Dr. Dale Bredesen
Appearances
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Got on the right diet and did the right, you know, basically resilience, getting herself resilient. And she bought herself about four years or so. Then she started noticing a little bit of backsliding. This was now several years ago. And she contacted me and I said, well, you know, there are some things that haven't been checked on you, and you need to be looking into these other things.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
So it turned out, and she kind of put it off for several months, and it turned out she had Babesia, so a tick-borne illness. And so that was treated and she now improved once again.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Absolutely. And then she found out that she actually had a large mycotoxin exposure. And it was interesting, you know, when I finally convinced her to get a TGF beta one, because that kind of tells you, are you fighting this ongoing inflammation? And you shouldn't have, it shouldn't be more than 2,380. Hers was 40,000.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
So she had massive, massive ongoing inflammation and it turned out to be due to both Babesia and to mycotoxins. And she's done a great job and she's doing well to this day. So unfortunately, yes, you've got to search. This is, you know, you've got to do a little Sherlock Holmes work here to figure out what's actually driving this decline. But the good news is exactly what you said.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Everyone can do the basics. The basics. And everyone can get a response to those basics. But then you're going to want to sustain that response. You're going to want to then continue to target the things that are actually driving the problem.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Yeah, it's a really important point. So if you're 40 or over, we recommend that everyone get a cognoscopy. So we all know when we turn 50, what are we supposed to do? We're supposed to get a colonoscopy, and it can really reduce your risk of dying of colorectal cancer. Of course, pap smears did a tremendous job for reducing cervical cancer.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
So let's talk about those seven basics, if you could walk us through. It's a great point. And you know, the only way for us to be efficient, because you can't do a million-dollar workup on every person. So my argument is, look, everyone do the basics, and then most people will never have a problem. A few people will fall through the cracks. Okay, now they need more evaluation.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
So let's start with the basics, as you said. And those are, start with diet, a plant-rich, mildly ketogenic diet with appropriate periods of fasting.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And by the way, the most common thing I've heard is people say to me, well, you're telling me I gotta go figure out where to buy organic stuff, I gotta figure out what kind of grass-fed beef to get, where to get wild-caught fish, how to prepare all this stuff. This is now getting simpler and simpler, and I give great credit
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
to Nutrition for Longevity, of course, founded by Walter Longo and his partner, Jennifer Maynard. They did a fantastic job. So they have now, starting today literally, put together the KetoFlex 12-3 diet. And this is a diet which is just based on synaptogenesis. How are you going to make and keep your synapses? And yes, it's heart healthy as well.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
By the way, it's also anti-diabetic because it's going to improve your insulin sensitivity. So you can now order meals. I've had them. They're actually delicious. I was impressed with the job that they did. And you mentioned before we started that you've actually been out to their farms.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And by the same token, getting a cognoscopy if you're 40 or over, and especially if there's been any sort of family history, but in general, for all of us, because we are all at risk. It dwarfs the pandemic. We're talking about 1 million who've died in the US from the pandemic. About 45 million of the currently living Americans will die from Alzheimer's if we don't do something about it.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
I couldn't agree more. And actually, you know, Walter is one of my colleagues all the way back from UCLA when we were both starting out. He was actually a graduate student and I was a young assistant professor. And actually, he and I published some papers together with his mentor there, Dr. Joan Valentine. So I really enjoyed Walter from his first day. And it was interesting to me.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
He was the grad student of all the ones I met over the years who knew from day one what he wanted to do, what experiments he wanted to do. Very impressive graduate student. So it's just great to see all the great work that Walter's doing. And I give great kudos to Nutrition for Longevity for coming out with KetoFlex 12-3. And as you mentioned, it's a different strategy.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
So I remember actually when I was on the NIA council, Walter came and presented to us at the NIH and presented his idea. This was many years ago, presented his idea for what became this longevity associated diet. And initially they were using it for cancer related things. And of course it has a nice anti-neoplastic effect.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And this is something that you do intermittently, whereas KetoFlex 12-3 is something that helps your brain every day. So it's a different strategy. And you can do both because you can do the intermittent work, for example, with a fasting-mimicking diet or with a longevity-related diet, as well as doing this mildly ketogenic plant-rich. And yes, it absolutely has protein.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
There's a pescatarian option we have and a flexitarian option. So it does have grass-fed beef and it does have chicken and all that sort of stuff.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
