Dr. Elizabeth Yurth
Appearances
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
The drug company is called Marius, M-A-R-I-U-S, Pharmaceuticals. And the drug is called Kizetrix, K-Y-Z-A-T-R-E. Excellent.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
And again, you can't go to your pharmacy. You can't have your doctor write you a prescription for this and go into your pharmacy. They don't know what you are talking about, okay? So you're going to have to find a doctor who works with the compounding pharmacies. And I will tell you, there's not a lot of compounding pharmacies that are using this either.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
They're only right now working with a few compounding pharmacies. We work with New BioAge, who is working with Marriott's. to distribute the product. So you have to find a pharmacy that also can get the product for you. And there's not a lot of pharmacies.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
So for those of you who want it, who want to educate your doctor about it, New BioAge, N-U-B-I-O-A-G-E is a pharmacy that is working with Marius to get that product to your doctor, you know, for you. So basically they can send the prescription to New BioAge. New BioAge will send it to you.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Exactly. You know, obviously our proportion of estrogen testosterone is much different than you guys, but we absolutely need testosterone and we need it for the exact same things guys do, right? We need it for libido. We need it for orgasm. We need it for muscle ability. We need it for fat loss. And it gets so ignored in women. It's sad. I mean, I and for orthopedics.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
So my background is from orthopedic world. And, you know, I put a lot of my orthopedic patients, they're trying to heal a fracture or trying to heal an injury and they have no androgens on board. They can't do it. And so it's very funny. I I put recently a patient who was having surgery on on. Some anabolics actually just help her heal from surgery. And of course, her doctor came back.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
It's like, what the hell? What are you doing that for? So for women, it gets really neglected. The gynecologist may look at progesterone and estrogen in women as they're getting menopausal, but not testosterone. Probably testosterone. It starts dropping very young. So when you look at women, usually progesterone starts dropping at a very young age. Testosterone starts dropping at a young age.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Estrogen stays high pretty long. And that's why you get these women who start having that estrogen dominant body. They have that kind of big belly, big breasts, skinny little legs. You see them all over, right? I was at a Billy Joel, Stevie Nicks concert. So it was all people my age. Right. And, you know, all these women had that exact body build. Right.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
They all had like the little round, you know, belly, you know, boobs and no muscle. And, you know, and that's just this estrogen dominant state where you have no testosterone, you know, you have no progesterone. So you have to balance these hormones. And as we age, it becomes even more critical because maintaining muscle is so critical to our overall longevity.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
You always say muscle is sort of our currency to life and you have to have muscle to be able to do everything in this world. If you get sick and you don't have muscle mass, you're not going to do nearly as well. If you have an injury, you're not going to do nearly as well. So we have to maintain muscle. It's absolutely impossible to maintain muscle if you do not have testosterone, right?
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
So I see these docs who are telling women to go exercise and their testosterone levels are, you know, 0.003, you know, for free testosterone. I'm like, you can go exercise all you want. You might as well just throw yourself down the stairs because you're going to get real sore, but you're not going to build any muscle. And, you know, and so it's sad because these women are trying.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
They're truly going to the gym. They're trying to exercise and they're trying to do everything right. Right. They're not losing fat. They're not putting on muscle. And that's because they're, you know, they're they're working with a detriment of having no testosterone.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Let's look at the younger women, because that's a group that scares me a lot. Because when you look at what birth control pills do, almost 50%, if not more, of women are on birth control pills from a young age, some even starting at 13. So when you look at that, and sometimes that may be the best choice to prevent pregnancy. Obviously, an unwanted pregnancy is also a very bad thing. Right.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
But there are other options. What women do need to realize is they are taking birth control pills. Birth control pills raise something called sex hormone binding lobin, which a lot of your listeners are aware of, but a lot of people aren't. And sex hormone binding lobin binds the testosterone, so it's not available to utilize for muscle building and all the things you need it for.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
And so what you'll see in these women is they have very, very high sex hormone binding lobin levels when they're on birth control pills. So they have no free testosterone, no available testosterone. So they have trouble building muscle. They have more injuries. They get more depressed. They get more anxious.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Remember testosterone, just like in men, symptoms of low testosterone in men, lots of times that anxiety, depression, that sort of low grade, just feeling beaten down by the world. Same thing happens in women too, right?
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
It's a little why men are always a little bit, you know, tend to be a little less anxious and a little less depressed than women oftentimes is this, you know, testosterone is very protective of them. until it drops. Well, same thing with us. So we have this very protective hormone that's telling us, you know, you can take on the world. You can, you know, fight against all this stuff.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
If I have no testosterone, I feel defeated, feel like I can't really do this stuff. Also, just like in men, helps with sleep, right? Testosterone, you know, if you think about guys fall asleep after sex, it's because this big surge in androgens. Same thing with women. If you have more androgens at night, you're going to sleep better.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
You're going to have more, you know, you're going to have more restful sleep. You know, so we don't, we always think about it for muscle building and maybe libido, but think about it for all the brain functions too. You know, depression, anxiety, sleep quality. Those are all really important. But there's very few women, very few. over the age of 40 who will have normal testosterone levels.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
And I will tell you, because I have a lot of young patients as well, I would say at least half of my young females have low testosterone levels. So if you're on birth control pills, you may need to supplement with some testosterone, right? And again, the dosing on that is so variable.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
You have to find the right dose, and you have to look at how people are metabolizing so they don't get side effects from it. But it's so critical, you guys, to well-being. And, you know, I get sad when I look at these women in the gym who I see over and over and over again in the gym.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
And they're there and they're doing things and they're actually lifting weights and maybe not heavy enough, but they're not, you know, they have no strength because they don't have any androgens, right? Yeah. you know, it's sort of the same symptoms as in men. It's just that men, they're protected a lot longer than we are, right?
