Naveen Jain

And there were, you know, tens of companies doing DNA testing, and everyone thought DNA is unique to every individual. If they could somehow understand the DNA, which they understood as the software of our body, if they knew your DNA, they could find out what is going on. And my first reaction, as in non-expert, was, Does your DNA change when you gain 100 pounds?

And there were, you know, tens of companies doing DNA testing, and everyone thought DNA is unique to every individual. If they could somehow understand the DNA, which they understood as the software of our body, if they knew your DNA, they could find out what is going on. And my first reaction, as in non-expert, was, Does your DNA change when you gain 100 pounds?

So if you do my DNA test today and I gain 100 pounds, has my DNA changed? And the answer is no. Now, if I become diabetic, has my DNA changed? No. If I have heart disease, my DNA changes? No. I have depression, anxiety, does my DNA change? The answer is no. And my point was, in fact, even after you die, your DNA doesn't change. So if you were to look at DNA of a dinosaur, it's the same DNA.

So if you do my DNA test today and I gain 100 pounds, has my DNA changed? And the answer is no. Now, if I become diabetic, has my DNA changed? No. If I have heart disease, my DNA changes? No. I have depression, anxiety, does my DNA change? The answer is no. And my point was, in fact, even after you die, your DNA doesn't change. So if you were to look at DNA of a dinosaur, it's the same DNA.

So if DNA can't even tell you you're dead or alive, how will it ever tell you you are becoming healthier or sicker? And that was my first thing was, as a non-expert, I say, wait a sec, DNA is not the place to look for. What changes? And then back to my Khan Academy, What happens to the DNA? And we say, what? DNA makes RNA.

So if DNA can't even tell you you're dead or alive, how will it ever tell you you are becoming healthier or sicker? And that was my first thing was, as a non-expert, I say, wait a sec, DNA is not the place to look for. What changes? And then back to my Khan Academy, What happens to the DNA? And we say, what? DNA makes RNA.

And it's the gene expression or your RNA that's always changing, but not your DNA. So your genes don't change, but your gene expression is always changing. So what does someone like me say? Let's go measure gene expression. We don't know how to do that. But in my framework, you never focus on how. You simply say, okay, so we're going to go measure gene expression. Does that solve the problem?

And it's the gene expression or your RNA that's always changing, but not your DNA. So your genes don't change, but your gene expression is always changing. So what does someone like me say? Let's go measure gene expression. We don't know how to do that. But in my framework, you never focus on how. You simply say, okay, so we're going to go measure gene expression. Does that solve the problem?

And then as I started to dig in, it turns out 99% of all the genes that actually are expressed in our body don't come from our mom and dad. They actually come from these microbiome that are in our gut, in our mouth, and all over us. 100 trillion, these microbes. So I say, why? So then I start doing the research.

And then as I started to dig in, it turns out 99% of all the genes that actually are expressed in our body don't come from our mom and dad. They actually come from these microbiome that are in our gut, in our mouth, and all over us. 100 trillion, these microbes. So I say, why? So then I start doing the research.

So you go to Google Research or Google Scholar and you see diabetes and microbiome, obesity and microbiome, heart disease and microbiome, Parkinson's and microbiome. It turns out every disease has microbiome that is connected to it.

So you go to Google Research or Google Scholar and you see diabetes and microbiome, obesity and microbiome, heart disease and microbiome, Parkinson's and microbiome. It turns out every disease has microbiome that is connected to it.

My first reaction was, if everyone believes the microbiome is so important and everyone believes the microbiome causes all these disease to happen, 10 companies probably they're doing microbiome testing, then why is this problem not getting solved? And then you go back to your first principle. What question are they asking?

My first reaction was, if everyone believes the microbiome is so important and everyone believes the microbiome causes all these disease to happen, 10 companies probably they're doing microbiome testing, then why is this problem not getting solved? And then you go back to your first principle. What question are they asking?

And it turns out to date, every microbiome company is asking the same wrong question. So every microbiome company is trying to find out What organisms are in Ilana's gut? What organisms are in Naveen's gut? What organisms are in the gut of people who have Parkinson's or Alzheimer's or diabetes or obesity? And, you know, my first reaction was organisms are like tiny human beings.

And it turns out to date, every microbiome company is asking the same wrong question. So every microbiome company is trying to find out What organisms are in Ilana's gut? What organisms are in Naveen's gut? What organisms are in the gut of people who have Parkinson's or Alzheimer's or diabetes or obesity? And, you know, my first reaction was organisms are like tiny human beings.

Just like human beings, they make... behave completely differently based on the environment. So same organism will produce something good in good environment and will produce something bad in the bad environment, just like a human being. You take a human being, put them in a good environment, good behavior, put them in the bad environment, the bad behavior.

Just like human beings, they make... behave completely differently based on the environment. So same organism will produce something good in good environment and will produce something bad in the bad environment, just like a human being. You take a human being, put them in a good environment, good behavior, put them in the bad environment, the bad behavior.

So what if we focus not on what organisms are there, but we focus on what they are producing, what they are expressing, and how it is interacting with the human gene expression If we can do that, we can solve this problem. That's all about my why this, why now, why me.

So what if we focus not on what organisms are there, but we focus on what they are producing, what they are expressing, and how it is interacting with the human gene expression If we can do that, we can solve this problem. That's all about my why this, why now, why me.