It's fantastic. Yeah. So it's got all these things and we agree that you want to avoid sarcopenia at all costs.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
I'm actually in the middle of reading his book right now. So Brain Energy. Yes. Very interesting work. And he makes a compelling case. And I know he's got data. I'm looking for... that first big series to say, okay, we did this in X number of people and what percentage actually got better. But I agree with you. And actually, Rob Lustig was the one who told me what a wonderful book that was.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And so I got it and I'm reading it right now.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
So again, nobody should get this. There's a tremendous amount you can do. Get a cognoscopy, which is some blood tests and a simple online cognitive test, as you mentioned earlier. and then MRI with volume metrics and some simple things you can do. We talk about the seven basics.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Absolutely. It's interesting to me. He looked at mental illness. We looked at neurodegenerative illness. We came to the same conclusions, that there's a mismatch. Not enough supply, too much demand. In my case, we're looking at demand for synaptogenesis. In his case, he's looking at demand for good mental health, basically. But, you know, you look at, for example, the studies in schizophrenia.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
There is a reduction in the number of synapses. There is a change in the structure of the neurons. So there are things just beyond, you know, DSM. I guess they're up to DSM-5 now, just looking at symptoms. There are functional and structural changes in And so energetics seem to play a large role in both the neurodegenerative side and on the mental health side, as he points out in his book.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And I think they're also gonna turn out to be important in things like autism and ADHD. I mean, all these things are coming to the same conclusion. And I should mention, we were talking about the seven basics just to not forget those. So diet, exercise, sleep, stress, brain training, detox, and some targeted supplements. Those are the basic seven things. And for each of them, we can optimize them.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And then there are things that we've talked about before and you've talked about with others as well. So as you mentioned, you want to have strength training. You want to make sure that's included. As I mentioned earlier, I like EWOT because it's giving you that, not just the aerobic part, but it's also giving you perfusion with oxygenation. So I think that has tremendous potential.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Yeah. So, yeah, you can actually look up. There's a number of these. You can look up Live02, L-I-V-E-O-2, as an example. That's one of them. There are others as well. And it's a facility that you go to? Well, so you can actually have them at home. Okay. Or you can go to facilities. And actually, some clinics are now starting to put them in their clinics because they seem to be so helpful.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
So it's a device. Yeah. So what it's basically doing is you are pedaling a bike or, and then you can use it with cross country if you want, but the typical story is you're pedaling a bike, but instead of being your typical Peloton, you're now pedaling a bike while you're breathing 100% oxygen. So it has similar effects to hyperbaric oxygen without the hyperbaric part of it.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Essentially, you're using the exercise part of it to get the perfusion.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Absolutely. Yeah, that's another way to go. That part doesn't give you the exercise part of it, but it does give you the increased atmospheric pressure. Now, some people have claustrophobia issues with that in some, and again, some of these things are huge, but in the small ones, some people can have some claustrophobic issues and others don't. So that's another way to go. It's E-W-O-T.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
So it's exercise with oxygen therapy. Okay, great. And Live O2 is one example. That's one example. We can put that in the show notes if people want to check it out. And there are others out there as well.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
So I've been doing it without the oxygen just because I haven't gotten to the point where that was a concern and I'm just now looking into getting this because I think my age is getting advanced now and I'm looking at adding that part of it. So I think it's a good idea.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And I should say they can go on, you can look at ketoflex123.com. Ketoflex123. And I think it'll be fantastic for people, whether it's someone in at home, someone at an assisted living facility, someone who's at an independent group like the Villages, someone who's in a nursing home. For any of these people, it's a very simple way and much less expensive than going out for food.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
In fact, in many cases, it's going to be less than going and finding all those things yourself and preparing it yourself.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
It's a great point. And we see yes and no. So I would say what I'm seeing is about a quarter of the people, their doctor will say, sure, I'll do these for you. No problem.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Yeah, or just even oxygenation. Even you can get an oximeter, put it on your finger. You can get an Apple Watch and wear that. You can get an Oura Ring now. You can even Fitbits and things like that. All of these will measure your oxygenation. In a perfect world, you'd have an SpO2, your oxygen saturation, that would remain 96% to 98% while you're sleeping at night.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
For many of us, it starts to drift down, and it can be from sleep apnea, it can be upper airway resistance syndrome, it can be for waking and sleeping. A lot of us will have bursts of adrenaline while we're sleeping, which interferes with deep sleep.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
