Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Great to be here.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, I would say that high, long, prolonged spikes is obviously pretty bad.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But certain things, like if you eat a grape, grape's pretty loaded with sugar, but it's a pretty transient spike.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It'll go up.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so that would be a transient one.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Actually, when you do strength training, for example, for exercise, you break down glucagon, which is a polymer of sugar that you break down, gives you energy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's important for when you're doing exercise and training, and that will give a glucose spike.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I get a glucose spike every morning when I weight train.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So that would be a normal healthy one, but it's transient.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It goes away pretty quickly.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
What's quickly?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Within 30 minutes, maybe most 60 minutes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Now, I'm a special case.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm a type 2 diabetic.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So my spikes go higher and longer than most people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So, yeah, mine are not good spikes, but we can get into that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So what is a good spike?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, the calibration people mostly use is time and range.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's a simple metric.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Meaning if you're a healthy person, your glucose is normally, for most people, around 90.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And if you're off, you will go higher than that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
For most people, you want to keep your glucose between 70 and 140.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
If you're healthy, for diabetics, they say try and keep it between 70 and 180.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that is what people try to do.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And most healthy people, it's pretty easy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I think one of the things we've done, you've heard about continuous glucose monitors, these devices.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I'm wearing one and some of your staff I know are wearing them as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they're over the counter now.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You put these on your arm and they measure your glucose every five minutes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So you can see exactly what's going on.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so we put them on so-called normal people, pre-diabetics and some diabetics.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That was already well-known.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Diabetics will spike their glucose through the roof too high for too long.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then the people devise, especially type 1s, control mechanisms for releasing insulin and controlling all of that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But for the average person, that wasn't so well known at the time we were doing this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it was a bit of a surprise to see that a lot of people, some did a very good glucose control, but some pre-diabetics were what we call moderate spikers.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We came up and named glucotypes as a way of quantifying this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then some people were spiking just as bad as diabetics and had no idea.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so it's a way of revealing what was going on.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So it's recommended that you try to stay in this 71-40, but it is a bit arbitrary, but it's not a bad rule of thumb to work by for the average person.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But again, some people have very, very good glucose control.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some are moderate spikers and some are severe.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it's pretty clear that excessive spiking, especially in diabetics, is associated with cardiovascular disease and other things.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
There's some pretty strong papers out there on that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So you do want to keep it under control.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And there's a very strong correlation between this time and range measurement I mentioned and something called hemoglobin A1C.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's a measure of your steady-state glucose.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so if you have...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
High hemoglobin A1C, that's typically how we classify people for diabetes and prediabetes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
If you're over 6'5 or over, you're classified as diabetic.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
If you're 5'7 to 6'4, you're prediabetic.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And if you're under that, you're so-called normal.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And this time and range will actually correlate very, very well with that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So it's a surrogate measure for that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But it's actually pretty cool because you can precisely see what's going on in real time.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Unlike a hemoglobin A1C measurement, which you get periodically.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So if you want to dig into that further, I would say that, you know, what's cool about these CGMs is that you wear them like I'm wearing one now.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You can wear them for about 14 days, depends on the particular device.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And you see exactly what foods do what to you.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we're all different.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So some people spike to bananas, some to potatoes, some to pasta, some to white bread, some to brown bread.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so this was shown by Aaron Siegel's lab at the Weissman, and our lab had found something similar.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it's very personal.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so we've been spending a lot of time trying to dig into what's behind that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
100%, yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
My four watches and my ring and even my hearing aids are sensors, believe it or not.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They are for hearing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We're going to get into all of that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, well, certainly sleepiness is one.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I can put myself to sleep with a piece of pizza.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm diabetic.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm an unusual diabetic.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We can talk about that too.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And yeah, if I eat pizza, my glucose goes through the roof and I will get sleepy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I believe so.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I mean, there are multiple things that affect sleepiness, and you probably know this better than me since you've covered sleep more.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But yeah, like tryptophanes, things like this can help induce sleep as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But certainly glucose, these large glucose spikes, I can say personally, make me very, very sleepy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And alcohol can make a lot of people sleepy too.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But you're right, there can be a lag because that first little shot of glucose can be a stimulant.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But very soon that shot can go very, very large of glucose.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And at least for me, it makes me very, very sleepy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I think it's very normal.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, you can mitigate that, of course, by doing a walk and try and burn off a little bit of that glucose.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We can get into that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, I think brisk walks seem to be better.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
There are studies from other people on that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
A brisk walk for 15 minutes or 20 minutes after you eat will help suppress those glucose spikes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
yeah so they're in fact some of these um companies that have set up around personalized management of glucose uh i'm involved with one called january i and there's others out there too they actually recommend that if you eat something that spikes your glucose you should take a uh a brisk walk and that will suppress your spike and they connect they'll actually teach you that
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And you can see it personally.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so one thing we've done, for example, most people spike to white rice.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Believe it or not, it's high glycemic index.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But glycemic is more personal than people give credit for.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Anyway, you will spike your glucose.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But if you take a brisk 20-minute walk, you can just see that spike is much, much less.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's what I assumed, yes, that you're burning it off.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
No, I haven't seen it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This is wild.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You mean electrical or a physical one?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, electrical.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, maybe.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You know, I think there's a lot of benefits, as you know, from exercise per se.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You make all these things called exerkines that have a lot of benefits in general.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I think exercise probably brought it and simply injected it in itself.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But anyway, maybe what you say would be helpful for people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You know, what I do, and there are others who do this too, you've heard of this phrase exercise snacks, especially for people who sit all day, the idea of getting up.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it used to be, well, get up and walk, you know, some brief walk.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But now there's some ideas, well, maybe get up and do more of the walk.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Maybe do some of the things I hadn't heard the one you said, but maybe that's a better thing to do.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, exactly.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we have people doing some squats now running a study like that and see what it does to their VO2 max and overall health measurement.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I'm a big believer, yeah, sitting for eight hours is probably not good for you.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
In fact, there are plenty of studies that show that, and these breaks are good for you.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Even walking is better than nothing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't do the treadmill.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I have tried the standing one.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I find I don't concentrate as well when I'm talking with people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I have to confess, I prefer to sit so I can be a little more engaged.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I do have a lot of meetings.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So for me, that seems to be more effective.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But it does mean I need to get up and take these breaks.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so I haven't – but for other people, I know they like standing desks.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I've heard for some people, though, it may not be overall as effective.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I don't know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Interesting.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
There's no way we sat eight hours a day in ancient times, yes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I 100% agree, yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
People had to be active.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They had to be active to gather their food and deal with the elements, yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
There's a lot to unpack there.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we have some studies where we put CGMs on people, smartwatches, we could track their activity.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They did food logging and exercise logging as well, tracked them in incredible detail.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they were also very well phenotyped for their glucose dysregulation.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we should probably talk about that a little bit about muslin's resistance, beta cell defects, things like that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we were trying to relate what was the glucose dysregulation of phenotype with their lifestyle.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And not just their lifestyle, what they did, but when they did it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And what we found is that, first of all, some simple things already known is that if you have your bigger meal first thing in the morning, you generally have lower glucose and not later at night.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So people had their biggest meal, their biggest energy consumption later in the day as dinner, which is awkward socially because that's what most of us have our big meal or many of us do.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Those folks will have a higher glucose.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And starchy vegetables is well known.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Those folks have higher glucose.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But interesting, fruits.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
People ate a lot of fruits as their major source of carbs had lower.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's because of the fiber that's in there that helps them.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Turns out most people don't get enough sleep.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so those who slept longer actually had lower glucose.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But some of the things we could tease out were –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
When should you exercise?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
If you look at the party line out there from various studies, well, you should exercise in the afternoon to get your best benefit.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But we found that that depends on the form of dysregulation you have.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
If your muscle is resistant, you actually get better benefit by exercising in the morning for glucose the next day.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So to unpack that a little bit, so you probably know that, you know, you eat something, you get glucose if it's sugary, and your insulin obviously, you know, helps control that, stimulates your cells and take that up.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And if you're insulin resistant, especially muscle insulin, because muscle is a major consumer of glucose, means you're not taking up your glucose right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So you're insulin resistant and you don't take up glucose and you wind up with high glucose spikes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But there are other forms of diabetes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So to break this down or glucose dysregulation, there are people who don't make insulin early in life.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That would be called type 1.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You can still become...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
insulin deficient and making insulin later in life for type 2.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But you can also have what are called beta cell defects.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So insulin is produced by your pancreas, your beta cells.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I myself am type 2 diabetic.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I have a beta cell defect.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It took me a while to figure that out, meaning I make them some fun.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
My cells respond, but I don't release it from the pancreas.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then there's things called hepatic insulin resistance.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So your liver is insulin resistant in other forms as well, fat insulin resistance as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we've now gotten into –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Dividing up diabetes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So basically, classically, people will group people into type 1, which is 10% of people, or type 2, which is the other 90% of diabetics.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, it turns out that's a really broad category.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That can easily be subdivided into what we call subphenotypes, these different forms of glucose dysregulation.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we think that's a big deal because it affects the drugs you take.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So, for example, I am a beta cell defect, and I didn't respond.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I went through exercises to be a runner, and I shifted to weight training about it'll almost be nine years soon.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
with the idea of building muscle mass, which failed miserably.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
My glucose was gradually going up.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I shifted to weight training.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I gained 10 pounds of muscle mass.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I do whole body MRI, 20 of them in the last eight or nine years.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I basically did gain 10 pounds of muscle mass that had no effect on my glucose control.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the reason for that was that I'm not muscle intolerant.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm a beta cell defect.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I can gain as much muscle as I want.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's not going to help me release
