Nathalie Niddam
Appearances
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And this is where it gets interesting. This is why a lot of people say nothing could possibly go wrong with a peptide. Peptides are natural. Your body knows peptides. Your body knows what to do with them, which is true and not true.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Because when we take a fragment of a peptide, we now reintroduce it into the body in a concentrated way in order to elicit a certain response, you're circumventing some of the body's natural pathways.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Now, the cool thing is you're not knocking out any of the natural feedback loops that may be in existence, which is why in the bodybuilding world, people are like, well, this is bullshit because I'm not going to get the jump in testosterone or HGH or whatever it is that I can get by bringing an exogenous growth hormone or testosterone. True that.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
But it's also not going to shut down your own body's endogenous production of growth hormone. So there's a natural piece to it that I agree gives them a profile that can be safer. But there's also a point where we're kind of like, it's almost like you're bumping to the front of the line and you're flipping a switch.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And, you know, there's checks and balances in the body that you're maybe you're you're going getting past. So, for example, you've got the melanotan peptides, which are very well known in the bodybuilding world. What's cool about melanotan peptides is that they are. Number one, they can give you a 10 with very little to no sun exposure. That's a big one.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Number two, they actually also have some metabolic effects, right? They suppress appetite, meaning if you use too much, you're going to get super nauseous, which is not necessarily what we want for building. But if we're a couple of weeks out from competition and we're in a process of cutting, that could be a really handy tool, right? But, you know, they also have antimicrobial properties.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
They also have anti-inflammatory properties. All really cool. But there might be a little possibility that nobody's really fully elucidated yet that there could be a problem in someone who's had a history of melanoma. of overstimulating those melanocytes, those cells in the body that produce pigment.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Like, I remember when university was over. saying to someone, I miss it. Like I miss learning. I miss the, I miss that being deep into, into that human physiology thing. And that was an extremely articulate way of putting that, wasn't it? Anyway. And, and, and so I've always, and because, and by, by staying, keeping a hand in fitness and, my whole career, it always kept my toe in the water.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And so there have been not very many, but there have been probably a couple of cases where people who had a history of melanoma had a reoccurrence after using a melanotan peptide. Really? Now, did it cause the cancer to come back or did it just drive the resurfacing faster? Nobody knows the answer to that question, but that gives us pause.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
That means we can't run around saying, oh, you could just use this. It's fine. Right. It's safe. Then you've got another one like BPC-157, which is body protective compound 157, which is the workhorse of the peptide world because it is great for healing the gut. It is really great for for promoting healing of soft and hard tissues.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
So tendons, ligaments, muscle, bone, all of these things regenerate and heal faster when you're using BPC-157, which is why if you're an athlete, using BPC-157 can help you recover faster in between workouts so that you can train harder more often. It's also really good for wound healing. It has properties for healing burns or eyes. It's got neuroprotective properties. It...
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
supposedly helps to balance the serotonergic, dopaminergic, and GABAergic centers in the brain. So it helps to balance neurotransmitters. Now, here's the really interesting kicker that not too many people like to talk about. There's a small set of the population that instead of helping them to be more balanced in their neurotransmitters, it actually messes them up.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
It makes them anxious or angry and gives them anhedonia, which means they don't feel pleasure anymore. So we don't know why and we don't know who those people are. So it means that you don't get to run around saying BPC-157 can be used by anybody anytime because there's no side effects. Right. So we we need to you know, it's the thing with peptides is they're so it's so tempting to make them sexy.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
It's so tempting to run around and say people. Oh, and and it's true that I mean, I've seen incredible healing. with peptides, but we need to keep the nuance in the conversation and try to stay away from those sexy sound bites because, especially because they're available through research labs still.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
So pretty much anybody can, or people go on Alibaba and get like a vial for five bucks, which is downright scary because you don't really know what's in there. We have a responsibility to help people to be more balanced in their approach.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
I think that's a theory that people have because as soon as you say angiogenesis, right, which is exactly what Dylan said, angiogenesis, the development of new blood vessels to bring supply to an area of injury, let's say, which is why BPC is so great for ligaments and tendons that we know don't have enough blood flow to begin with.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
I'm not saying it's impossible. I'm saying that to date, there is literally not a single piece of literature you will find in animal studies that would point to that right now. I haven't seen it. I haven't seen it anyway. I mean, it might be out there. I'm not Google Scholar, so I can't say that I've read every paper that's ever been published.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
But to this time, there's a possibility that in the body's wisdom, that is not a thing. Now, if you had an active cancer... probably wouldn't be smart to go there. Right. Right? Because if the body... And I don't know this... Again, like I'm not a doctor, right? I don't know this. I don't know if the body considers a tumor as an injury.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
If the body considered the tumor as an injury, then there would be a chance. But the truth of the matter is cancer tumors are pretty damn good at driving angiogenesis all by their little lonesomes. Right. That's their hallmark of cancer, right? It's one of the hallmarks of cancer is its ability to secrete chemicals that give it better blood flow.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And about 15 years ago, I just felt like it was time for a career change and it was time for me to go back to that thing that I never stopped missing. And so I went back to school and I became a holistic nutritionist. And then I got... And by then, like, I think that this was really early days of, like, Dave Asprey and the Bulletproof Diet and Rob Wolf with the Paleo Diet, Mark Sisson with Primo.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
