Dr. Benjamin Bikman
Appearances
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
When we're looking at smoking versus vaping, vaping is probably worse in terms of the damage to the airway and the insulin resistance that comes from it. But this gets worse because we know that insulin resistance is the core for most chronic diseases that are killing us, and there's a handful of other lifestyle habits that's contributing to it.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So the more the body has those stress hormones elevated because of, say, sleep deprivation, that's a very effective way to increase cortisol. Or they are drinking too much caffeine. That is a way to increase epinephrine quite strongly. If both of those signals are too incessant or they continue to be present and climb, then insulin has to work harder and harder.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And then we have insulin resistance. So stress is a cause of insulin resistance. But then next is inflammation. You and I were commenting earlier about how, boy, there's a cold going around. It's flu season.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Even then, if a person were wearing a continuous glucose monitor on the back of their arm, measuring their glucose levels, they would see their glucose levels are much, much higher, like significantly higher during the time that they're struggling with this infection. That is a reflection of insulin resistance. Insulin is having a harder time keeping the blood glucose levels in check.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
anytime inflammation is up, insulin resistance will be up as well. Even in things like autoimmune diseases, there are reports in humans that document the degree to which someone has, say, active rheumatoid arthritis. Their joints are achy because of an autoimmune attacking of the joints. They will note on some days, like every autoimmune disease, there is an ebb and a flow.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Some days it's good, some days it's bad. And on the bad days, if you measure their insulin resistance, it is absolutely locked with the degree to which their immune system is turned on or off or higher or lower. So inflammation is another cause. And then the last one of the fast lane of insulin resistance is too much insulin itself.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Now the astute listener will realize the kind of circular thing I've just presented by invoking high insulin as a cause.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
of insulin resistance because they will also think, but wait a minute, Ben, you just said that high insulin is also a consequence of insulin resistance, that back to the bouncer knocking on the door of the muscle cell, if one bouncer wasn't enough or one molecule of insulin wasn't enough, the body will say, okay, well, let's send 10 molecules of insulin.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So high insulin is both a consequence of insulin resistance, but it's also a cause. And this is reflective of a fundamental principle in all of biology, that if there is too much of a stimulus, a cell, if it's capable, will try to become resistant to that stimulus. This would be like a funny analogy of in the Bickman home, my darling wife is home with the children. That is what she wants to do.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
She is full-time mom. When I'm home, and I try to be home as much as I can, it's funny for me to note the difference in how quickly we each respond to our children. I will hear my child saying, mom, mom, mom, and she's not responding. Mom has heard this for so much that she's become kind of selectively deaf to when my children are demanding her attention.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I'm not as around my children quite as much because I'm working during the day. And so when I hear that, it's a very fresh signal to me. I've not heard it so much that I've become deaf to it. And so I will respond even though I'm in the other room because I'm so much more sensitive
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
to the clamoring for attention this is like the body in response to insulin if there is always insulin it's always going up always going up the body will start to say the muscle cell will start to say boy insulin you are knocking on my door all the time this is getting old i'm not responding anymore i'm not going to listen as much as i was before so in that sense
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
insulin, too much insulin becomes a cause of insulin resistance. And back to what I said earlier, I could take you into the lab, start infusing you with just a little drip of insulin to increase your insulin, and over just a few hours, you would become demonstrably less sensitive to it than you were before we started.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But again, as I take that away, give your body a few hours and it's back to normal. In every one of those instances, it's a fast onset and it's also a fast solution if we can take it away.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah. So especially all of these can contribute to a more lingering insulin resistance, but especially insulin. where I focus on that one the most because of not only its relevance to the slow lane, but also just how present it is, where 70% of all calories globally are carbohydrates. And now, perhaps with the best of intentions, our experts are telling us that we should be eating six times a day.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so we eat, we wake up in the morning, insulin has finally been coming down while we've been fasting overnight. Insulin gets to take a little bit of a break. We're fasting. Then we break that fast by eating breakfast. And in the UK, as it is in the US, by and large, this is going to be a very starchy, sugary breakfast. It's toast with some jam or it's cereal or it's bagels.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
That is going to be, that is almost pure glucose. And so what do we do? We wake up, we eat breakfast, we spike our blood sugar levels and insulin has to come up. Insulin will take longer to come down than the blood sugar will. It will wait in the blood to make sure that all the blood sugar has gone back to normal.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So depending on how much carbohydrate we ate for breakfast, it could take our insulin levels three or even four hours to come back down to normal. Long before it's had a chance to come back down to normal, we've had a mid-morning snack, of course. We need to go get a sugary coffee and another bagel or something. And so after just a couple hours, we do it again.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And once again, before insulin has had a chance to come back down, we have a starchy carbohydrate heavy lunch, then an afternoon snack, and then a carbohydrate heavy dinner. And then of course we have to have an evening snack before we go to bed. So the average individual is spending every waking moment in a state of elevated insulin.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And thus the signal never really goes away because they never give themselves a break. But one of the consequences of that I mentioned, which is that it directly causes insulin resistance. But when insulin is high, it starts to have a signal on the fat cell.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And that then brings us to the slow insulin resistance, where you have something happening in the fat tissue that begins to set the stage for insulin resistance in the entire body. And it takes longer to settle in, but it takes also longer to go away. That's why I call this one slow insulin resistance.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Now, in the case of insulin, most people, so the key with the, yeah, I'll explain it this way first. So the most relevant feature with fat tissue contributing to insulin resistance is the size of each fat cell. When we typically think of fat, we would maybe say, okay, Steve has, I'll do this in kilos for the UK audience. Steve has 10 kilos of fat on your entire body.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
That's probably too much for you. Ben has 20 kilos. And yet it's possible that I'm healthier metabolically than you. And that's because it's not the mass of fat that matters most. It's the size of the fat cell that matters. This is why women, despite universally being fatter than her male counterparts, are healthier with regards to insulin resistance and every single metabolic problem.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
My mission is to help people appreciate that much of chronic disease, we look at them as these siloed individual distinct disorders with totally distinct origins, and yet much of them share a common core. It's as if they're branches growing from the same tree.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It's because women, as a result of her particular sex hormones, have more fat cells, but they're smaller. So she has more fat, but smaller fat cells. And small fat cells are healthy, insulin-sensitive, anti-inflammatory fat cells. But the bigger the fat cell gets, the more it initiates a cascade of events or a series of events that creates insulin resistance.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
That's a really, really safe assumption for most people. Yeah, for most people, a fat cell, sometimes students will hear that fat cells are immortal. That is not true. But they're long-lived. Fat cells will live about 10 years. And so typically, by the time, if you look at a newborn, during infancy, childhood, and puberty, the number of fat cells is going up, up, up, up, up.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Once they finish puberty, so mid to late teens for a young woman, late teens or even early 20s for a young man, usually at that point, the number of fat cells they have is going to be very static.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Exactly. That's exactly right.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
In fact, it makes things worse. Please, let's make sure we come back to that. Because it really becomes, the person ends up, their vanity ends up really ruining their future metabolic outcomes. But there are differences across ethnicity. This is a little oversimplified, but not much. On one end, you'd have Caucasians, kind of Northern European Caucasians.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
On the other end, you'd have East Asians, like Chinese, Japanese, Korean, East Asians. And then if you look at that same spectrum of people making fat cells through their life, an East Asian will be making fat cells and then stop right about here. So very few fat cells, relatively speaking, across all the ethnicities, they have very few fat cells.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
A Caucasian on the other end of the spectrum, they went way higher. And so this guy, let's say American Ben versus Chinese Ben, overly simplified. But here we are. So much of fat mass isn't the number of fat cells, even though American Ben has more. It's the size of the fat cell.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So I could be the same percent body fat really as Chinese Ben, but that would just be because my fat cells were just that much smaller. But this is the problem then. If you have – let's say American Ben and Chinese Ben both gained 10 kilos of pure fat over the next 10 years, very easily done. Most people do that quite often.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And the conventional clinical care will look at these branches and give someone a prescription for a medication, which is only going to prune the branch back a little bit, never actually solving the problem. It can just grow right back.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Caucasian Ben just doesn't look as good in his Speedo, which as a pasty Caucasian, he's not going to look particularly good in that Speedo anyway. But I just am bulging a little more than I was before. But otherwise, I'm healthy. My blood pressure is fine. My blood sugar is fine. Everything is normal.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
put that same 10 kilos of fat on Chinese Ben, hypertension, type two diabetes, fatty liver disease, infertility. And that is because Chinese Ben had fewer fat cells to start with. And so those fat cells, as the body was told to store fat, those fat cells were getting much, much bigger, much sooner. And the fat, fat cell, promotes insulin resistance very, very readily.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so that logically moves into the question of, well, what makes fat cells grow? And it is two essential variables that we only ever look at calories And yet, if you take a person with type 1 diabetes and say, I want you to eat 10,000 calories, but don't give yourself your insulin injection, they cannot gain weight.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It is literally impossible for the type 1 diabetic to get fat if they are skipping their insulin injections. In fact, this is so known that if you take, let's imagine a young woman who would maybe have more pressure to be thin than her male counterpart, although it's happening more in males too. Imagine a young girl who gets diagnosed with type 1 diabetes at the age of 13 or 14.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Very impressionable time. She's very worried about how she looks and how thin she is. She learns that, wait a minute, I can eat whatever I want, and all I have to do is not inject my insulin, and I'll be as skinny as I want. And it works. It works so well that it's actually a formal eating disorder called diabulimia. So the fact that this exists is absolute proof.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
that the growing and the shrinking of the fat cell is more complicated than just calories being high or low. Because like I'd said earlier, when I talked about hormones, hormones are a way for the very tissues of the body to know what it ought to do with energy. And so a fat cell will have energy all around it. And if it doesn't have insulin to tell it what to do, it won't do anything with it.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Or maybe to make this more direct, back home in my lab, My students are growing fat cells in petri dishes. These fat cells are swimming in a little sea of calories, lots of glucose, lots of fats, and yet they stay really small until we add insulin. The moment we add insulin into that little petri dish, if we check those cells four hours later, they're immediately fatter.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so we can look at most of these chronic diseases that are killing us globally and then say, OK, there are, in fact, some simple lifestyle changes that can be implemented that will help reduce the risk of not only one or two, but all of the top killers from things like Alzheimer's disease to heart disease to type 2 diabetes to liver failure or fatty liver disease.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
If we check them four hours later, they're fatter still. Now they know what to do with the energy they have. So with slow insulin resistance, it develops when fat cells get really, really big. Because they have to tell insulin, insulin, you are telling me to keep growing? I can't keep growing. I'm so big that I'm going to pop.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I mean, literally, the fat cell can get so big that it degrades its membrane. It's like a water balloon that a naughty little boy has overfilled and it's about to burst. The fat cell doesn't want to burst. And so it tells insulin, insulin, you are trying to make me grow. You're telling me to grow. I can't listen anymore. I'm becoming insulin resistant to stop growing. So insulin makes you fat?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Oh, very much. Now, if you, so a moment ago, I said that the big fat cell is two variables. You must have both. You must have both a signal to tell the fat cell to get big, which is insulin. It is the, there's no other signal that can do it. You can, in a human, just simply take away the insulin, like type 1 diabetes. It doesn't matter any other hormone in the body. It does not matter.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
They cannot get fat. Again, they can eat 10,000 calories of chocolate cake. They cannot get fat. Not only can they not get fat, they can't hold on to their fat. Because if there's no insulin to tell the fat cell to hold on to it or get big, it has to shrink. It's breaking down its fat.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So the body goes into such a dramatic fat-burning state in the absence of insulin that keeping fat becomes impossible. So the insulin signal is necessary to tell the fat cell what to do. But the fat cell will say, okay, insulin, you're high, you're telling me to grow, but what am I going to grow with? That's where the calories come in.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Now the fat cell will say, hey, fats and glucose in the blood, insulin has told me to get big and so I need to pull you in to help me grow. You're going to give me the bulk. And if you have one without the other, it is death.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah. Yeah. So your body – now, it would partly depend on – there are people where if all of your fat cells had reached its maximum point, then you're done. You're not going to gain more fat. You're just going to become more and more and more insulin resistant.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So you kind of start limiting yourself. But there are studies in humans to show that if you give humans isocaloric meals, so the exact same number of calories – but in the same amount of protein, but you differ those meals based on the amount of carbs to the amount of fat. So let's say two meals, exact same calories, 2,000 calories, or in one meal that's too high, 1,000 calories in one meal.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
One version of this is the conventional way of eating, which is lower fat, higher carb. The other meal, same number of calories, but it's lower carb, higher fat. This lower carb, higher fat version will have a lower insulin response And they will store less fat from that meal. And someone would say, well, where do the calories go? It's the laws of thermodynamics. You can't destroy energy.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
The metabolic rate will go up. So when insulin is low, if you have someone going a full day, eating the same number of calories but lower carb calories, their metabolic rate will be almost 300 calories higher in that day. A metabolic rate is the... Yeah, that's the total amount of energy that it just costs you and I to just live.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
We risk going through the day. But that's a significant amount. If you and I were to go exercise and say, let's go burn 300 calories, we've got to be on the stair stepper for an hour or something. So it's 300 calories. But at the same time, if your insulin is low... you're burning so much fat that you start making ketones.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
all of them share a common metabolic core. That's my mission.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And I don't intend to get onto that topic quite yet, but suffice it to say, every molecule of a ketone has a caloric load roughly similar to glucose. And what the body, when it starts making a lot of ketones, it starts eliminating the ketones. So every time someone is breathing out ketones, they're literally breathing out calories.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Or they're urinating, and they're urinating out ketones if they have higher ketones in their blood. They're urinating out calories because ketones have energy. And so this is the way that if insulin is low, it becomes impossible for the body to hold on to its energy.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It is so determined to spend energy that it will both increase metabolic rate and it will make the energy, the calories be wasted in the breath and in the urine and in the form of ketones because ketones have calories. Ketones are energy. Now we're just dumping them out into the universe.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, it's a little-known problem called insulin resistance. In fact, when I first started... this topic, I stumbled on one paper that documented how when fat tissue is growing, it increases the risk of type 2 diabetes. That was this concept in the early 2000s that was really getting a lot of attention. Diabesity, this kind of dual epidemic of wherever we see obesity, we see more type 2 diabetes.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
There are some theories that are very interesting that attempt to explain why is it that we became so fantastically different from, let's say, our closest animal relatives, other primates like chimpanzees or apes. What was the difference that had us become so different than them? One of the leading theories is a theory called the expensive tissue hypothesis.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And it actually does have something to do with ketones. In the expensive tissue hypothesis, as the theory goes, Our earlier ancestors deviated in this kind of animal family line because we started eating more meat.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
We started eating food that was so nutritious, so nutrient dense, so loaded with good calories and all of the fats and proteins that we need that it allowed two very distinct changes to occur in us compared to other primates. One, our intestines became significantly shorter.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So if you compare the human digestive tract to any other primate animal, if we are a primate, then if you look at the intestines, they're fantastically different, particularly the large intestine or the colon. Because our ancestors, as the theory goes, began eating meat, we didn't need the colon as much. Because the colon is a place for food to ferment, right?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so if you're eating a lot of plant matter, like other primates do, you need a much, much larger colon. So we started eating food that was so nutrient dense, our colon shrunk considerably. We didn't need to waste energy on a big, busy colon. At the same time, as we were eating food that was so nutrient dense and so loaded with good fat,