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Testosterone levels, well, I won't say anymore, but used to be testosterone levels didn't start dropping until men got a little bit older. So they were more protected for a longer period of time. And women, they start dropping quite young. I mean, our optimal testosterone levels are usually around, you know, 15 to 18, honestly.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
People don't realize you can order your own labs. The only reason to go through a doctor for your own labs is if you want to run through insurance. But most labs are very inexpensive and you can go to LabCorp, just order your own labs. If you're going to cash pay that, You don't need a doctor to order labs for you. People don't even realize that.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
You can very easily order your own lab panels and you just need to learn how to interpret them, which, you know, like you said, there's resources to do. We put together a whole course on this. So we have this Human Optimization Academy, which if you guys go to boi.academy, we teach you how do you read your CBC? How do you read your CMP? How do you read a lipid panel?
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
What lipid panel do you need to know, right? You're right. It's not just your cholesterol. That means very little. So you have to know your hormone levels. From a young age on, yeah, and, you know, you look at the traditional lab panel your doctor gets, which is a CBC, a CMP, and a TSH maybe, and a lipid, which is, you know, just your basic lipid. It's not very useful for longevity.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
It might tell you you're not dying at that moment in time, but it's not very useful for anything else.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
I'm a fan of high cholesterol. We know that high cholesterol is associated with better brain quality, better muscle quality, but it has to be the right type of cholesterol. And that's not HDLs and LDLs. It's ApoB and ApoA. Nobody tests it. You need to know what your ApoB is. You need to know if you have an LpA, if that's high That's really critical to work on modifications.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
So that's stuff that, you know, if your doctor's not doing and most doctors don't, I see people all the time who hand me their lab profiles and I'm like, okay, this is useless to me.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
And the guys from you guys don't know it. LP little a is a genetically inherited thing. Diet won't change it. Exercise won't change it. You know, Statin drugs won't change it. There's nothing that will change the LPLA. You have to work on other modifications to try and make sure your blood, your cholesterol kind of stickier in a sense. So basically heavier and stickier.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
And so unfortunately, you know, Dylan and my husband has a high LPLA, two of my kids do. You know, it's just a bad, unfortunate gene. In the future, we'll have gene modification therapies and things like that to get rid of. But for now, you have to know you have it because as you said, it is a really big risk factor and most people never get tested.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Yeah, man. And I'll tell you the main reason is even that when standard drugs get recommended over PCSK inhibitors, because PCSK inhibitors are much safer and much better drugs, it's simply cost. It's because it's hard to get a PCSK authorized. Doctors go through all these hoops to get preauthorization for it. They're expensive. And so the protocol is put someone on a statin drug. It's cheap.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
It's easy. And if they fail that, somebody may talk to you about a PCSK inhibitor, but it should be really a first line defense in somebody like you, right?
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Most people aren't like you, right? So then what do you do, right? It's really hard. And that's the case where PCSK names sometimes are really hard to work with insurance on. And they're too expensive for any of us to afford. They're thousands of dollars a month, right? So you don't get insurance help on those.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Yeah. So, you know, you and I come from that same school where no, oral testosterone is bad, right? Because it's toxic to the liver. So you get liver damage. And so we always taught everybody to stay away from it. And so when this came out, which was pretty recently by a company called Marius Pharmaceuticals, it was a little surprising. We're all like, okay, you can't do oral testosterone.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
But there's there's workarounds, you know, if your doctor knows how to work with the system, they can typically get them for you.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
That's what scares you is that 90% of the population is just relying on their doctor, what the doctor tells them. And unfortunately, then they're missing all these things. And that's why you guys, God, you have to. You have to listen to Dylan. You have to educate yourself. You've got to go learn because you can't get it from your doctor. I'm sorry. I keep thinking maybe medicine will catch up.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Maybe it'll be better. I'm not going to say medicine has no... It does. I mean, you know, there's a lot of traditional medicine that's saving lives. So, you know, I'm a traditional medical doctor from training, but I will tell you, I don't do most of the things I learned in my traditional medical career because it's not the right way to go. But don't, you know, this is a balance.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
You don't just say, you know, I'm dying of a horrible infection. You need antibiotics, right? Right.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
But even if you went to your specialist urologist, for instance, or, you know, your specialist endocrinologist, because you feel crappy and your thyroid hormones, you know, and they test the TSH and they go, no, your thyroid looks fine. And you're like, God, I really feel like my hair is falling out and I'm freezing cold all the time. I'm really sluggish. Are you sure my thyroid's fine?
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
And then you go and you do a full thyroid panel on that person where you look at a TSH, a free T3, a thyroglobin, a thyroid antibody, and you realize, They've got thyroid antibodies. They've got a high thyroid globulin. They have a low free T3. And you're like, no, your thyroid is not fine. A TSH was just not enough to find the problem, right? But your traditional medicine doctor does not do that.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Even your endocrinologist doesn't do that most of the time. So even a specialist, unfortunately, you guys are going to have to, I hate to say it, but you have to do some education for yourself and you have to, and then you have to find a doctor who will work with you, right? So even if your doctor doesn't know it,
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
If your doctor, you try and talk to them about something, they'll go, no, that's just not the way it is. And they won't discuss it with you, then find a new doctor. I have people teach me things all the time. You know, I have people who argue with me about things. And if they can prove their point and convince me that they're right and I'm wrong, great. You know, I love that.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Bring me the evidence and I'm willing to read it. But you should have a doctor who's willing to talk to that stuff about you. So you have to find, even if it's a traditional doctor, somebody who's willing to say, yeah, I don't know about that. But if you know about that, let me read the research.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
But what they did is they devised an oral testosterone that was not processed by the liver. So it actually goes through the gut. It gets absorbed directly through the lymphatic system in the gut, bypasses any type of liver metabolism. So there's zero toxicity to the liver. And so it's extremely safe. No change in liver functions. They followed people for quite some time.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Right. Look for somebody else. Right.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
you know shift into SARMs right so what do you think caused the peptides to break through and and when did it kind of hit for you like whoa like we got something here well you know it's it's kind of interesting because you know you kind of come from this sort of bodybuilding world um you know in the bro science world and it's really where hormones I remember when I first started learning about hormones the bro science had more than the regular science did on right you kind of go oh
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
okay, well, they can give, the regular science can kind of give me some of the stuff, but the bro science people were figuring out how to use these in an effective fashion. You know, what could you do? What were the side effects? How can you push these?