But having said that, if you know you have cancer, I don't think it's a chance I would take.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And I mean, unless I was working with an oncologist and a doctor who have prior experience and understand the mechanisms of action. But I don't. I wouldn't recommend it. And if you have a history of cancer, you probably have to be more careful. Now, the flip side of BPC-157 is one of the other things that it seems to do very well is it protects organs. So it's really good for the liver.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
It's really good for the pancreas. It's great for the heart. There's some studies that show that it can help with managing blood pressure. It won't do it on its own. So if you've got high blood pressure right now, you can't just go run out and get some BPC and think your blood pressure is going to come down.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
But BPC-157 also, there's some really interesting literature on how it can help to heal kidneys with people with chronic kidney disease. It's going to be a piece of the puzzle. You're still going to have to fix your diet. You're going to have to make sure that whatever's offending the kidneys is managed, that your electrolytes are on board, that you're doing all the pieces.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
But it may well be part of the solution that helps to really turn the corner on those kidneys, which conventional medicine doesn't have.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Yeah. And we don't want to discount. Yeah, we don't want to discount a statement like that from someone who's in that world of researching and working with an organ. Right. So we just don't want to do that. But at the same time. You know, sometimes people get I mean, even I mean, I mean, he's sitting there in all of the knowledge that he holds. He's like, well, here's the thing.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
You know, here's how we know cancer tumors work. And this thing does this. It's not a stretch. No, no, it's not really a stretch. It's a logical it's as a matter of fact, it's a logical question to lay out as a hypothesis and to do a bunch of research on.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
See, I would, I would think that the top ones right now are any of the fat loss peptides. They're blowing everything out of the water.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
You know why? Because NAD exists with NADH. This is a little bit what we were talking about before, right? I mean, I will do NAD IVs a couple times a year, right? I use NAD support, right? So these are supplements that support my body's production of NAD but doesn't actually push NAD into the body.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
I use that on a regular basis.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
But I think what she's saying is all these people running around buying NAD and injecting it sub-Q day in, day out, week after week, month after month, you're messing with a system that needs balance.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
You know, like, that whole... All those guys were coming up, and I kind of was really interested in that. And within a couple years of graduating from... From nutrition school, Dave announced his first cohort of the Bulletproof Coach Training Program at the time. And I just, on a whim, I just signed up. I was like, I need to know more about this stuff.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And if you're going to throw something like that out of balance, you don't know what the consequences are. The other truth is that the NAD molecule itself is way too big to get into the cell. So there's still a lot of fuzziness in professional circles about what exactly are these NAD IVs doing.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
They're doing something, but there's a real belief that probably those NAD molecules are acting as signaling molecules on the outside of the cell. But nevertheless, we're stuffing extra food down the goose's throat. And I don't know. And I'm with her. I've resisted using NAD outside of my NAD supplement support and doing this one or two occasion a year.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
I kind of bring people on a medical retreat with me. And I did five days of NAD IVs in the spring. And I just went back recently and only did three days this time. And I won't do an NAD IV again until next May when I go back. Right. Unless I somehow become an alcoholic or a drug addict between now and then. And apparently NAD IVs are really great to help people with addiction.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Yeah.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Brilliant. She's one of my favorites. I've had her on my podcast, I think the best three or four times and I will continue to bring her back. Yeah, she's she's just awesome.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Yeah, they're smoked salmon and cream cheese. They're butter and jam. They're like all the things, you know, they go together like nobody's business. I mean, they complement each other.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Right. And what's interesting, I mean, TB500 is a fragment of thymus and beta-4, which is the full peptide. And I like thymus and beta-4 personally because it just has more, there's more to it. It has seven different docking points, so it's going to hit a lot of different marks. And as a matter of fact, what we're seeing as a trend right now in the oral peptide world is they're
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And even in the injectables, they're isolating some of those docs. So there are three to four amino acid peptides, which starts to bring them a little closer to that other topic we may touch on, which are bioregulators. But those three to four amino acid peptides actually can be taken orally, and they're much more specific.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Right? In what they do. But if you have kind of like a bigger issue and you don't really necessarily know, bringing on that whole 43 amino acid behemoth, which is thymus and beta-4, and partnering it with BPC-157, you just get a really nice dual action in terms of healing and even healing nerves, right? So even nerves get some benefit from... Both, either, or both together.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And that was really kind of like the gate that pushed me out into this space. And, you know, and after that, it's, you know what it's like, like you're learning and learning and it's one thing to the next to the next. And then I came across peptides a few years ago and I was like, wow, this is wild.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And I'm sure you're going to bring up next, you know, the third leg to that stool, which is the growth hormone secretagogues.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
It's a natural, right? It's what people call the Wolverine stack, right? And it can be extremely powerful. I've seen it be very powerful. But again, folks, just so you know, BPC-157, I think, is still on the no-fly list, according to the FDA. Thymus and beta-4 is on the no-fly list. CJC-1295 and ipamirelin is back on the
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
back on the list of okay we'll let compounding pharmacies and physicians in the physicians prescribe these and what those do and i'm sure they already know this from you because this is your world is they stimulate your body's own production of growth hormone And why that's so magic is, number one, growth hormone in and of itself is healing, right?