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It allowed us to have more time to be curious and explore. And so at the same time, our intestines were shrinking because we didn't need them to be so big. Our brain was growing. And it's because it had so much nutrition, including ketones. So ketones are an extraordinary fuel for the brain. In fact, one of the reasons why a baby that is born premature –
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
will be more likely to have learning disorders later in life is because premature baby didn't have time to get very fat. And fat baby is healthy baby. And fat baby gets into ketosis. Let's say you and I were to fast straight for two days.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
If you took a six-month-old baby, that baby would be in a deeper state of ketosis in two hours than you and I would be in two days because the baby is burning so much of its beautiful chubby fat. And the more the body burns fat, the more it makes ketones. And the tissue of the body that appears to benefit the most in response to ketones is the brain.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
The brain, the moment ketones hit the blood stream, the brain immediately starts taking in ketones for a fuel. Very often, I have students who have had a professor, perhaps with the best of intentions, but ignorant nonetheless, tell the student that the brain, the main fuel for the brain is glucose, that the brain prefers glucose.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And I show them just one or two papers to prove that wrong immediately. And it is reflected in this idea, which if to use some convenient UK units, if blood glucose is 5 millimolar, that's a concentration, a way of measuring an amount of something. Blood glucose may be 5 millimolar or 80 milligrams per deciliter for the American audience. That would be a normal glucose.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And if you and I were to fast for 24 or so hours, we may get up to about 1 millimolar of ketones. And yet even then, the brain has already switched to get the majority of its energy from the ketone. And so don't tell me that in this dynamic, the brain prefers this one because this one's five times higher than this one.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And even in that scenario, the brain is already getting more than half of its energy from the ketone. So all of this is my long-winded way of saying when we look at the principles of evolution, one of the leading theories is this idea that we began eating essentially a meat-heavy diet that, again, is so nutritious that it allowed our brains to grow.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Maybe one final point on this, although it is a bit of a barbed comment. People may find this somewhat amusing or disappointing or frustrating. The title of a book just published, which is that vegetarians have smaller brains. This is seen in humans, that the less a human eats meat, then the smaller the brain becomes.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And this manuscript outlined something that was to me a revelation at the time. It was so fascinating where when fat tissue is growing, it starts releasing pro-inflammatory proteins. That inflammation caused a problem called insulin resistance. And then that got me into this realm of understanding that other tissues of the body, as they become insulin resistant,
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
The brain is so dependent on the nutrient density that comes from animal-sourced foods that it will suffer when it doesn't get them.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It is, and you can cut it out. But it really is. It's a real thing. And why does depression go up so much when people stop eating animal source foods? It's because you are depriving the brain of what it needs.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, yeah. So at least, among other things, at least it would be the essential omega-3 fats. So there are three omega-3s, and we can only get one from plants, but it's one that the humans don't use. We need the other two, and they only come from animal source foods.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Absolutely. Yeah, you can. So the solution in that regard is the vegan must be educated enough to know what they're deficient in, and then wealthy enough to afford the supplements to make up for it.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Oh, yeah. In fact, it's funny that you bring the question up again because I realize I didn't quite answer it that way. So insulin resistance, why would it exist at all? It would probably be a way for the body to know when it was needed to hold on to energy a little better.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So now I say that now and someone would think, well, but you just why would I want to hold on to energy in a way where it's causing hypertension and Alzheimer's disease and increasing the risk of heart disease? Not all versions of insulin resistance are negative. So all the insulin resistance that you and I have been talking about is pathological insulin resistance or harmful insulin resistance.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Insulin resistance that serves no good purpose and it's making us sick. However, there is insulin resistance in human development, which is physiological or helpful. It's supposed to happen. And that is the two P's of physiological insulin resistance, puberty and pregnancy. Because in both of those instances, as we outlined earlier, when the body's insulin resistant, insulin is high.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And by regaining control of your insulin levels, he says you can regain control of your life. Insulin is a hormone that affects literally every single cell of the body. But if those cells become insulin resistant, you start to spread the disease. For example, they call Alzheimer's insulin resistance of the brain.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
That's not always bad because insulin wants things to grow. It is like a fertilizer in the body. Now, sometimes it's misplaced and results in problems like increasing the risk of cancer, for example. But in other instances, if you have a young child who needs some explosive growth during puberty, well, then that's really helpful.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Insulin's telling the body to store more energy, to build up tissues, including muscle and bone, but also including fat.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yes. So in the woman, after she's finished puberty, the only other time of growth she'll ever have will be pregnancy. And so those are the two instances where the body has become insulin resistant to take advantage of the heightened scenario where it can grow. Because the woman's body needs more fat. Goodness, yes. Yes.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So her body not only needs to grow tissue mass, like the uterus has to get much bigger. She has to grow a placenta. She also needs to become a little insulin resistant to give a little more glucose to her baby because she is, after all, now living for two people. And so as her body becomes insulin resistant, it actually facilitates the growth of the baby a little more rapidly.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But as you noted, it helps her store more fat. And progesterone is another hormone that even accelerates that process. But basically it's her way of – her body's way of saying, hey, I am committing to growing another human and it's going to be metabolically very demanding.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so I'm going to have as much extra fat or as much extra energy as I can in order to ensure that if there's any sort of scarcity in food that happens during the course of the pregnancy, I'll have enough fat.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
then you start to spread the chronic disease. And essentially coming to the conclusion that something like hypertension, high blood pressure, which is the most common cardiovascular problem and the main contributor to heart disease, Well, insulin resistance is the main cause of hypertension. They call Alzheimer's disease type 3 diabetes, or more accurately, insulin resistance of the brain.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
energy to get through it all and then maybe i'll even have enough to continue to feed the baby with lactation after the baby's born what is gestational diabetes yeah it's a great question gestational diabetes is essentially type 2 diabetes of pregnancy so it's perfectly timed question because if you look at the average woman who is very healthy very insulin sensitive at the beginning of her pregnancy so glucose is normal and insulin is normal
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Over the course of her pregnancy, she stays normal, healthy pregnant woman, which is to say she has physiological insulin resistance. She doesn't get diagnosed with gestational diabetes, though, which means her glucose is normal. But to keep her glucose normal, because she is insulin resistant, but for a purpose to help her body grow, her insulin levels are high.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And then the glucose is still in a normal range. And then in some women, especially if she has a family history of type 2 diabetes, the insulin resistance goes too far. Now she has high insulin, like all pregnant women do, but she's not able to keep her glucose levels in check.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Absolutely. So then she will go from the normal insulin resistance of pregnancy into the insulin resistance of diabetes. So it really is like type 2 diabetes, but a microcosm of it, a mini version that was really instigated or initiated because of the pregnancy, combined with a bit of a genetic predisposition, combined with her eating the worst possible way.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Oh, for sure it does, yeah. So think about, it's almost like the baby is literally developing in a hyperglycemic, hyperinsulinemic environment. So the baby gets hardwired to want to continue to exist in a state of high insulin and high glucose after the baby is born.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so, yes, the offspring of mothers who have gestational diabetes are significantly more likely to gain weight and be chubbier or fatter than their counterparts and to later develop type 2 diabetes. A resounding yes.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yes, I mean, a significant thing. And I say that with all of the sympathy I can for the mother who may be struggling with this. But it is certainly a motivation for mom to just be mindful of what you're eating.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah. Yeah, yeah. A few thoughts come to mind. Whenever I see these kinds of reports, I always make sure I look firstly at the, what are they actually measuring? So just to set the stage, this is the number of women who are being diagnosed with cancer. So not dying from cancer, but it's going up. So one simple explanation, although perhaps the most disappointing,
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
could be that more women are going in for testing younger. And so we're just seeing kind of an artifact of more women are just going in sooner and they're detecting a problem that they wouldn't have otherwise detected, you know, for 10 or 20 years, which is a good thing. You want to detect cancer as soon as possible.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So that's the boring answer, that it could be a reflection of just more women going in for ultrasounds or MRIs or mammary scans, whereas men don't ever get tested for anything. which is why we die more from everything possibly. But to give a more exciting answer, this is very, very likely almost entirely driven by breast cancer. Breast cancer is the main cancer for women by far.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so if I had to guess, I bet almost all of this increase in cancer incidence is because of breast cancer. Why might that be going up? I would suggest there's probably a couple instances. One, although people might not appreciate this, is that one of the best ways for a woman to reduce her risk of breast cancer is actually having babies.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Even the most common forms of infertility, in men, it's erectile dysfunction. Well, that's because of insulin resistance of the blood vessels. In women, the most common form of infertility is polycystic ovary syndrome, or PCOS. That's because of the insulin resistance affecting her ovaries and the ability to produce the proper sex hormones.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It's very well known, very well documented, that if a woman has babies and breastfeeds, her risk of breast cancer goes down. So yeah, in fact, it's very meaningful. I actually don't know the reasons for it. It could be the changes in estrogens during lactation phase.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Oh, yeah. I promised I was going to talk about that. I wouldn't leave that.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah. So as childbirth rates are going down, it does increase the risk of breast cancer. Now, I'm a cell biologist, right? I like to understand a direct mechanism. And so as much as I invoke the perhaps lower rates of childbirth among women, I don't know the mechanism. So I'm sort of loathe to describe it. The mechanisms I'm very familiar with are the metabolic mechanisms.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Which is if you take a breast tissue that is tumor tissue and compare it to – like if you take a breast tumor and compare it to the normal tissue right next to it, like that it would have shared its origins with, the cancer from the breast will have seven times more insulin receptors than the normal breast tissue. Okay.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So the idea of this tracking quite nicely with obesity rates going up over the past 20 years, I wouldn't say that it's the obesity per se, but I would say it's the entire metabolic milieu, which is the insulin resistance, that as much as the high insulin is promoting fat cells getting bigger, that high insulin is also accelerating the growth of the tumor cells.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Because again, one of the main mutations in breast cancer is a seven-fold, so a seven times increase in the number of insulin receptors. And insulin wants to tell things to grow. So it's no surprise that almost every tumor that's ever been measured for having insulin receptors will have a lot more.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It's basically telling its neighboring cells, insulin is going to come by and it's going to tell us all to grow. I want to grow more than you. And that's what cancer is. Cancer is growth, unregulated growth. Insulin tells things to grow. So the connection between obesity with the rising incidence of breast cancer is very, very likely a consequence of the rising incidence of insulin resistance.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Oh, yes. Yeah, it is. In fact, it went from not being even on the radar to being a top 10 killer. Now, it's interesting how people even die from Alzheimer's disease. It's a very kind of vague death. But yeah, Alzheimer's disease is one of the top 10 diseases now, certainly in the West. And I would argue it's because it has a metabolic origin.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Oh yeah, for sure. Insulin resistance is, it's kind of a, it's a disorder that has two parts. It's like a coin with two sides that as much as we think of, we think of one side just because we hear the word insulin resistance, but there's another part to it that I need to, that is very important. So insulin,
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
One of the interesting things about Alzheimer's disease is we have spent... billions of dollars on Alzheimer's research trying to identify the plaque. So just to set the stage here so that people listening can appreciate this paradigm shift that's occurred in Alzheimer's research.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Originally, and even in many people still, people thought that Alzheimer's disease is the result of these plaques accumulating in the brain. these kind of little proteinaceous, little thick things that are preventing neurons from sending the signals throughout the brain for the brain to think and have normal cognition.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And yet there are those of us, and I'm proud to say I have long been one of them, who has said that the plaque-based theory doesn't make sense. We have had drugs that have been available for human use for years that have effectively reduced plaques in the brain and yet did nothing to improve cognition. So that is an immediate challenge of the plaque-based theory of Alzheimer's.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Even further, even beyond older than that evidence, when you would look post-mortem or look at tissue donor people who'd passed away, you would look at the brains of people who died with confirmed Alzheimer's disease at the time of death and look at the brain of someone who died without any evidence of any cognitive decline or any compromised thinking whatsoever.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And you would be just as likely to find plaques in both brains. So whether the brain had Alzheimer's disease or not, you would still see plaques in the brain. So the whole idea that plaques mattered has long been controversial. And just to put a fine point on it before transitioning to the metabolic origins, about two or three years ago,
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
they found out that the very first published papers that implicated plaque as a cause of Alzheimer's disease were based on fabricated data. So the scientists who published those first reports that led to the entire theory that Alzheimer's disease is plaque-based were called out as fraudulent. And indeed, all of it was fabricated.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So the entire idea that Alzheimer's... And we have spent billions of dollars on studies to try to determine how do plaques cause Alzheimer's disease? Why, when we reduce plaques, it doesn't appear to help the disease? Because the plaques had nothing to do with it. That's just something that some brains have.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Some brains have more of these little specks than other brains, and they don't contribute to Alzheimer's disease at all. Now, what kept rising to the top, and I would hope now is the dominant theory, is that people with Alzheimer's disease almost always have some detectable instance of insulin resistance, if not full-on type 2 diabetes.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Now, I will say personally, I don't like the term type 3 diabetes because it makes it sound… like it's a whole new version of diabetes. To say it more succinctly and accurately, it is simply insulin resistance of the brain. And the brain is a very hungry organ.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Insulin, first of all, is a hormone that we make from the pancreas, a long kind of gland tucked underneath the stomach. And the pancreas is a very busy organ. It makes a lot of different hormones. It makes hormones that come into the blood. It also makes enzymes that go into the intestines to help digest food. But among the hormones that are being released into the blood is insulin.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It is in what I teach as a trinity of high metabolic rate organs, that there are three organs in the body whose metabolic rate is so high that it just really sets it apart from everything else. And the brain is one of them. The brain has a very high metabolic rate. So this is a very hungry organ that needs a lot of energy all the time.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But the brain is unique in that it primarily will only use two fuel sources, and I've mentioned them, namely glucose and ketones. But glucose, in that section of the brain that gets compromised with Alzheimer's disease, the glucose can't just come straight in. It needs someone to open the door for it, and that is insulin, of course, just like we described with the muscle cell.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
where in order for the glucose to go into the muscle, insulin had to come and knock on the door, if you will. And then the muscle, being a polite, responsive host, would open and allow the glucose to come in. The brain is similar, that in that section of the brain, it has doors that need insulin. It's locked until insulin comes and opens them.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So even though glucose levels may be high in the blood, like in type 2 diabetes, you would think, well, the brain can just get all the glucose it wants. And yet it cannot because it has insulin regulating the entrance of the glucose. And if the brain is insulin resistant, there's not enough glucose coming in.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And thus the brain is forced to rely on the only other fuel that it can rely on, namely ketones. But the same person who's eating all the time to keep their blood glucose high all the time has so much insulin in their blood that they're never making enough ketones to fill the gap. Mind the gap. And the brain has an energy gap now where the brain needs an amount of energy.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I'm kind of acting it out for those that are watching. But the brain has a certain energy demand that it needs. And if there's a lot of glucose in a healthy insulin-sensitive person, glucose will fill all of that need. But as the brain becomes progressively insulin-resistant, it cannot get all of its energy from glucose, and thus there's an energetic gap.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And in the absence of ketones, there's nothing to fill that gap. And the brain says, well, I don't have enough energy to keep functioning as well as I did before, so I have to reduce my function, which manifests as a reduction in the ability to think and process. In other words, cognition goes down. But what's so interesting...