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
So, you know, it was very interesting, this bridge between science and bro science, because the bro science people were practically putting this stuff into action and seeing what happened, right? They were doing the end-of-one experiments and saying, well, if you take too much of this, this bad thing happens, and if, you know, but you can take a lot of this.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
And so, you know, so the same thing started happening with peptides. I, you know, I think one of the world experts really on peptides is William Seeds. For the guys that don't know it, he wrote a great book called the Peptide Handbook. It's a really good... If you guys want just a basic education on peptides, it's just a really good... Probably have it here. Oh, yeah. Peptide Protocols.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
This is a great book by Bill Seeds. And it just gives you all the different peptides and sort of how to use them. But... Bill came from an orthopedic background like I did. And I met Bill actually kind of through more of an outside realm, but started hearing him. This was probably now seven years ago or so. He was actually sort of making his own peptides.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
And he was using them kind of in his orthopedic population of patients. And I thought, oh, wow. Because I came from this orthopedic background where it's a little bit of somebody hurts their knee and then you stick steroids in it and you put steroids in it and then finally you do surgery on it and then you replace it. It's sort of a stupid field. We never really fixed anything.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
You just kept sort of patching people together until something was replaced and then you do it for the next joint and the next joint and the next joint. Now what we know so much more is that these orthopedic injuries, degenerative joint disease is really a disease. And we can do so much modifying that disease using things like peptides that we never had the option before.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
They went through a large safety profile on it. So it's an FDA-approved drug. And Zero liver toxicity, no changes in liver metabolism. So they decided not to kind of go the traditional pharmaceutical route. So what they did is they're working primarily with compounding pharmaceutical companies, and they're selling it to the compounding pharmaceuticals.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
So when I met Bill and he was doing this, I thought, oh my gosh, I'm going to bring this into my orthopedic practice. I will start helping people heal better using these things. And so I started dabbling it more within the musculoskeletal world, even things like nandrolone. I mean, I was using nandrolone primarily
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
You know, you think about in the bodybuilding world, but I was using it, my little old ladies who had fractures, right? Because you could finally get them to actually heal a fracture because they would build their bone density up. They'd get some muscle mass on them. So, you know, so I used, you know, nandrolone.
The Dylan Gemelli Podcast
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And my little old lady said, if you look back at the literature, that's where Nandrolone actually got its medical start was in helping in osteoporosis, heal osteoporosis. Or MK-677, same thing. I used it a lot in my little old people who I couldn't get enough food into them. I couldn't get muscle mass in them. You know, I could use MK.
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I could get them to start eating more when they were trying to heal and recover, right? Yeah, because it increases your appetite so much. And so you have these people who are trying to recover from surgery, you know, and they're 75 years old and they, you know, they're trying to recover from an injury. Like they fell and they have a little vertebral fracture and they're not eating protein.
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So, you know, you can use things like MK or Nandrolone and you could actually get them to heal. So that's where I started sort of dabbling in this is kind of in that, you know, bridging that world and then started expanding them more into the performance world. I opened my longevity clinic about 18, 19 years ago now, but I actually did both my orthopedic by day and my longevity clinic by night.
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And then only really five years ago did I kind of bring them together because my orthopedic clinic was just silly to try and teach people anything in 15 minutes. So, you know, left and just now every, all my orthopedic people see me here. But the key is that these started in this realm of we can use them for healing. Well, now we realize we could use them a whole lot more in performance.
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And the bro science people do that way before, you know, but it took in the medical world moving from this, okay, how can these actually be utilized in a true healing capacity? And now we can push them into that performance side a little bit more.
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So I started using peptides and learning more about peptides about probably seven years ago and mostly from Bill Seeds because he's really, I think, one of the biggest experts in them. And then, you know, And then why did, you know, everybody start getting into it?
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Because, you know, as... And this... We'll give the bro science credit on this one much more than the doctors because that's who started expanding them, you know, word of mouth, right? Wow. I, you know, I tore my tendon and I was better in three months as opposed to a year later, right? You started seeing them in the athletes coming out.
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They're all banned by WADA, unfortunately, but... You know, you started seeing them come out in these realms too, but used to be, you know, even... Before peptides got so famous, the pro athletes were using them a lot. So I think that that's what expanded its realm.
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And now it's only really been, I'm on faculty, I teach peptides to doctors, and I would still say not very many doctors know much about peptides. But hopefully, I don't know. I mean, I would like to say the same thing happened with hormones, right? That now everybody should be using hormones, but they're not. Is everybody ever going to use peptides? No.
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But hopefully that, so I think, you know, you and I've watched the growth, just like we've seen, you know, the growth in hormones and anabolics and SARMs and things like that. We've watched that growth a little bit. You get to see it from the more practical aspect. I think in the medical world, it's still not very, none of it's very well accepted, right?
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Because if you look at where most of us who are doing hormonal medicine work, And what you recommend to a lot of your clients, we're working with compounding pharmacies a lot, right? And so their feeling was that was going to be a better place to educate people was through the compounding pharmacies. And so they will sell it to the compounding pharmacies.
