got a free four-part video series called GLP-1's Uncovered that will lead you into the big course and then you can dive into the big course if you're interested from there.
So if you go to drtina.com, that's D-R-T-Y-N-A forward slash Ozempic Uncovered, that's what it used to be called. But I cover all the GLP-1s in there, so we had to change the name. And then that will lead you into the bigger course if you're interested because I don't think GLP-1s in a silo work. I think this is nonsense to think that they will.
And I'm excited that this has been written up, but it's still very short-sighted in that A, I don't think that microdoses are going to last long for type 2 diabetes as being effective. And I don't think they're going to really make a negligible mark on obesity or weight loss. So
Chapter 3: What is the pen-click method and why is it important?
You can lose a few pounds here and there, but I think, and this is a conversation for another day, but I think that the MediSpas and the people advertising that you can microdose for weight loss are completely missing the mark and they are going to regret what they've said because eventually that microdose stops working.
I know this because anybody that I've worked with who has lost weight on these at a very small dose inevitably needs a higher dose to keep the weight off if weight loss is the actual goal. So I want to say this again with conviction. This was never meant to be a weight loss strategy.
It does induce weight loss in those who are already metabolically optimized and who are just dealing with a tiny little bit of insulin resistance, maybe due to menopause or due to aging or due to an illness they just had. So please do not take this home thinking... And I even think that these clinicians or these endocrinologists may find themselves in the same pickle.
I don't think that microdosing is a strategy for either diabetes or weight loss long-term. But... The exciting part that they are acknowledging is that sometimes we need to use more personalized, smaller doses to onboard people. Or maybe we need to titrate them up more slowly to the more standard dosing.
And I think with type 2 diabetes and with weight loss, what I've seen clinically is folks really do need a more standardized dose. So anybody who's telling you they're microdosing for weight loss, I don't really think they get it. What they're doing in most cases, and a lot of clinicians, including my friends, have come at me and said, we've been doing this for years, Tina.
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Chapter 4: How does microdosing differ from standard dosing?
You didn't pioneer anything. Au contraire. I'm trying to have a conversation over here about all the myriad of benefits that GLP-1s in tiny increments may help with. However, they've been using standard low dosing. So maybe the first one or two tiers of the standard dose, they do not bring people up slowly up to that dose.
They hit them with the standard dose and then they might go one tier above and they're calling that microdosing. That is not microdosing, that's just low dosing. You're just standard low dosing.
Chapter 5: Why is personalized care critical in GLP-1 treatment?
That's not at all the conversation I've been trying to have, but unfortunately the conversation about weight loss has dominated all of this and the type two diabetes weight loss conversation is always the overriding. point that people want to discuss no matter what podcast I'm on. So I'll go deeper into that another day, but I think the inmates are running the asylum here.
However, this paper is exciting and I'll just cover some of the highlights. Do you love honey? Who doesn't, right? Have you ever tried manuka honey? Are you looking for a little sweet treat with health benefits to use as a pick-me-up or after a workout? Well, I've got something for you. I've recently gone back to using my favorite type of honey again and I'm loving it, so I wanted to share it.
If you've never tried Manuka honey, you are missing out on an incredibly healing type of honey. Not only is it rich and dark and complex, but it's got a plethora of health benefits. I prescribed it many a time for my patients for wound healing with excellent results. It's awesome for skin in general. It supports good oral health, supports gut health.
Chapter 6: What are the misconceptions about GLP-1 microdosing?
It can soothe sore throats and cough, and it even promotes deep sleep. I take a spoonful daily either on my yogurt or usually I just eat it straight. I particularly love using it as a little pick-me-up in the afternoon or like I said after a workout. The brand of Manuka honey I'm loving right now is Manukora honey. It's rich, creamy and honestly one of the most delicious honeys I've ever had.
It's ethically produced by Manukora's master beekeepers in the remote forest of New Zealand. The bees collect the nectar from the Manukora tea tree in New Zealand. It's ethically produced by Mauna Korra's master beekeepers in the remote forests of New Zealand. The bees collect the nectar from the Manuka tea tree in New Zealand.
The nectar is packed with bioactives and the honey that is produced has three times more antioxidants and probiotics than your average honey. A special antibacterial compound called MGO also comes from the nectar of the tea tree. Tea tree is amazing. Monocora third party tests every single harvest for this MGO and makes these results available through their QR system.
Chapter 7: How can GLP-1s be integrated into a metabolic support plan?
All you need is one heaping teaspoon each day to get the most out of the amazing bioactives in Manuka. It's honey with superpowers. If you want to try Monocora honey, head to monocora.com forward slash Dr. Tina to get $25 off the starter kit, which comes with an MGO 850 plus Manuka honey jar, five honey travel sticks, a wooden spoon, and a guidebook.
That's monocora, M-A-N-U-K-O-R-A.com forward slash Dr. Tina for 25 bucks off your starter kit. This season is a potent time for transformation if you utilize it right. I plan on getting into a solid training routine myself, purging the clutter from my home and closets and cleaning up my cells to ensure that I hone my resilience as much as possible.
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Also known as zombie cells, they're old and worn out and they don't serve a useful function in our health anymore, but they're taking up space and utilizing energy and nutrients from our healthy cells. I would like to get rid of these.
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