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
is I just got finished describing a scenario that scientists refer to as brain glucose hypometabolism, or a reduction in the amount of glucose the brain is using. There are scientists that measured this.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
We don't in my lab because we don't do these kinds of techniques, but you can actually infuse people with the glucose that you can take pictures of and see how much the brain is taking it in and metabolizing it. In Alzheimer's disease, the brain is not getting as much glucose. So they call that a hypo or a reduction in metabolism of glucose.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And as much as you and I are describing that scenario as relevant for Alzheimer's disease, you can essentially open up the book of neurological disorders and see the same thing. Depression has a brain glucose hypometabolism to it. Migraines have a brain glucose hypometabolism. Epilepsy and Parkinson's disease.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So all of these disorders of the brain, of the central nervous system, the one thing they all have in common is the brain isn't getting enough energy from glucose. And another way of saying that is the one thing all of those seemingly unrelated brain problems have in common is that they all have some degree of insulin resistance.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Now, in the person with type 1 diabetes, their immune system has destroyed their beta cells, so they don't make insulin anymore. That's why for a person with type 1 diabetes, insulin is a life-saving therapy. You're giving them what they're not making anymore. But for everybody else, we have beta cells, and they're releasing insulin when they need to. Now, usually the main stimulus is
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But then it's no surprise that they all benefit when ketones can swoop in to save the day. But that only can happen if the person is giving their body a break from the insulin long enough to actually start making ketones better.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, again, I don't love the term, but I appreciate the use of it, which is it does suggest a metabolic origin. But even you look at those ranges, Stephen, you'd say, well, one was 40, one was 80. Boy, what a difference. I suspect a lot of that is just how did they measure insulin resistance?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
If they were looking at the glucose like so many do, you're just going to miss a lot of people.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Well, yeah, and that's just that's right. That's because there's not enough training, which is at the beginning of the conversation, you asked my mission. One of my missions is to help people learn what to look for.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, they need to be looking at insulin.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Well, it is technically easy to measure. It's just that we don't have enough systems in place to enable it. Like, again, if someone listening in the UK were to go to their GP and say, can you measure my insulin? In many instances, they literally can't get it done. The system just isn't in place to take it to the lab and measure it. Now, some do.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I know some physicians in the UK who do so, and they have developed their own way of getting it done. And they're incredible advocates of this whole idea. But it is harder in the UK and Canada, where the system is such that they have said, out of ignorance, but perhaps well-placed or well-intentioned, they will say, well, insulin isn't a marker that matters. It is.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And if you're measuring insulin resistance, just to put things back to where we had talked about it earlier, many people with insulin resistance have normal blood glucose levels. It's the insulin that's high. And so I would say if a person can get their insulin measured, get it measured. In US units, if it is anything above about 10 microunits per mil, that's a warning.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
In UK units, if it's anything above about 40 picomoles, that's a warning. Insulin is high. You could have insulin resistance.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yes, especially depending on the ethnicity. Like if someone listening to this is East Asian and they say, well, I'm quite thin. I don't have insulin resistance. You very well could. It depends. Even in young women, a group out of northern Canada, which is, of course, pretty far north, they found that even in young, healthy weight women with PCOS,
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
If they compared them to their – identically matched other women without PCOS, they were more insulin resistant than the other group. So anyway, that's my way of saying even if you look at yourself and think, well, I'm kind of lean. I'm not insulin resistant. You very well could be.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Oh, for sure. And in fact, I wouldn't be surprised if she does because the fact that she has PCOS is not absolute evidence, but very likely evidence that she has insulin resistance, which would mean at any given moment, her insulin is at the risk of being a little higher than her non-insulin resistant counterparts. So if she goes and gets the test done... I bet her insulin would be high.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
The main reason the beta cell is releasing the insulin is because blood glucose levels go up.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so all that would mean is... Which is good. I mean, knowledge is power. And my hope would be that as someone goes and gets their insulin measured, and there are a handful of other tests they could also look at, but that's the most succinct, then it would be all the more impetus or encouragement to say, OK, I listened to Stephen and Ben. I really do need to start making some changes.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And even the most common forms of infertility, erectile dysfunction and PCOS, insulin resistance is a heavy contributor. Now, 88% of adults in the US have some degree of insulin resistance. And people hear this and think America is just fat and metabolically sick. But we're not actually the worst country when it comes to this. And part of it is because of how different ethnicities store fat.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And even in PCOS... there are reports that document the absolute reversal of the disease with nothing more than just dietary changes.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Well, the second part of that statement is not true. They're more resistant to obesity... But they are, like, it's an interesting dichotomy.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
You eat sugar or not even something as obvious as sugar, but bread or crackers. White rice. Chips. Oh, yes, yes. So basically anything that falls into the family of a carbohydrate. So if the earth grows it, that's a carbohydrate. If it's a plant, it's a carbohydrate. Maybe that's a better way of describing it.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, so to find a Japanese man who's as fat as the average American, boy, you're going to have to look. It's hard. It's hard. But to find a Japanese man who is just as much likely to get diabetes, type 2 diabetes, very easy.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, so on that ethnicity, now there's a lot of kind of wiggle room here, but on one end we'd have Caucasians, blacks would be right nearby, African ethnicities would be quite close to the kind of Northern European ethnicity. And then we would move through, and I don't mean to miss anyone here, but on the other end it would be East Asian, and then sprinkled through that would be Latino,
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Latino would be somewhere in the middle and Hispanic and then other Southeast Asian and then East Asian kind of on the worst end or the least sensitive or the most sensitive to their fat, the most sensitive to their fat. This actually is a concept that has been presented called the personal fat threshold.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
which is this really interesting idea born from a group in Australia suggesting that across every individual body, which of course is heavily influenced by both ethnicity and sex, like we'd mentioned earlier, a body is going to have a rate at which it can store fat in a healthy way. And then once that threshold is met, any further pressure to store fat will start creating insulin resistance.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And that threshold is essentially How many fat cells do you have and how much room do they have? So if you have more fat cells, you have a higher fat threshold. You can get fatter before it starts to hurt you.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, so Caucasians, so let's say Northern European, African, both store more of their fat subcutaneously, which is the fat just beneath the skin or the fat that you can pinch and jiggle. That has an ability to expand more because there's nothing really to limit it.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
However, the other place for people to store fat is their visceral adipose, which is the fat that is tucked within the abdominal cavity, so tucked around the organs. It's sort of surrounding the kidneys and the intestines and the liver. That is an unhealthy place to gain fat. But in East Asian, all things equal is putting much more fat there than they are subcutaneously.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
The advantage of subcutaneous fat is... Which is the fat on the outside. Yeah, so the fat beneath the skin. Yeah, the loose belly fat, the fat that can pinch and jiggle. That fat has a greater ability to make new fat cells. So as much as earlier you and I said fat cells remain static, for the most part they do. There's a little bit of wiggle room where it can go up.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And that's purely subcutaneous.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so it's going to have starches and sugars, which all kind of falls into this family of carbohydrate. Depending on how much starch or sugars that it has, then that will result in a bigger or smaller blood glucose or blood sugar response. But then if blood sugar is too high for too long, that becomes very harmful to the body. So insulin comes in and helps lower the blood glucose.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yes, and so the problem with visceral fat is this is such a finite space. There's so little room within the core of your body that if we allowed those fats to multiply, it could theoretically start physically compressing on tissues. Right. And so those fat cells only grow through hypertrophy, which is the thing we talked about earlier with slow insulin resistance.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Subcutaneous fat cells are more abundant, but smaller. Visceral fat cells are fewer, but much larger. And so any ethnicity, including Hispanic or Asian, that promotes relatively more fat storage in the visceral space is going to suffer from the consequences of that fat much sooner. And again, it still comes back to size. The bigger the fat cell, the sicker the fat cell.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Although over the past few years, life expectancy actually turned down for the first time in the So who knows if it will continue to go up. But yeah, it could be people are living longer. I mean one of the effects of modern medicine is that people live longer with disease, Alzheimer's included.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But it's absolutely a consequence further of our overall metabolic milieu that we put ourselves in a position where we're making our brains insulin resistant and thus they're going hungrier and hungrier.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, in the animal that received it.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, so just to be clear, if we took... What they did in this study, just to reflect why the different depots of fat are harmful. And so the human body has two distinct fat depots. And you and I described them. Subcutaneous, which is the fat beneath the skin. Or visceral, which is the fat tucked within the organs of the abdominal space. And if you move subcutaneous fat...