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
insulin from my pancreas.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So knowing your subphenotype is a big deal, but then I respond to certain drug, rapinolide, that actually promotes that release.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So knowing your subphenotype determines your drugs, but it also turns out this whole lifestyle thing I mentioned earlier is a big deal and coming back to some of the food stuff.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we found that if you're...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
basically insulin resistant, muscle insulin resistant, you will spike to potatoes and pasta, but not if you're insulin sensitive.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And if you have beta cell defect, you also spike to potatoes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So you actually, you can sub-phenotype people according to what their glucose dysregulation is.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that affects how you react to foods.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so then the obvious thing to do is modify your eating behavior on those foods so that you can basically live a healthier life is the idea.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so how are you going to subphenotype?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, the way we do it now is super expensive.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We do these gold standard tests, take several hours, hundreds if not thousands of dollars, depends how you do it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We, believe it or not, can do it just from a simple glucose curve.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So you may not realize that when you put one of these glucose monitors on you and you drink a shot of glucose, you'll have a curve.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that shape is different for different people, and that depends on their subphenotype.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So meaning if your muscle is resistant, you'll have a certain shape.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And if your beta cell is a different shape and if you're a combination of things.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And there are other factors, by the way, that play in here like your microbiome.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So the gut's in your – the microbes in your gut all play in this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so they basically affect the shape of your curve.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And now we're not there yet, but we're good for some of these like for muscle is resistant.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We can quite accurately predict –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
whether your muscles are resistant just from the shape of that glucose curve, which you can get now from an over-the-counter purchase at a drugstore.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, we haven't.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Taken apart for that particular study, the difference between resistance training and – there's more a general activity measurement.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So people are more active in the morning.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
If they're muscle-resistant, will benefit, have better glucose levels the next day.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we haven't yet done resistance, but I'm very interested in this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
In fact, we have a separate study around high-intensity training running versus long-distance running.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I'm happy to talk about that, but that's still in progress.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I wouldn't say we've totally done what you've gotten at, but we would like to dissect the resistance training versus an aerobic or endurance type of training.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I mean, the bottom line is, of course, exercising any time is better than not exercising at all.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I think we'd all agree with that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But we do think you get better glucose benefits if you are muscle and resistant during the morning.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I also do believe that, yeah, building your muscle mass will help with actually reducing muscle and resistance.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But it's more than that, meaning there's a beta cell defect where you don't release insulin from your pancreas.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That has nothing to do with insulin resistance.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's more a mechanistic thing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Now, why that defect exists isn't so clear.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
My case is kind of interesting, although we still don't fully understand it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But then there's also incretin defects.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So incretin are these GLPs that everybody's heard about.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Ozempic is a mimic of those and Mongero and things like that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so there are people with defects that way.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we're all different, and we can now subtype that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We can say this person's got mostly an incretin defect.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This one's muslin-resistant.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This is a beta cell defect.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And some people are combinations of those.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's not pure one or the other.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we think actually the subtyping is a big deal because, again, it determines your lifestyle, choices you might make to better control your glucose, and, of course, drug responses as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we think that's important.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, if you include beta cell defects as part of insulin management, then the number is probably very high.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I honestly don't know the answer.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't think we fully know the answer because people haven't done the sub-phenotyping like I've described.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We don't know how many people have incretin defects.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We are getting there with insulin resistance and such, but I don't think we're fully there.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I want to correct something that you said.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I mean, it's very much the case when you see someone who's thin, you can't assume they're not diabetic.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This is very common, especially in South Asians, to see them diabetics.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I'm a good example.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
No one would call me overweight by any definition that I'm a diabetic and I have a beta cell defect.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I used to think a lot of people who are thin diabetics probably have beta cell defects.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But it's not that simple.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some do and some don't.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some are insulin resistant.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then there are other people, believe it or not, who are very obese by any clinical measure or what have you.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they have very good glucose control.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So there are a lot of things we don't fully understand.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
A lot of it probably does.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It fits in this idea that this is not a simple process.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We have many organ systems involved in glucose control, your liver, your pancreas, your muscles we've mentioned, but even your brain is a major glucose consumer.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so we have all these different organ systems.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Then on top of that, we have all these different biochemical pathways that are engaged as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We mentioned the insulin one, but there's incretin.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
which are these GLP things that promote insulin release, but they probably have other effects as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't fully understand.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't think everyone does all the effects of incretins.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Their receptors were all over the place.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
In fact, some of these drugs you may have heard are actually now being touted as maybe anti-longevity drugs because they seem to improve cognition and stuff.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Now, whether that's tied to
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
weight and things like that is less clear.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
As longevity drugs.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Thank you for that correction.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
If I can intersect there.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I am a type 2 diabetic and they were great for me.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
My hemoglobin A1C got to 8.4, which it's not the highest, but it's pretty high.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I went on the GLPs and I went down to 5.7.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Pretty fast.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
No.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, initially, yes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's a little complicated.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I went on a lower-dose thing called Farcega, and that one dropped me down to about the 6.4, 6.5 level, and I didn't lose too much weight.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I did lose some.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then I went on Monjero because I had some nausea effects.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That is a common side effect.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They were modest, but they were there.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so I shifted to Monjero, which is a more potent version.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that dropped me down to 5'7".
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I did lose weight.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I went from 144 to what I am now, 128, which I didn't like, to be honest.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I can tell you, I mentioned I do whole body MRIs.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I've done 20.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
As I say, over the last almost nine years and I could just see my fat evaporated once I went on these.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm the coldest guy in the room now.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Mostly, yeah.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I do it every day.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I have light days because you can't strain yourself.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
hard every day, that's a problem.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I have light days with more reps and then heavier days for more of the strength stuff.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then I have a specialty day where I do like snatches and things and build my core, this sort of thing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so a combination of those things.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so I do it every day.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the goal was to keep my muscle mass up.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I mostly did it because I do get measured a lot.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Although it plummeted when I got in a bike accident and hurt my shoulder.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
and then certain exercises I couldn't do, and so those things, as you might imagine, diminished.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I did lose some muscle as a consequence of that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I have mostly built my strength back up, not entirely back to where it was, so it's still there, but...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, it's not 100%.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then there's a question of how much strength versus muscle mass is important.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Maybe you know the answer to that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But anyway, I do try to keep it up.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's down a bit in terms of muscle mass and a touch in strength as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Again, my hemoglobin A1C isn't too bad, but I don't like losing that much.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'll be honest with you.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I thought I looked a little gaunt.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So actually I'm now backing off on the Mongera.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't do it every week like you're supposed to.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm on the lowest though.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I'm a great responder there.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And by the way, when you get in these drug response, it turns out a metformin non-responder.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I did try that early on.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Oh, I didn't know that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So anyway, that's a little – And this is becoming a big deal now, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Hypoglycemia is now –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
being recognized as a big concern, actually.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And people are picking up a lot of this with the CGMs.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, and it's probably been out there more than people realize in the first place.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And now with the CGMs, people realize, well, we talked about these glucose spikes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, it's very common if you get a really giant spike, you make a lot of insulin.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So the consequences and you come down on the other side and you actually get too low glucose from those spikes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So people are recognizing that and that can – people are now concerned about that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It certainly leads to fatigue.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This is what I want to do, by the way.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Cognition is a big one.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it's certainly something people worry about a lot as they get older.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's almost becoming the number one thing people worry about as they get older, getting dementia and related conditions.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So – and there's – you know, we'd like to see more studies out there, but there's some evidence that it may improve cognition.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Now, how much of that is intertwined with weight loss and things like that I don't think has been totally deconvoluted.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I think we need to sort all that out.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But, yeah, but people are now –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You may know that people used to talk about Metformin, this diabetes drug, as potentially the longevity drug.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This may be the way to live a lot longer, healthier.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the side effects are not high, as far as we know, if at all, for most people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And now a lot of people are very interested in these JLPs as possible longevity drugs.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
There are trials underway to look at this sort of stuff.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we'll see what ways they improve people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Good question.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't know, but it's pretty clear that people do do strength training.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Again, larger studies would be nice, but it's pretty clear they can reduce their muscle mass loss.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's clear, and it's definitely been the case for me.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I mentioned my bike accident.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I went from pretty good about maintaining muscle mass, and I did lose some when I lost some of that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I can tell you personally I had an effect.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I do have a theory that you're cycling versus your health.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
There's an inverse relationship, or it's a constant, I should say, meaning I'll probably get killed by a car possibly someday, but I'll stay healthy in the meantime because it is my form of aerobic exercise.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But we need you around, Snyder.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Ha, ha.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I don't go up those mountain things where there's no even bike paths that they have.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, correct.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But there's no room in some of those places to go.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I mostly, I mean, I do it to go to...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Lab and back, and I do it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's also a form of mental release for me at the end.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I love what I do, but I do work long hours, and it's just a great release to get that bike ride home at the end of the day.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Of course, yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that's turned out to be pretty critical when I've had more than one accident, I hate to say.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But never – no cars run into me, I'm thankful for.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I hit a rock and got knocked out once or something like that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I woke up briefly in an ambulance.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm telling you, Stanford professors.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I'll say healthy in the meantime.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I like to think I'm pretty healthy now minus my diabetes and –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm glad you're doing that because I think it's huge.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, I'm not an expert here, but it does seem pretty clear that obviously fat around your organs isn't good, fatty liver being a good example.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And by the way, when I went on GLPs, I had a little bit of fatty liver, just disappeared.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I think a lot of people are thinking this way, that your pancreas and beta cells in particular are very subject to stress.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And fat does put stress on your organs, no question.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so it may be one of the reasons, you know, your pancreas, your beta cell in particular is very sensitive to fat is because it does cause stress.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We know fat is very associated with inflammation.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So obesity is a good example.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
