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Huberman Lab

Dr. Peter Attia: Supplements for Longevity & Their Efficacy

1998.888 - 2025.917 Dr. Peter Attia

At that moment, again, this is about 25 years ago, a hypothesis emerged, which was we have two different strains of yeast. And in one of them, when you overexpress SIR2, this gene, they live longer. And in this other strain, if you calorically restrict them, they live longer. The understandable hypothesis was caloric restriction, which we had known was life-extending, is working through sirtuins.

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