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
The belly fat, and from one animal to another, you couldn't do this in humans. If you move belly fat, if you will, or subcutaneous fat from one animal to the other, the animal's very healthy. It's no problem. Subcutaneous fat is inert. It really is just sort of hanging out there and minding its own business.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But in that same study, if you move the visceral adipose over, now all of a sudden that animal that got that extra dose of visceral fat is going to become sicker. It's going to become more insulin resistant and diabetic because you've increased its visceral fat, the amount of fat that it has in that space.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
The body wants to limit the amount of fat that it has there because if the fat, again, if the fat grows too much, you can physically start compressing and squishing organs that you need to be functioning, like the kidneys and the intestines.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I have. I don't know him personally.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Right, right. Well, I want to address this because this is a real person, so I want to address it very politely and diplomatically. I think that I want to distinguish the difference between longevity research and science, which is a very real, living, breathing field, and I'm proud to know individuals who are longevity scientists, and distinguish them from…
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Longevity, you said poster child, so the gurus of longevity, and that's not the same thing. So what I say, I don't mean it to be an indictment of longevity research, but I don't mind if people hear a bit of an indictment in my voice of the modern longevity guru approach.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So these individuals, and he is certainly the most well-known, they do have the advantage of never really being able to be proven wrong. So there's an inherent problem here. But I will say that the application of being a longevity expert or not a scientist, but a guru, and I don't mean for that to be negative, but it does have a bit of a negative sound to it, is that you have to rely on
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And then having done its job, insulin comes back down.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
what I would call weak evidence. Now, what do I mean by that? So all of the approaches to longevity nowadays rely on either correlational studies or basic research or animals and insect studies, and then extrapolating that results or assuming those same results will apply to the human. So let me briefly just mention my concerns with correlational research. So the longevity guru will say,
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Correlational evidence suggests that people who eat meat die more. Well, a correlational study is, by my estimation, some of the weakest evidence that you can ever generate. A correlational study would just have someone come to your home and say, Stephen, can you please answer this survey about what you eat? You answered the survey. You may lie. You may not remember.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
You may have things that you don't even think about including, like, for example, that you're part of a very well put together religious organization. And I actually use that example very deliberately because people who are known to be – part of good, tight social circles like a formal religious group, always live longer than people who don't. Maybe you're really lonely.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Loneliness is a greater contributor to death than cigarette smoking, and it's not even close. So there could be things on that survey that you just cannot capture. And yet we end up making a conclusion. And so all of that correlational evidence is deeply flawed research. And yet that becomes the basis for the longevity guru to determine diet.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Perfect. It's like a taxi. Yeah, that's right. Look, it's a shuttle. It's a taxi saying, hey, glucose, come on in. I'm dropping you off at the muscle. So mostly, just as an interesting tangent of insulin before I finish answering insulin resistance, insulin will open the doors for blood sugar to come in and drive the taxi in, mostly at the muscle and the fat.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah. So my view on longevity is a metabolic view. No surprise. I'm a metabolic scientist and I don't mind someone sort of smirking at me declaring that or admitting it. But I'm somewhat justified. Just by way of setting the stage, the earliest, the birth of the modern longevity research If it didn't start, it was heavily influenced by the work of a woman named Cynthia Kenyon, K-E-N-Y-O-N.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Cynthia Kenyon was one of the kind of – she really did in my mind kind of give birth to the modern longevity focus. What her lab found using an insect model, and this is again a problem with the longevity gurus is that they rely on insect data, for example, but it was compelling what she found. I think it was worms.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
She found in worms that if they restricted the glucose that the worms were eating, they would live 50% longer or some fantastic increase in how long the animals lived. That kind of gave birth to the idea of fasting being beneficial. But it also allowed her lab to start playing around with some of the genes of these little insects.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And when they started knocking down or underexpressing some of the genes involved in insulin, they didn't have to restrict the food. The animals just lived longer. And so that touches on this metabolic aspect. And everyone nowadays is really interested in autophagy. Autophagy is a term for a cell essentially cleaning itself out.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, that's... Yeah, yeah. In fact... Yes. So that is partly why fasting has been so embraced within the longevity community. It's because if you can promote longevity or autophagy, rather, if you can promote autophagy, the cell keeping itself cleaned out, that is thought to be a key contributor to longevity. So autophagy equating to longevity. I don't disagree with that.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I think that probably is a very valid view. Then the question comes, well, how can I control autophagy? Well, there is a humble hormone that comes from the pancreas that has a very powerful effect on autophagy called insulin. So as much as people are fasting, what's the value of fasting and reducing autophagy? It's because insulin comes down.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Now, what becomes interesting is what happens if you were to put someone, allow them to eat calories, but the calories are such that their insulin is staying low. and they're making ketones, in other words, a ketogenic diet. You also enable autophagy. There was a very well-done animal study finding that they didn't have to restrict calories and fast the animals.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
They could let the animals eat as much as they wanted, but it was a ketogenic diet. They lived significantly longer than their other littermates that were eating the normal high-carb chow, similar to what humans eat nowadays. And so autophagy probably does matter for longevity. all the more reason to keep your insulin in check because insulin is a powerful inhibitor of autophagy.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So as much as we have longevity gurus who are taking thousands of dollars worth of supplements, I can't help but look at that and think, just control your insulin. That within every cell, there's this battle. There's a yin-yang of growth and death or building and breaking, to say it a little more politely. In fact, that is metabolism.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
The very word metabolism encompasses anabolism, which is anabolic or building up, and catabolism or catabolic, which is breaking down. The key to a healthy, growing, living cell is this nice ongoing balance of build and break, build and break. You have to build something up and then modestly break it down, and then you build some things up again.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Muscle and fat tissue need insulin to come and bring the sugar in via taxi. However, other tissues, and the brain a little bit as well, other tissues will still respond to insulin, but they don't need insulin to tell it what to do with the sugar. It just takes it in. But even on those, like the liver, for example,
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And autophagy is a very important part of that breaking cycle within the cell, that, hey, it's time to get rid of some old parts and now we'll rebuild some of that again. Now we're going to break down these parts and rebuild it. Insulin is the key to that process. If insulin stays high for too long, you never allow the catabolic or the breakdown.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
This is one reason why insulin is so facilitative to cancer. Insulin wants things to grow. Cancer is a disease of growth. We don't ever let the cancer start to break down. Insulin won't let it, in part.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I have.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, we are. But rightly so. I mean, ketones are a very vilified, misunderstood part of the body. And to my great delight, it's getting a sort of new appreciation.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yes.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
That's right. Yeah. In fact, most of the longevity research was sort of a final point on this is that when you look at these studies that look back in time and say, OK, what is it about these people? What variables tend to go along with the longest lived humans?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
One of them is that they're insulin sensitive and their blood glucose levels are, in fact, a very well done study just last year out of Sweden. I think it was just one year ago. They looked at all, and Sweden is meticulous in its record keeping, which is an advantage. In a fairly homogenous society, so it kind of eliminates some confounding variables.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But they attempted to document what were the variables that were just the most consistent theme of people who lived very long. One of them was good glucose control. And this next one is very controversial because they found that they also, the longest-lived people, had high cholesterol levels. And isn't that funny?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It is one of the most consistent themes of longevity research that the longest-lived people have higher cholesterol. And yet we live in a world that hates cholesterol. And the moment cholesterol goes up, we put them on a cholesterol-lowering medication. We could be doing the perfectly wrong thing to help these people live longer.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And then low uric acid and there's a handful of other little variables that fit into this.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
That's right. That's what the Sweden study found, for example. The paper just published a year or so ago what were some of the most consistent themes. They had good glucose control and high cholesterol. I'm a great defender of cholesterol. It is a molecule of life. And so much depends on it.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Mitochondria, for example, mitochondria have to have a cholesterol molecule in them in order to work, like the very powerhouse of the cell. And the more you lower cholesterol through, say, drug interventions, the more you compromise the mitochondria. The sex hormones, all sex hormones are built on cholesterol.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It's no surprise if someone takes a cholesterol-lowering medication, their sex hormones go down. This is why some men experience such terrible loss of libido, because he's becoming low testosterone because of the war on cholesterol.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
If the liver sees sugar driving by in the taxi, it just opens the doors and lets it in. It doesn't need insulin to come and tell it to let the sugar in. However, even at the liver, and every other cell has a similar degree of this, the liver doesn't know what to do with it.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Well, as the story goes, yes, and yet I think that's overly simplified, where people will say LDL cholesterol is the bad cholesterol, And yet that gets included in these studies of longevity. So I think the good and bad aspect of it is not entirely fair or accurate. We need LDL. And LDL is just as much a component of the immune system. LDL actually helps the body fight infections.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So it's also an unsung hero of immunity.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, well, you say that, and yet maybe our anti-cholesterol view is the bizarre one. And so as a cynic who's very familiar with biomedical research, I sometimes will look at clinical markers and say, why are we so obsessed with glucose? Why not insulin? Why are we so obsessed with cholesterol? Why not triglycerides?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Which is another lipid that can be measured that is far more predictive of who's going to have a heart attack or not. And I think it's because we have chosen markers in modern medicine that we have well-designed drugs. So it's a really, really good way to sell a lot of drugs. So there's no drug that's going to address insulin. So let's not measure it.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But there are lots of drugs that will lower glucose. So let's measure glucose because then we can diagnose the problem and then we can give them a drug and make a lot of money. That's a cynical view, but I don't think it's unjustified. Similarly with cholesterol. Why look at LDL when triglycerides, another lipid marker, are a much better indicator?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It's because we don't have a drug that effectively lowers triglycerides. You can with diet, but we do have drugs that very effectively lower LDL.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, so they found that if you took healthy nonsmoking people and had them start smoking, they became insulin resistant. I believe I invoked that study in the section where I was talking about inflammation. where when you cigarette smoke that elicits, there's a lot of junk coming in and there's a powerful inflammatory response and that contributes to insulin resistance. Is this vaping as well?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Oh, that is a very good question. I have in fact published now multiple papers with a very good friend and colleague who is a lung expert at my university guided by the name of Paul Reynolds. Paul and I, we have published reports together looking at cigarette smoking and the inflammatory and insulin resistance effects that come from that.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So this is back to something I'd mentioned earlier where insulin's thematic effect at the entire body is to tell the body what to do with energy in all of its forms as these kind of caloric rich molecules, what to do with lactate, what to do with ketones, what to do with fats or glucose, what to do with amino acids. So insulin will tell the body what to do with all of those things.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And now we've even started looking at the molecules, the hyperheated molecules from vaping, and they're terrible. In fact, yes, very similar results. If you were to take a comparable amount of the chemicals from normal cigarette smoke with its filter versus vaping, the vaping ones are probably worse, chemical for chemical.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
In terms of their insulin... Yeah, in terms of their inflammatory effect, the damage to the airway, and the insulin resistance that comes from it.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It is, in part because of just how common it's become. Does smoking make us fat? Oh, that's a great question. It doesn't because it replaces other interests. So if the cigarette smoker ate the way everyone else was eating, it would. But because the cigarette smoke satisfies a craving, they have less of an interest in food.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
What's so interesting about cigarette smoking is, again, as I said, you begin to smoke, other things don't tempt you as much, like the cookies and the cakes. But one of the ways the smoker helps kick the habit of cigarette smoking is actually eating candy. Like they will literally start carrying around little candies in their pocket.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So if they feel a craving for cigarette smoking, they will take out a little candy, open it up, and pop it in their mouth. And so it's no surprise that very commonly when a person quits smoking, they gain significant weight. They end up trading out their addictions, if you will.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And unfortunately, in humans, all of the study of addictions with food, people only manifest an addiction to one type of food, and that is carbohydrate. There's no evidence of addiction to fats or proteins.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, that was one of the studies I just was referring to with regards to my colleague Paul Reynolds. Paul and I, that was one of the papers we published looking at these inhaled particulates. The reason I was interested in this field of study in the first place was just to continue to kill the caloric model of obesity. So this touches on an earlier part of the conversation.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Overwhelmingly, if you ask someone, why do we get fat? Well, because you eat more calories than you burn. Why do you lose fat? Because you eat fewer calories. And I have long just been frustrated by how naive that view is. Yes, energy matters. But again, the fat cell must be told what to do with the energy that it has.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
That, of course, points an obvious finger at insulin, which is the strongest of all signals. But what we found in that study is that even something as seemingly unrelated as diesel exhaust particles, mind you, we did not do this study in humans. Full disclosure, we did the study in animals where we could perfectly control how much diesel exhaust they're getting.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So we have this mechanism in Paul's lab where you can aerosolize these particulates and know exactly how much the animal's breathing. And then at the end of the study, even though they ate the exact same amount of food, the animals that were exposed to the diesel exhaust particulates had fatter fat cells and more insulin resistance than the animals that had just been breathing normal room air.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, in fact, this evidence would suggest that it goes beyond theory. So our evidence would state conclusively that yes, what you breathe does matter. Then theoretically, we would say, well, how much does that apply to humans? That is where it would get into the realm of theoretical. But the evidence certainly suggests that... Yes, the very air we breathe matters.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But again, its most famous effect is to control blood sugar. And that's not wrong because its most powerful activator is blood sugar. So with all of that in mind, insulin resistance is two problems wrapped into one. The one problem is the most obvious one, which is that insulin isn't working as well as it used to. So back to the analogy of the taxis dropping off sugar.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And you see this at a population level. Look in areas where there are—now, there are confounding variables here. Here I am invoking correlational research, and I was just criticizing it a moment ago with regards to longevity. But you look in areas where they have higher pollution levels, where the particulates are higher in the atmosphere, and those same areas are always fatter and more diabetic.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Interesting.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Exactly. Yes. Thank you for pointing it out. But again, as much as you and I are citing the problem with the correlational study there, we need to always cite the problem with correlational studies when it comes to informing nutrition policy, like don't eat eggs because they cause diabetes. But when you actually look at the studies, you find nothing of the sort.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah. So there are the ones that you inhale. A handful of inhaled particulates will matter. We have shown in my lab alone with my collaborators, diesel exhaust will do it, cigarette smoke will do it, and we have a funded grant right now to look at the effects of vaping. So apparently stuff we breathe will matter. to some unknown degree, things that we drink will, that are non-caloric.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So there can be, like people have heard of the microplastics. Microplastics are things that you can, they're so small that you drink them and they will absorb through the intestine and get into the bloodstream. For reasons that are unknown to me at the moment, one of the sites where those micro particles will go is the fat cells.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And once there, they will directly promote the growth of the fat cells. So that's actual microscopic segments of plastic. But separate from that are molecules that can come from plastics and soaps and detergents like BPA or diethylstilbestrol, D-E-S. That's actually an estrogen memetic, kind of what we referred to earlier with regards to other endocrine disruptors.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But there are other chemicals that a person can drink. or inhale, like I mentioned earlier, but that will directly impact the growth of fat cells or mimic what insulin wanted to do, which is tell the fat cell to grow.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
