Daniel Orrego
Appearances
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
Daniel? Indeed. And I am the third co-founder along with Dr. Howard and Dr. Howard at Hippocrates Research Foundation.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
Yeah, it's an essential component, right? In fact, Dr. Seyfried characterizes it as a drug-diet combination. Why is this? Well, as Dr. Howard and Dennis have already mentioned, Using nutrition as a drug, right? Carefully titrating your fat grams, protein grams, carb grams, so that you lower the threshold of available glucose to disease is one component.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
One cannot really do this with the glutamine side. So there's any number of novel substrates out there, such as, you know, sodium phenylbutyrate, you mentioned oxaloacetate, even EGCG has, you know, green tea extract has EGCG. some mild effects in this regard. But it's really the 6-diazo-5-oxo-L-norleucine, otherwise colloquially known as DON, that has the most powerful effects.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
And this is a key component of the pulse side of the PRESS pulse therapy, right? Glucose control is chronic, in other words, every day. And then at interval, one selectively lowers glutamine using the 6-diazo-5-oxo-L-lucine. And what Dennis is mentioning is that this is where what Seyfried talks about in terms of dosing, timing, and scheduling is so important.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
So you get your glucose into that 55 to 65 milligrams per deciliter range, maybe 40 minutes or a few minutes before you go into the hyperbaric chamber, you dose the 6-diazo substrate, right? You may have also included other elements like mabendazole or other substrates like berberine and metformin to further optimize glucose lowering.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
you enter the chamber with all of those elements of the PressPulse protocol on board. And so that is, I think, a comprehensive summary of the level of precision that's required to extract these effects.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
It would be every day? No, it would be at interval. Yeah, so not with the six diazo protocol, you're doing that on every fourth day. And then there's an interval period between dosing. This goes back to the dosing timing and scheduling components. But on the days that you are dosing it, you want to make sure everything is in play, right? You've got your glucose where you want it.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
You've got your other substrates on board. You dose the DON just prior to entering the hyperbaric chamber. Okay, what's happening here? You're metabolically isolating cancer in a way where it's two primary fuel substrates, the glucose and the glutamine, are in short supply.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
You're using mebendazole, whose mechanism of action is to inhibit the formation of microtubules, very important for cellular proliferation. and division within cancer cells. And then you're further impugning tumor viability by massively upregulating reactive oxygen species with the use of hyperbaric oxygen therapy. So this is where you are quite quantifiably producing tumor cell death.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
And the great news is, is one can refer to the magnificent work of Dr. D'Agostino, which demonstrates these mechanisms of action. These are known quantities. Yeah.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
Yeah, that's Dr. Slocum's group at the Chemothermia Clinic. In fact, he's published with Seyfried. So there's already a pre-existing collaboration there. Any number of the people that we've worked with have benefited from going to that clinic, which combines the standard of care with metabolic therapies.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
Yeah, the feeling is always there's more work to do. In other words, it's always important to acknowledge what I like to call progress of a kind, but it's not over. And it's still not over. He's got work to do. We've got work to do. In other words, the task is not, and Dr. Howard put a fine point on this earlier, the task is not to make tumors disappear.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
The standard of care is very effective that you can cut one out, you can burn one out, you can poison one out. That really doesn't contribute very much to overall survivorship. one must consistently and chronically impugn tumor viability in a sustainable fashion that makes the rest of the body healthy. That is the task.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
So when we see improvement in people, yes, acknowledge and immediately back to work. You can never relent your vigilance in this regard. You have to keep your foot on the throttle. at all times. And that doesn't mean that you don't make adjustments, right? You do make adjustments.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
In fact, that's one of the things that sometimes is easy to miss, which is daily, weekly adjustments are part of your response and reaction to facts on the ground. Like, I don't feel well today. Okay, we have to deal with that. Or I have a stressor that I can't do anything about right now, like a cold or a flu. Okay, we have to deal with that. Or I have some other issue.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
Sometimes, you know, people, they have challenges with metastatic progression to the bone and they have ambulatory issues. Okay, that needs to be dealt with. In Dennis's case, he had a pleural effusion, which is an infection of the lung that had to be dealt with. Right.
Dhru Purohit Show
A Controversial Yet Promising Approach to Cancer: Is This The Future of Cancer Treatment?
So one, you know, this is also, I think, important is that, you know, a human cannot be reduced to a glucose number and a ketone number. Right. They're a whole human. You have to deal with them as such. And that is a process of constant attention to detail every day. It's a 24 hour a day endeavor.