Paul Tough
Appearances
Fresh Air
Are Kids With ADHD Being Treated Effectively?
To a huge extent. So in this article, I focused on kids for a variety of reasons, partly because the science is more clear because scientists have been studying ADHD in kids for much longer. But as a phenomenon, as a diagnosis in the United States, it is among adults that all of the growth is happening. So the fastest growing groups for the diagnosis are people, adults in their 20s and 30s.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
But even adults in their 40s, 50s, 60s, all of those diagnosis rates are going up really quickly. And prescription rates are going up by a huge degree as well.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
We don't. It just hasn't been studied to the same degree. I don't think there's reason to think there's a different result that we would see among adults, but there hasn't been a similarly rigorous study like MTA for adults.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Absolutely. Those are great stories. And yes, and I've heard lots of stories as well, not only in my reporting, but just from friends before the article came out and then in great numbers since the article came out. And I think what's hard for us is that when we hear two different stories like that, it's hard for us not to think, well, just one of them has to be true.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
But the reality is they are both absolutely true and that different people have different experiences of this condition and of its treatment. There is no one size fits all solution.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And so to me, that is what is reassuring and even exciting about this new research by giving young people and families the message that this is not just a sort of singular biological condition that you have or you don't have.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
At that point, the questions were pretty basic. We didn't exactly understand what this condition was and what treatments were the right ones to use. So Ritalin doctors could see, families could see that when kids took Ritalin, there was this, in many of them, this overnight change in their behavior. But we weren't sure why that was happening. And the diagnoses were expanding at such a great rate.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
that in fact symptoms often fluctuate over time, that there are different sorts of treatments that work for different sorts of kids, that that gives them maybe less certainty, which can sometimes be scary, but also more of a sense of possibility, that this is something that can, like the young person you're talking to who was sort of cured by chess, that there may be ways that life can change that will really change these symptoms as well.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Yeah, so this is a psychiatrist named Charles Bradley who ran a home for children with psychological problems in Rhode Island. And at the time, this was in the 1930s, Benzedrine, which is a kind of amphetamine, had become this really popular drug among jazz musicians, actually, and among college students who felt like it helped them focus. It sort of amped them up in various ways.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And he thought, maybe I should try this on these kids. There was nothing that was seeming to help them. So he did a very small but rigorous experiment where he gave 30 kids a daily dose of Benzedrine. And he noticed this, in about half of them, this vast change in their behavior. So they were more placid. They were more easygoing. They could get things done. They felt better about their work.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And it felt to him like this kind of miracle cure.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Yeah, so I spoke to this NYU researcher named Xavier Castellanos, who actually told me about the Charles Bradley paper and said that he sees the same things now when he first prescribes Ritalin or Adderall to kids, that overnight there's this kind of miraculous change.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
transformation for a lot of them that their their behaviors really change what he said was frustrating though was that when you look at the sort of academic results for kids even though they are able to sit and focus more and get more seat work done their test scores don't go up and that i think has been this puzzle that doctors have been wrestling with for the past couple of decades
Fresh Air
Are Kids With ADHD Being Treated Effectively?
