303 | James P. Allison on Fighting Cancer with the Immune System

2904.335 - 2927.306 James P. Allison

And the people that called it a gas pedal, what they did was they had T cells that put them in culture, activate them, and then add an antibody, and they'd get more. And they said, okay, well, that's a gas pedal. That's what we did earlier in the 80s, showed that CD28s and other molecules, like the gas pedal. So the antigen receptor you could think of is the ignition switch. That's all it is.