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
But on top of that, with BPC-157, you have a peptide that is upregulating the expression of growth hormone receptors, which means if you have an injury... and there's more receptors or there's a greater expression of growth hormone receptors at that site of injury, and you have more growth hormones circulating in the system, it's going to help to increase the speed of healing at the injury site.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
It's interesting because it would have to have some pretty interesting technology to get, because those peptides are too big technically to get across the skin. I mean, I've come across a product recently that actually can and does. Um, And this is where it's going, right? Like these people are cracking the code on how do we get molecules. And I mean, we've always had DMSO.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
I'm sure that you're familiar with DMSO. You don't mind rocking around smelling like sulfur. And the challenge with DMSO, though, it's a little too strong. So it can be very irritating. God forbid you have a bacteria on the surface of your skin. It's going in along with it. So there are more nuanced, better products out there now. Like I have one I talk about. You've got your gel.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And, and, you know, and I almost turned my back on it because my husband was like, dude, you keep going in different directions. Like you need to pick one thing and commit to it. And I was like, yeah, but this was really cool. He's like, no, nope, nope. You've got like, you know, you've got, what did he say? He said, you've got shiny object syndrome. You need to like focus on one thing.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
But I think we need to, again, we need to apply critical thinking.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
When you have one of those, like I can't use thymus and beta-4 or CJC or ipamirelin, right? So let's go back to this conversation about, oh, all the peptides are great for all the people. Well, it turns out that one of the fragments of thymus and beta-4 is one that destabilizes mast cells.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And although I don't think of myself as someone who has histamine mass cell issues, apparently I have enough that for me, thymus and beta-4 pisses off my immune system big time.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And then CJC apomorelin, which is the other peptide, it is one of the combination, it's one class of peptides that I've seen more people, again, have histamine immune responses to. My body's just like, yeah, it's a big, big fat no other.
The Dylan Gemelli Podcast
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And I stopped running. Yeah. I mean, here's the thing, guys. Listen to your body. It's like the BPC-157 thing I talked about earlier. Then some people, it drives anxiety and hedonia and anger. Like, in the event that you're that person that's going to decide to self experiment, which I'm not saying you should.
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And especially if you have complex issues, I really would advise against it without guidance. Um, If you're going to wear this mantle of the biohacker, N of one, experimenter, right?
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If you're going to assume that personality and take that on as a responsibility, then you need to be really aware of how you feel and what the impact is of these things on your physiology from the first day that you bring them on board. Because with the BPC, what I've seen is people who either were unaware or decided, no, I'm just going to push through.
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and they end up in a really bad way for months. And I'm telling you guys, there's other ways to heal the body. It doesn't have to be a peptide. I mean, peptides are great, but there's lots of other modalities out there. You've got red light, you've got lasers, you've got so many different things available to you. It doesn't have to be a peptide. So it's just, it's not worth it.
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If there's a question in your mind, about, let's say, I don't know, maybe colon cancer runs like crazy in your family and you haven't had a colonoscopy in a really long time. I don't know. Be smart and understand that these are very, very powerful molecules. Think about it. Oxytocin, for example, which is something that is used to drive labor in pregnant women.
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Well, there was, who was it? I think it was, oh my God, what's his name? Carl. You know him. You know him. Anyway.
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And he's right. But I have since reframed my shiny object syndrome as I'm a, I'm a, I'm a perpetual learner. And this peptide space has been just the most incredible journey. And what happened very shortly after I came across peptides is I started a community on Facebook. pretty much devoted to peptides in a way just for me to learn more, but also to connect with other people in the space.
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Anyway, he was interviewing a peptide doc quite a while ago, a number of years ago, who talks about how oxytocin also has anabolic benefits. And so next thing you know, everybody's rushing out to buy oxytocin and use it post-workout for its anabolic benefits.