You could spend hours, and I know Matthew Walker, a professor over at Berkeley, has done a beautiful job with his book, Why We Sleep, in looking at all these issues, because Your ability to get that deep sleep is huge for detoxification for your brain. Your ability to get enough sleep and to get enough quality sleep, get enough REM sleep, all of these are different pieces that are critical.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And so many of the things we do from poor sleep hygiene, staying up too late, having exposure to to EMFs all night, to watching TV late at night, getting activated. I know I am definitely guilty. I'll be doing emails late at night and then try to just shut down the email and go right to sleep. And it does not work very well. So we wanna take some time to ease into sleep.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
We wanna make sure that it's dark enough. We wanna make sure that it's quiet enough. We wanna make sure that we have enough sleep. So many of us, again, you're gonna get more work done if you only get four hours of sleep a night. The very first patient, patient zero,
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
came in and one of her big problems was she was working like crazy for the government and getting four to five hours of sleep per night. That was one of her many issues. And definitely improving that has really helped her. And by the way, she started in 2012. She's now 11 years into this and she's now a brain health coach and doing great.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Yeah, so they're running things, again, which makes sense when you look at what is important for innate immune activation and for energetics. So they're running HSCRP, and they're running homocysteine. And TGF-beta-1 is actually a very good thing to know about yourself, that or MMP9. Again, these are things that are responding typically to biotoxins and other inflammogens.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Yes. Because it's so critical. And so many people will ignore that. And that's an important part of getting optimal outcomes.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Yeah. And so stress. And again, that's another big one. One of the interesting things is as long as you see that threat.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
So we talk about the biochemical threats and the microbiological threats, the P. gingivalis that's worked its way into your brain, the herpes simplex that's gone up your trigeminal nerve into the ganglion and gone up into your brain, the candida that's circulated, the Lyme disease, all these things. But what we tend to forget is there's also a mental stress and threat.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And this is equally important. As long as your brain is saying, I am being assaulted, whether it's by organisms or or inflammations or whether it's by concern that, oh, my gosh, you're going to get fired from your job or some, you know, someone's pushing you to have something do by tonight and you're you're going to be up all night working on it.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
I think about, you know, all the times as an intern when I was up two and three nights in a row without any sleep whatsoever and how horrible that was for me. So that sort of thing is going to give you a problem. So managing the stress and look, check your heart rate. Heart rate variability or HRV, easy to do. And let's see how you do for your age.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And by the way, notice, you can see your heart rate variability jump two or three fold by one minute of slow, deep breathing. It's striking. So telling your amygdala, I'm not dying, I'm not under that much stress, things are gonna be okay. And yeah, short periods of stress with resolution, fine. It's that chronic, oh my God, I've got something to do every day.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
and just keep going, that's a problem. Then we've got brain training, and this is Professor Mike Merzenich, who is the father of brain training, who did a great job, started Posit Neuroscience, has developed BrainHQ, and has worked with Tom Brady and so many others who want to improve. In his case, it was improve his visual field, and it has worked very well for him.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
So improving your cognition and reducing risk for decline, things like brain HQ and stimulation, and by the way, other forms of stimulation, photobiomodulation, great. Things like V-Lite and Neuronic and groups like that have done a really nice job. Mild stimulation in appropriate wavelengths and with appropriate frequencies has been very successful.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Yeah, and your circadian rhythms, huge. And then there is detox. And again, you could spend a lot of time just talking about detox, but there are some basics from filtered water to your elimination, your sweating. The study that's always quoted out of Finland, people who did saunas six days a week versus those who only did them two days a week.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Huge issue, a huge difference in the risk for dementia for that group. So the people who did more saunas, much lower risk of dementia. And the effect was large. And then, so all these sorts of things for detox and making sure that you don't have exposure to toxins.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And again, to go back to Robert Lustig in his excellent book, Metabolical, much of the food that we eat really could not be classified as food. It should be classified as poison. because it doesn't have nutritive value and it does have toxicity in it. So as he pointed out, it's more correctly classified as poison.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And so just getting that detox, getting rid of that, getting on whole foods, plant-rich diet, very helpful. And then finally, some targeted supplements and improving your BDNF with things like whole coffee fruit extract, actually first mentioned to me years ago by David Perlmutter. So thanks to David for that. I think it was an excellent suggestion.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And then you're looking at your HOMA-IR. So you're looking at your fasting glucose, you're looking at your fasting insulin, you're looking at your hemoglobin A1C, you're looking at your methylation. You know, we're now, there are some new things so that you can now look at your epigenetics. And you mentioned earlier the advanced lipid profile.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And many, many people, of course, have used that strategy. Of course, you can also increase it with things like exercise. And then for many of us, we're too low in magnesium, too low in zinc, too low in iodine, too low in potassium, making sure that those are optimized. Many of us are too low in choline and vitamin D as well. So making sure that we're okay there.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And then many of us too low in B12, for example, which will increase your homocysteine, which is again, another risk factor for cognitive decline.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