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Unfortunately.
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A lot of mistakes made along the road, right? Yeah.
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I mean, you're right. But how, you know, there is that little piece. I mean, that is unfortunately the fact that there are people who are willing to experiment a little bit. You know, that's throughout time how we've learned something. It's like, oh, look, there's this really cool berry. And somebody started thinking, oh, this would work medicinally. And it did in a low dose. Right.
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And then somebody ate too much of it and died.
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Don't do that. Right. Unfortunately, there is a little bit of a learning curve to that. Right. Unless you have the ability to test everything on animals first. The good thing about peptides is most of them have had a lot of good animal testing behind already. Right. We know in general. These are very safe. In fact, much safer than hormones. It is very hard to hurt yourself with a peptide.
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It is much easier to hurt yourself with a hormone than a peptide. Things like BPC or thymus and alpha-1, you could massively dose them. You could bathe yourself in them and nothing bad would happen. And we know that from a lot of animal studies. Now, we've done it with patients, right? We've used it in patients and we've tried it and we see the outcomes. Yeah.
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But, you know, kudos to the people who, you know, in our world have had the guts to try things and we've had the opportunity to learn from them. Right. I mean, even ourselves. Right. I'm sure you've done things where like, well, that was a bad idea. Oh, yeah. Right.
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But you're like, oh, I'll try this new supplement and maybe I'll try it at a little higher dose because it wasn't working well and then something horrible happens. You're like, okay, well, I won't do that again. So, you know... I think we're always going to learn somewhat by trial and error, by end-of-one experiments. The key is trying to put these end-of-one experiments together.
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I'm involved with this big group of doctors. We call ourselves the Longevity Docs. It's kind of from across the world. But we have this, you know, just WhatsApp chat line. And we just throw stuff into it. And you start, you know, as data starts accumulating, you could start putting together, you know, sort of a clinical trial.
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Despite the fact that it's not an expensive thing. pharmaceutical run clinical trial, when enough people start utilizing something in a similar fashion, we can put together these trials. And all it takes is a bunch of us kind of putting our information together.
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The compounding pharmacies will then sell it to the physicians. So a little bit different. You can't just go to your regular pharmacy and get this drug.
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Yeah, that's interesting, right?
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It has to go through a physician that knows about it, knows working with compounding pharmacies, which on the downside is probably going to be most of your doctors who are traditional medicine doctors are not going to know about this drug and not going to utilize this drug. But if you really look at how many
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I love that deal because you are right. I guess that we couldn't have had this conversation a while ago. We couldn't have talked about, you know, you know, wow, nandrolone can actually be used in medicine and, you know, because that was 200 grand. So you're right. We've made advances, right?
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And, you know, one of our passions at Boulder Longevity Institute is because there's brilliant people like you who are passionate and knowledgeable from life experience, right, which goes a long way. See, these doctors who went to medical school and they learned this sort of set protocols of things. And one of the things we realized is it's very hard to un-teach these set protocols.
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You know, one of the reasons I left my orthopedic practice was because literally one day one of my partners came up to me and I, you know, I started this practice. I'd been in practice for 30 years. And, you know, and when I practice, you know, we don't really want and they knew I started doing peptides and things in the practice. You know, we don't really want you doing this stuff here anymore.
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We don't really do medicine here. We do orthopedics. And I have a very good friend who's a cardiologist, and he's in a cardiology practice, but he's doing what we would do with cardiology, right? He's not going to be putting everywhere on statins and PCSKs. And recently, his group came to him and said, you know what? We don't really like you using hormones and peptides on the patients.
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We just want you to use statins. And so he's probably going to move over and join us. So what we've realized is it's very, very hard to take traditional medicine and turn them into... educating people in this stuff, right? So we're going to have to rely on an army of passionate, smart people like you to educate other people who become smart, passionate people and educate other people, right?
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Because I don't think, as much as I would love to say medicine's going to change, I just don't think it's going to.
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There's something else, right? There's something else that's controlling it, right?
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traditional medicine doctors are even doing much hormone replacement, even though they should be, it is very few. So yeah, maybe if you're completely bottomed out to zero on testosterone, they might treat you. But for most part, they're not the doctors who are doing a lot of this.
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Right. I bridge the two. Right. Yes.
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And yeah, that's so good and so cool. And that's how we're going to change the paradigm. is people like you coming in and doing this and your listeners going, wow, okay, I can actually change this. I can actually do something. I can take control of my health. I don't have to rely on a doctor to do it. I can order my own labs.
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If I learn how to read those labs, don't abandon your doctors altogether. I don't want you guys to die because of a horrible infection, but you've got to know the questions to ask. You've got to find the right physicians to work with. You have to you know, that's where people like you can be huge advisors to people, right?
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You know, even if you don't know it all, you know, that's one of the things, you know, Dylan and I talked about is we, you know, we can educate people and then they can, they can act as advisors to other people, right? Yes.
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And he's like, wow, they were like really high. Wow.
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So I was- Right, so that you can't drink up and deliver toxicity, right?
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So this is a really nice new addition because a lot of guys, and there's nothing wrong with injections of testosterone, right? It works very well. and you can do it twice a week, once a week dosing, twice a week dosing, or even smaller dosing even more frequently than that. So there's a lot of ways you can do testosterone, but a lot of guys don't like doing injections. So this is another option.
The Dylan Gemelli Podcast
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So GLP-1 agonists, which you guys know, like the Ozempics and Ligovis and Monjarros, you know, those include semaglutide, which is the first generation. It's like Ozempic. And then Monjaro is the second generation, Tirzepatide. And GLP-1 agonists basically, glucon-like peptide receptor agonists sit on a glucon-like peptide receptor. And they have all sorts of benefits.