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Well, the thing about oxytocin is when you're using it, you're using 0.75, like you're using as little as 0.5 micrograms or 0.75 micrograms, maybe 100 micrograms. Because think about how powerful a compound is that you can introduce into your belly fat and one to two minutes later, you get a crazy head rush.
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You didn't even put it into your blood.
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You put it into belly fat.
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And it's like a milli-itty-bitty little teeny-tiny drop. And it elicits that kind of physiological response. Like, this is where we just have to sit and wait and go, these are... I mean, they're amazing. I think that over time, they will revolutionize the way doctors practice medicine. It's going to take time. But they are incredibly powerful. So with power comes great responsibility.
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That's right. So we need to treat them with respect. And... And so, you know, sometimes when I'm having conversations like this, I feel like I'm the wet blanket because everybody's walking around saying, oh, my God, these things are amazing. They're fantastic. And legit, right? Oral BPC-157, if you have gut issues, it can really help to move the needle for people.
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And sometimes it can even help with musculoskeletal issues taken orally if you don't have a major biomechanical driver to your injury. But I guess I've taken on this role because I feel like nobody else is out there saying this. And so I don't think wet blanket is a really good moniker.
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And do your blood work.
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And when you're not doing that, do blood work again. Like with SARMs, you got to be smart.
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Well, it depends on what you're doing, but anything that's touching your hormones a hundred percent.
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And I mean, the cool thing is now you've got some great services. Like, I don't know if you've heard of Cyfox. Like they send you a kit in the mail, you put your finger, you put some drops on a card, you send it off and it's super affordable. Yeah.
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The world of labs is evolving so fast. The technology has moved forward. It's leapt ahead by light years. And even if you have old blood work, you can load it onto their platform. It's almost like there's... Whereas it used to be really hard because you had to somehow hypnotize your physician to get them to ask for blood work they didn't think you needed.
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And then, you know, you have to get yourself to the lab and you have to do the big blood draw and then you have to wait and the whole thing. These guys now, it's like it's a subscription and it's less money than almost anything else. And you can just get insight into how your body is responding to different protocols. That's right. It's pretty powerful.
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And then about a year and a half after that, I launched the podcast. And the podcast is what, like the Facebook community kind of It started to tap into this love of learning and teaching that I have.
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So tesamorelin is the same family as the other gross hormone secretivox.
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It differs by maybe just a couple of amino acids, right? It was developed, and it is a drug, right? So it's available, but it was developed specifically for men who are on HIV meds that was causing them to develop visceral fat. And so tesamorelin was developed for that population and turned into a drug.
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But if you look at it, all you're doing is using that growth hormone secretagogue at a way higher dose than you would be using CJC.
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So CJC, typically people are using it anywhere from, let's say, 100 to 300 micrograms a day. Pops, right? Tesamorelin, if you read the literature, is one to two milligrams a day.
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Right?
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Yeah. And so now what I would say to you is I cannot touch tesamorelin because of my body's issue with gross hormones. Okay. Um, it works really well for belly fat, but it's a bit, and because it's a growth hormone secretagogue, it's going to crank up your growth hormone. It's going to be easier for you to build muscle. It's going to be easier for you to recover from your workouts.
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It's also got some lip. Well, obviously it's called lipolytic, right? It's going to burn fat specifically around the middle. Like it can be fantastic, but it's pricey and it's a one pathway monkey. And one pathway in the sense that it ups growth hormone and then growth hormone does all the things. Got it.
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When we're going to talk about the GLP-1s, what's fascinating about those guys is they are not a one pathway monkey. They're hitting the body in four or five different ways to get people to the point where their body is releasing weight.
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Right. I kind of have that dual thing going on. And then the podcast is the is is now I feel it's like the full expression of of me allowing me to learn and inform and guide at the same time. So that's how I why I do what I do.
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Right. So and I've seen the growth hormone secretogogs. Typically, I find men respond much faster and better from a fat loss perspective. I've seen lots and lots of people, certainly with the CJC epimrelin, they don't get the fat loss benefits. And maybe that's because they've got other. Well, for sure, it's because they have other stuff going on.
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Whatever the case may be, they can also drive water retention.
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Right? Because excess growth hormone, you know this from the bodybuilding world, if you take too much growth hormone, you're going to get puffy, which is the nightmare of the bodybuilder because there goes that definition and the veins and the whole thing. So modernized triations go, jeez, wait. They were there five days ago, I swear. Here's a picture.
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Um, so anyway, so it's, it's great, but I would say Tessa Morellen has fallen out of favor ever since for, for fat loss, specifically fat loss ever since the GLP ones have hit the stage. They've just kind of gone move over baby. We've arrived.
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I think they're used properly. They're fantastic.
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That's my short, short answer.
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Yeah. So, I mean, I just want to say something on the microdosing thing. I think microdosing from it depends on the person. Right. And it depends what you mean by microdosing.