There was also a question of why that was, why suddenly it had doubled in just a few years.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
That at least in the short term, these medications seem to have a powerful effect for some kids on their symptoms. But over time, they don't seem to have an effect on academic achievement, at least measured in test scores.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
So I'd never heard of this test before. It's called the knapsack test. But apparently it's pretty common in psychology and computer science. You give a kid a backpack. In this case, it's a virtual backpack. And it's just this kind of game. You give them a bunch of different things of different weights and prices.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And you say, what's the best way to pack this backpack to get the most value of stuff into it? So it's a little sort of logical puzzle. And these researchers in Australia gave this test to a bunch of young adults. And they tested how well they did when they were on stimulant medication and how well they did when they were not.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And what they found was that when they were on stimulant medication, they, from the outside, looked to be doing much better. They were working more quickly. They were more diligent. They were more focused. But when they looked at the results of how well they were doing on the SNAP-SAC test, they weren't doing any better.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And what they saw was that that was because they weren't actually making better decisions. They were just sort of randomly pulling things in and out of their backpack instead of focusing on it. So what I think some researchers believe is that this is a clue to why sometimes behavior in the classroom can improve on stimulant medication, but academic results don't.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
It's possible that these stimulants make you sit still and behave better, but they're not actually helping your brain process information better.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
So James Swanson, the researcher who helped lead the MTA study, one data point that he really focuses on in thinking about this as a long-term treatment rather than a short-term one is that in the original MTA study, when young people took stimulant medication over the course of years, it had an effect on their growth, on their physical growth, on their height, that the kids who had consistently taken Ritalin were about an inch shorter than the kids who had not.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Yes. So this was the Multimodal Treatment of ADHD Study, or MTA. And a number of researchers at six sites around the United States and Canada decided that they wanted to test different treatments of ADHD. So there were stimulant medications, specifically at that point it was Ritalin, but there were also behavioral interventions. So coaching, parent training, and
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And so Swanson and the other MTA researchers have continued to study this group through adolescence and even into adulthood.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And the most recent study looked at them when they were 25 and continued to see this height differential, that the ones who had consistently taken stimulant medication all the way through childhood and even young adulthood, they continued to be about an inch shorter than the ones who had stopped taking it or who had never started at all.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
There isn't a definite explanation. No, we don't exactly know why that is. The most sort of logical one is that these medications affect appetite in a big way. So when I would talk to young people who were taking these medications, that was the thing that they talked about the most, that you just don't want to eat.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And if you're an adolescent and you don't want to eat, you're very different than other adolescents. This is a time when kids are eating a ton and that's helping their growth. So that would make sense as part of the reason for this. But there haven't been enough careful studies to say that that's the real reason.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Amphetamines as a whole can be addictive. The way that the medications are formulated, especially the ones that release the medication over an extended time, over the course of a day, those are certain safeguards that make them less likely to be addicted. The young people I talked to who took these medications did not feel that they were addicting at all. They found them very easy to stop.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
So, yes, they can be addictive. There are certainly anecdotal stories about people who become dependent or even addicted to these medications. But that doesn't seem like a very big problem for most kids.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Well, I heard a variety of things. So I think every young person's experience is unique. But mostly, I felt like they had a pretty complex relationship to these drugs. So I think the way that these medications and the diagnosis in general is portrayed is that this is a medical condition that has a medical solution.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And in fact, the young people I talked to saw this as much more of a kind of constant negotiation between them and their medication. A couple of the young people I talked to talked about, used the word sacrifice when they talked about their stimulant medication. They saw that there were benefits to it. They saw that it was going to help them in some significant way going forward in life.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
But they didn't actually like the experience of taking them, often not at all. I mean, one of them said, I just hate taking it. You know, you first of all get this real rush. You feel like you're on top of the world. But then there's a real crash. And so he didn't love it, but he saw that in certain circumstances it was the right thing to do.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And they wanted to see scientifically which would work best. So they did what scientists do, which is they created this randomized controlled study. And at each site in the United States and Canada, they divided the children who were between seven and nine who had been diagnosed with ADHD into different treatment groups.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And that's what I heard from a lot of kids, that they had gotten to the point where they knew what this medication would make them feel like. And rather than think of it as, say, diabetes medication, something you've got to take every day in order to survive, it was much more situational. It was something that they would take at certain times and certain moments and then other times not take.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Yeah, that was something that I heard from a lot of people, that their sort of love of life, their sense of humor, that a lot of that would change when they were on this medication. That they were, you know, at lunch, they were not the happy social person that they had been. One of them said, you know, it's not like I'm unhappy. It's just like I'm kind of flat.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
There was one girl who I spoke to, I didn't include in the article. who talked about how it did sort of suppress her emotions. And she said that she had been having this day a couple of days before I spoke to her when her friends were going off to college and she wanted to say goodbye to them all.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And she decided that day not to take her medication because she wanted to feel, she wanted to have this emotional connection. And she knew that if she was on the medication, she just would feel more flat.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Well, I think this is where this question gets really interesting to me. And the person who I think is sort of leading the way, the researcher who's leading the way on this is a British researcher named Edmund Sunuga Bark, who has been studying ADHD for 35 years. And in the last few years, he has really started to change his approach. And I think that's been influential in the field.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
So he talks about ADHD as not having any kind of natural cutting point where you can say this person has it and this person does not have it. but instead that ADHD symptoms exist on a continuum where almost everyone has some of these symptoms and that there are some for whom it is really an extreme problem, but there's not a natural cutting point.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And to him, this distinction is important not only scientifically, but also kind of like psychologically and emotionally, that it enables us to tell young people that this is not just a case of them having a deficit of a certain skill or
Fresh Air
Are Kids With ADHD Being Treated Effectively?