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One is controlling blood glucose, right? Which is where they first got their start was in treating diabetes very effectively. Right. Now, what they found out is, wow, actually, they also worked very well for weight loss at a little bit higher dose. So that was a much bigger boon than diabetes ever would be. And they made it into the weight loss world.
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Because once they made it into the weight loss world, everybody started using them and they became hugely controversial. Like, number one, everybody's cheating to lose weight. And they have all these horrendous side effects, right? That's all you read about in the press. It's like now, you know, somebody has a complete...
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gastric obstruction and people are dying and people are losing all their muscle mass. And I will tell you guys, I know GLP-1s very well, and that is complete and utter bullshit.
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So things are very, I will tell you, we used GLP-1 agonists for a long time before they ever got into the weight loss world, not just for diabetes, but in our longevity world for all sorts of other things, because there are GLP-1 receptors on every organ in your body, including your brain, including your liver, including your kidneys, your immune cells. and your muscle.
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And in fact, used appropriately when they were first designed, they were actually found to push glucose into the muscle. So help with muscle building in a diabetic population who was having trouble muscle building. They would actually help muscle building. So really what happened is people started dosing these inappropriately.
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They started using them, you know, sort of rampantly and you started seeing the bad consequences of doing anything that way. If I take a GOP1 agonist and I have no appetite and I stop eating, I will lose muscle. And these are very effective drugs at lowering your appetite. I will tell you, remarkably so. People just don't have cravings to eat.
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The problem is if you don't have cravings to eat, you also stopped eating all your protein. And if I stop eating my protein, I will lose muscle mass. But if you can maintain somebody eating high protein while they're on the GLP-1 agonist, which is sometimes hard, and you have to dose appropriately to do that, they will put on muscle.
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So as long as you get their protein intake up into the 100-gram range, 120 gram or higher, depending on how big you are, range, you will put on muscle on these and you will lose fat. The fat, the ozempic face, yeah, you get ozempic face because you lose all the fat in your face. That's a consequence of losing weight no matter how you lose weight. But the loss of muscle should not occur.
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And I do not see it in my patients because I maintain that they have to stay hydrated and they have to eat protein or I will take them off the drug. So I have them send me their macronutrient profiles. I watch what they're eating. If they're not eating enough, I'm like, okay, we have to pull back the drug because you're not eating enough.
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The other thing is that if you're taking these at high doses and not eating enough fiber and things like that, then you start to get horrible constipation and people start to gain gastric obstructions. So again, not dosed appropriately, not people following appropriate diets to be on these drugs. I don't see that in my population of patients ever.
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You will see nausea, side effects, things like that. Sometimes you have to dose them down. But the most powerful thing about these drugs is, and I take a low dose GLP-1 every day, is their effect for other structures. Like you talked about your liver. They are super liver protective. I had an autoimmune liver disease, almost had to have a liver transplant about 20 years ago.
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I was taking an antibiotic that kicked off an autoimmune liver disease. And talk about liver functions, mine were in the thousands, like 1,500. And, you know, finally got it under control, but my liver has never been perfect. And so I take these because they're very liver protective. They're in phase four trials for brain. So for dementia prevention.
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So they're super protective to brain, which is the main reason I take it is brain and liver. Because I had a mother who died of dementia. I do not want that. So I take a low dose. At a low dose, you will not lose weight. I don't need to lose weight. I'm 5'9", 130 pounds, so I don't need to lose weight. But the key is I want a small dose of these as a neuroprotective.
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So they're going to get authorization probably in a year or two for dementia prevention. And then you look at immune function. The GOP1 agonists are tremendous for helping T cell function. So what we do a lot, almost all my patients are on GLP-1 agonists as a longevity agent to protect their immune system, protect their liver. It also converts brown fat or white fat into brown fat.
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So it takes metabolically inactive fat, turns it into metabolically active fat. So they have so many benefits. And the press you're reading, number one, bad press sells. So, of course, you're going to pick up a magazine that says, Ozempic, killing people, right? And not, you know, Ozempic's the best wonder drug.
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And because these are all over the place, you can buy them from any source online now and use them however you want. And not know. If I don't... They make you not want to drink, too. So you basically... You've got to drink water. You've got to eat protein. You'll do fine on these drugs. But they should be done with somebody who knows what they're doing and under guidance or learn more about them.
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But I think these are marked... incredible drugs. You know, if you look at the difference, so there's semaglutide, then terzeptide, and now rather trutide, which is going to be even the best of the bunch with lower side effect profile and more benefits. They all are good. They just are a little bit better each generation. So guys, please, please stop listening to the press on this.
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These are such valuable drugs. And they also have some really interesting benefits for helping change behaviors. So very interestingly, yeah. So you can use them in addiction. So people who have alcohol or drug addictions, they will actually change the desire to drink or take your drugs. But you can also use them for positive behavior reinforcements. There was a great study done.
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This is really well tolerated by people. It has a couple of advantages over using injectable testosterone. And so number one, when we do injectable testosterone, if you're a younger guy, you have to protect testicular function, right? Because you're going to reduce your own production of testosterone. And... potentially reduce spermatogenesis and your own LH and FSH drop.
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If you put somebody on GLP-1 agonist and had them exercise continuously, they will more likely adopt that into their lifestyle than if they were not on the GLP-1 agonist. So they seem, because of their brain effect, they actually help bring some of the neural pathways that form to help us reinforce both good or unreinforced bad behaviors. So these are really cool drugs.
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And I think maybe one of the most advantageous longevity drugs has come into existence in our past 10 years, honestly.
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So I usually end up semaglutide just because it's less expensive and it works, right? But if people can't tolerate semaglutide for some reason or they can afford Cheers Appetite, then I'll go to that. But I do semaglutide just because it's cheaper. And it's effective. The GLP-1 egg is in and of itself without anything else are effective. So usually I'll use GLP-1. And you microdose it.