The more obese you are, the higher BMI.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Again, not perfect correlation, but higher inflammation.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so all that does tie together.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And your immune system is tied in this in ways I would say we don't fully understand.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But in general, the party line is that visceral fat is worse.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I think it's because of putting stress on your organ systems, yeah, say versus subcutaneous fat.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, the party line is that you should not eat three hours before sleeping.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I believe that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that's true from the studies we've run, that people who do have a gap and actually people who walk after dinner have lower glucose the next day.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And if you go into the evening with a high glucose spike, in general that correlates with poorer sleep.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think it's more complicated than that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think, again, the party line will be, well, your glucose is kind of high at night and gradually goes down during the day on spike in the morning.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You get a cortisol spike, as you probably know, when you wake up, and that's normal and that's healthy, helps energize you for the day, and cortisol and glucose are related.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But when you actually look at people's glucose patterns, it's much more complicated than that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I think a lot of that has to do with what their subphenotype is.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We don't fully understand this.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We're trying to sort this out.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And what you did the day and especially the evening before, eating that big piece of pizza and then falling right asleep probably is not a great thing for you.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You will go to bed with a high glucose spike for many people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Again, unless you have perfect glucose control.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So, you know, I think getting your glucose under control, it is a bit of a problem for me.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We tend to eat late in my household just because both my wife and I work kind of late.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so we tend to eat a little bit later.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I definitely do better if I can –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
try and eat earlier.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then I definitely don't snack before bedtime, that sort of thing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And these days I try not to make my biggest meal, my dinner, which again can lead you into sleep with that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we always take a walk.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We have dogs and walk our dog after dinner.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's become a routine.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You mentioned earlier about behavior, and I think the key for good behavior is to get into these routines where you can just get into that, and I think it really makes a difference.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So, yeah, always, and as I'm sure you know, going to bed.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We had found that in some of our studies as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Going to bed the exact same time, those folks have lower glucose than those who have highly variable sleep timing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Now, that's not so great for me because I travel a fair amount.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I try when I'm not traveling to keep constant hours.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
At least that part I'm okay at.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, again, I don't know from the metabolism standpoint.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I like to say the things we do the most, we understand the least.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Nutrition, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
How exactly does that work on all your different organs?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Sleep, you know, I do like the idea of the sleep.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You may know your...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You would know this better than me, but your spinal fluid and such expands and contracts.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
The idea of emptying out the garbage, so to speak.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, and I like that concept, I think.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And to what extent that is beneficial, I'm sure it is.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And all the other facts.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But even people argue what's better for you, REM versus deep sleep.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Even some of that is debated by experts in the field.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Again, I'm not a sleep expert.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I have a tendency to move into fields I know nothing about.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So because I'm so naive, I hope to learn something, especially these areas that aren't so well understood.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So it's an area we're going to be studying a lot more around the glucose control.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But there's no question, if you look at some people, they're spiking glucose.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Really bizarrely, and I have mixed days myself.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm trying to sort that out.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Somewhere I do hit the party line.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Higher glucose gradually go down by the morning.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But then I have nights where I'm quite irregular.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I want to correlate that with what's going on.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it's not just me.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's true of a lot of people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I don't think that's sorted out.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
In my mind.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I think metabolism in general, at some point we can talk about the micro-sampling stuff, but we found that we had 32 people drink this Ensure shake while they were fasted.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they all reacted very differently to it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This is during the day now, not sleep.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And for some people it was pro-inflammatory, for others anti-inflammatory.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I assume a lot of this got set early in life because your whole microbiome, so backing up a little bit, just so people realize that, you know, you have a lot of microbes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You have, in fact, more microbes in you than are human cells.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they're critical for digesting your food and all this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they heavily interact with your immune system.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
70% of your immune cells are in your gut.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So you have this whole interplay between your immune system and your gut.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And obviously then the food you eat
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
which goes through your small intestine first and the small molecules like glucose get absorbed.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But then all the fibers, the big molecules go into your culinary, your large intestine where they basically are interacting with these immune cells.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And a lot of that gets probably set early in life.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
In fact, people have shown your microbiome gets set in your first three years of life.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I think that interplay all gets established and then you are reacting to some of that – your food later in life.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's at least the postulate.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Not that you can't modify it.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
In fact, switching from carnivore to veggie diets or Mediterranean-type diets, which are sort of –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
healthier like fish heavy veggie diets I think are helpful for people but I do think some of this gets set early and I think getting that set right I think we probably need to
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
as a society, get that all set a lot earlier, probably now, too.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it's estimated, some work from Justin Sonnenberg, that native populations, these aboriginal, they have three times the number of microbes that
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
say, people in the U.S.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we just don't have the same community that is probably handling diverse foods and probably making essential ingredients for our health that we're now missing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we probably need to restore that in some fashion.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Otherwise, this obesity and diabetes trend is just going to continue.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
By the way, some of this has been broken down of, say, how much is your microbiome for general glucose levels versus genetics.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I think for the general...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Microbiome, it's about 20 to 30%, depends on the cohort that was studied.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
There's some work from the Weissman.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then for genetics, it may be about 20% as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
No, the other way around.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Sorry.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Of your glucose levels, 20%, 20% to 30% is determined by your microbiome and about 20% by your genetics.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It is.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So as you're alluding to, fiber is very heterogeneous, very different.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we even break it down further than that.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You're probably thinking of soluble versus insoluble or resistant starch versus starch.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I look at fiber as like just a giant community of different substrates, if you will.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we have long chain, short chains, hydrophobic, hydrophilic, positive, negative.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's like saying all animals are the same.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Humans are the same as cockroaches, the same as cats and dogs.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You can't, and their effects are very, very broad.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so we've started tearing this apart.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I was a chemistry undergrad by training, so I guess that's where I'm coming at this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we just started, and being somewhat practical too, we started putting people on, we took two common fibers, arabinoxylan and inulin, which are these two, just commonly used, arabinoxylans and physium hus, and it's associated with mesomucil and inulins and those chicory pea fiber things.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, Metamucil is a good example for the – Arabiziland would be a gnat.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Arabiziland is kind of interesting.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
As the name sounds, the chemist has arabinose and it does have some glucose, but it has polyphenols in it too.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I don't know if you probably have covered this on your show.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They are.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they're being, especially in the last, I'd say, you know, six, ten years, being more and more appreciated for all their positive effects as antioxidants and the inflammatory.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So anyway, they're part of a rabbi's island.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This inulin is a glucose polymer, but they're a short chain and a long chain.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That has different properties as well too.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's in various certain fruits and certain other things.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And when we went into this, if you read the literature, you would
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
say, well, there'll be some say, well, inulin lowers your glucose, and others say, no, it has no effect.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And some saying it lowers your cholesterol, and others it doesn't.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Same with the rabizolidin.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It was all over the map, although there might have been more of a consensus about this rabizolidin lowering cholesterol.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we just did it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We took 18 people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I know it doesn't sound like very many, but they did what's called a crossover study where they went on increasing doses where they took either 10 grams a day for the first week as a supplement, 20 the next week, 30 the next week, and then did a washout and then switched to the other one.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So they're randomized.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They might do a rhabdoxyl in the first period and then inulin in the second, then a mixed fiber, which the party line would say is supposed to be the best for you.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we put – and then we do what we're known for these deep measurements, these deep – we measure as many molecules as people's blood as well as clinical measures.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so what we discovered is that as a general rule, Arabizan did reduce cholesterol and actually quite substantially.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It went down about 25%.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Most do, actually.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Oh, okay.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But they have other things as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So these are generally mixtures like apple fiber will have three major types of fiber.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's back to this heterogeneity of fibers.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we're now getting the others like beta-glucans, another fiber.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Resistant starch is yet another one.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So there's a whole series of these fibers out there.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
yet they're not studied for their individual effects.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it may be the case, of course, the complex mixture is a big deal as well, meaning getting the right combination.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But we're starting with individual fibers, trying to see what their effects are, and then we will do combinations.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we're just finishing up a study where
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Same thing, instead of two fibers, we added two more, beta-glucan and resistant starch, and we're trying to see their effects as supplements.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the idea ultimately is I think people do supplements.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's why we're doing supplements.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Not that I'm a big fan.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'd rather they eat healthier, unprocessed food.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Or both.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Or both.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But, yeah, most people don't get enough.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You probably know that it's recommended women have at least 25 grams of fiber a day, men 35.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the number that people get is something like 12 to 15.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Wow.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They're off by a factor of two in the amount of fiber they consume.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So, you know, minimally supplements could help bring that up.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Anyway, I mentioned that rhabdoxylin as a general lowered most people's cholesterol.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And by the way, neither affected glucose.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we think other things are important for that.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But if you look at individuals, we did see some people where rhabdoxylin had zero effect, meaning their cholesterol stayed flat even when they went to the higher dose of 30 grams per day.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yet their inulin promoted their decrease.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
in cholesterol.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So what's going on?