So some got behavioral training, some got Ritalin, and some were just left on their own to figure out their own treatment.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
and that that's a disorder that has to be treated medically, but instead that their problems may have more to do with a misalignment between their own unique brain and the situation that they're in.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And if that's the case, sometimes medication can still help make that environment more tolerable, but there also might be things that we could change in their environment, that they could change in their habits and patterns that would have the same kind of positive result that medication would have.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
You know, it's interesting. It might not have implications for treatment, but it changes, I think, the way you think about your treatment and the way you think about yourself, the way you think about your own brain. I think when we give kids the message that this is a brain-based problem, that it's a disorder in the brain,
Fresh Air
Are Kids With ADHD Being Treated Effectively?
that that's something that they take in as a sort of identity, as a message about who they are and what they can accomplish. And if instead it is portrayed, I think more accurately, as a mismatch between where you are and how your brain works, that says something very different to kids.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
It says maybe medication is the right thing right now, but it's also possible that in the future this is going to change, that you're going to find your way to another kind of situation that's not like high school English class where your brain is actually going to be really powerful and really well-suited.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
That was after 14 months of treatment. And what they showed was that the most effective treatment for behavior, for symptoms, was Ritalin. That the kids who had taken Ritalin were doing significantly better than the other groups.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Yeah, so this is the research of a researcher in Oregon named Joel Nigg. And I think this is really important. I think that one of the downsides of us having perceived this condition as this sort of yes or no black or white disorder is that it has obscured the fact that there are really lots of different degrees of intensity of ADHD.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
So, you know, the young guy I talked to who, you know, was using it for baseball as much as he was using it for school He almost certainly does not have a really intense case of ADHD, but there are lots of kids who do. And what Joel Nick has found is that between 30 and 40 percent of young people diagnosed with ADHD also have symptoms of intense anger as children.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And that that is often the beginning of real psychological problems. When you have both hyperactivity and impulse control and intense emotional dysregulation, that's a real warning sign. And that those kids, it's not just about changing their environment.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
They really do need treatment, which might include stimulant medication, but it also might include other things that those young people have are more likely to have coexisting other disorders, oppositional defiant disorder, depression, anxiety disorder. And so they need a more careful set of treatments.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Well, I'll say first that that particular claim that Wes Crenshaw asked for an interview is not true. So the reason that Attitude is responding so intensely, I think, is because I wrote about this magazine about Attitude in my article.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And one of the things that I noticed in Attitude was that there were a number of articles aimed at parents of children who were resisting the diagnosis and resisting medication treatment. And I talked to a lot of these kids, right, who were themselves being treated and who had really mixed feelings about it.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And so the idea that parents need a strategy to persuade their kids to take medication felt really out of keeping with the research that I was reading, that medication works for some kids. but it doesn't work for all kids, that on the whole, the benefits of stimulant medication outweigh the deficits for most people. But for individual kids, sometimes it is not the right choice.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And I don't think that it's the job of parents to try to persuade their kids to keep taking this medication when they don't want to, as the research shows that lots of them don't want to and lots of them stop. And so these articles that from...
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Attitude magazine that I mentioned that they're responding to, were all in one way or another trying to give parents arguments and approaches to try to convince their kids to take this medication. And so that's what I wrote about. It's true I didn't go follow up and interview these people because I was just quoting accurately the articles that they wrote in this magazine.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And I think that the magazine felt wounded by the fact that I'd identified these articles as being a part of that movement.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
I think so, yeah. I mean, I think there's a mix of feelings about it. I think there are hopes that that sort of, you know, intense scientific research will help us. But I think there are more people, including some of the researchers who I wrote about, who said that that's not where our research focus is going to be most useful. That there may be two directions that seem most useful.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
One is what Joel Nigg is doing and trying to figure out if there are subtypes within this group that is diagnosed with ADHD who have different problems with different maybe genetic signatures and different needs for treatment.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And if we, instead of saying you've got ADHD or you don't, if we can be more precise in what intensity of ADHD, what type of ADHD you have, we can give you more helpful treatment suggestions. And then I think the other angle that I find really reassuring is to think about environments. So instead of to think of this as just a Think about the environmental side of it.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
So there were two things that were really troubling James Swanson. And one was that that initial expansion of diagnoses from about a million kids to about 2 million kids, that made sense to him. Because scientists thought that about 3% was the most accurate guess of what percentage of children sort of naturally had ADHD. And 2 million was pretty close to 3%. But then it kept going up.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And a lot of the research suggests that as environments change for young people, their symptoms change as well. But mostly what we see is that just kind of happens as you go through life. There is not a big push. And I think there hasn't been a lot of study of if we are actually intentional about how we change young people's environments, can we predictably make a difference in their symptoms?