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Right. So there's people who are taking one fifth of the starting dose and having really good results. For someone who has a broken metabolism, who's been yo-yo dieting their entire life and walking around with 100 extra pounds, there's a really good chance that that little tiny itty bitty microdose isn't even going to hit the mark. Right. It's not going to start anything.
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So it depends who you are, why you're using it and what you're using it for. Which is the same thing as why you're using it. Sorry, I'm repeating myself. So to answer your question, what they do, remember we said they do what they do in many different ways. So the first thing I'll talk, I mean, I'll start from the top and work my way down.
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It is. I mean, I don't think Meta... Meta's recently closed down two very similar communities to mine. I feel like our days are numbered. We have almost 30,000 people in there, but I don't know. The group, if anybody's interested, is called Optimize. It's Biohacking Superhuman Performance, which used to be the name of the podcast way back. Bit of a mouthful. So it's still there, but it's
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Number one, they hit the food reward center of the brain.
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So they make you just not as interested in eating food as you used to be.
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That's why they're being researched for addiction because they have that same impact. It's that whole addiction center in your brain. They seem to kind of shut it down.
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Turn it down. So one of the things that you'll hear people say when they're using GLP-1s The food noise is gone. Right. I'm no longer eating something and thinking about what's the next thing I'm going to eat. Right.
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So which to some of these people is like it's almost like they've been living in a world where they had headphones on blasting music in their ears 24-7 and all of a sudden it's gone quiet. Like it is remarkable how transformation all this truly is for some people. It's not everybody, but for some people, right?
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The next thing they do is they slightly raise your resting metabolic rate. And this is why people see their heart rate go up. And they also see their HRV tank, especially at the beginning. The body often over time adapts.
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But at the very beginning, if you're wearing an aura or ultra human ring, whatever ring you're wearing or whatever device you're using, you're going to notice that your HRV, your heart rate variability goes in the toilet. And that's because your resting heart rate's gone up. Like that whole ratio, that balance between the sympathetic and parasympathetic nervous system is kind of off.
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It's getting thrown off by the thing. But the reason for that is it's raising your resting metabolic rate. And so your burn rate is higher at rest. You're basically burning through more calories at rest.
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Okay. Number three is it slows down gastric emptying. So what does that mean? It means that your stomach's not going to be able to move food through the system as fast. What does that mean in practical terms? You stay fuller longer.
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So you have less appetite to begin with. You're not you're not like the pipes not draining the food as you're eating. So now you're like kind of building up food. So you're going to feel fuller faster and you're going to stay feeling full longer. The dark side of that, there's two. Some people it can drive cause really bad heartburn, like really bad.
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And in sometimes for those people, it's enough that they can't use them. or what they need in some cases if, number one, they eat smaller meals. And I suspect that some of those people are eating through, they're not hungry through habit. Right. They're overriding the peptide a little bit.
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Or if that's not the case, sometimes using digestive enzymes with those guys, it helps the body because most of us don't make enough digestive enzymes to begin with. So the food sits there and it just kind of ferments. It doesn't get broken down properly. So if we add digestive enzymes to the mix, then the food is at least getting broken down.
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And when it's time for it to move through, it's better digested. It's ready for its next phase. Right. The other dark side of the slower motility, and this is a bigger issue with, you know, I don't want to get you in trouble, so I'm not going to say the brand name.
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And the bigger issue is semaglutide, which is Ozempic, the first one that came out, versus terzepatide, which is Mungero, the second one that came out. Sorry, did I say semaglutide was the second? It's the first that came out, right? And it's the first of the big ones. I mean, GLP-1 agonists have been around for a long time. There's liraglutide.
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There's all these other ones beforehand, but never have they hit the mark the way these guys have. Especially more so with ozempic is constipation can be a massive issue.
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And constipation is such a rampant issue in society that it makes a bad problem make it worse.
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You have to be extremely vigilant about that. You got to get your fiber in. You got to get your hydration in. You got to get your healthy fats in. And you got to watch it. And that's what I would... Yeah. If it's a problem, if all of a sudden you're pooping once a week or less... It's a problem. It's a problem, right? And it can make you really, really sick.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
So I'm just going to sit here in this section and talk about some of the black box warnings and issues. The next one is in... Not a lot of people, but in some people, it can cause pancreatitis.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
You know, we're skating on thin ice because a lot of what we talk about is so controversial. And to be fair, the community, it takes on a life of its own when it gets that big. And it's very hard to manage, you know, people giving out medical advice who shouldn't be doing so.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And pancreatitis is a big, bad, nasty, horrible, painful, can lead to pancreatic cancer down the road. Nasty. So you got to talk to your physician about your health history. And what I mean, I've seen and I'll tell you, like I've seen it happen to a couple of people in my in my membership community. And it was not in the Facebook community.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And it's and it's, you know, like when you see it happen, you're like, OK, this is a thing. This is the thing. This person didn't do anything wrong. Now, did this person already have a pancreas that was compromised? Are they heavy drinkers?