I take it every day. Yes, absolutely.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Yeah. And again, you can check your RBC magnesium. So again, you kind of want to make sure that you are in the right range and an optimal range.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And it can be a life that will keep you from having cognitive decline until you're 100. I mean, that's our goal is to make everyone get to 100 with good cognition. And you're right. Look, if we just optimize their energetics, get them so that they're doing good exercise and that they have insulin sensitivity
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
and that they don't have chronic inflammation and don't have chronic stress, most people are gonna do very well. And then the few people who begin to have symptoms, do not wait. Do not let your doctor tell you it's normal aging because you don't have to have this with aging. Get in there, get evaluated, and then get optimized for those things.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And that way, most people won't need a lot of evaluation. They can do some basics and do quite well.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
So you're looking at, you know, how are your lipids looking and do you have an inflammatory pattern or not? And then you're looking at, do you have toxin exposure? And we see this a lot where people will have biotoxin exposure, often in association with low platelet counts and or low white blood counts.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And this is something that Dr. Joe Pizzorno has pointed out many times in the past, that many of us are exposed to toxins. And one of the things that we see and that we don't often pick up as physicians, is that people will have often low white counts and or low platelet counts. And it's telling you there's something that is interfering with these.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Great point. So if you go back, the toxins that cause cognitive decline break down into three groups. There's the inorganics, and that's air pollution, and mercury, and things like that, heavy metals. Because actually, not only does amyloid, not only is it part of your innate immune system, it is a metal-binding protein, actually quite tightly. So it binds zinc and copper extremely well.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Secondly, organic toxins. So things like formaldehyde and glyphosate and toluene and things like that. But then thirdly, as you mentioned, biotoxins. And these are typically things made by molds, although there are other organisms that make biotoxins as well, but they're typically trichothecines. Those are the ones that I worry about the most because these are made typically by Stachybotrys.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Um, so it's, you know, the, the, the, the five big mold species that you worry about with these are stachybotrys, penicillium, aspergillia, aspergillus, um, ketomium, and walemia. Those are the five typical bad guys. Uh, and so, and they're making things like trichothecines and ocratoxin A and gliotoxin, uh, and things like that, that actually turn out to impact your immune system.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And you know, you're, The mold wants your immune system to be turned down so that it can live, so that it can stay there. And so it is trying to turn that down, unfortunately. And of course, your immune system is saying, no, I want to recognize this and I want to get rid of it. So these are ones that I am most concerned about.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
It's such an interesting point. And, you know, it reminds me of these old movies you see, you know, where there are 10 people and it's a rainy night and they're in a hotel together. And then suddenly there are only nine. One of them gets killed and then there's eight. And, you know, they keep looking at each other to say, who is the murderer here?
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
You know, you're looking at this, now there's seven. Murder mysteries, just like there's one with John Cusack years ago. And so the mold's a little bit like that. It's like, we're looking around like, what is causing this decline? Like, could it possibly be this mold that like is everywhere? And, you know, it kills me to say that it does seem to be a common contributor.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
I asked the physicians who were doing the trial, what percentage of your patients do you think mycotoxins are a contributor? The answer was 80%. I couldn't believe it. So now that's not to say it's the only contributor. It's one of many.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
Would they put it in the top five? Yeah, I think for sure it would be in the top five. I think in many it would be in the top three. What we find, we published this years ago, that probably 15 to 20%, it's the main thing. It's the main thing. It's the thing that you're really out of focus.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
But Dr. Christine Burke over here near Sacramento, I thought made a really interesting observation and others have seen this, but I think she brought up a really good point. which is when she sees her patients and she does exactly the things you're talking about, she gets them to be metabolically flexible, she gets them to do the basics. We started talking about the basic seven.
