Dr. Peter Attia
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Do you prescribe it? Oh, yeah. I'd be interested to hear your experience with it. We have prescribed it now to maybe a half a dozen patients. One of the silly challenges we have with it is we actually have no idea if they're therapeutic because trying to get their blood drawn to figure out when to draw their blood to actually see the level.
Do you prescribe it? Oh, yeah. I'd be interested to hear your experience with it. We have prescribed it now to maybe a half a dozen patients. One of the silly challenges we have with it is we actually have no idea if they're therapeutic because trying to get their blood drawn to figure out when to draw their blood to actually see the level.
For example, if a guy takes the drug at eight o'clock in the morning and then at one o'clock in the afternoon, which is sort of what we're told is a great window to take it so that you get that mid dose, mid dose, right? If he does his blood draw at seven o'clock the next morning, he's been 18 hours off drug. He has unmeasurable testosterone. He's going to show up at 200.
For example, if a guy takes the drug at eight o'clock in the morning and then at one o'clock in the afternoon, which is sort of what we're told is a great window to take it so that you get that mid dose, mid dose, right? If he does his blood draw at seven o'clock the next morning, he's been 18 hours off drug. He has unmeasurable testosterone. He's going to show up at 200.
He's going to look like I did 50, 20 years ago. His LSH and FSH are still completely suppressed because that doesn't go away over 18 hours. But I don't know how to interpret what is he walking around at during the day, which is what I care about. It's hard to know.
He's going to look like I did 50, 20 years ago. His LSH and FSH are still completely suppressed because that doesn't go away over 18 hours. But I don't know how to interpret what is he walking around at during the day, which is what I care about. It's hard to know.
And what are you dosing it at? It comes in 100 and 200.
And what are you dosing it at? It comes in 100 and 200.
Interesting. So this is not something you used when you're trying to get a guy from 300 to a thousand. You could, but probably not the first choice. Yeah. And now you're taking 500 twice a day or something crazy like that. Yeah. And twice a day is a big deal for men. It is. What about Natesto? How are you, are you using?
Interesting. So this is not something you used when you're trying to get a guy from 300 to a thousand. You could, but probably not the first choice. Yeah. And now you're taking 500 twice a day or something crazy like that. Yeah. And twice a day is a big deal for men. It is. What about Natesto? How are you, are you using?
What's the experience like? We've never used it.
What's the experience like? We've never used it.
And do you find that the clot risk is proportional to hemoglobin hematocrit? Absolutely. At what level are you saying?
And do you find that the clot risk is proportional to hemoglobin hematocrit? Absolutely. At what level are you saying?
One of the things we do with patients who are injecting testosterone cypionate, and we have some patients who love doing this. I think it would drive me nuts if I were trying to do this. They inject it every day. So they'll do 10 to 15 milligrams every single day. And it actually produces the same effect, which is they don't have the polycythemia. Right. Because they don't hit the peaks.
One of the things we do with patients who are injecting testosterone cypionate, and we have some patients who love doing this. I think it would drive me nuts if I were trying to do this. They inject it every day. So they'll do 10 to 15 milligrams every single day. And it actually produces the same effect, which is they don't have the polycythemia. Right. Because they don't hit the peaks.
They never hit these crazy peaks. 10 years ago, everyone I saw that was prescribing this was prescribing, the standard was 200 milligrams every two weeks, which was crazy. Highest risk. Yeah. Yeah. So what is your typical injection schedule?
They never hit these crazy peaks. 10 years ago, everyone I saw that was prescribing this was prescribing, the standard was 200 milligrams every two weeks, which was crazy. Highest risk. Yeah. Yeah. So what is your typical injection schedule?
Oh yeah, I do them all. The pellet also, I don't know the kinetics of it, but I would imagine you're pretty super physiologic for a month or so, maybe? Yep. So pellets are like the long-term contraceptives for women.
Oh yeah, I do them all. The pellet also, I don't know the kinetics of it, but I would imagine you're pretty super physiologic for a month or so, maybe? Yep. So pellets are like the long-term contraceptives for women.