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, we don't know, but to me, it's logical that your microbiome, maybe it's your immune, maybe it's other parameters are playing into this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This is why ultimately what I want to do is just get your microbiome, do a blood draw and say, aha,
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Here's the foods that will be healthy for you and here's the ones that won't.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think this is very personalized and complex.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It comes back to what you were saying before about meats and things having different effects on people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And you probably know a lot of people with bipolar now the solution for a lot of people is a ketogenic diet, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it seems to really work.
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
There are studies out there where it's been very transformative.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Oh, yeah, because I think we are, I mean, the way I look at it, we're homeostatic systems.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We're very – and complex ones at that, right?
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Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We have all these organs, all these biochemical pathways.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the one we also understand least is people's behavior.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That came up earlier and I'm sure will come up again.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And you have to tune all this stuff to keep it right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And in general, most people do pretty well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I think we could –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'll improve that, I'm sure.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that is the goal.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's to keep this, you know, your car, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
If you want it to run forever, you want to keep all the systems working right and in balance.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You don't let things get off too far.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I think there's a tendency, and I think there's a problem with medicine today, we wait until things are broken and then try and fix it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so, obviously, what you want to do is have people as well-tuned cars for their entire life and then, you know,
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
pass away then.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's how it should work.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so I think that's what we want to do, keep people tuned.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so we probably don't get off to a good start early in life when we start people with all these not so good diets, like all the success of processed food and sugar and losing our microbiome diversity.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think we really want to keep our car
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
off and running right from the get-go.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's a little bit late for some of us because we're probably a little bit hardwired, although I think we can tune that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I try to do that as best I can, I guess.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, anyway, we'll do it the best we can.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, I think that would be good.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'd love to know your microbiome.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And these are the sorts of things we're trying to sort out now.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't have an answer.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I imagine the microbes you have in you, they have certain hydrolases that break down these fibers.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And everybody's microbiome is very, very different.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we have communities of microbes, and every person's community is different.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so we have these enzymes, hydrolases, that do break down these fibers.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And my guess is that we already know that yours is going to be different from mine.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so maybe if you eat a certain fiber, you're not as prepared to handle it as the next person.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So this is why we need to collect the right data.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it may be at the end, well, you need to add the right probiotic, the right microbe to go with that fiber to better get the tuning you're looking for.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And in the long run, if you probably want permanent –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
incubation of this probiotic into your gut, you may actually have to add a community because they're all interdependent.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They get personalized again early, and so you basically formed your own personal guild.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
One problem with probiotics is that they don't stick that well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
A lot of them wash out, although what a prolonged use can help colonize some of that may be possible.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, that's right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, but are you avoiding it because you're getting inflammation?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You said some don't agree with you.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Is that because of gas or is that because of inflammation?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But if you can figure out which fibers might be inducing that specifically, maybe you can avoid those foods with those fibers.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And again, fiber seems to be very personalized.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I think it is something you can try.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's a pretty easy experiment to do.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think most people like the idea of –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
fibers again we like to do individual fibers because ultimately i want to understand the effect of every fiber make combinations that would be personalized for people but uh you know if you were to get apple fiber oatmeal is yes it's got a lot of uh metamucil and the arabic but it has other things in there too and it's probably true that the combinatorics are important uh the
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
and we'll get there at some point with the combinatorics.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I mean, I, I guess I'm a, you know, I am a big data guy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I like the idea with 8 billion people on the planet.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
If we even got 1% of those, uh, doing food logging with sugar monitors and things like that, we'd have a lot of combinatorics all figured out.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, we have studies running all the time.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Maybe for them, inulin will be the trick.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We're a little smaller now, but yeah, we're still a good bunch.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm just lucky to have amazing people in my lab.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I consider myself very fortunate.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, let me tell you a little how we got into this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we set up – it comes from my philosophy that I think medicine is broken.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We tend to do sick care rather than health care.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we started when I moved to Stanford now 16 years ago, this idea maybe we should – first of all, you don't measure people very much when they're healthy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You don't measure them very often.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So just – it started with me, but the goal was to do a bigger group, which we did –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
profiling people, collecting as much data as possible while they're healthy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So people would give blood, their microbiome, all urine, and we would take these and do what's called omics measurement.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We'd make as many measurements from their blood as possible on top of deep clinical measurements using all these new tools.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we would do it every three months and we do it while they're healthy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
If they got ill, like from a viral infection, things like that, we would take more samples to be able to collect more carefully to see what was going on when they first got ill.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so we've been running this study on me now for about 15 and a half years.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
and for this group of people about almost 12 1⁄2 years.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we've been profiling this group of people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some have dropped off by now because it takes a lot of energy to be part of that particular study.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But anyway, others have come in.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so, yeah, we've been running this for some time.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the idea is to see what a healthy profile looks like.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
How does it change over time, which we interpret as aging?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You know, what happens when people first get ill?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we are very enamored by these technologies.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
In fact, we invented some of them.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Our lab did for these omics technologies like something called RNA-seq where we can measure all your transcripts and we have ways of following all your proteins with protein chips and things like that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So our lab did invent a lot of these.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They're called omics technologies.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So it's ways of collecting big data from, again, your blood, your urine, and even your microbiome.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so we basically sequenced people's genome, made all these measurements, and followed them over time.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I was going to say we're also curious whether we could use some of these technologies like genome sequencing and, you know –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This method for measuring transcripts, aren't you seeking things for better, you know, maybe managing people's health.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then we brought in the wearables when they were first fitness trackers.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We thought, well, maybe they're a little more interesting than just fitness trackers.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we put them on for health monitoring.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I can tell when we started, it was a bit controversial at the time.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
A lot of the physicians are not like sequencing the genomes of healthy people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This shows when we – it was right after genome sequencing was first coming out.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they were worried we were going to turn everybody into hypochondriacs, going to cost millions of dollars.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And most people have warmed up to it now, not 100%.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
A lot of people still don't like that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They still don't like the wearables.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm sure we'll talk about that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But anyway, we did show that a lot of people learned some pretty important things from the genome.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
One young guy turned out, he had a mutation of heart gene and his father died right around the time we sequenced his genome.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
His father died of a heart problem.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And sure enough, he has a heart defect that was uncovered by genome sequence.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we had examples like that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then same with the wearables, uncovered things, all kinds of things popped up.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Actually, 49 people had what we would call major health discovery just in the first three and a half years of running the study.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
With all kinds of things.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That was the thing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It was no one technology.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
What we're doing is we're getting a much more complete picture of people's health.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we discover these things then before they have symptoms.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we're profiling people while they're healthy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we're looking for things that might be off.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so the way I like the analogy I like to use is that if your health is a thousand-piece jigsaw puzzle, the way when you go to a physician's office today, we would say they measure five or six of those thousand pieces.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They just don't get a very good picture.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We're trying to measure five or 600 pieces, get a much clearer picture.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so 49 people, we uncovered something pre-symptomatically, caught someone with early lymphoma, two people with pre-cancer, two people with serious heart issues, one from the genome sequencing, one from the wearables.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we spun off a medical version of the CISIS-Q bio that does whole body MRI, which most people will tell you that most physicians will tell you, you should not do that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And what'd you think?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think it's part of the broken healthcare system, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They have 15 minutes to spend with you.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So when people show up with their – I mean the number one concern about whole body MRIs is they'll find nodules, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
If you go high enough resolution, you're guaranteed to find nodules.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Men have them in their prostate, women in their ovaries if you go high enough resolution 100% of the time.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Then people show up and say, well, I got these nodules.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, or they're just not even growing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They're just there.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They may have showed up early in life.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I mentioned I've had 20 of these things and I have nine nodules.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the point is it's not whether you have nodules or not.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Do you have any growing nodules?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Right, right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that's the key.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And if you've never done a baseline, you'll never know if they're growing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I'm happy to say none of my nine nodules that have been spotted are growing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm relieved to hear that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I know that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And you probably have seen a similar situation.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But a friend of mine, you know, woke up one day and couldn't move his arm.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so they rushed him in the emergency room.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They scanned the relevant area.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They saw he had a tumor on his spine.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So they took it out and –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Things seemed fine.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Then they did a whole body MRI follow-up later, and they found three more nodules.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So the question is, were they there to begin with?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
or had his tumor metastasized.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
No way to know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They had no baseline.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I think having these baselines is super important for everyone.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You can.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And in fact, we should be doing that stuff at home anyway.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We can talk about that later.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But yeah, what Qubio does is they do whole body MRI and they've designed ways that they can do it in about 40 minutes, 35 to 40 minutes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So it saves a lot of time.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then they also do a medical version of what I was telling you before.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They don't do, for example, the transcript on the RNA-seq stuff, some of that, because they have set it up in a way that it's actionable information because you can then take the data to your physician who will know what to do with it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so, yeah, it turns out, just like you're saying, just from the first 100-plus people, they discovered early ovarian cancer, all pre-symptomatically, just like in our study, the 49 people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