If the muscle tissue has become insulin resistant, insulin is coming and trying to pull the sugar-loaded taxi into the muscle, but the muscle's not listening.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah. So this is an opportunity for me to do a little bit of nutrient biochemistry or a little discussion of metabolism so that people appreciate what ketones even are and where they come from. So the entirety of the human body is a metabolic hybrid in that the body is largely burning fuel from two sources. It is burning blood glucose or sugar, blood sugar, or it's burning fat.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Those are the two main fuels for the body by extension. Now, the brain was an exception. The brain is glucose or ketones, but I'll get to where the ketones come from. The rest of the body isn't really relying on ketones as much. It's fats or glucose. or blood sugar. Insulin is what decides which fuel is used.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So as much as the metabolic engine has two fuel sources, insulin will decide which one is opened and which one is closed. If insulin is high, the body is sugar burning. And you can measure this in the whole body level by measuring the amount of oxygen and CO2 that the body is producing. Because different biochemistry or the burning of the fuels will produce a different amount of CO2.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yes. Yeah. So we could hook you up to something called an indirect calorimeter and measure that your RER, the respiratory exchange ratio, the balance between CO2 and oxygen would go higher. So we increase your insulin. Like if I infused you with insulin in the next few minutes, we would see that your RER would go up and we'd say, boy, you're sugar burning.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
or we allow insulin to come down and then the RER goes down, which is reflective of fat burning. So it's insulin that determines whether the body is sugar burning or fat burning. Now, when insulin has been low for about 16 or so hours, something interesting starts happening at the liver. So the liver, with insulin being low, is burning a lot of fat, including its own fat that the liver can store.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
The liver can store fat, but also fat coming from fat cells. Because if insulin is low, the fat cells are just leaking out fat to be burned by the body. And because insulin is low, the liver keeps burning it. And the liver essentially burns, continues to burn so much fat that it fills its own needs. It meets its own needs and says to itself, hey, I don't need to keep burning fat.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I have all the energy I need. I'm doing great. But it can't stop burning fat because insulin is low. And if insulin stays low, fat burning keeps going. And so... Because the body doesn't have enough glucose... Well, it's acting, yeah, so in this sense, it's doing it to help replace the glucose that isn't coming in. That's the value of the ketone.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Well, not technically. Yeah, but just to sort of go with your metaphor. But maybe to use another one, insulin comes and knocks on the doors. It's like the bouncer at the door. It's coming and knocking on the door of the muscle saying, hey, muscle, I've got some sugar that wants to come in. And normally the muscle will say, oh yeah, sure, okay, open it up the doors and let the sugar come in.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So as the liver is continuing to burn fat, it essentially gets to a point of fat burning where it's burning more fat than it needs. And that excess, if you will, is what becomes ketones. So ketones are kind of a metabolic release valve for the liver cell to say, I can't, I don't know what to do with all this fat burning. Okay, I know what I'm going to do. There's not a lot of glucose coming in.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so the brain may start to get hungry, so I'm going to start making ketones. And so ketones are nothing more than a product of a lot of fat burning. And anyone who even fasts for 24 hours, you wake up that next morning, you're in some degree of ketosis, lest anyone think it's an extreme thing. People are going in and out of ketosis, ideally, often. Now, why do I say ideally?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It's because ketones are, as we've already outlined, perhaps the best fuel for the brain. The brain thrives on ketones. You can take a person with early stage Alzheimer's disease and have them go through a series of cognitive tests and they do horribly on them. Like one example is you ask the patient with Alzheimer's to draw the face of an analog clock.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And I'll come back to that. But there's two roads to insulin resistance. So there's the fast lane. And I could make you insulin resistant in six hours with either of these common three things. But if I removed them, your resistance would go away just as quickly. Now, the slow lane, that's a problem.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
a circle with one, two through 12, and then some hands on it. And it is utter chaos. This is published reports. You then put them into ketosis, ask them, can you please draw the face of a clock? It's still sloppy, but it is absolutely the face of a clock. You ask them when they're not in ketosis to try to tie their shoelaces, they can't think through the puzzle of tying the shoelaces.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Ask them to do it again when they're in ketosis, all of a sudden they can tie their shoelaces. More than that, they can get themselves dressed. All of these are published case reports. It's just my long-winded way of saying the brain thrives when it has ketones as a fuel source. But the benefits don't stop there.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
My lab published a report finding that when humans were in ketosis, which is just a term for ketones being elevated, We pulled out small pieces of belly fat and measured the metabolic rate of that belly fat. And we found that in ketosis, the metabolic rate of that belly fat was three times higher than when the people were not in ketosis. What does that mean?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, so that means that the fat was suddenly behaving in a much more energetic way. That fat tissue has a very low metabolic rate. And then all of a sudden, when the ketones came into them, they started getting much more active and they started burning more energy, which is going to be very helpful for someone who wants to lose fat.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
If your fat cells now have a three times higher metabolic rate, that means that the fat cells are starting to act a little bit more like your muscle cells. And they're just burning more energy.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yes, absolutely. And that is what happens. There are very well done controlled studies to show that if you control for all calories, when a human is in ketosis, their metabolic rate goes up. Your whole body is just burning more. It's just everything's kind of been turned on a little more. The furnace of the metabolism has just been – you have a little more fuel kind of stoking the fire.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
When the muscle is insulin resistant, the bouncer's knocking. Maybe there's even, I'm almost getting ahead of myself, but one bouncer, maybe two or three bouncers pounding on the doors of the muscle cell, but the muscle cell's not listening. It's become deaf. That's the insulin resistance of what we call insulin resistance, where some of insulin's effects are
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So ketones will increase metabolic rate of fat tissue. We found a paper that we published documenting how we took muscle cells and kind of insulted the muscle cells to determine how tough the muscle cells were. When we incubated the muscle cells with ketones, they were much more resistant to injury. So the ketones act to protect muscle tissue.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And in a way, that is reflective of a function of ketones. Ketones are a defender of muscle. Ketones are basically the way to tell the brain, saying, brain, you think you need a lot of glucose, and if you don't get enough glucose, you would start stripping the protein from muscle to turn it into glucose. But I'm here as a ketone, so you can eat me instead and leave the muscle alone.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So we published, again, a direct report finding that ketones actually make muscle more resistant to injury. And this could be why you're seeing more and more elite athletes using ketones as an actual— Ergogenic aid or like a supplement to help them better, be better.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So at my university, at BYU, just this year, our men's and women's cross-country team took the national championships, the best college runners in the nation. Pretty impressive. One of the things they do is they take these ketone drinks before they train and before they race. Some more and more of the Tour de France teams. Take ketone supplements because it is just another fuel.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It is something that the body can burn. That we always say, well, once you start running out of glucose, you're going to bonk or you're going to hit the wall. Well, what if you don't really use glucose because you're burning a lot of fat and a lot of ketones instead? And that keeps your glucose kind of untouched. or you're not relying on the gluten. And we see this in humans.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
If there's a human that has adapted to a ketogenic diet, they burn fat at a higher rate than was ever thought humanly possible. That fat is basically fueling all of their muscle movement during the exercise session, rather than relying predominantly on glucose. The body has adapted.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It's burning fat for fuel, and when available, it's burning ketones for fuel, and it's leaving the muscle as sort of a last resort when it really needs a big kick.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yes.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Well, there's a bunch of different types. If you look at the spectrum of ketones, on one end you have the cheapest, most readily available, although less effective, called ketone salt, where it takes a molecule of ketone and binds it to a mineral like calcium or magnesium.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Not as effective, and it's a lot of minerals, so people will find that they may get a lot of plaque on their teeth, maybe increased risk of kidney stones, so it comes with some consequences. Then you have the ketone ester, which often comes in shots. Then you have the bioidentical BHB, or the bioidentical ketone. One company, which is Original Ketone, They make it.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Now, these ones are more effective. You take a little bit of these and you will get an increase in ketones. They're a little more expensive too. But as the space is becoming more competitive, the price is coming down.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, yeah. So it would result, so you're drinking it in, you're immediately absorbing it from your gut. So if you were not in ketosis, let's say you had, and I'm not encouraging people to do this, you had just eaten two bagels and a cup of sugary coffee, no ketones, undetectable, because insulin has come up, it's inhibited ketone production.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
like helping lower blood sugar, it's not working very well anymore. And the muscle is just an obvious example because there's so much of it. You know, it is the biggest tissue on the average individual. Someone who's very obese perhaps now has more fat tissue. But even people who are overweight, most of us is muscle. So that's a good tissue to look at. So part of insulin resistance is...
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And then you drink a shot of the ketone, within an hour, we would detect your ketones. They would have gone up maybe to one millimolar, which is a pretty significant bump. And they're capable of that kind of movement. And maybe you do so because you're thinking, I really need to be sharp right now. Would that make me sharper? Well, that's where we have to speculate.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
There's no, my lab published animal evidence suggesting that yes, indeed, it makes you sharper. That we had these animals navigate mazes and recognize objects. And when the animals were on a ketogenic diet, they were much sharper. They were much quickly, much better at solving problems and remembering solutions to previous problems.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Which is high.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
That's not problematic. I mean, that is just proof positive that you're on ketosis, which itself is proof positive that you're burning a lot of fat, and three, that your insulin levels are low.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Exactly. Exactly.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So the power there is, like, if you'll allow me to kind of springboard off of that comment, the power of, so if someone is listening to this and they're thinking, okay, I need to shrink my fat cells.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Unfortunately, they don't realize that there's two variables to what caused their fat cells to grow in the first place. They have no awareness of the value of insulin in this formula. All they do is pay attention to the calories. And so the average individual is looking down the road of this fat cell shrinking journey, and they're thinking, okay, what I have to do is just cut my calories.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And what do they do to cut their calories? They do the exact wrong thing. And before I even answer that, let me just present the scenario. Let's imagine that Stephen and I, everyone listening is invited. Stephen and I are hosting a buffet. We have the world's best chefs. It is going to be a table filled with the most delicious foods you can imagine. You're in our invitation.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
We say, come hungry because you're going to want to try a little bit of everything. Everyone listening, ask yourselves, what would you do to come as hungry as possible? You'd probably do two things. Or think, how did you go to your Thanksgiving or your Christmas dinner as hungry as possible? You would eat a little less in some period of time before the event, and you would exercise a little more.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And it would work. You would be very hungry. That's why the traditional advice given for weight loss doesn't work. Because we tell people, eat less, exercise more. Sure, you maybe lose a little bit of weight in the short term, but all that does, you've given them the perfect recipe to promote hunger. And hunger always wins. As a good example, in the U.S., we have a game show.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Maybe there was some version of this in the U.K. called The Biggest Loser. It was essentially who can lose the most weight. And it was through a punishing regimen of caloric restriction. Eat less, exercise more. That is like the perfect embodiment of that approach. They were starving and they were exercising to insane degrees. And oh my goodness, did they lose a lot of weight.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And yet you never see them again. They don't do a reunion tour five years or ten years later because they gain it all back. Do you know they gain weight back? They do. In fact, a paper published in the U.S.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
from the National Institutes of Health documented not only the degree to which they gain weight back, but also how it almost literally breaks their metabolism, that normally a person's metabolic rate is connected to their body mass. A bigger body has a higher metabolic rate. A smaller body has a lower metabolic rate. This is just human physiology.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And no surprise, when someone loses weight, there's less of body and so metabolic rate goes down. As they gain weight back, metabolic rate will typically go back up as well, except for the contestants and the biggest loser. They started with a high metabolic rate because of a high body fat level. They lost a substantial amount of weight No surprise, metabolic rate went down substantially.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
that of all the things insulin is trying to do, including lower blood sugar, it doesn't do it quite as well as it used to. Some of the cells or tissues of the body have become deaf to insulin's demands. Now, however, at the same time that's happening, insulin levels are higher. And that is really important.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But this is such a dramatic change that as they started gaining weight back, metabolic rate did not come back with it. It stayed lower than it should have. Normally, it's connected sort of one to one. Wherever body weight is going, metabolic rate is going, except in these people.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
That method of dramatic weight loss through such severe restriction, which is based purely on the caloric theory of obesity, leads to significant hunger. So no surprise if a person's attempting to shrink their fat cells or lose weight, if the first step is I'm going to cut my calories and they don't address their high insulin, they're never going to lose weight in the long run.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
They're going to step right back to where they were because if they start cutting calories but insulin is still high, that's going to make them very hungry because insulin wants to be storing energy. A professor from Harvard named David Ludwig found this.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
If you have people eating a lower calorie meal that spikes their insulin, it makes them much hungrier than a lower calorie meal that doesn't spike insulin. So that's the key. Anyone listening, if you're thinking, I need to be on a fat cell shrinking journey, let the first step of that journey be I'm going to lower my insulin. Which means? Which means I'm going to control my carbohydrates.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I'm going to stop eating carbohydrates that come from bags and boxes with barcodes. And while I am restricting those carbohydrates, I'm going to focus more on protein and fat. So control carbs, prioritize protein, and don't fear the fat that comes with those proteins. Fat and protein together is a miraculous combination of helping you feel full And it is literally giving everything you need.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
There are such things as essential proteins. There are such things as essential fats. So focus on those. And that will be the key to helping insulin come down. Then as you have found, you haven't, and when you're hungry, eat. If you're not hungry, don't eat. But what the person will find is they're lowering their insulin
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
all while their metabolic rate is going up, they're learning how to burn their own fat for fuel. Because remember the metabolic hybrid, that metaphor, that if you wanna lose fat, you need to burn fat. You're not gonna lose fat if you're always burning glucose. It's fat that you need to burn. And as you start burning more fat, you realize that it's like the hump on a camel.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
That hump exists because it is a big source of fat for that animal to be using its own fat for energy. We have our own version of that. You think about the average individual who's chubby, they have hundreds of thousands of calories waiting to be burned in those fat cells. It's just that their chronically elevated insulin is never letting them burn it.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so as the person starts making these changes in their diet to lower insulin, they now can finally start relying on their own fat for fuel. So it's no surprise that their hunger starts to come down. Let that be the natural way in which you're controlling your calories. Don't control your calories because you're forcing yourself to be hungry and eat less.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Control your calories because you simply aren't hungry.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And I'll mention an example in just a moment that highlights the difference between the two. But we have to consider any time we talk about insulin resistance, we think of two things happening in concert. One, insulin isn't working quite as well as it used to in various places of the body. At the same time, insulin levels are higher.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah. Yeah. Okay. So first of all, let me just add a hearty amen. I'm an advocate of a ketogenic diet, although it can be applied differently across different people. But I would say anyone would benefit from having some modest period of time of elevated ketones, at least in some portion of the day. Now, how do you maintain muscle mass in the midst of such obvious weight loss?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I can only speculate. Now, there are peer-reviewed studies that I can cite which do support the idea that a human can be on a ketogenic diet and have a total maintenance of muscle and strength. That is published, so we know it's possible, although that doesn't seem to be what happened with you. I would suspect that there were two things, two things happening, possibly.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Now, I'm speculating here and I'm pretending to be your coach or your expert here. One could have been that you had relatively lower energy during your workouts because of a slight degree of dehydration. And then the other one would be calories, which I'll come back to in a moment. I just wanted to put it out there.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And that kind of takes us back to the muscle cell where I've mentioned, getting a little ahead of myself, that a bouncer is knocking on the door. And once upon a time, the muscle cell would hear that one polite knock from that one bouncer or one molecule of insulin, if you will. And it would open the door and let the glucose or the blood sugar come in. But now the muscle cell...
