Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks
Dr. Matthew Hill
Whereas 2-AG seems to require a bit more concentration in the synapse to be able to bind to the receptor. So it has a lower affinity for the receptor. But once it binds to the receptor, it's like... pretty heavy duty. So it evokes a very robust intracellular signaling response. Why we have two endocannabinoids, we're not totally sure. Some of us have theories.
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