who found their things, they found cardiovascular conditions are pretty serious.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They found even early pancreatic cancer, which is almost never found early.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so they discovered these things, and sometimes it was by the longitudinal measurements they saw things shift.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Sometimes what we call multivariate, they'd see several things shifting.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We discovered that as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We might see one thing off.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And you'd say, well, I don't know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But when you see three things all going in the same direction, you worry about that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And a good example is if you go to a physician today and your glucose is high and it's normally been low and it might spike up.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They'll say, well, were you ill yesterday or something like that?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
All that explains it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Let's ignore it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Come back in two years.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that's just not enough.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that might have been a clue for something big.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we've seen that in our study.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We'll see somebody who shifted off their liver enzymes and they'll come to me and say, Mike, I'm still in the normal range even.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And this is why we're big on baselines.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's a big theme in our work.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
No way you're healthy baseline is like the MRIs.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they'll be running in the low end of a normal range for their liver enzyme and suddenly it'll double but still be in a normal range.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they'll call me up and say, hey, what's going on here?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I say, I don't know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Why don't you go get another measurement?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Sure enough, then they shift it out of normal.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I think the trajectories of these measurements is key.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think knowing how you're progressing is a big deal, and that's how we think about
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
just like your car.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
If you see something going off, you want to see it when you catch the first symptoms, not once your car is broken down on the side of the road, the engine's blown up or something.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I think that's how we have to shift medicine.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm a big measurement guy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
All right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I have my – this is my Fitbit.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This is my Apple Watch.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then I happen to have a company that's called Sensomics.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It has two different – this is a new one they have out and then the older one.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so they all measure heart rate variability and reasonably accurate, meaning not that far off.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so, again, for the listeners, resting heart rate, everybody knows.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But heart rate variability is an important measurement, more and more appreciated these days.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
When you're ill, your variability drops.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And both those are fairly accurate these days for most devices.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Oh, and I have a ring.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This one happens to be a circle.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I used to wear an aura ring.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Which one is that?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's called circle.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They have their different parameters.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So there's no right or wrong to this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Same thing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You have to match it to your lifestyle.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some, you know, you charge them while you're in the shower.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They're charged for five days.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And others you have to charge for an hour, hour and a half to keep it –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So you have to find the one that works best for you.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I do think wearing them overnight, it's a great time for health monitoring.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I'm a big fan of that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Anyway, they measure that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some measure blood oxygen.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some of that's accurate.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some it's not accurate.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Depends on the device.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some measure skin temperature.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Again, some of that's accurate.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some it's not.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Depends on the device.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They also measure something called galvanic stress response.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some do.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's conductance on your skin.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that is not something we normally measure in a doctor's office.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But it turns out it has value for hydration because when you're diabetic, you'll have drier skin.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I should have figured this out earlier when I first became diabetic.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I got itchy because my skin got dry.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Anyway, you can measure that with your smartwatch.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
and get that in real time.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, and also as a measure of stress.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
When you're stressed, you sweat more.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so you can pick that up as well with these devices.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So there's a fair number of things.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then some of them you can measure, you know, an EKG.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And sleep, of course, super important.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Their accuracy for the stages is still questionable.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It depends on the device.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They're getting better, though.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'll have to give it a try.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I got to try it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I thank Matt for that tip.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's one of my biggest weaknesses.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't sleep that well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I do do that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Interesting.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I haven't measured it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I haven't looked at the data on that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think it probably is.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, exercise is supposed to be one of the best ways to do this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Again, I'm not a cardiologist.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm not an expert there.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't know for sure, but I know personally keeping my stress down and sleeping better seems to help.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I've noticed that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Recently, yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
One of these AI programs, again, happens to come from January.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They take all your data, bring it in, and they were like looking at this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And my HRV, believe it or not, went up like 28% or some incredible number.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I was trying to figure out what it was due to.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I think I'm sleeping better, actually.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
No, I used to.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I know I need to make more time.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
In some sense, maybe my bike ride is the equivalent of that at the end of the day.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And on the weekends, I try and do a little bit of gardening.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's my form.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm a big believer you need some form of calmness.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I used to meditate for like five minutes after exercise.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I need to get back to that for sure.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So one minute every day?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I haven't tried the breathing stuff.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That'll slow your heart rate.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
A lot of people are saying that's really good.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I didn't know that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Maybe, yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
No, I do love what I do.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And for me, there's no better rush than a great result.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm an academic at heart.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We spin off the companies that try to get, I think, the things we're doing, you know, I hope out to a broader group of people, which, you know, it also is a way of showing the stuff really works and that it's not all BS that you're doing in a lab.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I do love what I do.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I don't know, I'm very fortunate.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I have amazing people in my lab, as I mentioned before, who...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They come up with a lot of the ideas.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I view us as a team that tries to push forward on these various things.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I try to create an open environment where people aren't afraid to share ideas and push things forward.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Anyway, I realize we got away from the organ aging part.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
If you want to go back to that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
On the aging, I mentioned how we're doing all these measurements and tracking people over time.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We've now been doing this for over 12 years on this 109.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some have dropped off and say new ones have popped on.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And what we discovered by just looking at the healthy time points
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
is that people, you know, they do change over time, even in the healthy times, but they're all changing differently.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Meaning we look at the biochemical pathways.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some will have their top biochemical pathway, dilated cardiomyopathy pathway changing, or sorry, that was dilated, sorry, that was hypertrophic cardiomyopathy signaling pathway shifted.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Other people, it's metabolic.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some are immune.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We call these agotypes, aging pathways.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I kind of like that a little bit better than organ aging because some of the things you pick up are like oxidative stress, which go across lots of organs, or the inflammatory inflammation that's kind of cross-organ as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we call these agotypes, aging patterns that we see.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it turns out everybody's different.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So some people will be the cardio, some people will be the metabolic, some are liver, some are kidney, based on the markers we see in the blood, and some are immune, and some are all the above or parts thereof.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we're all different.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And what's cool about it is it's actionable information, meaning a metabolic ager, when you actually see, they'll see how they're shifting,
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And, again, I have another company involved in this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They do this micro-sampling I'm sure we'll get into where they measure your metabolic patterns.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And, by the way, we think your metabolism is the best way to see these shifts of all the different – proteome is good too.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And my colleague, Tony Vizcoras, he basically has looked at this organ aging stuff as well from the proteomics – from proteomics meaning group of proteins.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
He's followed this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And same thing, you can follow this –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
these age of types, if you will, these aging patterns, and the information is totally actionable.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You can see, as I say, for the metabolic ager, some of the folks seeing this, they lost weight or they exercised and they improved their patterns.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Now, I'm not saying they got younger, but they did improve their age of types.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think the information is very actionable.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so, again, and this is one where we commercialize because I want to – it's a very simple test.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You can get these little drops of blood, mail it in, and they'll profile 650 metabolites.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the information is actionable.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They make recommendations.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it's not just exercise more, eat better, but very, very specific.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's called IOLO, I-O-L-L-O.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It is.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it will tell me... They'll send you a kit.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's a very special kit because not any... Like putting things on cellulose is not the best way to save your blood.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Anyway, it's a special kit.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You mail it in.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, no, with something called metabolomics and mass spectrometry, you can profile...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's a targeted assay, 650 metabolites.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they cover all these areas.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Most of it's in the scientific literature.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's just not in the clinical labs, like things around your kidney function, your heart, things like this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they give you these profiles.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they say, these are normal.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
These are going off.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then they can even predict your, again, biological age.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So you may know your biological age is not necessarily your chronological age, your age in years.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And if that goes – if things are off and maybe are not so good direction, you can actually take action.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You can say, well –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
My inflammation is fine, but my heart age is off.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they can give you very specific recommendations to do around that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Or if it's kidney, again, same thing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Maybe eat more of certain things and avoid other things.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think the Horvath clocks are correct, meaning they do measure biological age.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But the problem is it's not actionable.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