Fresh Air
Are Kids With ADHD Being Treated Effectively?
My hope is that those two strands of research together will make a real difference, that we not only will be able to say, well, this is the particular signature of ADHD that you have, that we'll also be able to say, and this is the kind of intervention, whether environmental or pharmaceutical, that might help your symptoms the most.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
So as the study was going on, it went up to 5%, to 6%, and he couldn't see a reason why that was happening. The other thing that he found disturbing was that he and the other scientists that were running the MTA study continued after those 14 months to carefully study the children who were in the original group.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And what they noticed was that the advantage that the kids in the Ritalin group had had after 14 months, it started to really fade. And by 36 months, there was no difference in the symptoms of any of the groups. The kids who had taken Ritalin weren't doing better in terms of their symptoms than the children who had been assigned to the behavioral group.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And they weren't even doing better than the kids who had not been given any treatment at all.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Yeah, I think mostly what he's concerned by is that that original study of the 14 months got a lot of attention, and the message really went out that Ritalin works, that it's the right treatment for most kids, but that the second study, the one that found that over time those effects fade, that it did not get the same type of attention, and that it's not reflected in the way that a lot of practitioners are now treating ADHD.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
One of the things that's so striking in talking to scientists, including neuroscientists who have studied this, is that they say that they actually understand the biology of ADHD less than they did 20 years ago. So normally, the course of science is that as time goes on, they get a better and better understanding of what's really going on in the brains of children with a particular diagnosis.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And in this case, that's just not true. So 20 years ago, there was this belief that there were clear biomarkers, clear indications in the brain in terms of electrical signals or a particular gene that would predict ADHD or differences in the size and shape of certain parts of the brain that you could say, this kid has that biomarker. He does have ADHD and this one does not.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And as the last couple of decades have gone on, that belief has slowly been undermined so that now there is no clear biomarker for ADHD. And I think most neuroscientists accept that that's the case.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
ADHD can be incredibly disruptive in a child's life, in a family's life, in a classroom. When kids are having trouble sitting still, focusing, getting work done, keeping themselves organized, controlling their impulses, it makes life really difficult. And it especially makes life difficult when you are going to school. A lot of the school day, you've got to sit still, you've got to focus.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
There's a lot of homework, I know, as a parent. And when you are struggling with impulse control, when you're struggling with attention, those things are really difficult. And I think within families, that often leads to real conflict. And so what originally starts as just a problem in one child's life turns into a problem for a whole family.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Yeah, so it is a very tricky disorder to diagnose for a lot of reasons. The first one is that the only way to do it is by using a symptom checklist that is in the Diagnostic and Statistical Manual. So there's this list of symptoms. If you have six symptoms, you officially have ADHD. If you have five, you don't. There are other criteria. It has to last for a certain amount of time.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
It has to exist in at least two different settings. But what makes it even more tricky is exactly what you're talking about, that there is great overlap between these symptoms and the symptoms of lots of other things, of early trauma, for instance, of anxiety, of depression.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And to make it even more complicated, what the CDC has found is that there is a lot of overlap among children who are diagnosed with ADHD. with other psychological problems. So about three quarters of kids who have received an ADHD diagnosis have also received a diagnosis for another psychological disorder or a learning problem.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And according to the DSM, if the symptoms of a child are better explained by another diagnosis, they shouldn't be diagnosed with ADHD. So that makes it really tricky that there is sometimes overlap between two things, but you're only supposed to diagnose ADHD if it is the one that is causing these symptoms.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Yeah, I think that's another part of the complication of this diagnosis. There are some doctors who think these are two entirely separate conditions that each should have its own listing in the DSM. And, you know, in fact, over the years, there have been lots of different sort of envelopes around ADHD. Its name has changed. The symptoms that predict it have changed.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
There's clearly something going on in a lot of kids who are having trouble focusing, having trouble sitting still and paying attention. But in individual children, that expresses itself in lots of different ways. And that's another real struggle, I think, for clinicians, for families who are trying to figure out, you know, there's something going on with my kid. What is it?
