Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks
Dr. Matthew Hill
I think that's how most people have tried to conceptualize what's going on. It seems to involve the insular cortex. At least the anti-nauseant effects of cannabinoids are involved through the insular cortex. Maybe you have burned out those receptors from chronic use. That endogenous mechanism isn't working or it's somehow flipped in the other direction now and that circuit becomes sensitized.
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