Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

1740.878 - 1764.392 Dr. Matthew Hill

So the way anandamide binds to the receptor is it's what we would call a high affinity, but low efficacy agonist, or molecule at least. And what I mean by that is... Very low levels of anandamide are required to actually bind to the receptor. But once it binds, its ability to stimulate a biological response in that neuron kind of caps out pretty fast. So it doesn't have like a sledgehammer effect.