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And ADHD, I think, has become this sort of catch-all diagnosis that we use to just put together a lot of kids who may, in fact, be quite different.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Well, I don't think we know exactly what's going on, but what studies of amphetamines, the drug at the root of the two most popular medications for ADHD, what amphetamines do is they help make whatever you're focused on seem more interesting. And so I think that then makes sense, right?
Fresh Air
Are Kids With ADHD Being Treated Effectively?
If you're having impulse control, if you're distracted by everything else that's going on in the room, when you take this medication that makes whatever you're supposed to be looking at seem more interesting, it makes it easier to focus, easier to sit still.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Scientifically, there is not yet any real data showing that there's any particular sort of parent training or behavioral techniques that makes things better, which I think is really frustrating for a lot of clinicians and a lot of parents. And I think, as a result, tends to make medication seem like a more attractive alternative.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
But lots of clinicians have found their own ways of working with kids and with families that are just about like helping to create a calmer atmosphere in the classroom, a calmer atmosphere at home. you know, things as basic as, you know, post-it notes and calendars and just ways of helping you organize your thoughts, organize your schoolwork.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
If you're a kid in school, you know, none of those are a perfect cure, but a lot of them seem to help. And I think they're really individualistic and, you know, a good clinician can help a family figure out the solutions or the tools, the interventions that are most helpful for that child.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Yeah, so he's written a lot about it. Probably the most well-known, the most prominent doctor, scientist when it comes to popularizing our ideas about ADHD. And what he talks about in this speech is that ADHD is basically diabetes of the brain. So it's a chronic condition that you're going to have to treat for your whole life. And he tends to focus on the downsides of ADHD.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
He takes very seriously the real problems that can occur for kids and adults who have ADHD, including higher rates of traffic accidents, of early death, of drug addiction. And the way that he looks at ADHD is to look at it as this very much sort of black and white, yes or no diagnosis, like diabetes. If you've got it, you've got it. If you don't, you don't.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
Well, the main point of that consensus statement was exactly to defend the diagnosis against critics. And so a lot of that statement is just about the basic fact that this is a real diagnosis that has real consequences.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
What I was drawn to in that statement was the focus on biomarkers, on particular biological signatures that could let us identify ADHD and in the process say, this is clearly a biological condition, not just a psychological one. And it focused on three particular biomarkers. One was certain electrical signals in the brain that seemed different in kids with ADHD and without.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
The other was on genetics. There were early indications in the early 2000s that there was a specific single gene that predicted ADHD. And the third was about the kind of physical signatures you could see in the brain on MRIs, that there were differences in the volumes and sizes of particular parts of the brain in kids who had been diagnosed with ADHD.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
No, that part has not really held up to further study. It's become much more complicated, this search for the biomarker. And there are many scientists now who say that the search for a biomarker was just a red herring, that that's not what any scientist should be focused on. Instead, we should be focusing on The experience of kids with ADHD.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
So each of those three biomarkers that I mentioned have been undermined in one way or another. The study of these electrical signals, repeated studies to try to replicate that turned up to have no result. Genetics is more complicated. There are still indications that certain combinations of genetic qualities are predictive of ADHD.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
But the very sort of simple and straightforward, you've got this gene, you've got ADHD that scientists were hoping was the case 20, 25 years ago, that has proven not to be true. And then the third is this idea that there are differences in the volume, the cortical volume, scientists say, in certain parts of the brain.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
And that was studied in this giant global study called the Enigma study done by this consortium of neuroscientists and psychiatrists. And that similarly showed almost no difference between people with ADHD and people without. Among adults and adolescents, no difference at all. Among children, just a tiny difference in the cortical volume of certain parts of the brain.
Fresh Air
Are Kids With ADHD Being Treated Effectively?
But the consensus is that there are clearly both biological and environmental causes somehow combining to create these symptoms in kids. But beyond that, there's not much consensus. There's not a clear agreement on the relative role that environment plays and that biology plays.