Dr. Peter Attia: Supplements for Longevity & Their Efficacy

2476.161 - 2498.032 Andrew Huberman

So in that case, you still get some normal expression of the gene from the endogenous genome, but now you have a transgene that's inserted there. And there are all sorts of important intricacies that relate to this. For instance, where the transgene is inserted. If it's downstream of an enhancer that's muscle-specific, then you can get a... mouse that it overexpresses sirtuins just in muscle.