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So when insulin comes down, one of the many effects in the body is that another hormone comes down called aldosterone, which is one we've never invoked yet. But low insulin leads to lower aldosterone. When aldosterone comes down, the kidneys become much – begin to eliminate salt and water much more rapidly.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Now that's not problematic, but it does mean that a person does have to focus more on hydration and salts. So if someone's going on this strategy in the exercise fairly often, you need to be much more focused on your hydration, literally drinking more because you will be urinating more, which is partly why people's blood pressure gets so good so quickly.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And just to pause on that point, if someone is on one or two blood pressure medications and they adopt a ketogenic diet, they usually have to stop their medications within two days because their blood pressure goes to normal so quickly that if they stay on the medication, they're going too low. So one could be that you were actually working out a little less intensely because of the dehydration.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But then two, it's possible that you were eating too few calories to actually maintain muscle. Muscle is a hungry organ. It is metabolically expensive for the body to keep that muscle on. And as you start to get leaner and leaner, It gets harder and harder for the body to defend that muscle. In fact, that's the difference between fasting and starvation.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
The longest known evidence of a fast was a man in the UK who fasted for 384 days, literally not eating or drinking a single calorie. He was under medical supervision, getting vitamins and minerals and water, and he went on to live a perfectly healthy life. But what was the difference? Why was that not starvation? Starvation is when you run out of fat.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So you might have gotten to the point of so lean that you didn't have enough fat to burn to make enough ketones to fuel the brain. If you don't have enough fat to burn to make enough ketones and the brain is saying, all right, well, I wanted to switch to ketones so that I could spare the glucose. But I can't. There's not enough ketones here, so I have to rely 100% on glucose.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But if you're not eating glucose, now the body has to start stripping the protein from muscle. And it sends those amino acids to the liver. Then the liver is so capable, it will turn those amino acids into glucose. So it turns my muscle... Into glucose to feed the brain.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So my comment then, finally getting to my answer is, in your version of a ketogenic diet, with your level of muscle mass and your inherent metabolic rate based on your body size and your activity, you probably ought to eat more fat.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
You might have been, but it could have been that you were simply not eating enough calories. So this is an instance where... That's what I'm trying to do this time. So eat more fat. Like every time you're making a steak, put butter on there. And when you're drinking a cup of coffee, as crazy as it sounds, I drink yerba mate every morning. I will put a big dab of butter
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Like a big dab of butter in my tea and I'm sipping on it while the world's still asleep and the kids haven't woken up yet. And so I know because I want to keep my muscle. As a guy who's almost 50, I find that during my strict ketogenic phase, and I'm currently in it as well, every January I go to kind of a carnivore diet.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And I mostly do it to, one, lean down, but also to check any addictions and habits. I don't like feeling addicted to things. And my wife will comment. And even as an almost 50-year-old, it's fun to see my six-pack coming. I don't want to lose my mass, my muscle mass, because you have to work so hard to get it. And what I find is if I increase my fat, I always get plenty of protein.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
The bouncer, insulin's knocking on the door, but the muscle doesn't listen. It's resistant. And so the body has adapted and it learns, okay, well, if one bouncer wasn't enough, let's send an angry mob of bouncers. And then the glucose, the muscle will start to open the door. And indeed it can. So those two problems go together. On one hand, insulin isn't working as well as it used to.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But if I increase my fat content, I have an easier time maintaining my bulk.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
The only downside I can articulate... So, in fact, I didn't even finish, because I distracted myself, mentioning some of the benefits of ketones. But ketones are further anti-inflammatory. Like, they directly reduce inflammation in the body by inhibiting inflammatory processes. And they also improve antioxidant defences, so it helps reduce oxidative stress.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So ketones do have benefits that go beyond even what we've taken the time to articulate. If there's any negative to a ketogenic diet, it could be that you start you acutely or you temporarily become less metabolically flexible. Now that's me invoking a term we haven't brought up yet. But metabolic flexibility is a term to refer to the body's ability to, when it eats glucose, to burn glucose.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
When it's not eating glucose, it burns fat. So you're shifting between the two metabolic fields that we outlined earlier. When someone has been adhering to a ketogenic diet for some time, it's almost as if their body is stuck in fat-burning mode.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And that if you and I, being in such adapted ketogenic state as we are, if we were to go to lunch and eat two bagels and a sugary drink, it would take us a very long time to clear that glucose from our blood.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And there's certain lifestyle habits and problems with our diets that are massively contributing to slow insulin resistance. Now, thankfully, this can be resolved through four pillars, which are very simple. We'll get into that. But why don't we just sack all this off and just take a Zenpec? Well, because people may not know about the negative side effects.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
much longer than otherwise like let's say we go out with the production team they're eating a normal higher carb diet all things equal same body size same activity their glucose levels would come up and down in 90 minutes for perhaps yours and mine may take 180 minutes to come back down so the person may say well gosh steven and ben are no longer burning glucose very well And that's true.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
In that one moment, our bodies had almost forgotten what it was like to burn a bunch of glucose because we had adapted to fat burning.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yes. Well, what a naive thing to say, if I may gently reprimand your friend. There's no evidence to support that there's any harmful change in the microbiome. In fact, a paper was just published that looked at a man who went from a normal omnivorous human diet with abundant plant matter to a purely carnivorous diet, literally zero carb.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And they documented precisely no change in his microbiome, none whatsoever. But is he eating plants? No. Well, he had been eating plants. So the case study was a person eating a normal diet of plants and meat, a normal omnivore diet, and then looked at the microbiome and then adapted to a purely carnivorous diet, purely meat. And the microbiome didn't change at all. What's the time period?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Months, I think. The problem with the microbiome, the reason I don't take microbiome research too seriously as a scientist, is that it is a big black box. You came from the UK to London, to LA, to California. If we took a microbiome sample analysis of your time in the UK... Now, it would be different now.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Even though you're eating the same, but you're drinking different water, you're breathing different air. I was just on a plane from Utah to California. Give me a day or so, I would have some sort of shift in my microbiome. So the microbiome can change in response to all kinds of things. the idea that you somehow have decimated your microbiome because you aren't eating fiber is absolutely false.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
That's what gives it the name insulin resistance. But there's another part that is equally present, which is that blood insulin levels are higher. Now, earlier at the outset of the conversation, I mentioned that even infertility has an origin, has some degree of development because of insulin resistance.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
That is completely false. Now, there might be a change in some of the population of your microbiome, more of one, less of another, But there's no evidence to suggest that's problematic. Your microbiome is intact. Those bacteria do not die. They're just simply metabolizing other things. Maybe they're relying more on short-chain fatty acids. Maybe they're relying more on amino acids.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
They're not eating fiber, but there's still stuff in the meat or the eggs that the microbiome will eat.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, but Stephen, but even then there's a bit of an assumption built into the question because it's, do we know that the microbiome will be less diverse? The case study I just mentioned found that in this one single man, it didn't change his microbiome at all. It was the exact same populations in all the same proportions.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, so the fiber is. So fiber will. But again, that's not the only thing bacteria can eat. Bacteria can eat fats. Bacteria can eat amino acids. They can eat glutamine, for example. Even meat will have a little bit of glucose in it, where the muscle has something called glycogen. And so there's trace amounts of glucose in even the meat that you're eating.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I do not look at the argument that, you know, you're destroying your microbiome. That has no scientific support. You may be changing your microbiome, but who's to say that's a bad change? Maybe it's a better change. You certainly are feeling better. You're thinking better. You're getting leaner. Your insulin sensitivity's improved. Cognition's improved.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I would argue if there is a change in your microbiome, it's probably one that's for the best. And no one can prove that wrong. As much as I just stated that comment in a speculative fashion, it's speculative because there's no evidence. This is why I look at the microbiome and just say, yeah, it appears to matter, but in ways that we don't know.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I'm not agreeing to that.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I don't know if that's true. And again, I would cite that one case report I just mentioned now, which is a man who did this. They reported that the microbiome was identical, that there was no significant change.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It was one man. It was a case report, which is not a randomized clinical study. So, but even still, with my speculation heavily handed here, I would say probably more plants would result in a more diverse population.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
microbiome but i would say but then the next step is a harder one which is is that good or bad i don't know maybe all you're doing is promoting the growth of bacteria that make more gas because they're fermenting the fiber and you just have more flatulence as a result of it people dieticians will say well a diverse microbiome is a good microbiome we'll prove it How do we know that?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
How can you prove that to me as a basic scientist? I want to see the hard evidence. Because what I can prove is that we can take humans who are overweight and diabetic and hypertensive, eating a standard American or global diet, and put them onto a ketogenic diet, which is going to be a much simpler diet, and yet every clinical marker gets better.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And it's a perfect example of both of these parts of insulin resistance, where in some instances, insulin isn't working very well. Always with insulin resistance, blood insulin levels are higher. So for example... Erectile dysfunction is the most common form of male infertility.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so if someone were to say, yeah, but sure, you've reversed your diabetes and your hypertension, but your poor microbiome, I would say, well, I don't care about my microbiome. I care about the human. And so if there's less diversity, but every single clinical marker has gotten better, perhaps more diversity is not what we want in our bacteria.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And I'm speculating, but so is the person who states that.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, and I don't know. But do you feel healthier now?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, it accelerates the aging.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It's entirely possible. Yeah, yeah. I would just ask that we be careful with the assumptions that if there is an increase in diversity with more plant matter, that's an if. Is that change... beneficial? Are the bacteria that we're now promoting the growth of, are they better for us? Or are they just bacteria that exist in order to handle more fiber?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And again, the outcome being that perhaps it's just making more gas. You know, the more plants you eat, the more gas you have to produce by fermenting more fiber. What if those bacteria are only existing to just eat the fiber and not actually improve the human host at all?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
My thought on it is that... a person would benefit from some state of ketosis on a frequent basis if for no other reason than to really give the brain a heavy dose of just straight energy.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
In fact, its connection to insulin resistance is so strong that just a few years ago, I was so struck by a title of a paper that had just been published, which stated something like, is erectile dysfunction the earliest manifestation of insulin resistance in otherwise young, healthy men? Now, what is the connection? It's because in the normal erectile function,
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Not that everyone needs to be as strict as perhaps you and I are being at the moment, but I would say the more a person has a disorder or a disease that benefits from ketosis, the more than they ought to focus on it. Like if someone has type two diabetes, if they adopt a ketogenic diet, they will be off all of their diabetes medications in months. All of them.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
If someone has epilepsy or migraine headaches, if some of the... From 1913, I think, was the first published report on this. If there's someone who suffers from migraines, as long as they're in ketosis, they may never have another migraine again. I mean, it is completely curative or preventative for the disorder. Same with epilepsy, the many forms of epilepsy. So depending on the person...