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
I don't know all the answers to those questions, but this is why you've got to sit with your physician who's probably seen this over and over and over again and can at least start to ask the questions to make sure, right? Right, right, right. Before BPC-157 got taken off the table by the FDA...
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
There are a number of physicians that would give people BPC-157 with the GLP-1 as a protective mechanism for the pancreas. Okay. Now, the other black box warning is for a particular type of thyroid cancer that they've only really observed happening in rats. But, you know, as time goes on, I'm hearing a bit more chatter about the risk of it in humans.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
So anybody who has a history of thyroid cancer probably is not a candidate. There's the chatter I've heard. I haven't seen the studies yet, but the chatter I've heard is possibly that it would be linked to long-term high dose use, right? So we just have to be, again, we have to be mindful.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
I think the thing that we have to be really cautious about with the GLP-1s is that we take our time, we go low and slow, we use our minimum effective dose and be patient. It took you a long time to get to where you are. It's not going to resolve in two months.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Okay. So now let's move down. What else is the GLP-1 doing? This is where it gets exciting, right? It actually improves the pancreas' response to glucose in the system. And it makes you more insulin sensitive. One of the problems that got us to where we are in the first place is we become insulin resistant. So the body doesn't respond to insulin properly.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And then the pancreas sometimes doesn't release enough of insulin. So if it helps the pancreas to release insulin in a more appropriate manner when needed, plus it makes it easier for your body to respond to insulin, which means it gets glucose into the cell, which means you're going to store it as glycogen. And guess where it really, really works? Oh, at skeletal muscle and cardiac muscle.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
People asking for medical advice who, you know, like I understand that people are desperate for answers and looking for solutions to problems that have not, they haven't been able to solve through conventional means. But in a world, it's a little bit like Reddit. Right.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And this whole storyline about how the GLP-1s eat your muscle is the biggest bunch of crap I've ever heard. Because it will cause your body to consume muscle in the event that... You don't eat enough protein and you don't exercise.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Are you going to lose? Am I saying you'll lose no muscle? Hell no. You might. You might lose a little bit of muscle. But if you lose 40 pounds of fat and a little bit of muscle with it, guess what? You're way ahead.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Like you're way ahead. You're metabolically healthier. You can build back the muscle.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Right. The big problem is people who overuse them at too high a dose don't prioritize protein and do not exercise. They figure out that, you know what, I can sit home. I can't eat as many donuts as I used to, but I can still eat donuts. I don't actually have to go do that sweaty, nasty thing I got to do. And I'm still going to fit into my size six jeans. How amazing is that?
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
OK, it's amazing, except you still you're not that much healthier metabolically. Right. And now you really can't come off them.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Because now you've lost your most important organ for managing your your weight loss and your metabolism is your muscle.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And if you've lost the muscle, guess what? The minute you come off these things and go back to eating a normal diet, you're cooked.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Yeah, you don't need as much muscle to carry less of you around.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
You know, like I would I wouldn't go there personally. That's not. But I know the docs like Dr. Yours will have her patients using very small doses as an anti aging. Yeah, there's some anti inflammatory stuff and keeping the insulin. I you know, I think it just depends on the person. Yeah, I agree.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
So in a world like that, you start you get all kinds of people and you get on the one hand, you get professionals that have big hearts and want to contribute. But you also get a bunch of yahoos who think they know and who are giving out information that they have no business doing. From my world and everything in between. Right. So so with respect to all the people in that community.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
You're doing the work and you're in the gym and you're you're dialing in the diet and the whole thing. I mean, you know, again, I'm not a doctor. Right. It just depends. She probably knows stuff I don't. I'm less inclined that way. But that's just my personal opinion. That's not my medical opinion.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Yeah, I haven't really done my homework on the red atrutide, so I'm not as well versed on it. But I can tell you that terzepatide is a dual incretin, so it hits two different pathways. Semaglutide hits one. Semaglutide is just GLP-1 agonist, whereas terzepatide is GLP-1 and GIP agonist. Got it. So it's two different pathways.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
So, and what would happen with semaglutide is after a while, for a lot of people, they hit a wall and they can't go and like their body's just like, it's almost like the body's figured it out and said, ah, no, okay, we're done with this.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Your body, like, don't forget that there's a set point in the hypothalamus. The body, don't forget that it is an evolutionary advantage to be able to keep a buffet on board in case there's a famine. Right. And all that yo-yo dieting that you've done through the years has taught your body that there's times of famine coming.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And so it better hang on to this extra stuff for that next time you're going to decide to starve it.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And so the benefit in my mind of the low and slow fat loss, like the first time and, you know, postmenopausal women are the perfect candidates for this stuff because we wake up one morning and we look down and we go, who the hell is this? Like, what just happened?