What do you do?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Your methylation pattern, that's a modification of DNA, has shifted, and it gives you an overall value.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, what do you do with that?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You don't – no, you wouldn't – yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they can predict something called grim age these days, your time to death, your mortality.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Oh, nice.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Same thing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I mean what are you going to do with that?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
What's special about the age of types is that they're breaking it down.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so they say, all right, your immune age is off.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You can do X. Your oxidative stress is off.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You do Y. So it's basically actionable information.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I think it makes all the difference.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And conceptually, it makes a lot of sense, too.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's like your car.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I know I keep coming back to that analogy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But your car gets older.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But certain parts wear out first.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, maybe some people do.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They replace their whole car.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But generally, you would fix the parts that are wearing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And ideally, you'd catch it before they break.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I think that's how we think of ageotypes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You can go in.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so I mentioned this company earlier, Iola.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
What they do is they're tracking your ageotypes because they're doing these deep metabolic profiles.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they actually make – they use AI.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They pull in things and make very specific recommendations.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then you can – they'll tell you exact foods to eat and things like that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And 95 percent of people improve their markers.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Again, I'm not going to say they're getting younger.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But at least they're improving their metabolic markers in the right direction.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so it's actionable information and it makes a lot of sense.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And some people think she may have cheated, but it's not clear.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Oh, really?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, that's right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that does seem to be the cap.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so most of our research is built around extending health span.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It is the case that for...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Lifespan in general, it's estimated to be about 16% of your lifespans due to genetics.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
One-sixth.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Now there's a big error bar on that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That comes from twin studies and family studies.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So although it's thought that for people who live to be 100 or older –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
then it might be higher.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Some people have said 60%.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So to live – to be really long, you may need good genes in general, but there's still a lot there, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
There's another 40% that's due to lifestyle.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But for the average person, it's only one-sixth.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So your lifestyle is by far your biggest factor.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And you look at people in these blue zones, these areas where people – there's an enrichment for people who live to be 100 or more.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They have several things in common.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
One is they tend to eat –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
a diet with not much ultra-processed foods or processed foods in general.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And generally, they tend to be towards the Mediterranean, vegan kind of diet.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yes, for sure.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And getting fiber through that as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then they tend to have – they're fairly active, meaning – but their form of activity can vary.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they have really good social networks.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So either through family or through community networks.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so that's pretty clear.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
My prediction is they probably sleep pretty well too.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't know if that's been as well measured as the other parameters.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I think you do need all of those things if you want to live a long, healthy life.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that weight may vary from one person to the next.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I think...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's the kind of thing we want to look at.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Again, I view people as a combination of things.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They're genetics.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They're epigenetics.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You know, I don't know if I told you all the details of when I became diabetic.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It was predicted from my genome.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Atul Butte actually predicted this from something called apologetic risk score, these ways of analyzing genomes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I'm at the extreme end.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It doesn't work for most people, by the way.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I'm at the extreme end that worked for me.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So he predicted I was high risk for diabetes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I didn't become diabetic until after a viral infection.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's a very strong correlation.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Because I measure myself a lot, I figured this out.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's respiratory syncytial virus, which actually, you know, it's not that common in adults.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's more common now.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But anyway, I was literally in bed, which is a little unusual for me.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I got a very high temperature.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I wound up several weeks later becoming diabetic.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's very fascinating because we actually looked at the modification of my DNA.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's called DNA methylation.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It actually shifted in something like 100 metabolic genes in their control regions called the promoters.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
The thought is that I was genetically at risk and then in combination with this viral infection, it's environmental, that's what triggered my diabetes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Now, I don't think that's true of most people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We're tracking people, I may have mentioned.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
In the first part of the study, we saw nine people become diabetic as we've been tracking them.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And seven gradually became diabetic.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So it was accumulation of something.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But two people, one of which was me, something triggered it, meaning it kind of got there and stayed.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It wasn't just a transient spike.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so how often you get these – they're called epigenetic modifications.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Happening is not so clear.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But it's now the case you may know with COVID, 2% to 4% of people are becoming diabetic.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
after a COVID infection.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So it's not unreasonable to think that they're having epigenetic changes like me.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It hasn't been measured.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's something we'd like to pursue.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But the effects of these viral infections and stuff, you may know a lot of people get something called chronic fatigue syndrome after some adverse, say, pathogen.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's not always clear what's causing it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It seems to be different for different people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But the idea of these intense stresses, maybe from a viral infection or other pathogen,
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
triggering some long-term chronic effects is maybe more common than people realize for autoimmune disease, for chronic fatigue syndrome, in my case for diabetes, maybe, as I say, more prevalent than people realize.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Once again, that homeostatic system concept that you're – yeah, maybe if your genetics is a little bit weaker, we've noticed that we found a new –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
if you will, set of genes involved in ALS and that those genes tend to be underexpressed and, you know, called IPS-derived motor neurons, the relevant cell types for ALS patients.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So it may be that, you know, if your genetics is a little weaker in some areas than others and other things could trigger that sort of thing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I like that general concept that we're – in some cases, maybe that's beneficial.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm not saying getting ALS is beneficial, but maybe we're attuned certain ways because in ancient times, we had to deal with things like TB and stuff and the idea that you would be – well, the classic is sickle cell, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Folks with sickle cell mutations might be more resistant to malaria.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So maybe some of this tuning helps you in some ways but is adverse in other ways or –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
makes you more susceptible, let's put it that way.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think so.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, I mean, there are cases.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It can't be that simple.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's correct.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
A good example would be Huntington's, right, where you have an expansion of a specific genetic locus.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
There are elements that shift there.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that's highly associated with Huntington's.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Those would be single condition things that trigger it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that does happen, but that's not most disease.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's more the exception than the rule.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And by the way, even in those cases, there are people that escape it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, who have somehow escaped that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Not always understood, although they may hold clues to perhaps how others could be helped.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, first of all, I'm not an ALS expert.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This is where my genetics came in.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We came up with new ways of analyzing genomes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we applied it to ALS for reasons we thought might work.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Here I just had an amazing postdoc, Sai Zong, and a great collaborator, Jonathan Cooper-Knock, who basically sort of said, Mike, this is a great problem to apply these new methods we had for analyzing genomes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So there were seven genes known and we wound up finding 690 genes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that's true with these new AI methods we have for analyzing genomes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it explains a lot more what's called the heritability of the disease.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then, yeah, and that's how I got into it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I mean, there still is no cure for ALS.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And how to modify lifestyle, I don't know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I do know I'm on sabbatical at UC Irvine right now.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And there's people who are trying to take this sort of thing on.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We'll see how well it works.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It is clear there is a study that if you overexercise, that's worse for you for ALS.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But whether that helps you predict, I don't know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I think it's still...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, not very much known there, at least not to me.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You may know more than I do.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, of course, there's motor neurons for ALS versus others.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Right, motor neurons for ALS.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I don't know how similar or different.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But, you know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Back to behavioral modification.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, exactly.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
the way?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You're good.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You're at PM 2.5 of 3, PM 10 of 4.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I see.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, it was one earlier, so it's let in.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
How...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Probably would have gotten to 200, maybe more.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Probably, yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, no, I bring it all the time.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's always next to me.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Oh, yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I've been doing this for eight or ten years now.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
No, probably.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
People ask, and I'm always honest.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I tell them what it is.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It hasn't been so bad.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Where it will get bad is during the fires, but there are a few times.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I'm doing it, backing up a little bit.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's a very underexplored area, and that's kind of, again, the academic side of me.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I want to understand –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
how does your environment impact your health?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it's not just air, but that's the area we decide to start in.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And, you know, what are you breathing right now?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You have no idea, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so that's the principle.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm a sort of big data guy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
As you can tell, I do all these measurements on the inside.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
What about the outside?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we know from plenty of work from others, you mentioned
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
you know, particulates in the air.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This is where the PM2.5, that's thought to be the stuff that penetrates your lungs and causes all kinds of problems.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, not good.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So anyway, and these days, as you know, plastics and microplastics have erupted as a pretty big health concern, but nobody is 100% sure why.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
what it means but they do know now that when you dissect people's brains of folks who have died and you'll see microplastics they're everywhere and so what is it doing to your health I don't think we fully know but we're starting by just trying to measure this stuff so we've
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Decide to start with airborne, but you could argue, you know, what are you drinking?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