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
So when she does the basic things, she buys them nine to 12 months, they do well. And then after that, if she doesn't find the specifics that are causing this, if she doesn't find, oh, there's pathogens that I need to deal with, or there's mycotoxins, if they don't deal with those specifics, they won't sustain that improvement. But I thought it was a very important observation
Dhru Purohit Show
How to Make It To 100 With A Sharp Brain And Good Mobility
And we've seen it before. And Julie Gee, who works with us and who herself is APOE4 for, she's the one who founded the website, APOE4.info, and has done such a wonderful job and has taken herself from 35th percentile to 98th percentile. She's sharp as a tack. And she's now over 10 years on this overall approach. She had about four years. So she was doing things, you know, really, really well.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
It's a growing problem. When I was training many years ago, we never saw people in their 40s, 50s. This was a disease of late 60s, 70s, 80s, 90s. Now, one of the most common things we see is people who are in their 40s or 50s who are getting diagnosed with Alzheimer's. So yes, we're getting a little better at diagnosing it for sure.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
There are new blood tests, et cetera, but there's no question it is on the increase in these young groups.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
It is possible. That's one of the many things, you know, we're hearing from RFK about all these different things. One of the issues is, what are we doing about metabolism? We do not have an optimum, as you know, we do not have an optimal metabolism in most people in this country. too much high-carb food, too much ultra-processed food, and a lot of damage, frankly, to our metabolic systems.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
And so this is one of the possibilities. And there are other things as well. There are things you can do to avoid that. But improving your insulin sensitivity, of course, what Ozempic will do will increase your endogenous insulin as well. The problem, of course, is that there are some side effects, and we don't yet know the long-term effects of using GLP-1s.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
Yeah, it's a great point because they're both. That's the problem. So they have one effect, which is to reduce the overall inflammation. And as I pointed out in the book, which as you know, this book is really about saving synapses for all of us.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
You know, in the US, whether you live to 80, 90, 100, 110, of course, people are trying to push that up far to 140, 160, whatever it is, your lifespan, unfortunately, is not met often by your brain span. So you get to 40 or 50 or 60 and things just collapse, as you know. And so as you indicated, more young people having a problem.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
So this is a time in which you've got to look at what are these different drivers and whether, so what'll happen with the statins? Yes, you lower the inflammation, which by the way, you can do with other things. You don't need statins to do that. But you also lower the support for the brain. You lower the cholesterol. And to be fair, you make some in the brain as well.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
But if you use a statin, if you have to do that, and we recommend you do other things first. There are things like Zetia and Bergamot and just changing your diet and exercise. A lot of things you can do before you ever need statins. And there are also things beyond. PCSK9 inhibitors can be even better than this.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
But if you're going to use a statin, use one that would be called a hydrophilic statin, that would be like a Crestor, instead of one that is a hydrophobic statin, which would be like a Lipitor.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
Yeah, it's a great point. And for some people, it'll be okay. But here's the problem. When you have any sort of dairy can produce some degree of inflammation. So if you've got someone who already has some degree of cognitive decline, or if you're trying to optimize your brain span, then you want to take that into account. You want to get rid of grains, which can damage your lining of your gut.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
You want to get rid of dairy. And it's not to say you can't slowly reintroduce it in the future. But you have to remember, when you see someone who's beginning to have some cognitive decline, only one of two things will happen. Either you will help them to improve, and we've published that many times, or they will die. They will go on to develop Alzheimer's disease and pass away.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
So we want to do everything possible. We want to pull out all the stops to get the optimal reversal of cognitive decline. And we were the first to publish that back in 2014.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
uh and so that does we want to do everything possible that includes getting rid of some grains that includes getting rid of dairy and includes getting rid of simple carbs and then you want to have a plant-rich mildly ketogenic diet you want to have appropriate exercise as you said and just go right down the list managing stress optimizing sleep these are things that people aren't doing when i ask people you know how much did you sleep last night what did your wearable show for your sleep
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
They don't know. So you want to have at least seven hours of sleep at night. You want to have at least an hour and a half of REM each night. You want to have at least one hour of deep sleep each night. And you want to have an oxygen concentration saturation in your blood of at least 94 percent while you're sleeping. So many people don't have that.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