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
they would benefit from being in ketosis forever. For everyone else who's just sort of a normal individual who wants to be lean and keep their brain healthy and happy, et cetera, I would say it's generally prudent to just control your carbs, be mindful of the type of carbohydrate you're eating. And as I said earlier, just try to focus on the carbs that don't come from bags and boxes with barcodes.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I'm actually quite liberal in my view when it comes to whole fruits and vegetables. I'd say eat them, enjoy them liberally, but then also make sure you're getting some good protein and fat because there's no such thing as an essential carbohydrate. That sounds controversial, but humans do not need, we have no requirement for carbohydrate. We do have requirement for fat and protein.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, great question. There is such a breadth of diversity when it comes to sweeteners, from artificial to natural to another rare sugar, more and more, you know, there's all these random, I'm not random, but a very broad range spectrum of molecules that we have developed or found that taste like sugar but don't have the effect of sugar.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So on the good end are things like that have been shown to have no insulin effect. And so, you know, I appreciate everyone listening, letting me kind of stay with that as my framework because people are going to go on and criticize all kinds of other things about other sweeteners. And that's just too broad. That's a topic for a whole book.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
With regards to just insulin, on the good end where they have no effect, it would be one as common as aspartame. So like diet drinks, not the zero drinks. But the diet drinks will have aspartame as the sweetener. Is there a difference? There is a difference. And I'll get to that other one in a moment. So I should be having diet instead of zero? Well, I personally go to diet rather than zero.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But that's because aspartame is the sole sweetener in the diet. And it has no effect on insulin. So too erythritol. Sorry, erythritol is a little right around. Aspartame is generally a good one. But monk fruit extract, stevia, and especially allulose, those are inert when it comes to insulin. You know, allulose, stevia, monk fruit extract, aspartame, no effect. Erythritol, no effect.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But erythritol, that ending O-L... is reflective of a class of sweetener called a sugar alcohol. And that does not mean it's alcoholic. That just refers to the actual chemical structure that puts it in the alcohol family. Once you get into the sugar alcohols, you start to get a little problematic.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
where erythritol is a good one, and xylitol is generally a good one, but then you get to things like maltitol and mannitol, and they do have an insulin effect.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, so often you can get mannitol in artificially sweetened chocolate sometimes. For reasons that I don't know. I don't know why the food formulator puts them in some things and not other things. The problem, I chuckle because it becomes so apparent, with some of those artificial sweeteners, like the sugar alcohols, is that as you eat them, you taste it sweet in your mouth.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
In order for the man to have normal erectile function, he has to experience a pretty dramatic increase in the size of the blood vessels in his body. The blood vessels expand, that increases blood flow, and then he has normal function. Part of that signal that tells the blood vessels that it's time to expand is actually insulin.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And it doesn't have any caloric value in the body because it stays in the intestines. And this is something that is largely unique to the sugar alcohols, where as it stays in the intestines, it starts pulling in water from the body, which starts to create a fairly inconvenient degree of flatulence and diarrhea.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so a person will know if they've eaten too many of those types of sweeteners because their intestines will tell them so. But also on that spectrum, kind of in the middle, is the one that's in the zero drinks, which is one called sucralose. And while sucralose is generally not a problem with insulin, it is a sweetener that has been shown to cross the blood-brain barrier.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so the reason I avoid the zero drinks and refer or go to the diet drinks is that aspartame does no such thing. Aspartame just gets divided into amino acids. We just digest it and absorb amino acids. Sucralose can cross the blood-brain barrier, and I don't know what it's doing there, but I don't want it there. And so I avoid the zero drinks because I don't want that sweetener.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But personally, when I'm adhering to this diet, diet soda is my actual indulgence where I want something sweet and yet I don't want the metabolic effect of it.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah. So I'm interested to hear that your physician would have said your salt is too high. That is very rare that that gets measured.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, they could have measured sodium and that could have been higher. They absolutely could have. It's just not common. So salt has earned a terrible reputation because of a series of studies that implicated salt consumption as a cause of high blood pressure. And really briefly, as a momentary physiology professor, that is a real effect.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
If you and I were to go eat salt, our body for the next several hours afterwards would retain its water in order to balance out the salt so that we didn't get too salty. So we would retain water in order to keep our salt at a normal level. And so that could be reflected by an elevated blood pressure.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
However, multiple huge studies have found that if you go to a population of humans that have high blood pressure and you tell them you need to cut your salt in order to correct your blood pressure, they may at most move their blood pressure by one or two points. It has an absolutely negligible, irrelevant effect. It's because salt is not a key contributor to blood pressure.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It's actually insulin resistance. Insulin resistance will force the body to hold on to salt. Insulin resistance will force the blood vessels to be very constricted, all of which play together to make for a very high blood pressure. So as much as we have been telling the world that we should be cutting back salt,
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so this is what I said earlier, where insulin does so many things in the body, and we only think of it as being relevant to glucose, and that's not fair. Insulin does a lot of stuff, again, including telling blood vessels to expand. Now, unfortunately, in the case of this unfortunate man, his blood vessels become insulin resistant.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
No, we should have been telling them to cut back on what spikes your insulin, refined starches and sugars. But with regards to salt, it's interesting for me to note, where did that whole view come from? Within the United States decades ago, there was a study that was published and they called it the DASH diet, Dietary Approaches to Stop Hypertension, DASH, the DASH diet.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And in the DASH diet, one of the critical changes was to tell people to eat less salt. And when they found that when people adopt a DASH diet, it's amazing, their blood pressure goes down. However, unfortunately, they also tell people to do lots of other things with the DASH diet.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Like when they tell someone to go on the DASH diet, they also tell them to eat less sugar and less refined starches and sugars. Well, it's possible, indeed, I would say it's absolutely the case, that what's actually lowering their blood pressure isn't that they cut their salt back. It's that they were cutting their refined starches and sugars back. And it's that that had the main effect.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And the cutting the salt was just some innocent bystander. But to put a fine point on it, in human studies, if you have humans cut back their salt considerably, they become insulin resistant. So take a healthy group of humans, say you need to eat less salt, and they do so.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
If you measure them a week later while they're adhering to this, they will be significantly more insulin resistant than before they ever cut back their salt. It's one of the ironies of the whole scenario where a physician may be telling a patient with high blood pressure, you need to cut back your salt. and they end up eating less salt, and yet their blood pressure gets worse.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It's because the main contributor to high blood pressure is insulin resistance. And by telling them to cut back on their salt, you made them more insulin resistant. And that whole mechanism is because one of insulin's many, many effects is to want the body to hold on to salt and water. And so if you start cutting your salt, All of a sudden, insulin says, well, there's little salt coming in.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
I need to do what I can to retain whatever salt we do have. And so it starts retaining salt in water more in order to try to offset the lack of salt coming in. And while insulin is going higher and higher, the body is becoming more and more insulin resistant. So salt restriction can cause insulin resistance in humans.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yes. So when it comes to controlling insulin resistance, the key is to manage macronutrients. And the best way to manage macronutrients is going to be a strategy that helps lower insulin. Lowering insulin is the key to both slow insulin resistance and fast insulin resistance. So the more the strategy lowers insulin, the more effective it's going to be. And there are four pillars.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So the first one, control carbohydrates. Second, prioritize protein. Third, don't fear fat. And then fourth, after the first three have been taken care of, four, frequently fast.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So now it's insulin coming and knocking on the doors of the blood vessels saying, hey, it's time to expand and increase blood flow. but the blood vessels don't respond. They don't listen. So they stay constricted, blood flow stays insufficient, and thus he has erectile dysfunction.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So with the first one, very briefly, by controlled carbohydrates, I mean that it is time to focus more on whole fruits and vegetables, eat them, don't drink them, and then don't get your carbohydrates from bags and boxes with barcodes.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
That the more you're opening up a package and getting your chips or your crackers or your cereal or your bread, the more you're going to be spiking your glucose and your insulin. Keep that on the shelves at the grocery store. Focus on whole fruits and vegetables. That's going to be the key for, number one, control carbs. Now, while you're eating fewer carbohydrates, You need to eat something.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so prioritize protein. I would say particularly animal source protein, which is the best source of all of the amino acids that humans need. And then with those proteins will come fat. Don't fear that fat. That's number three. Fat is very satiating when combined with protein. When fat and protein come together, we digest it better.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Sometimes people will find that if they just have a scoop of whey protein, it can be very upsetting on their stomach. It's because we're not supposed to eat protein alone. In nature, that never happens. In nature, protein always comes with fat. That's how we should eat it. We digest it better.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And human studies have shown that when a human eats pure protein, there is some degree of muscle growth, albeit microscopically, minuscule. But when we eat protein with fat, we have significantly greater muscle growth than we do with the protein alone. So that is the three pillars that encompass the macronutrients or the big parts of our diet.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But once a person has done that, then they are well positioned to adopt a strategy, a structured strategy of fasting. And that can be there are as many ways to fast as there are people who want to do it. There's no right way or wrong way.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
My goal by invoking that fourth principle, and I do think it should come last once you've learned how to eat better food, your body has adapted to burning its own fat for fuel, but it can take intermittent fasting where it's one meal of the day you're fasting through. It can do where people do alternate day fasting. There are countless different ways to do it. Even if I'm in ketosis?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
then you don't need to do it as much because you're already lowering your insulin. So if a person's already in ketosis, in fact, if a person were in ketosis and frequently fasting, depending on how lean they are, it's going to become extremely difficult to retain muscle.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So those are the four pillars. It will be an extraordinarily effective way to address insulin resistance. But the problem, as I started, that I mentioned, is that while these concepts are simple, that does not mean they're easy. Because humans show addictive tendencies to only one macronutrient, not fats, not proteins.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
All of the evidence of the neurobiology of addiction in humans points to carbohydrates. And so as much as I lay out this simple plan, it can be difficult. And this is why this self-discipline required is difficult enough that it's why people find that they have to result in relying on drugs for these kinds of things.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, I'm really glad you brought up exercise. I'm an enormous advocate of exercise. The best exercise to improve insulin sensitivity is the one you'll do.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so if someone listening to this is an 80-year-old grandma, if her form of exercise is walking around the street, down around the block with her girlfriends, but then if someone else has the ability to go cross-country skiing or CrossFit, do it. So the best exercise is the one you'll do. Now, having said that, The better exercise is the one that you'll do that keeps muscle.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, right. Yeah. So the origins are so important because it helps us understand why we've gotten into the situation we are, where it's the most common problem worldwide. There are two pathways to insulin resistance. So two roads that get to the same destination. Again, the destination being insulin resistance.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
For example, 40% of the weight that people are losing on these drugs is coming from... Holy...
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Muscle building work is going to be, minute for minute, a more effective way of improving insulin sensitivity than any kind of aerobic activity. And that's because muscle is the great consumer of glucose. And back to the—in fact, not only does muscle eat the most glucose from the blood, but it's also how it eats the glucose when it's exercising.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So earlier, we talked about how insulin kind of comes and knocks on the door of the muscle cell. And then the muscle cell will open the door and allow the glucose to come in, thereby lowering blood glucose, unless the muscle is exercising. When a muscle is exercising—and I'm kind of mimicking the contraction and relaxation of a muscle—
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
when the muscle is exercising, it has its own way of opening those doors. So there's an insulin independent method, where the muscle cell essentially tells insulin, insulin, I know normally I have to wait for you to come and open these doors, but I'm so hungry during this exercise that I'm not going to wait. And so the door's just open.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So the contracting muscle has its own way to rush, to pull the glucose in, which means, of course, that a person's going to have an easier time controlling their blood glucose, which in turn would mean a better time controlling insulin. But The more muscle a person has, the easier it is.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And this could be one of the reasons why, if you look at longevity and look at the markers of muscle strength versus the markers of cardiovascular aerobic fitness, The aerobic fitness markers are terrible predictors of longevity.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It's muscle and strength that predicts longevity for multiple reasons, including just the very act of living and moving, but also because if you have more muscle, you're going to control your glucose better, which means you're going to control your insulin better. Then you're back to these variables that people use to predict or what are the most accurate indicators of longevity.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It's who has the best glucose control. More muscle helps that happen.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, I am unabashedly in favor of carbohydrate restriction. I would say for two reasons. One reason I think that carbohydrates should be the macronutrient that is most scrutinized is because it's the one we eat the most of. 70% of all calories consumed globally come from carbohydrates. That is the one that has the biggest insulin effect. And that's a problem for all the reasons we've discussed.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
But two... Carbohydrates are not essential. This is controversial. People don't like to acknowledge it, but there is literally no biological need that humans have for carbohydrate. In the United States, a report decades ago from the Department of Agriculture looking at the needs of human nutrition, there's a quote there, and I'm not going to get it exactly right, but I'll get it pretty close.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
There's the fast lane, which I call fast insulin resistance, and it actually has three lanes, which I'll describe in a moment. Then there's the slow insulin resistance, which is a more, it takes a little longer to get there, but at the same time, it takes a little longer to get away from it.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
It's stated in this document that the lower limit of carbohydrate consumption in humans is zero. In other words, there is no such thing as an essential carbohydrate. Now, I'm not saying, well, then let's not eat any of them. No. But I am saying, why is that the one we focus the most on as 70% of all calories globally are coming from that one?