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And now I think it's getting better because we're more informed as to the fact that we become insulin resistant as we go through menopause. Everything changes. That diet that you used to eat that you got away with, gone. All those stupid memes about women going through menopause, drinking, chugging a bottle of wine is, by the way, ladies, killing you.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Just here to tell you, find another way to deal with your stress. But postmenopausal women. So, you know, you pack on. It's like the magic 10. Only the magic 10 you don't want.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
So there's 10 pounds that show up. And the problem is that every year you tend to add one or two pounds. Extra pounds to that. And now you add to the fact that you're stressed out because your kids or whatever, and then your parents need you more and you've got a career on the go and you've got all this stress. So now the cortisol builds and like this, this kind of perfect storm happens.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
So the GLP-1s for women, postmenopausal women are incredibly powerful. But we have to be able to do all the things we just talked about. We have to be eating a protein forward diet. We have to be hydrating, getting the fiber in, getting to the gym, like doing all that stuff. But the first time I used a GLP-1, it took me, it wasn't even a year though.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
and the ones trying to help. But I think you have to be very, very cautious in these communities about who you take advice from and what you ask for, because it's a very slippery slope.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
I mean, it was pretty good, but I had also dialed in my nutrition and dialed in all the things. But it took at least nine months for me to drop about 12 pounds that I really didn't need. Wow. And then by keeping it off for the next, I'm going to say, I mean, keeping it off for quite a long time after that, you allow, like the hypothalamus resets your set point over time.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
But you've got to be able to stick with it. And then, you know, for me, every once in a while, if I feel the wheels coming off the bus and things start to creep on me, that's when I'll microdose.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
It's also a reminder. Oh, guess what? You got lazy. Guess what? You thought you could just have a croissant every time you go by the store. You thought you could have pizza every time you want it. I can have pizza. But it's a slippery slope. As you start to let that stuff back into your life, you go from once a month to once a week to once twice a week to, oh, well, what the hell?
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And then you end up in a situation where you're really stressed out and the wrong people quit on your team and you're barely keeping the wheels on the bus and you wake up two weeks later and you're like, uh-oh. How the hell did we get back here again? Right.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And so we have this really interesting tool that we can kind of go back to help us to get back on track, dial it in again, still do all the right things and get back on track. So it depends, right? Like, I mean, genetically, I'm predisposed to being insulin resistant. Every single person on my mother's side of the family had developed type two diabetes later on in life. It's a thing.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
I would love to. And we can talk about Red or True Tide next time. I'm, I'm cautious with Red or True Tide. I know it works really well for some people.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Um, I get a little bit worried sometimes because, number one, it's not through its phase three clinical trials.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And I see people stacking, like making a fruit salad out of all the different. Yeah, it's insane. I find it. I'm I'm I'm. I'm just reserving judgment. I'm more conservative than than a lot of people.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
I think in a perfect world in a community like that, if we could really control the flow of information, is to try and give people information that gives them the next step in their quest, but doesn't give them the answer that we're not qualified to give.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
I get it. And you don't you know, you don't have to listen to me, but I'm just not going to jump up and down on that bandwagon just yet. And I have more information.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
They're jumping the gun. Now, people could be sitting there laughing their asses off going, what a bunch of hypocrites. So you're using BPC-157. That's not cleared. Right. But now you're telling me Ritter True Tide, oh, it's not through its phase three clinical trials. I, you know, I'm like, you got to pick your battles. I think we have two other products that work really, really well.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
I feel for the most part, and I'm sure there's exceptions to this, but for the most part, if you're doing the work, One of those two is going to work for you.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
It had been around for a long time.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
It's a thymus peptide. It has immune benefits at the same, like we haven't even touched on the immune peptides. Like, you know, we haven't even touched on the bioregulators. Like, I mean, there's so there, there's so many other ways to go here. Yeah.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
It's just, you know, I think the GLP-1s, in a perfect world, everybody would have enough understanding and knowledge of themselves to know when they really need to go there and then use them properly.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Right? I mean, that whole thing of Ozempic face, that was a big deal. Anytime you lose a ton of weight fast, it's going to take it out of your face. Not to mention the fact that some people just lose weight in their face before anything else to begin with. Right. It's a thing. It's like you said. If you're going to lose a bunch of weight, you're going to lose some muscle with it.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Right. That's that's the those are the guy. And it's not kowtowing to meta. It's just being responsible.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
It's going to happen.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Yeah. No, you get fluffy. You get fluffy face. Yeah.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Yeah.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