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So instead of doing a bigger dose once a week, you do a small dose. And we're talking about a weight loss dose, for instance, of semaglutide is going to be somewhere around 5 milligrams a week. So 2.5 milligrams twice a week or 5 milligrams once a week. So we'll use like maybe 0.5 milligrams twice a week or three times a week.
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So you're never getting into the weight loss range of the drug, but you're getting the benefit. And smaller people, you can even use a smaller, you might even use 0.25 milligrams three times a week. So you can dose these like a three time a week is I think ideal when you're doing them on a preventative basis. I get like injection fatigue.
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So I usually do twice a week at like a 0.5 milligram twice a week dosing for its protective benefits on myself.
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I mean, I will tell you, just from your longevity bend and your biohacker bend, these are really good drugs. Yes. For a whole lot of reasons. But the cognitive is really important. None of us want to lose brain function.
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The liver protective benefits. Yeah.
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You need to do some liver protection. Yeah. And these are actually very, very useful for liver protection.
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I mean, I think there's really not one. If you look, I have a great little picture I show my patients that, you know, basically shows, you know, and there's kind of if you name an organ system, these are going to be beneficial for their muscles. There's immune, it's kidney, it's liver, it's brain. So there's not much left here.
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But interestingly, there's two studies that have come out in the past two years. that show musculoskeletal. So actually in orthopedic realm that they are preventative against osteoarthritis as well. So they appear to slow progression or even halt progression of degenerative joint disease.
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And that's because when you look at these diseases, these are immune mediated diseases and I can modify them by modifying the immune system. So I think that's a benefit that we're just learning about and kind of just exploring. But probably that group of patients who have, you know, multi-joint osteoarthritis, who have had, you know, a knee replaced and hip replaced.
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Those are other people who should be thinking about being on these drugs too.
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Yeah, I do. You know, but it may be cost prohibitive to be doing. I mean, the good thing is on these smaller doses, it ends up being less expensive, right? Because, you know, you're not doing it with the massive therapeutic doses for weight loss. You can do a small dose. It's less expensive. The question will be, will the bang for the buck be enough to say it's more beneficial?
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So you're going to actually get atrophy of the testicles and all the things that go along with that. So this does not do that. So very interestingly, when you do small dosing orally, it does not have the same detrimental effects on testicular function. So we're not seeing guys have to adjunct it with things like in clomiphene or HCG who are trying to preserve fertility. And
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I don't know that yet. And they are significantly more costly. Some of the glutathione has come down to a much more reasonable price than the others yet.
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So the main difference is a semaglutide is just a GLP-1 agonist. And then registered, they added a GIP, a gland insulin peptide, So basically a GLP, a GIP, and red shoot type actually works on three different, different receptors.
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So basically each one, and you know, one of my friends always describes this as like, they're all going to get you to the same place, but one might be like driving your Honda, the other, like driving your, you know, your Ferrari, right?
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It's probably going to get you to the same place. It's going to be maybe a little bit better, maybe well, more well tolerated. at what the more expensive was. I don't know at this point. I think especially for weight loss, ratatouille will far out surpass the others.
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Because when you get to these higher doses of these drugs, the side effect profile, like the nausea, is hard to deal with for some people. And so I think that that's the key is that you definitely decrease the side effect profile as you get to the more expensive drugs that added the GLP-1, GIPs. That side effect profile goes down.
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But the smaller doses, the side effects are pretty low anyway, right? I don't know if the true benefits to other organs besides weight loss are going to be that far surpassed that it's going to be worth the money or not.
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Right, right. And these definitely got from the weight loss perspective, bar none. Okay. Yeah. the third-generation registered diet is going to be by far the best for weight loss. It's going to be more powerful, and it's going to have less side effects. But I think if you're using it for its other benefits, I'm not sure it's going to have as much. It's not going to be such a difference.
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Yeah, exactly. Yeah. You don't need to lose weight to be careful. But for you, like just a low like a point five milligram twice a week kind of dosing for you just for liver protection, for brain protection, really big and immune stuff. I see definite improvement to lymphocyte function on people on these drugs.
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I think by far the most commonly used peptide is BPC. I think everybody knows about it, right? It can be used for so many things from gut. I mean, orally, it's incredible for gut protection. If you take BPC, like if you're taking an anti-inflammatory drug,
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And you take BPC along with the anti-inflammatory, you completely reduce the damage to the gut that occurs with the anti-inflammatory drugs, completely prevents that. So you can use it orally very nicely for gut protection or for healing ulcers for people who have a lot of GI distress stuff. And you can use it for all its musculoskeletal benefits. And it has great glucose control benefits.
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And it has great immune benefits. It's really one of those peptides that, you know, honestly, it's, it's, and we know its safety profile is, you could take a bottle of it and be fine. So, you know, and I use it both orally. Orally, you can buy it as a supplement now. So, orally, you know, you can, you can simply, you can buy a supplement. It still is injectable.
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But also, because you're dosing it twice a day, it has very, very nice physiologic curves to what your normal testosterone surges are. Kind of surge up in the morning, they surge up in the evening. So basically, you can keep this very nice physiologic dosing, and guys seem to really like it. So what I've seen...
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We have to buy it, we have to use it from a compounding pharmacy. But, yeah. I do think the injectable works better when we're talking about healing musculoskeletal injuries. For people who just want something, getting it over the counter is great.
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And then I think, you know, if I look at, you know, the thymic peptides, thymus and alpha-1, thymus and beta-4, alpha-1 is a tremendous peptide for immune system health. I used it a lot during our COVID world type time, you know, ongoing. But just to protect the immune system and to help, I think it's one of those peptides that your immune system is going to start declining as you age.
