How to Use Exercise to Improve Your Brain’s Health, Longevity & Performance

3867.187 - 3889.122 Andrew Huberman

So the point is that BDNF has to be released in order for that to happen, but the release of BDNF itself is activity dependent, and it acts best on neurons that are already active. So if ever there was a mechanism that could explain why it is that people that exercise regularly seem to maintain healthier brains into later life, it's that one. It's that BDNF is activity dependent.