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
You're telling me that most of what we eat comes from what we don't need? Why not put the focus on the things we do need? There are such things as essential fatty acids. Let's eat fat. There are such things as essential amino acids. So let's eat protein and make sure we get what we need. And then on any remainder of the plate, we can get some other things that we want to nibble on, like plants.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Why don't we just cycle this off and just take a Zenpec then? Ah, yeah, great question. So I have kept my finger on the pulse of the whole field of gut-derived hormones, which is what we talk about with these weight loss drugs, almost since their beginning. My dissertation work was in a lab, one of the first funded labs to look at these drugs
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
although in the context of diabetes, and then it's blossomed into the context in the use of obesity. This is the class of drug, GLP-1 receptor agonist. First of all, what is GLP-1? GLP-1 is a hormone that we all make from our guts. Our small intestine will make GLP-1. We're making it all the time to varying degrees. Some things we eat will result in a higher GLP-1.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Sometimes it'll be a lower GLP-1. Like, for example, a paper just published a few months ago found that if you have people eat the exact same meal of calories but lower carb or higher carb, the lower carb version of the meal will increase GLP-1 three times higher in the blood than the high carb version of the meal.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, so what's the point? Who cares about GLP-1? One of GLP-1's main effects is to tell the brain that we're full.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
More satiety. Yeah, more GLP-1, less hunger, which is very impactful. In fact, I would be remiss if I didn't mention a study that was published in Humans a while ago. They took obese humans and lean humans and had them eat fat. and found that, like pure fat, and they found that the GLP-1 response was the same. Whether you were lean or obese, you had the same amount of GLP-1.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
That would suggest that whether you're lean or obese, both of your brains in both of these populations will have the fat and have the same sense of, I'm full, because it was matched with GLP-1. However, when they had these same groups eat pure carbohydrate, The lean group had a robust GLP-1 response, big GLP-1. In other words, they would eat the carbohydrate and say, I'm full.
The Diary Of A CEO with Steven Bartlett
The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
So I'll start with fast insulin resistance because the slow one ends up getting a little excitingly complicated, but in a cool way. So with fast insulin resistance, there are three things that I could take you to a clinical lab and I could make you insulin resistant in six hours with either of these three things.
The Diary Of A CEO with Steven Bartlett
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because GLP-1 would tell them so. However, in the obese group, they ate that exact same amount of carbohydrate and they had an almost negligible GLP-1 effect.
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In other words, they would eat the same amount of carbohydrate as their lean counterpart and then just say, okay, what's next? I'm still hungry. And so it is prudent to focus on GLP-1. GLP-1 is a powerful hormone that does have an effect on human health.
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What I feel inclined to comment on is the negative side effects because the only thing we hear about is social media influencers extolling the benefits. And hey, I'm on this weight loss drug and I've lost 50 pounds. Someone has to be the voice that says, yeah, but what about this? And there are some significant but what abouts when it comes to these weight loss drugs. One of them is
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is the loss of muscle mass or lean mass. You've mentioned a couple papers from the New England Journal of Medicine, a paper a couple years ago from what was called the Step 5 trials looking at these drugs. They found that for every six pounds of fat a person was losing on these drugs, they were losing four pounds of fat-free mass or lean mass.
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So 40% of the weight they were losing on these drugs is coming from lean mass, like including muscle and bone. So there are now case reports of young healthy women who are overweight who go on the drug for some period of time and after they get diagnosed with osteoporosis where they have eroded their bone health. They're losing lean mass. So again – They've eroded their bone health.
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Yeah, so 40% of the weight that people are losing on these drugs appears at these high doses is coming from lean mass. So fat-free mass, including muscle and bone. The reason I find that so troubling is that in the UK, at two years on the drug, 69% of people get off the drug. They don't want to be on it anymore. And now imagine this individual. Imagine, if you will, a 60-year-old woman
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who's been on the drug. I take that age and that sex on purpose because it's so hard for her to grow new muscle and bone. Let's say she's been on this drug for a year and she's lost 20 kilos. Well, 40% of that will have come from her lean mass and 60% of it came from her fat. And then when she gets off the drug, Now, all of a sudden, her lean mass, her muscle and bone, that's never coming back.
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The muscle and bone that she has lost is gone forever probably at that age because we can't – after the age of 60, good luck developing new muscle and bone. But what can come back rapidly is the fat mass. And so at two years, she decides to get off the drug, which again, about 70% of people do. They're going to gain that fat back, but they're not going to gain their muscle and bone back.
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But as quickly as it settles in, if I remove those things, your insulin resistance would go away. So these are fast causes and they're fast resolution. They are stress is a primary cause of fast insulin resistance. So too is inflammation. And then lastly, and this is going to sound somewhat paradoxical, too much insulin is also a cause.
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That is a significant loss that may be, depending on their age, gone forever.
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Yeah, I wonder. She's so lean. I wouldn't be surprised if she had it even worse than normal because we see it has become, I don't mean to suggest this is the case for her, but you do see people using these weight loss drugs who are already very lean.
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But see, this is what people are doing. They're basically using it to facilitate an eating disorder in the people who are lean. This has become so common that there are complaints saying that lean, healthy people are getting the prescription and people who are obese and diabetic aren't because of shortages. I've seen this. I know someone personally who is already a perfectly lean, healthy woman.
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And then she now looks sickly. And what caused it? Well, she wasn't lean enough. And when you take enough of that drug that you just have no more hunger because of how it's acting at your brain, you do just stop eating. And the malnutrition, at least in part, is going to cause a loss of lean mass.
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But that also – it is even further exacerbated by the mental health problems where there was a paper recently published with the use of these drugs finding that people, when they begin the drug, their risk of suicidal thoughts doubles. It goes up by over 100%. And their risk of major depression triples.
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And this – so as much as we talk about these drugs and we say the drug helps you control your cravings, What it's doing is perhaps reducing your craving for everything, that while you're eating less food, which is resulting in the weight loss, you also are not interested as much in exercise as you used to be, which is going to make it even easier for you to lose your muscle and bone.
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You're also less interested in hobbies like going to play pickleball with your friends or going out and drinking with the boys. So there is this kind of what's reflected across all of their interests is that their cravings for everything starts to decline.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
Yeah, it's heartbreaking.
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But we do know, based on that one report, that 40% of weight loss is coming from fat-free mass. And so it is in people's best interest to be mindful of that tendency and that if they're going to explore the use of the drug, to do so responsibly. And I want to mention that kind of caveat or angle to everything because I don't want someone listening to me thinking,
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All right, Ben says I should never touch this and it is uniformly evil and bad. I'm not saying that. I find that I have to speak a little more boldly about the negative consequences because nobody talks about them. What would she have done if she knew about them, for example? No one knows about these kinds of negatives because people want to sweep them under the rug.
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And I'll end with that one because I think it's the most important. Then transition to slow insulin resistance. So anytime the body is experiencing too much stress, it will very quickly become insulin resistant. Now, as a professor who teaches endocrinology, no surprise, I define stress in the context of hormones.
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Now, I believe there is a use case for these drugs. although different from how it's being used currently. In my mind, the best use of these drugs is to help someone learn how to control their carbohydrate addiction because it will help you control your addiction. Sweet cravings goes down significantly within six months of the person taking the drug.
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So I think in addition to getting proper education, and if I may be so bold, I would say it's those pillars I mentioned earlier. Control carbohydrates, prioritize protein, and don't fear fat. All the more reason, prioritize protein and fat to help preserve your muscle and bone. Muscle and bone are not made of carbohydrate. They're made of protein and fat. Eat protein and fat.
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Lift weights to keep any of that lean mass you can. Keep the integrity of your bones intact. But take advantage of the drug helping reduce your cravings for sweet things especially.
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I would say find the lowest effective dose you can where you are able, with a little bit of self-discipline, where you're not assigning all of the self-discipline to the syringe that you're going to inject into your tummy. There is value in learning to deny yourself something you know you shouldn't be doing. There's life lessons to learn there.
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And so enough of the drug that makes it a little easier for you to overcome your carbohydrate addiction. At the same time, you're learning how to eat well. You're learning how to eat properly by managing your macronutrients and lifting weights. And then over time, ideally, I would say, you find that you are able to reduce the dose of the drug and then eventually get off of it entirely.
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Yeah, so I actually think it's an artifact. That's a term that we would use as a scientist to say that it's an effect that's happening without being a main effect. So I don't believe the GLP-1 drug is attacking the bone. I think it's because the person has just stopped eating and stopped moving. Remember what I said earlier, people find that they're just less interested in doing stuff
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like going to the gym, for example. And so that is probably combining where a little bit of malnutrition combined with a little less physical activity means you're accelerating some lean mass loss.
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I do. From a metabolic perspective, I absolutely do. Liposuction is not dangerous to fit into the clothes you want to wear, but it's deeply problematic for metabolic health. And that's because, as a reminder, it's not the mass of fat we have that matters most when it comes to metabolic health. It's the size of our fat cells.
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So let's imagine an individual who has more fat than they want in some particular part of the body. The best way to help reduce that fat is to shrink your fat cells. So that's very important for people to realize. When you lose weight, you're not killing fat cells. You're not getting rid of them. You're shrinking them. And small fat cells are very healthy fat cells.
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And there are two primary stress hormones, cortisol and what we call in the US epinephrine or in the UK adrenaline. Those are the two stress hormones. Now, those hormones are very distinct. They have almost nothing in common. But like when you are feeling a little stressed, It's both of those, especially adrenaline slash epinephrine, that are making you feel a little jittery.
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They are literally anti-inflammatory. They're releasing hormones that fight inflammation in the body. And they're very insulin sensitive, which helps the body by extension be very insulin sensitive. So very healthy. Small fat cells are healthy fat cells. The problem with liposuction is that you are going in and rather than shrinking the fat cells, you are sucking them out.
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Now, let's say like a study that was done in the U.S. in women. They found that when women had liposuction from their buttocks and hips area, which is where most women gain their weight, which is because of sex hormones telling her body to store that weight there, they may look at that fat on their buttocks and hips and say, there's more than I want. I'm going to suck it out. So they do.
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But they don't change their habits. So they're still eating the same way they were before. Essentially, now they have fewer fat cells, but the body wants to store that same amount of fat based on how they're eating. In other words, there's enough insulin telling the body to store a certain amount of fat, and there's enough calories to fuel that fat storage.
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But the fat would be saying, hey, we don't have all these fat cells in the buttocks and hips like we used to. Let's go somewhere else. And so it's no surprise that over the ensuing years after she's had liposuction, not only does she not experience any improvement in any health marker, nothing gets better with regards to her health.
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And that is, again, reflective of the fact that it's the size of the fat cell that matters. Maybe she has lost 10 kilos of fat. That might be a little much for liposuction. Six kilos. And you would say, well, you have six kilos of less fat. Clearly, you're healthier. And yet they're not at all. Nothing has gotten better.
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And then if you follow them over the years, they cannot gain that fat back on their buttocks and hips because it was literally sucked out. And adults have a hard time making new fat cells. So it's no surprise that they start storing more fat in an area that wasn't sucked out, namely their belly.
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And so a woman who's gone through liposuction, yes, she will have lost fat by liposuction at her buttocks and hips, but if she doesn't change her lifestyle habits, the body will take those six kilos and say, well, I need to store those now somewhere else because you're eating in a way that makes me want to store that much fat. And so her remaining fat cells that are intact
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get bigger and store a bigger burden. And so over time, it's no surprise that health outcomes can start to get worse. By having fewer fat cells, she's increasing the burden that the remaining fat cells have to carry. Not only does that result in a change in where she's storing fat, namely storing more on her abdomen, but all the fat cells will get bigger and thus metabolic health can get worse.
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What a fun question. Um, thank you. Um, Probably my wife, frankly. I just adore her. I think about, so when we were newlyweds, we got married quite young, if you'll allow me to be a little personal for a moment. We both really wanted a family. We knew that we wanted to be mom and dad. And she really wanted to be an at-home mom, just full-time mom. which I loved. I benefited.
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It's making your heartbeat a little faster. You're a little more alert. That all starts to play into a stress response. But what those two hormones have in common... is that they both want blood glucose levels to climb. It's kind of their way of saying, hey, we don't really know what's going on right now, but we want to be ready to run away. That's the fight or flight kind of aspect to stress.
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My mother, who died when I was quite young, she was a full-time mom. And most of my memories come from her being home when I would come home from lunch or I had a tummy ache and she would come pick me up. And I mean, I thank God for my mother, of course, but also for the time I had with her because I had so little. And we both really wanted Cheryl to be able to be full-time mom.
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Mom is just that special. That meant, as a young, newly married husband, I was anticipating a future where I would be the sole provider for the family. And it was very daunting, very scary for me as a 23-year-old. That's how old I was when we got married. And I worried, how am I going to provide for my family? And I would look at the trust that my beautiful wife had in me, and I felt inadequate.
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And I have moments where I remember young Ben in his early 20s as a newlywed and how scared I was and how my wife's ongoing devotion put us in a position where I both make a wonderful amount of money to provide for the family and help secure our future.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And then at the same time, still have a schedule that lets me be really home to go home early and help one of our daughters with her homeschooling, which I do, to always not go into work until I've made breakfast for the kids. And we've had some family time. So much of all of it is just the support of my wife, because at any moment, if she would have said, no, I'm done.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
You got to go get a job right now. I would have. I love her and respect her enough and even rely on her insight that I would have done it. But she just really believed that, okay, Ben, you're not dumb. I didn't marry you for your looks. I think you've got something. I'm going to trust you. And that trust was, it was both humbling and scary, but also very empowering.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And it's given us a beautiful life.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
My pleasure. Thank you.
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The Insulin & Glucose Doctor: This Will Strip Fat Faster Than Anything! The Fastest Way To Alzheimer’s! The Link Between Sugar & Cancer! Dr Benjamin Bikman
And so they want to push blood glucose levels up, and they do very well. That, of course, puts them at odds with the hormone insulin. Because these two, epinephrine or adrenaline and cortisol, the two stress hormones, they're pushing glucose up. Insulin wants to push it down.