So they are getting this is why the brain span in America does not equal the lifespan in America. And that's something that clearly can be improved.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
Yeah, it's a great point. So there's so much now for all of these things that we know that we didn't know even just a few years ago. So as you said, HIIT, this high intensity interval training has turned out to be the one that seems to be the most effective at reducing your risk for cognitive decline. But then beyond that, there are things like Katsu bands.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
These are restriction bands you can put on your arms and your legs. And what they do is they actually give you more bang for your buck because what happens, Megan, is you get different mechanisms. So when you do strength training, you are improving your insulin sensitivity, which is critical for your brain and critical for preventing cognitive decline of Alzheimer's disease.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
On the other hand, when you do the aerobic training, you are improving blood flow and oxygenation. This is one of the reasons something called EWOT is so helpful, which is exercise with oxygen therapy. EWOT gives you better blood flow and better oxygenation at the same time. So many people find this very helpful.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
So there's a lot of new understanding about what works the best and what are things that are available to get best outcomes in that area.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
So the big three are things that are in organics, and that would be things like air pollution, we know is a huge issue, and that's been published repeatedly as increasing risk for Alzheimer's disease. Here in California, the California fires, big issue. Also things like mercury amalgams, things like that. So those are all under the in organics.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
Then these, the organics, and that's things like anesthetic agents. People have these long anesthetic procedures and then start to go downhill after that. So you need to detox from that. Things like benzene, toluene, glyphosate, all of those are in the organic group. And then finally the biotoxin group.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
And again, this is something that hasn't even been recognized, hasn't been talked about nearly enough. There are biotoxins that we live with things like trichothecines and opratoxin A. And these are things that are typically made by different mold species. And as you know, Megan, one of the ones that's been talked about a lot lately on the organic part is microplastics.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
There is increasing evidence that, number one, we're all exposed to these things. They're in the air, they're in the water, they're in the food, things like that. What we know now is that they concentrate in your brain. We are all exposed to and ingesting, on average, one credit card worth of microplastics each week. So the increase in our exposure has been dramatic.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
Yeah, so there are a couple of things. So air filters, things like HEPA filters for your home, very helpful. In addition, you could now undergo things like plasma exchange. Plasma phoresis will reduce this by about 70%, dramatic reductions. In these, whether you do through plasmapheresis, you can also do it through things like sauna and sweating, followed by showers with non-toxic soaps.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
So there are lots of ways to get at this. Increasing your glutathione level, you can take things like NAC and acetylcysteine, or S-acetylglutathione, any of these sorts of things. Some people will actually go and get IVs with glutathione in them. Something called the PK protocol could be very helpful. So on and on and on, there are things that can be done.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
But as you said, you've got to recognize this. You've got to know that we are exposed to this. And we now know that they do concentrate in the brain more than the liver, more than the kidney. And we know that they're associated. Your level of microplastics is associated with your risk for cognitive decline. What's not clear yet is whether these are causal or simply in effect.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
It may be that as you're getting dementia, you allow them into your brain more. That's not been clear yet. So the concern at the moment is that these probably are part of the overall causation of risk for cognitive decline.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
Absolutely. And in fact, we're rapidly getting to a point where we are able to make sure that nobody gets this. So here's the big problem, Megan. The current standard of care in medicine has got the biggest gap in history between what is being done with the standard of care and what is actually possible and available.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
You just mentioned today that you had your home renovated because it was full of mold. Who's doing that? Not very many people are doing that. There is so much that this gap is what we hope is going to be addressed by the new administration.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
You know, when you hear RFK talk about peptides, about bioidentical hormones, about stem cells, about all of these things that have not been the standard of care, what's available today is far more than what is being utilized. And our health is suffering for it.
The Megyn Kelly Show
Megyn's Response to Clooney, Hegseth Saga Gets Personal, and Stopping Alzheimer's, with Rich Lowry, MBD, and Dr. Dale Bredesen | Ep. 1055
Thank you, Megan. Great to talk to you as always.