Digital Social Hour
Biohacking 101: Reverse Aging & Boost Mental Clarity | Mark Gordon DSH #1158
Mon, 03 Feb 2025
Unlock the secrets to reversing aging and achieving peak mental clarity with Digital Social Hour! Join Sean Kelly as he dives deep into the world of biohacking with health expert Mark Gordon. From the groundbreaking role of peptides in brain recovery to the surprising connection between inflammation and hormone production, this episode is packed with valuable insights you can't afford to miss. Discover how brain health impacts your body, the hidden dangers of chronic inflammation, and actionable tips to optimize your hormones naturally. Mark Gordon shares inspiring stories of recovery, cutting-edge research, and his passion for helping veterans heal from traumatic brain injuries. This is your ultimate guide to Biohacking 101! Watch now and subscribe for more insider secrets. Hit that subscribe button and join the conversation to stay ahead in the world of health and wellness! Don’t miss out—your journey to a healthier, sharper you starts here. #peptides #biohackingtips #orthobiologics #functionalmedicine #hormoneguru #brainfog #biohackingtips #achievepeakperformance #agereversalstudy #selfimprovement CHAPTERS: 00:00 - Intro 01:15 - Inflammation and Hormone Production 04:16 - Causes of Depression 07:00 - Inflammation Duration and Recovery 08:13 - Brain Rescue Techniques 10:57 - Inflammation as Disease Root Cause 12:18 - Understanding PTSD 17:58 - Clomid Overview 20:10 - Testosterone Insights 22:51 - Head Trauma Mechanisms 23:55 - Cellular Mechanotransduction Explained 27:50 - Inflammation Post-Surgery 28:38 - Impact of Heavy Metals on Hormones 33:48 - Parasites and Health 37:08 - Stem Cells in Medicine 44:24 - Health Perspectives in China 49:28 - Brain Rescue Techniques Part 1 50:02 - Reversing Alzheimer’s Disease 55:20 - Inflammation and Autism Link 57:15 - Finding Mark’s Products APPLY TO BE ON THE PODCAST: https://www.digitalsocialhour.com/application BUSINESS INQUIRIES/SPONSORS: jenna@digitalsocialhour.com GUEST: Mark Gordon https://www.instagram.com/drmarkgordon SPONSORS: Specialized Recruiting Group: https://www.srgpros.com/ LISTEN ON: Apple Podcasts: https://podcasts.apple.com/us/podcast/digital-social-hour/id1676846015 Spotify: https://open.spotify.com/show/5Jn7LXarRlI8Hc0GtTn759 Sean Kelly Instagram: https://www.instagram.com/seanmikekelly/
Chapter 1: What role do peptides play in brain recovery?
Well, with some of the peptides that we have, we can accelerate the healing of the brain. Some of the peptides, ARA, 290, N-acetyl C-max, cerebral lysine, just to accelerate the process for them getting back in line to be, you know, back into life.
I love it. What's the deal with peptides? Because I saw some articles that they got banned in certain states.
Chapter 2: Why are peptides banned in certain states?
Yeah, it's the FDA is banning it. And some of the states in the internal pharmaceutical guidelines in every state stating that certain things can and cannot be made or cannot be imported. I mean, in California, where I am half the time and the half time I'm in Texas, I can't import our blended testosterone that's manufactured in Texas into California. Wow. They restrict it.
So there are a lot of peptides that both from the FDA and from the state pharmaceutical boards are restricting peptides that have incredible benefits. People with MS or people with Alzheimer's or dementia, certain of these peptides can help regenerate the nervous system. One of them that I use a lot is C-Max, which stimulates a chemical in the brain that actually tells the brain cells to improve.
It's brain-derived neurotrophic factor. Also, as a side effect, it drops inflammation. In the world that I work in with traumatic brain injury, it's the inflammation that causes a shutdown in a lot of the chemical processes in the brain. So if you have inflammation, it shuts off your brain's ability to tell the pituitary, the master gland, from making testosterone or making DHA or thyroid or...
Chapter 3: How does inflammation affect hormone production?
you know from the signal the cascade for stereogenesis that's crazy i didn't know there was a link because a lot of people have low testosterone right now oh yeah and this is a paper that i just came out with which is a clomiphene paper which incorporates some of the key factors that are being missed two of the key factors that are being missed is this relationship between inflammation and shutting down hormone production the article started coming out in 2013 and just had
built in the number of articles, so they're substantiating each other. And then in 2018 out of Denmark, of all places, came a group of articles or a article that started it that said that if we're using things like ibuprofen or naproxen, which are called non-steroidal anti-inflammatory medication, probably one of the most commonly used anti-inflammatory over the counter,
200 milligrams, but my military people get 800 milligrams. And what we found or what was found in the literature and the research is that it shuts down both in females and males, their ability to respond to us from a signal in the brain called luteinizing hormone to turn on testosterone production in a female and a male. Whoa.