What's in your food?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's all very relevant, by the way.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But we'll start with the air.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so what we're doing here, it's not just measuring PM 2.5 and PM 10.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's basically...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's sucking up air.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
There's a pump in here.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And underneath the intake valve, there's a filter that captures all the particulates like pollen, bacteria, fungi.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And under that, there's a chemical absorber.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's called zeolite.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It captures both hydrophobic, hydrophilic, positive and negative.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then not in real time but offline –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We'll measure all the biologicals like the fungi, the pollen, the whatever that's captured on the filter, and we'll measure the chemicals using something called mass spectrometry, the things that have an airport that measures bombs and things like that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we're trying to measure that in real time to see what's going on, and then we try and correlate what's outside with what's inside because we'll measure your blood as well with these deep profiles.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
What we've discovered is, first of all, you'll be getting exposed.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
For me, I'll do one of these during the week, one on the weekend.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We don't do it every five minutes kind of thing because you have to collect enough sample, but we will basically determine what kind of exposure you're getting.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And if you're at high risk for certain things, you may want to know this, like asthma or allergies.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
What are you exposed to?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
There I can give you an example.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I used to have moderate allergies.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Now they're pretty mild because allergies can fluctuate a bit.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they would come every spring.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I just assumed it was pollen.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, it is pollen in the end, but I assumed it was pine.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But when we did the correlation, well, it turns out it correlates better with eucalyptus
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then it's like, duh, I should have realized this, but I don't get them on the northeast where there's no eucalyptus.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so in the end, it makes a lot of sense.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So that one hasn't affected my lifestyle, meaning I still have a big eucalyptus tree out back that I have not chopped down.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Mind you, it's on Stanford land, so I can't do that anyway.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, at least I know what's going on.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But then like on the chemical side, which is very interesting, we discover there's DEET everywhere, even in my office at Stanford.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
DEET?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
The insect repellent.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Of course, I had to worry about getting West Nile or something else.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's a different issue.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
From the water.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Interesting.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Interesting.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Anyway, and same with pesticides are most places.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And carcinogens, of course, are everywhere.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But their types vary.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the amounts vary a lot.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So like when I'm in UC Davis giving talks or something, I get a pesticide exposure.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, it's rural areas.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Because all the fields are out there.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And same with when I was in Fresno.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So you can see these correlations.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so that's what we're doing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We'll measure what's where.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then we'll measure how does that relate to what's going on inside.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we can see what microbes are outside relating to inflammation markers like cytokines, things like that on the inside.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And same with some of the chemical markers like your glucose levels.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And right now that's mostly been built as models around me, but we're trying to run the study with a lot of people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we can, first of all, even break it down further.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
What's the difference between your kitchen and your living room and outside your house?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And same thing, how does that relate to some of the levels of key markers, your metabolites, your inflammatory markers?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we want to correlate that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We know studies from others have shown, right, pesticides correlate with Parkinson's and things like this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we want to...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
See what's going on there.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I can tell you some fun stuff that we just made.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Again, these are all correlations.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Now we do something called mediation analysis.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It can let you get a little better about causality, not proof in many cases, but a better idea.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Anyway, here's a fun thing we discovered.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We found a correlation between...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Something called pyridine, which used to be common in paints and in other places too.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They recently don't put it in paints.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But pyridine exposures are associated with lack of fungi, meaning I'll have more bacterial plant or other exposure.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So my house was painted by a green guy, no pyridine in the paints there.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I get a fungal exposure when I'm at home.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so is that good or bad?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But imagine I was very allergic to black molds.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, maybe I do want purity in my plate.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We can make that association with the allergies, of course.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Anyway, you get the idea.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We're trying to correlate what's going on in the outside with the inside.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, in that case with other outside things, but later with the inside.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, where measurements will make these things.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That'll lead to hypotheses that we could then probably test by either mouse models or in humans who live in certain places who wind up sort of testing whether they're trying to or not.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Imagine you live near humans.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Obviously, you live near certain areas, you will see if you live near mines, you will see autoimmune disease, things like that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we can try and make these associations and then you correlate with similar people who aren't living near mines to try to test that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they're all over our body too.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They've been talked about endocrine disruptors and things like this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I've only recently switched.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I should have done it eons ago.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I see.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Thousands.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
first of all, we don't get measured very often when we're healthy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
This idea that we mostly practice sick care, not health care.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And why do you go to a physician all the time when you're healthy to get measured?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think that's a barrier to getting measured.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So can we come up with more, you know, facile ways of measuring people?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
The wearables are obviously one and they're perfect because they're
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You know, passive monitoring and continuous, so you're really collecting a lot of data just in the background.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I mean, the inconvenience is wearing and charging these things.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But we don't measure what's on the inside, and I think that still has value.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the idea about trying to set up home tests for this sort of thing I think is powerful.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So that was the motivation.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That was the motivation for our Theranos, I think, too.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And our, you know, shtick, if you will, was to try and do this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But we're not trying to measure the exact clinical values because some of that is hard.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
How do you measure LDL droplets in microsamples?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's probably doable, but it's a lot trickier.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We were just trying to – it fits with our idea of doing deep data profiles on little drops of blood.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the key is to find a format that would keep the analytes, as we call them, the molecules stable.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so we tested.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We spent seven years actually trying different things, finding formats.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
The old format was to use paper actually, cellulose, to collect the stuff.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that doesn't work very well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
The analytes oxidize.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's a mess.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so ultimately, we test a lot of things out there.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We were trying to invent a few of our own.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the net result was we did settle on some that were out there, tested them.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They're being used in a more limited fashion.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we showed you could actually do the kinds of things we do, the metabolomics, it's called lipidomics, and proteomics.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And again, with certain...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
The configurations, the proteins, most of them are quite stable, not 100%, but most are.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We can measure all this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Metabolites, same thing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Most are lipids, some are, some aren't.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we figured out which ones are, which ones aren't, and then we basically did just that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We showed you could do this, did fun experiments.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Like in my case, we took a sample every hour for seven straight days to try and correlate.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, at night when I was sleeping, no.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Although when I did wake up, I would take a sample sometimes, yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, not so great for sleep disruption, I suppose.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But anyway, and the idea there was to correlate what's going on with – and I was wearing a CGM and a smartwatch, like a follow activity, doing food logging, all that sort of stuff.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And in the end, we're trying to correlate –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Basically, people's activities, people's biochemistry and physiology with their activities and heart rate and things like that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so we found literally thousands of correlations.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's pretty cool.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
A lot of which is known, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
After your...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Insulin goes up after your glucose, but we can precisely measure.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
For me, it's 10 minutes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We know exactly the magnitude with certain kinds of food and that sort of thing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We also discovered, and I don't know if this will go anywhere, but we're pursuing it, alpha-synuclein, which is involved in Parkinson's and dementia, actually showed an interesting pattern.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It seemed to fluctuate with stress, actually.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, well, that's what we're trying to figure out, what kinds of stress.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I don't think we have that sorted out yet.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah, so anyway, I'll leave it at that because we don't have it all sorted.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So that's the thing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We're trying to measure that, see exactly what it correlates with, and then –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Maybe that's a useful assay for trying to manage that and therefore push off dementia.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's the hypothesis.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
No guarantee that's right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But these are the kinds of observations we make that I'd like to see if they turn into real-world value that we could then help maybe get out there to help people in some fashion or other.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So this is the kind of stuff we do.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
These are what you're calling observational trials.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Take deep data measurements on people to better see what's going on, make hypotheses, and then, yeah, ideally roll it out into the real world.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm down on sabbatical at UC Irvine with Shaisna Malik, who runs an integrative health institute where they bring in nutrition, exercise, and things like acupuncture into trying to better manage people's health and lives.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it's been very fascinating for me because they're doing it on the clinical side.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm kind of a big data measurement guy, and so I want to see what's going on, if there's ways that make sense to collaborate.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And as you point out,
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
acupuncture has been around for 3,000 years or some incredible number.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
There must be something to it, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
People use it a lot for pain and apparently for fertility and other things as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And there are plenty of people who swear by it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And she uses it for blood pressure, okay, for blood pressure management.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I run a little high on the blood pressure, not –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Nobody's overly panicked, but I tend to be in the high 130s, but I guess because I was getting a very large grain, I was in the low 140s.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so I measured myself right before acupuncture, very specific time of day with my monitor at home.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And yeah, I was running 140 over the low 80s, something like 82, 83, did five measurements.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I did the acupuncture, which is designed for blood pressure and diabetes, and maybe I can go off the GLPs if all this works.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But anyway, the next day I measured it, the exact same time, and son of a gun, it was 25 points lower.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's the high teens, like 118.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Wow.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It was unbelievable.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I can show you the data.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the other one went to like 72, right, the diastolic.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Okay.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I just, with one treatment, that was electroactive puncture, I should say.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So they zap you.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they, yeah, had 30-some points.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And they've added a few more since.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So you do it every week for eight weeks.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I've now done four of these things.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I can tell you that my blood pressure stayed low.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's running in this one high, one teens, maybe 120 range.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
