Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas
303 | James P. Allison on Fighting Cancer with the Immune System
James P. Allison
After our stuff started coming out, Tosco Hanzo in Japan, plus Arlene Sharp and Gordon Freeman at the Dana-Farber discovered this other checkpoint. C-24 was the first checkpoint. defined as a cell intrinsic, a molecule on the surface of a T cell itself that helps give a negative signal. So the T cell receptor obviously is a positive signal, it's the discharge switch.
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