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Short Wave

New Antivenom, Thanks To 200 Intentional Snake Bites

Wed, 21 May 2025

Description

What's it like to get bit by a venomous snake? "It's like a bee sting times a thousand," Tim Friede says. Tim would know. Over the past few decades, he's let himself be bitten over 200 times by all kinds of venomous snakes — black mambas, taipans, cobras, kraits and more. With time, he's gradually built immunity to multiple types of venom. Could scientists help him share that immunity with others? Science reporter Ari Daniel joins Short Wave to explain how antivenom works, what scientists discovered and where the research may lead. Plus, what does Tim Friede have in common with Princess Bride?Want to hear about more medical discoveries? Email us at [email protected] to tell us what areas of science you'd be interested in.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

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Transcription

What are the dangers of venomous snake bites?

174.071 - 175.932 Ari Daniel

Yes, I've memorized that movie.

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176.314 - 182.596 Tim Friede

Perfect. So you already know that in the movie there's this fictional poison called Iocane powder.

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182.736 - 185.237 Ari Daniel

Yes, this is what I thought of as soon as you told me about this story.

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185.317 - 186.858 Tim Friede

Right. I smell nothing.

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187.498 - 194.681 Wesley

What you do not smell is called Iocane powder. It is odorless, tasteless, dissolves instantly in liquid, and is among the more deadly poisons known to man.

195.393 - 209.507 Tim Friede

Wesley, he's one of the main characters who was just speaking, he ultimately reveals that he's built up an immunity to this poison by starting with a small dose that wasn't enough to kill him and gradually increasing that dosage over time.

210.228 - 212.951 Wesley

I spent the last few years building up an immunity to iocane powder.

215.037 - 225.272 Tim Friede

This is more or less what Tim did, Regina, except with snake venom. He admits it's been something of a rocky road, though. Right out of the gate, he says this happened.

225.512 - 225.612 Tim Friede

What?

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