which is pretty good, roughly where you want to be.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the other is always around maybe 74.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So it's like it was never running like that before.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I can show you my data.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's great.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's pretty incredible.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So it does seem to be working now.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
How long does it last?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm only halfway through my treatments.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't know, but I will track all this stuff, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I'm a responder, no question, to this treatment.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It really does work.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I mean, I go into this stuff completely open.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It may not work.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I don't know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I didn't even – she said, oh –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Because first of all, she said, well, just try acupuncture.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I wasn't even sure what kind she was going to try.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So in the end, she said, oh, yeah, we'll do blood pressure and diabetes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Now they've added on some stress points as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I don't consider myself – I'm probably in a high-stress job, but I don't consider myself a very stressful person.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think I generally handle it all right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But anyway, they're putting all these things on me and I didn't – 24 hours later, is it going to work?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But the data, I mean, that was a pretty big jump, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Maybe to put it in context, so this all started when a postdoc joined my lab, was very interested in mental health and knowing that we're
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Good at measurements and the idea.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I thought about a lot and I realized that we don't measure mental health very well, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Surveys are still the gold standards for most things.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so how do you know if you're getting better?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You do more surveys.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That whole concept is very unsatisfying to me.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we thought with the wearables, right, there's got to be a lot of physiology around this thing, this biochemistry.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We do a lot of micro-sampling, mentioned earlier, where you can out-profile deeply.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we thought we could bring this kind of stuff maybe.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we're still – it's a growing area in the lab.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'm very interested in this because I feel like there's a lot going on in the mental health space.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's just –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
unexplored.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the biggest problem is we just don't have good biomarkers for the meetings I'd been at for the stuff that keeps popping up.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Number one, we don't have good biomarkers.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we think the digital meaning from the wearables, the, um, uh, um,
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
microsampling could ultimately prove to give us good biomarkers.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We're already seeing some evidence of that now.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we ran several studies.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We did one with Byron Katie, who runs one of these immersive programs.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I don't know any about this stuff.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so I basically said, all right, we're going to do this.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Let's bring in, first we brought in a colleague, George Slavich, who you may or may not know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
He's
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
He's basically an average childhood, but knows a lot more than I do about the childhood.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I met him and he's a very, very bright guy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So he, you know, we came up with some surveys because we have to compare up against something.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We put smartwatches.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
The one on Byron Katie didn't quite work out, but we did do blood sampling and stuff for her and even microbiome for people before and after.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that case, it went out for a way.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then we, so we ran that study and then
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Shortly thereafter, we ran a pilot one with Tony Robbins where we had a smallish number of people who did the Tony Robbins, and we profiled them before, right before, immediately after, and then at that point.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think that study was done out for several months.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then I'll tell you about the large one in a minute.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so we had them do these surveys and things.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I went in.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I have no idea if this stuff works or not.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And son of a gun, these people really did improve by these questionnaires, by the standards in the field.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Basically, they improved their markers.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Their mental health, yeah, by the surveys.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So that first – and that was true for the Byron Katie one.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It was true for the Tony Robbins one.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the Byron Katie one, we now have some of the omics data back in there.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They do seem to improve in their inflammatory markers as well.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we have some data there.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's not yet published.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I've never done it myself.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So anyway, we did see a positive result on the pilot study, and that was 20 – I don't know, 27 people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I may have the number wrong, but it's a small number.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then we now have done a follow-up and –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, I should say actually for the first one, that actually went out even further now.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They have some additional data points.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But in the follow-up, there we did a much bigger one at 600, almost 700 people who went through Tony Robbins.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then we had another set of people
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
who didn't do Tony Robbins, who we also profiled.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And same thing, they wore smartwatches.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We had to scramble to get the IRB approval.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's always a rate-limiting step.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we didn't get as many wearables on folks ahead of time, but we did do the micro-sampling.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We did do all the surveys, and we have a battery of wellness surveys.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It wouldn't be official depression scores and things, but they're things about, you know, are you depressed and anxiety and burnout and all kinds of stuff.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So it's a series of questionnaires.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They did it before.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They did it immediately after.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
One month, three months, six months, one year.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it's a pretty sizable study now.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Like I say, it's almost 700 people who did it, 700 people who were controls.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But I will say the cavities are not randomly assigned because the people who did it signed up for it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And the people who didn't do it, well, they did it separate.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So that's the only caveat that I see.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But the bottom line is the ones who did do it, once again, they improved like virtually all these things, anxiety and depression.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Significantly.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Significantly, yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And we have just put together a paper on the psychological part now.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then on the – we're still doing the omics stuff.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So we actually did the micro-sampling I mentioned earlier where they gave samples before for – not everybody.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Not everybody signed up for that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But it's like 130, 140 people who did the micro-sampling before the – immediately after each of those same time points.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so we will see that data is still coming in.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And hopefully we'll know in a few months.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
But at least on the survey stuff, these people did all improve.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that control group, which was separate, did not.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And it is significant.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I'm sure we'll put the paper up on either bioRxiv, which is this preprint thing, or can even send you a copy.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'll see if my person who's been running that is up for that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So anyway, yeah, it does work.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's pretty amazing, actually.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So again, people – not everybody is in the so-called –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
depressed state or whatever.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It kind of worked out half and half.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And their values all improved.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Again, not 100%, but pretty darn most of them.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It sort of surprised me.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And obviously in the control group, we didn't see anything.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So it looks pretty good.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
People have asked me, Mike, what the hell are you doing here?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I said, I don't know.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'll just – but let's take – like thousands of people do this stuff.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Shouldn't somebody look at this?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think the answer is yes.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Well, I used to, and I'd like to get back to it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Absolutely.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Oh, sure.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think you bring up a good point.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I think we're trained to be siloed.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's part of the problem as you go through graduate school and things like that.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Even medicine, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You have people trained in very specific areas, so they never look at the whole.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Yet we know, again, that we are homeostatic systems that involves all these different things.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And you'll never solve it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I like to say when I got – because everybody on my father's side has died of heart problems.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I used to have high cholesterol until I went on satin.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I'm on PCSK9 inhibitors, and they're amazing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And, you know, my heart guy would tell me, well, you need to raise your sentence.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
He didn't think it was low enough.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
He said, well, when I do that, my glucose goes up.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And that's very textbook, by the way.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I finally called him.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I said, look, your job has stopped me from getting a heart attack, but you don't care if I have all these other complications, right?
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I would say the same to the diabetes people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I'd say, well, you're trying to control my glucose, but you – some of these other things.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I just don't think that's the right way you want to look at people.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We need to bring in all the data, all these things we've touched on, these points about genetics and epigenetics and lifestyle.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And I think the whole –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
The communication side, the whole socialization, very understudied.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I also like it from the academic side because when you go in these areas where you don't know anything, even when you stumble around, you're going to learn something.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So that's kind of how I view our work in mental health and now socialization, I hope.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So I just hope that we can learn some kind of cool stuff that will be useful.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then I think now we're in an amazing position, right, where the tools with AI, because no one person can do this right.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You don't want a doctor who doesn't use AI now.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
You want someone who can pull in all that information.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And this is what the companies are really good at.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Again, it's one of the reasons we spin these things off.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Like January has this, they call it mirror, that builds kind of,
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It'll take all your data, your genomics data, all your reports, all these various things, and runs an AI engine, obviously trained in a certain fashion, and gives you back an incredibly long report.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Although you do get a summary so you can decipher it.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And then it pulls all the stuff together to make insights.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
And so, for example, I didn't realize I knew my CD8 T cells.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Again, this gets a little specialized, but...
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
They were low, which I did see on the report, but it has this whole zinc recommendation thing.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I don't know if that's right, but I'm going to look into it more.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It can make suggestions that no doctor is going to figure out with all this stuff.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
So you do need –
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
these new systems, and that is the future.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
We're all going to have our own personalized systems pulling data.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
I mentioned earlier about IOLO, same thing about your metabolic profile, pulling other information to give you recommendations.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
That's going to be true.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Again, those are specific examples for me, but I think that every one of your doctors of the future is going to have to do this stuff.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Otherwise, you're not going to get full value out of all these measurements, which we should be doing that will better improve our health.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
100% agree, yeah.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
Thanks so much for having me here.
Huberman Lab
Transform Your Metabolic Health & Longevity by Knowing Your Unique Biology | Dr. Michael Snyder
It's been a blast.