291 | Venki Ramakrishnan on the Biology of Death and Aging

4522.956 - 4551.284 Venki Ramakrishnan

And those drugs will often have some of the benefits of caloric restriction, maybe many of the benefits of caloric restriction. One of them called rapamycin was discovered in this very odd way. It has a fascinating history, how it was discovered. But it inhibits a major pathway called the TOR pathway. but which is also restricted by caloric restriction, inhibited by caloric restriction.