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You want to keep maintaining that because that's a big link to longevity. Yeah. And so I think the thymosin alpha-1 should be utilized by most people. Thymosin beta-4 also has huge benefits in terms of healing and recovery. Yeah.
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And then your growth hormones secretagogues, like the CJC, ipamrolin, tesamrolin, ipamrolin, secretropin, seromrolin, those are all, you know, probably kind of the next in line. What I do with my patients is I have this kind of protocol, longevity protocol that I cycle the peptides through. I work on the mitochondria. I work on the immune system. I work on the musculoskeletal system.
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We sort of cycle that through. And that to me is, you know, I always go by the theory, replace what you lose. You're losing, just like you're losing hormones, you're losing these peptides. A lot of these peptides are naturally made by the body.
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NHK copper, BPC, thymic peptides. Those are all naturally made by the body. They decline as we age. Let's give them back, right? Yeah.
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Yeah, we're constantly, yeah. You know, we're always looking for new stuff too. I mean, that's kind of a fun thing about this field.
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Because if you keep an eye on it, right, it's so changing so rapidly.
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It's really hard to keep up, right?
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I'm reading literally people ask, how do you keep up? I go, I read two hours a night. I just, you know, I've, you know, Google caller sends me alerts for everything I'm interested in. I'm reading papers every night. And it's even hard to interpret research, right? It's like, cause so much research is warped to somebody trying to have a secondary gain.
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So you have to even figure out what the right research to look at is. It's, you know, so it's a hard field to keep up on and it's hard field to know where to get your information from.
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Yeah, it's topical, really.
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You found that pretty useful just for injuries?
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in my men who have been put on it is that they, I've switched over from injectable to this, is that they're actually reporting a little bit better sex drive and erection quality and muscle building. So I think there may be something to that more physiologic dosing that is actually going to be beneficial as well.
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Yeah, we should do it simultaneously, yeah.
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So I still I still like Carterine a bit, too.
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I appreciate you, Dylan. I really appreciate you doing what you're doing and inviting me on so we can spread this world. I'm so anxious for us to work together more.
The Dylan Gemelli Podcast
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What Dylan and I were talking about is how do you educate yourself? And we realized that that's hard because it's hard to figure out where to get that education. How do I learn how to look at my lab? So we actually put together a course. So if you go to BLI, which stands for Border Longevity Institute, bli.academy, that takes you to our Human Optimization Academy.
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You can also go to, forget that, just go to borderlongevity.com, but bli.academy. Human Optimization Academy has all these courses you can do. How do you read a CBC, a CMP, your hormones? How do you look at a lipid panel? What lipids... do you need to know about, right? So it teaches you all that and we have ongoing Q&A sessions that are really fun.
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We just did one a couple days ago and those are incredible. There's a lot of doctors in there too, you know, kind of progressive doctors and health advocates and everybody asks very interesting questions.
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So if you guys sign up there, it's a good place to start and get some basic learning so you can then just, okay, I'm just going to order these labs and I'll look at them myself and then if I need help, I can reach out and I can find, you know, doctors and then you can find us
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boulder longevity.com um and you know we're certainly happy to help you go through labs and things like that as well but please please please start educating yourself start you know start learning this and then educate your friends because then we'll start spreading health medicine and not disease medicine which is the only thing that's really ultimately going to change how long we live healthfully
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One of the downsides, downside is cost, is certainly more expensive than doing a sub-Q or intramuscular injection of testosterone. Even if you're dosing testosterone high, this is going to be a more expensive option for you. You know, with time, we'll come down in price maybe. But, you know, it ends up being really probably about $100 a month.
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And it's at Dr. Urth.
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Thanks, Dylan.
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So definitely more expensive than traditional testosterone, but not out of reach for a lot of people. And, you know, I will certainly have a lot of guys who have really found it just better, simpler, and they're happier with the outcomes.
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I think there's a lot of guys who will, especially if you're like you, you know, younger guys, you know, as you get older, maybe the preservation of testicle function isn't as important, but certainly in our younger population, that is important. And it's always a little bit of a, you know, when do you start testosterone? You have, I have 25 year olds who have low testosterone.
The Dylan Gemelli Podcast
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Welcome. Thank you, Dylan. Thank you for having me.
The Dylan Gemelli Podcast
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They need treatment, but I should be very cautious with my 25 year olds that I'm protecting spermatogenesis, right? Yeah. Various pharmaceuticals who make schizatrix is just doing a really long-term study on spermatogenesis. The early studies to get all the authorization showed no effect on spermatogenesis.
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They're now doing a much longer-term study to see if that pans out, but it looks like it's going to. It looks like we're going to not see that effect, so it's not going to affect fertility for men. I'm going to reserve saying that's 100%, but we'll follow it. We can follow that. We can follow that very easily on younger men. And I think if you look at the effects on LH and FSH, it should not.
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We're not seeing that same effect that I see with testosterone. You know, I'm, you know, as a female, so they make it right now in dosing. So typically it's anywhere from 200 milligrams twice a day to 400 milligrams twice a day. So it depends on, you know, how much testosterone you need. So it's a high dose for women.
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But one of the things I'm having some women do who want to try it is actually freeze the capsules and then cut them. Because once they're frozen, they're a gel cap, basically, because testosterone is an oil base, right? So they're a gel cap and then cut the capsule and try it in a smaller dose for women.
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Because it's a nice option for women, particularly because it does have a little more rapid act. And for women... For things like libido, where that seems to be a problem for a lot of women, you can actually get a little bit more of a direct effect. So if you do it in the evening, you can get a little bit more direct effect to help the libido too.
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So we're kind of experimenting with that with women right now. They will hopefully eventually come out with some female dosing on it. That would be nice, but they're hitting the male market first.