So when a doctor or a healthcare provider has an opportunity to do a blood test and find out that they're low testosterone, the knee jerk is usually to just put them onto testosterone instead of asking two questions. Have you had any head trauma? That's the inflammatory. Or have you ever used ibuprofen and naproxen or any of the non-steroidal anti-inflammatories? And they don't ask that.
And therefore what happens is you jump ahead and assume that they're testosterone deficient because of what? Genetics? Because of age? But there's a causation. So everything that we do in our practice at the Millennium is based on looking at the foundational causes. Why does this happen? Why do people get depressed?
And depression is not because your mother didn't suckle you or your Irish father didn't give you enough whiskey or whatever the situation might be. It really has to do with the biochemistry of the brain. And we know that when there's trauma or inflammation in the brain, that a chemical is produced. They call it peroxynitrite.
And what it does is it stops the enzymes that are responsible for making serotonin, which is the antidepressant, and also melatonin, which helps you sleep. So in the group of... military that we see.
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Chapter 4: What treatments are available for traumatic brain injury?
Yeah, will that inflammation go away over time naturally?
Oh, great question. There are two forms of inflammation. Acute, like, for instance, you get a cold. Your cold symptoms of irritability, light sensitivity, sound sensitivity, irritability, you know, stay away from me, leave me in my bed, body aches and pains are all due to inflammation that is generated because of the viral process or bacterial inflammation.
And after a couple of days, it starts waning and you get better in a week or two. But there's a chronic phase where the inflammation that started never abates, never reduces. So what can cause that? And the people that we see in sports with chronic repetitive injury or CTE or What happens is there's always reoccurrence of the trauma to keep the process going for a long period of time.
So the chronic state causes an increase, like a catch-22, an increase in the production of inflammatory chemical that leaches away at the brain, that starts destroying more areas of the brain because of the inflammation. So can you reverse that? Yes.
you already experienced it right you know this brain rescue i'm feeling it yeah i'm feeling it i always feel yeah yeah we've got about 10 000 people a day who are feeling it and um it's our core product for helping reduce the inflammation it took 16 years to develop that before we released it we did a study which is called the marine 2020 study pilot study
Not pilot like airport, but, you know, baseline research or study. We took Marines from Camp Pendleton. They were sent to us by the surgeon. Marines who were getting ready to be medically discharged for problems from being in the front line all the time, the first recon group. And we put them onto this product every morning for 90 days.
Every 30 days, they filled out a questionnaire with 18 questions on it. At the end of the 90 days, 65% of them were 50 to 100% better. People with migraines were better. People with anxiety were better. Depression had abated. libido had improved, their exercise tolerance had improved. Wow. And 90 days.
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Chapter 5: How do lifestyle choices impact recovery from depression?
And some of them, after that 90-day period, they never reverted to where they were before because this has in it a combination of anti-inflammatory products like fish oil, DHA, very important as an anti-inflammatory in the brain, quercetin, what else, vitamin E, G-gamma, vitamin E, which is very special in the brain.
N-acetylcysteine, which went through testing with the government, did studies out of Walter Reed showing the benefit of N-acetylcysteine, which is a natural product. That's the beauty. It's 100% natural.
That's why I like it. Yeah. I try to be as natural as possible. Yeah.
Healthy. You don't want the aberrant chemistry in their body. You know, I did a presentation from an organization, and the title of the presentation, 17 Minutes, was In Search of the Prozac Lamp. Where's your Prozac gland? Couldn't tell you. Where's mine? Where's your Bilify gland? Where's your Paxil gland or any of those medications? Where are the glands? There aren't any.
So what they're doing is they're substituting in a pharmaceutical chemical to try and simulate something missing from the body as opposed to going and finding what it is that's missing from the body and trying to fix that. And it's usually not something, quote unquote, missing. It's the fact that the deficit is precipitated by the inflammatory cascade.
I mean, I said, I sound, you know, monotonal in terms of talking about inflammation because it's at the core of everything. Cancer, diabetes, cognitive impairment, ALS, multiple sclerosis, all inflammatory processes.
Wow. Yeah, I've heard BRCA say it's the root cause of all disease, right? Yep. So if you had no inflammation in your body, is it possible to get sick?