I can't believe it's been an hour either. This is fun. All right.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Thanks, Dylan. So the podcast is Longevity with Natalie Nidham. My website is natnidham.com. It's undergoing a huge overhaul. So for now, if you go there and you go, God, this is kind of meh, it's about to get better. Instagram is at Natalie Nidham. And also on my website, you can sign up for a newsletter, which I think it's a pretty cool newsletter.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
There's also a peptide-specific newsletter if you want it. And then the membership community, that information is on the website as well. So natnitm.com is kind of like, even though it's slightly imperfect right now, it's ground zero for all the other stuff.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Thank you. Thanks for making the time for me. Thank you so much.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Yeah. They're infamous for this.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Yeah. And, you know, the problem is people can be really unkind and mean. You don't know who you're dealing with. We've had to remove people from the community who've gotten very angry. So what's ended up happening is I've withdrawn myself a lot from that community. I have a membership community on another platform. I mean, people do have to pay to be in there, but I'm,
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
personally present a lot more in there. And I think that it's a tough thing, guys, because I know that there's people who don't necessarily have the means to pay. But I mean, I've kept it really reasonable, as reasonable as I can. But as soon as people are paying for a community, it tends to filter out a lot of the people that are more difficult to deal with.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Hey, Dylan. Nice to see you again. And thank you for having me. This is going to be fun.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
It took me a while. I didn't start until a couple of years ago.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
It's been our first conversation. This is going to be
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Yeah. So I mean, so I started I did a course like kind of an introductory course with a company at the time. I don't know if they're still out there in the same way called Appear On. So it's Dr. Dan Stickler's community. And and that was my like that was kind of my first formal sort of grounding experience.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
I interviewed a lot of people like, you know, at the end of the day, you got to talk to people who are way smarter than you.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Right.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And you I learned a lot from the community. I learned a lot from the doctors and the people in the peptide space who became my mentors. I did the like there's the A4. You know, I bought the A4M certificate first level certification. Yeah. Like, you know, you consume the challenges. There wasn't at the time a lot of information, formal education out there.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And so, you know, to that degree now, I don't practice, right? I educate people and I educate people to a point. But when it comes to personal use for people who have problems like issues, medical issues, I do not. consult with those people anymore. I direct them to physicians who can help them or professionals who can help them. But I'm very clear about my lane. Right.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And I see myself as a person who shines, shines a light on different directions that people can go. And sometimes I will go knock on a door for them and help connect them to the person they need to connect to. But but that my role is not, you know, it's funny, people call me a peptide expert and it makes me very uncomfortable. Really?
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Because as much as I know about peptides, there's a lot more out there. And I know enough that I can I feel like I can really give people some a good foundation from which to go forth to. right?
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
But if we're, like I said, if we're talking about people like, you know, people in the Lyme community, the Lyme, the mold community, these MCAS, like people who've got really intractable issues that the conventional system just is stymied by. When those people are looking for help with peptides, what's really important for them to understand is that there's a very
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
There's a very defined order of operations when you're dealing with issues like that. And they don't all involve peptides.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Right. Sometimes you have to stabilize your system before you can bring the peptides on board. Sometimes the peptide can be helpful. But if you bring a peptide in too soon, sometimes it'll make you worse or it won't do anything. Right. And you're wasting your money and your resources. And frankly, you're wasting time when you could be getting better. That's right.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
You know, kind of peddling on the spot. So I think in the peptide space, we... Those of us who are in it have to be mindful to be really responsible and to guide people in the best possible way and take our egos and stick them to the side and really look at the person in front of us and say, what's going to serve this person? What's going to help them?
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Well, thank you for that. So my story is, I mean, I've always, since I was young, been kind of like, I was like a science kid, right? I was always really kind of geeky into science and I studied physiology in university and And I was a fitness instructor. And at some point, I kind of got sidetracked and ended up on the corporate world. But I never let go of the whole science piece, right?
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
And you're a bodybuilder and you're trying to get 10,000 calories a day.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
So... So what a peptide is, is a small protein. It's as simple as that. There are 50 amino acids or shorter.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Right. And an amino acid, as I'm sure your community knows because of their background, are the building blocks of protein. And we know the proteins are signaling very powerful signaling molecules in the body. That's what they do. They're folded up into little origami shapes. Sometimes they have to unfold a little bit.
The Dylan Gemelli Podcast
Episode #10 Featuring Longevity Biohacker and Peptide Expert Nathalie Niddam! THE PEPTIDE EPISODE! Peptides safety and efficacy, nuances of use, potential risks, The Role of GLP-1's in insulin sensitivity, BPC157, TB-500, Tesamorelin and MORE!
Sometimes that origami shape presents something like a lock and key, like you have a receptor. The origami shape is the perfect fit for that receptor. And that's how the peptides work. So that's what they are. And what is so fascinating about them is because All the peptides that we're talking about really are fragments of proteins that are naturally occurring in the body.