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It's probably going to be, so 150 to 200 milligrams is probably going to be about 400 milligrams twice a week. Although I have been able, some guys, 100 to 150, get away with the 200 milligram twice a day dosing as well.
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So 200 milligram twice a day dosing, if you're in that 100 to 150 range, if you're more up closer to the 200 a weekly range, then probably going to have to get up to more of a 400 twice a day dosing to get to the same levels.
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Yeah, it's hard to say. I think in the younger population, and we don't have enough long-term experience yet to say for men who have been suppressed for a long time, are we going to see them now start to improve testicular function? Don't know the answer to that.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Yeah, 42. So at 42, are you going to be able to recover? 42 is still young. It'd be interesting to see. I think that's where our experience and more and more doctors using this. There are so few doctors right now who are even aware of this drug, right? I mean, you're in this biz and you haven't heard about it, right?
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
So it's pretty, you know, it still has a long way to go in terms of educating people. But they're, you know, I know Allie's doing her Silverback Summit coming up. I know they're going to be there. I think, you know, so they're trying to get out there now and get a little bit more recognition. So I think we'll start seeing them grow and then we'll have more data. We'll have more.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Wow, I am seeing my patients actually reverse on this, right? I've only been using this now for, you know, a few months because it's really only been available that long. And so I think this is going to be a fun new sort of venture and we can follow. You and I talk six months from now, we'll have a lot more data to put together.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
But I think it's, you know, it's such a nice new option for people because you're right. I have a lot of guys who do not want to deal with injections, especially if you're traveling or things like that. Right. And you're having to travel with needles. You know, I have guys who are traveling a lot, you know, and they're on planes going overseas and things like that.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
And, you know, they're gone for a month at a time and they're having to travel with their needles and their injectable vials of testosterone. It's just a little bit of a hassle. Right. It is going to be a whole lot easier.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
It's just tedious, right? I do tons of peptide injections and it's just tedious. And I fall off the wagon because it's just tedious, right? And so anything that we can make easier in our lives is certainly going to be a welcome change.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Yeah, we were so lucky to have a chance to work together at Olympia recently. And so Dylan and I got to kind of know each other a little bit better being on some panels together at Olympia, and we both became very rapidly fond of each other. So I'm honored to be here with you today.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
We're seeing much less aromatization to estrogen as well with the oral. It just says it's going through the lymphatic system because that has to do with the metabolism of the- testosterone, right? When you're going directly into the lymphatics, we're not seeing that aromatization. So much less.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
So it's one of the groups I've switched over are my guys who I really have trouble controlling estrogen conversion. This seems to be a much better option for those guys. So I think that that's going to be, again, will we see some guys still convert? Maybe. I don't know. Again, don't have enough experience with it yet. But
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
Just if you look at the mechanism of why testosterone aromatizes, you should see less of it with this lymphatic version.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
So I think this is going to be, I mean, honestly, this is going to be really, you know, a game changer in our world. You know, we'll see. I don't, I don't know if you're going to get up to like, you know, our bodybuilders who are doing, but you know, really super high, super physiologic doses. Maybe you can dose to that, to that level with an oral form. Don't know.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
But I think that, you know, from most of us, this is going to be where you can get a good, really nice high physiologic level of testosterone. And, and, and again, again, I think that, that dual cycling, that getting a little bit in the morning, getting a little bit in the afternoon,
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
You know, when we do injections, even if you're doing like a twice-week injection, you still get this like peak drop, peak drop, right? So, you know, you're super high. If you test your testosterone right after you've injected it, it's going to show up really high in your blood test, right?
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
If you test it, you know, the day before you do your injection, it's going to be really low or, you know, somewhat low. You know, so if we can keep this a little bit more of this, which is what testosterone normally does, that should be better for our body. It should be better for our brains. It should be better for muscle building because that's really how the body was designed to do it.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
I'll tell you, even in my field, I would say one out of every hundred of doctors who are doing true functional hormone medicine know about it yet. So these guys are trying to get out there. They're trying to promote it. We're trying to help them. We're trying to, you know, get word out because I think it's such a nice option for people. For me, I'm excited as a woman.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
I'm excited for some female dosing, honestly, because I think the same thing with women. I think with women, the problem is, you know, again, you get these super high levels if you're doing injections, right? These super high levels that come down or people are doing pellets, the same thing. You put a pellet in, your levels are super high for a while and they drop down, right?
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
So you get this super physiologic levels for a while just to maintain a nice normal level for some period of time. And then you're going to potentially get some of the side effects associated with these high levels just so that you can, at most of the time, be at a normal level.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
So if you can avoid that, I think we're going to see less problems with women with acne and hair loss and things like that by using these kind of more smaller doses in a physiologic fashion. So I'm excited for them to come around. I don't know when they're going to start working on it. It's too bad. Too bad that women always get a little bit thrown into the downside.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
But I am going to try, even myself, I'm going to try playing with cutting the little capsule in half. I thought it might screw up the absorption, but I talked to them and the scientific advisor just recently, and he said, no, it doesn't matter. It's not the capsule that's causing the absorption. It's the oil base that is in itself that's affecting the absorption. So you can sit very safely.
The Dylan Gemelli Podcast
Episode #8 Featuring Dr. Elizabeth Yurth MD, ABAARM, FAARM, FAARFM! GLP-1 Benefits, Misconceptions and their Future, Comprehensive Hormonal Testing, Women and Testosterone Importance, The Evolution of Peptides and MORE!
You couldn't do that with a slow release medication because the capsule is too important. If you cut it, you screw that up. But this is not the same and it doesn't change the way it's absorbed by cutting it. So that's an option. It's even an option if guys want to save money, potentially, you know, if you can go with a lower dose, you could buy the higher dose capsule and then, you know.