Yeah, it's still possible to get sick, but the point is how your body responds to that inflammation. So you get a virus. You got a healthy immune system because you're not taking in a lot of chemistry that suppresses, like alcohol suppresses the immune system. You don't want to do that. Or you're taking a little bit of DHEA to boost the immune system or 7-keto DHEA to boost or growth hormone.
These are all known to improve the ability of the immune system to respond. So if you're under attack by a virus or bacteria, you want the inflammation. Inflammation has a role, and that is to get rid of the attackers. So if it's bacteria, viruses, mold, or poisons put into our body through injections.
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Chapter 6: What is the relationship between testosterone and inflammation?
If you have dysbiosis or you have gastritis or there's a medication you're taking, like you're taking aspirin or you're taking... non-steroidal anti-inflammatories that can cause inflammation aligning of the gut. It can lead to the release of these inflammatory chemicals because they're trying to protect the gut.
And it goes right into the brain and turns on the cells in the brain called microglia. And they start dumping microglia. inflammatory cytokines. They call them pro-inflammatory cytokines. And so all our treatment regimens are directed towards dropping these cascades of inflammation.
And the reason why hormones like testosterone are so very important is we think of, you know, all the gender hormones, the sex hormones, the reproductive hormones, testosterone, the estradiol, the progesterone, the pregnenolone, we think of them as sex hormones. but they're more than that. They're called pleiotropic, which means multi-effects, multi-layers of benefits, pleo, many.
And it turns out that testosterone will shut off four of the worst inflammatory chemicals in the brain, interleukin-1, 1-beta, tumor necrosis factor alpha, and interleukin-6, and at the same time turn on the most anti-inflammatory chemical in the brain called interleukin 10. So we need that. And then looking at estradiol, it has an array of things it does to lower inflammation in the brain.
That's why when you see studies coming out, women who are deficient in estradiol have a 50% greater occurrence of Alzheimer's and cognitive impairment. Dang. Yeah. And there's also pregnenolone and allopregnenolone. Pregnenolone is what comes from cholesterol. Cholesterol right into pregnenolone. Pregnenolone is called the mother of all hormones.
So we need that mother of all hormones to become all the other hormones like DHA, testosterone, estrone, estradiol, cortisol. So if we have a breakdown in the conversion of cholesterol or not enough cholesterol to go to these hormones, you lose the hormones, you lose the protection in the brain. It's about 35 hormones in the brain called neurosteroids.
And then below the neck, there's another group of neuroactive steroids that are produced by the glands, the endocrine glands throughout the body. I didn't know there were steroids in our body.
Oh, where else are they? In the syringe. That's the ones I heard of. And those are not good for you.
Well, you know, everything appropriately done, you need to check the patient, see what it is that they're deficient in, and do things to get their own body to generate it. September, October of this year, released after 15 years of collecting data, took about 14 months to write the paper.
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Chapter 7: Can subconcussive injuries lead to long-term effects?
Clomid study to figure out what the ideal dosing is of Clomid. You pulse it. You don't give it every day. So we have people that are every 72 hours, every three days taking one tablet and it turns on the testosterone production in males. So we don't suppress.
our system from the hypothalamus to the pituitary, to the gonads, male or female, what we do is we encourage the system to turn itself back on. So we have people who come into us with testosterone deficiency. We look at their trauma or the inflammatory component. We look at their Skittles and vitamin M, which is the Motrin ibuprofen.
It's their love term for these medications that they take tons of and it shuts off their, their, testes' ability to make testosterone. And so we put them onto the Clomid or the E-Clomid. We have over a thousand people on it and they're producing testosterone levels like kids. That's incredible.
I'd rather do that than take a needle in my butt.
And there are people who don't like the needle. And then there's at the... recent biohacking, there's a doc there that, or a company there that's developing an oral form of testosterone that has FDA approval for it, is my understanding, which will be revolutionary, but it's still a testosterone.
So again, try to get the body to make its own hormone before you put something in that we know will shut down your own innate production of testosterone.
Right. Because after age 40 or 35, I think you drop 1% a year of testosterone on average. Yeah.
It's 40 in most people, but it can be accelerated if you have ibuprofen. It can be accelerated the more traumas you have. So you can have subconcussive traumas like 50 caliber gunner or someone who's doing jujitsu and someone who's, doing wrestling. You don't have to have loss of consciousness.
This is something that has been gaining more attention is repetitive head injury like CTE, but subconcussive. And what subconcussive means compared to concussive is that in concussive, you know you've had your bell rung because you're disoriented. You might be nausea, vomiting, blurred vision. You might be lethargic, tired. You might be disoriented, amnesia.
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